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Protein

Stomatin-like protein 3

Gene

STOML3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stomatin-like protein 3
Short name:
SLP-3
Gene namesi
Name:STOML3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:19420. STOML3.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type III membrane protein By similarity

  • Note: Detected in lipid rafts.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini50 – 291242CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939552.

Polymorphism and mutation databases

BioMutaiSTOML3.
DMDMi60415939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Stomatin-like protein 3PRO_0000094033Add
BLAST

Proteomic databases

EPDiQ8TAV4.
PaxDbiQ8TAV4.
PeptideAtlasiQ8TAV4.
PRIDEiQ8TAV4.

PTM databases

iPTMnetiQ8TAV4.
PhosphoSiteiQ8TAV4.
SwissPalmiQ8TAV4.

Expressioni

Gene expression databases

BgeeiQ8TAV4.
CleanExiHS_STOML3.
GenevisibleiQ8TAV4. HS.

Organism-specific databases

HPAiCAB014880.
HPA012892.

Interactioni

Subunit structurei

Homodimer. Interacts with PIEZO1 and PIEZO2.By similarity

Protein-protein interaction databases

BioGridi127771. 1 interaction.
STRINGi9606.ENSP00000368952.

Structurei

3D structure databases

ProteinModelPortaliQ8TAV4.
SMRiQ8TAV4. Positions 86-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000217040.
HOVERGENiHBG004815.
InParanoidiQ8TAV4.
KOiK17286.
OMAiSIWACIK.
OrthoDBiEOG78D7KJ.
PhylomeDBiQ8TAV4.
TreeFamiTF105750.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR028519. SLP3.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF49. PTHR10264:SF49. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSRVSSPEK QDKENFVGVN NKRLGVCGWI LFSLSFLLVI ITFPISIWMC
60 70 80 90 100
LKIIKEYERA VVFRLGRIQA DKAKGPGLIL VLPCIDVFVK VDLRTVTCNI
110 120 130 140 150
PPQEILTRDS VTTQVDGVVY YRIYSAVSAV ANVNDVHQAT FLLAQTTLRN
160 170 180 190 200
VLGTQTLSQI LAGREEIAHS IQTLLDDATE LWGIRVARVE IKDVRIPVQL
210 220 230 240 250
QRSMAAEAEA TREARAKVLA AEGEMNASKS LKSASMVLAE SPIALQLRYL
260 270 280 290
QTLSTVATEK NSTIVFPLPM NILEGIGGVS YDNHKKLPNK A
Length:291
Mass (Da):32,135
Last modified:June 1, 2002 - v1
Checksum:iB51A7DD5E96E1935
GO
Isoform 2 (identifier: Q8TAV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MDSRVSSPEKQDKENF → MNSRGEL

Note: No experimental confirmation available.
Show »
Length:282
Mass (Da):31,044
Checksum:i28522DDC2A2D6627
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616MDSRV…DKENF → MNSRGEL in isoform 2. 1 PublicationVSP_042937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304159 mRNA. Translation: BAG65047.1.
AL445590 Genomic DNA. Translation: CAI40973.1.
BC025760 mRNA. Translation: AAH25760.1.
CCDSiCCDS45040.1. [Q8TAV4-2]
CCDS9367.1. [Q8TAV4-1]
RefSeqiNP_001137505.1. NM_001144033.1. [Q8TAV4-2]
NP_660329.1. NM_145286.2. [Q8TAV4-1]
UniGeneiHs.327794.

Genome annotation databases

EnsembliENST00000379631; ENSP00000368952; ENSG00000133115. [Q8TAV4-1]
ENST00000423210; ENSP00000401989; ENSG00000133115. [Q8TAV4-2]
GeneIDi161003.
KEGGihsa:161003.
UCSCiuc001uwx.4. human. [Q8TAV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304159 mRNA. Translation: BAG65047.1.
AL445590 Genomic DNA. Translation: CAI40973.1.
BC025760 mRNA. Translation: AAH25760.1.
CCDSiCCDS45040.1. [Q8TAV4-2]
CCDS9367.1. [Q8TAV4-1]
RefSeqiNP_001137505.1. NM_001144033.1. [Q8TAV4-2]
NP_660329.1. NM_145286.2. [Q8TAV4-1]
UniGeneiHs.327794.

3D structure databases

ProteinModelPortaliQ8TAV4.
SMRiQ8TAV4. Positions 86-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127771. 1 interaction.
STRINGi9606.ENSP00000368952.

PTM databases

iPTMnetiQ8TAV4.
PhosphoSiteiQ8TAV4.
SwissPalmiQ8TAV4.

Polymorphism and mutation databases

BioMutaiSTOML3.
DMDMi60415939.

Proteomic databases

EPDiQ8TAV4.
PaxDbiQ8TAV4.
PeptideAtlasiQ8TAV4.
PRIDEiQ8TAV4.

Protocols and materials databases

DNASUi161003.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379631; ENSP00000368952; ENSG00000133115. [Q8TAV4-1]
ENST00000423210; ENSP00000401989; ENSG00000133115. [Q8TAV4-2]
GeneIDi161003.
KEGGihsa:161003.
UCSCiuc001uwx.4. human. [Q8TAV4-1]

Organism-specific databases

CTDi161003.
GeneCardsiSTOML3.
HGNCiHGNC:19420. STOML3.
HPAiCAB014880.
HPA012892.
MIMi608327. gene.
neXtProtiNX_Q8TAV4.
PharmGKBiPA134939552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000217040.
HOVERGENiHBG004815.
InParanoidiQ8TAV4.
KOiK17286.
OMAiSIWACIK.
OrthoDBiEOG78D7KJ.
PhylomeDBiQ8TAV4.
TreeFamiTF105750.

Miscellaneous databases

ChiTaRSiSTOML3. human.
GenomeRNAii161003.
PROiQ8TAV4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAV4.
CleanExiHS_STOML3.
GenevisibleiQ8TAV4. HS.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR028519. SLP3.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF49. PTHR10264:SF49. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiSTML3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAV4
Secondary accession number(s): B4E285, Q5JS35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.