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Q8TAW3

- ZN671_HUMAN

UniProt

Q8TAW3 - ZN671_HUMAN

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Protein
Zinc finger protein 671
Gene
ZNF671
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri192 – 21423C2H2-type 1; degenerate
Add
BLAST
Zinc fingeri285 – 30723C2H2-type 2
Add
BLAST
Zinc fingeri313 – 33523C2H2-type 3
Add
BLAST
Zinc fingeri341 – 36323C2H2-type 4
Add
BLAST
Zinc fingeri369 – 39123C2H2-type 5
Add
BLAST
Zinc fingeri397 – 41923C2H2-type 6
Add
BLAST
Zinc fingeri425 – 44723C2H2-type 7
Add
BLAST
Zinc fingeri451 – 47323C2H2-type 8
Add
BLAST
Zinc fingeri479 – 50123C2H2-type 9
Add
BLAST
Zinc fingeri507 – 52923C2H2-type 10
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 671
Gene namesi
Name:ZNF671
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26279. ZNF671.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Zinc finger protein 671
PRO_0000233990Add
BLAST

Proteomic databases

PaxDbiQ8TAW3.
PRIDEiQ8TAW3.

PTM databases

PhosphoSiteiQ8TAW3.

Expressioni

Gene expression databases

ArrayExpressiQ8TAW3.
BgeeiQ8TAW3.
CleanExiHS_ZNF671.
GenevestigatoriQ8TAW3.

Organism-specific databases

HPAiHPA046099.

Interactioni

Protein-protein interaction databases

BioGridi122975. 2 interactions.
IntActiQ8TAW3. 1 interaction.
MINTiMINT-8247557.

Structurei

3D structure databases

ProteinModelPortaliQ8TAW3.
SMRiQ8TAW3. Positions 164-534.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12072KRAB
Add
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAW3.
KOiK09228.
OMAiFPRKEGR.
PhylomeDBiQ8TAW3.
TreeFamiTF342033.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAW3-1 [UniParc]FASTAAdd to Basket

« Hide

MLSPVSRDAS DALQGRKCLR PRSRRLPLPA AVRAHGPMAE LTDSARGCVV    50
FEDVFVYFSR EEWELLDDAQ RLLYHDVMLE NFALLASLGI AFSRSRAVMK 100
LERGEEPWVY DQVDMTSATE REAQRGLRPG CWHGVEDEEV SSEQSIFVAG 150
VSEVRTLMAE LESHPCDICG PILKDTLHLA KYHGGKARQK PYLCGACGKQ 200
FWFSTDFDQH QNQPNGGKLF PRKEGRDSVK SCRVHVPEKT LTCGKGRRDF 250
SATSGLLQHQ ASLSSMKPHK STKLVSGFLM GQRYHRCGEC GKAFTRKDTL 300
ARHQRIHTGE RPYECNECGK FFSQSYDLFK HQTVHTGERP YECSECGKFF 350
RQISGLIEHR RVHTGERLYQ CGKCGKFFSS KSNLIRHQEV HTGARPYVCS 400
ECGKEFSRKH TLVLHQRTHT GERPYECSEC GKAFSQSSHL NVHWRIHSSD 450
YECSRCGKAF SCISKLIQHQ KVHSGEKPYE CSKCGKAFTQ RPNLIRHWKV 500
HTGERPYVCS ECGREFIRKQ TLVLHQRVHA GEKL 534
Length:534
Mass (Da):60,972
Last modified:May 5, 2009 - v2
Checksum:i701BC2C02BC95124
GO

Sequence cautioni

The sequence AAH25728.1 differs from that shown. Reason: Frameshift at position 534.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491A → V.1 Publication
Corresponds to variant rs3746207 [ dbSNP | Ensembl ].
VAR_026151
Natural varianti237 – 2371P → S.
Corresponds to variant rs34419645 [ dbSNP | Ensembl ].
VAR_055240

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027159 mRNA. Translation: BAB15677.1.
AC003006 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72529.1.
BC025728 mRNA. Translation: AAH25728.1. Frameshift.
CCDSiCCDS12961.1.
RefSeqiNP_079109.2. NM_024833.2.
UniGeneiHs.180402.

Genome annotation databases

EnsembliENST00000317398; ENSP00000321848; ENSG00000083814.
GeneIDi79891.
KEGGihsa:79891.
UCSCiuc002qpz.4. human.

Polymorphism databases

DMDMi229462791.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027159 mRNA. Translation: BAB15677.1 .
AC003006 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72529.1 .
BC025728 mRNA. Translation: AAH25728.1 . Frameshift.
CCDSi CCDS12961.1.
RefSeqi NP_079109.2. NM_024833.2.
UniGenei Hs.180402.

3D structure databases

ProteinModelPortali Q8TAW3.
SMRi Q8TAW3. Positions 164-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122975. 2 interactions.
IntActi Q8TAW3. 1 interaction.
MINTi MINT-8247557.

PTM databases

PhosphoSitei Q8TAW3.

Polymorphism databases

DMDMi 229462791.

Proteomic databases

PaxDbi Q8TAW3.
PRIDEi Q8TAW3.

Protocols and materials databases

DNASUi 79891.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317398 ; ENSP00000321848 ; ENSG00000083814 .
GeneIDi 79891.
KEGGi hsa:79891.
UCSCi uc002qpz.4. human.

Organism-specific databases

CTDi 79891.
GeneCardsi GC19M058231.
HGNCi HGNC:26279. ZNF671.
HPAi HPA046099.
neXtProti NX_Q8TAW3.
PharmGKBi PA142670518.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8TAW3.
KOi K09228.
OMAi FPRKEGR.
PhylomeDBi Q8TAW3.
TreeFami TF342033.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 79891.
NextBioi 69710.
PROi Q8TAW3.

Gene expression databases

ArrayExpressi Q8TAW3.
Bgeei Q8TAW3.
CleanExi HS_ZNF671.
Genevestigatori Q8TAW3.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-149.
    Tissue: Lung.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiZN671_HUMAN
AccessioniPrimary (citable) accession number: Q8TAW3
Secondary accession number(s): A6NF07, Q9H5E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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