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Protein

Zinc finger protein 671

Gene

ZNF671

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri192 – 21423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 671
Gene namesi
Name:ZNF671
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26279. ZNF671.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670518.

Polymorphism and mutation databases

BioMutaiZNF671.
DMDMi229462791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Zinc finger protein 671PRO_0000233990Add
BLAST

Proteomic databases

PaxDbiQ8TAW3.
PRIDEiQ8TAW3.

PTM databases

PhosphoSiteiQ8TAW3.

Expressioni

Gene expression databases

BgeeiQ8TAW3.
CleanExiHS_ZNF671.
ExpressionAtlasiQ8TAW3. baseline and differential.
GenevisibleiQ8TAW3. HS.

Organism-specific databases

HPAiHPA046099.

Interactioni

Protein-protein interaction databases

BioGridi122975. 3 interactions.
IntActiQ8TAW3. 1 interaction.
MINTiMINT-8247557.
STRINGi9606.ENSP00000321848.

Structurei

3D structure databases

ProteinModelPortaliQ8TAW3.
SMRiQ8TAW3. Positions 164-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12072KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri192 – 21423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAW3.
KOiK09228.
OMAiGEEPWVY.
PhylomeDBiQ8TAW3.
TreeFamiTF342033.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPVSRDAS DALQGRKCLR PRSRRLPLPA AVRAHGPMAE LTDSARGCVV
60 70 80 90 100
FEDVFVYFSR EEWELLDDAQ RLLYHDVMLE NFALLASLGI AFSRSRAVMK
110 120 130 140 150
LERGEEPWVY DQVDMTSATE REAQRGLRPG CWHGVEDEEV SSEQSIFVAG
160 170 180 190 200
VSEVRTLMAE LESHPCDICG PILKDTLHLA KYHGGKARQK PYLCGACGKQ
210 220 230 240 250
FWFSTDFDQH QNQPNGGKLF PRKEGRDSVK SCRVHVPEKT LTCGKGRRDF
260 270 280 290 300
SATSGLLQHQ ASLSSMKPHK STKLVSGFLM GQRYHRCGEC GKAFTRKDTL
310 320 330 340 350
ARHQRIHTGE RPYECNECGK FFSQSYDLFK HQTVHTGERP YECSECGKFF
360 370 380 390 400
RQISGLIEHR RVHTGERLYQ CGKCGKFFSS KSNLIRHQEV HTGARPYVCS
410 420 430 440 450
ECGKEFSRKH TLVLHQRTHT GERPYECSEC GKAFSQSSHL NVHWRIHSSD
460 470 480 490 500
YECSRCGKAF SCISKLIQHQ KVHSGEKPYE CSKCGKAFTQ RPNLIRHWKV
510 520 530
HTGERPYVCS ECGREFIRKQ TLVLHQRVHA GEKL
Length:534
Mass (Da):60,972
Last modified:May 5, 2009 - v2
Checksum:i701BC2C02BC95124
GO

Sequence cautioni

The sequence AAH25728.1 differs from that shown. Reason: Frameshift at position 534. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491A → V.1 Publication
Corresponds to variant rs3746207 [ dbSNP | Ensembl ].
VAR_026151
Natural varianti237 – 2371P → S.
Corresponds to variant rs34419645 [ dbSNP | Ensembl ].
VAR_055240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027159 mRNA. Translation: BAB15677.1.
AC003006 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72529.1.
BC025728 mRNA. Translation: AAH25728.1. Frameshift.
CCDSiCCDS12961.1.
RefSeqiNP_079109.2. NM_024833.2.
UniGeneiHs.180402.

Genome annotation databases

EnsembliENST00000317398; ENSP00000321848; ENSG00000083814.
GeneIDi79891.
KEGGihsa:79891.
UCSCiuc002qpz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027159 mRNA. Translation: BAB15677.1.
AC003006 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72529.1.
BC025728 mRNA. Translation: AAH25728.1. Frameshift.
CCDSiCCDS12961.1.
RefSeqiNP_079109.2. NM_024833.2.
UniGeneiHs.180402.

3D structure databases

ProteinModelPortaliQ8TAW3.
SMRiQ8TAW3. Positions 164-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122975. 3 interactions.
IntActiQ8TAW3. 1 interaction.
MINTiMINT-8247557.
STRINGi9606.ENSP00000321848.

PTM databases

PhosphoSiteiQ8TAW3.

Polymorphism and mutation databases

BioMutaiZNF671.
DMDMi229462791.

Proteomic databases

PaxDbiQ8TAW3.
PRIDEiQ8TAW3.

Protocols and materials databases

DNASUi79891.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317398; ENSP00000321848; ENSG00000083814.
GeneIDi79891.
KEGGihsa:79891.
UCSCiuc002qpz.4. human.

Organism-specific databases

CTDi79891.
GeneCardsiGC19M058231.
HGNCiHGNC:26279. ZNF671.
HPAiHPA046099.
neXtProtiNX_Q8TAW3.
PharmGKBiPA142670518.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAW3.
KOiK09228.
OMAiGEEPWVY.
PhylomeDBiQ8TAW3.
TreeFamiTF342033.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79891.
NextBioi69710.
PROiQ8TAW3.

Gene expression databases

BgeeiQ8TAW3.
CleanExiHS_ZNF671.
ExpressionAtlasiQ8TAW3. baseline and differential.
GenevisibleiQ8TAW3. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-149.
    Tissue: Lung.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiZN671_HUMAN
AccessioniPrimary (citable) accession number: Q8TAW3
Secondary accession number(s): A6NF07, Q9H5E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 5, 2009
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.