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Protein

Stomatin-like protein 3

Gene

STOML3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Protein family/group databases

TCDBi8.A.21.1.3. the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Stomatin-like protein 3
Short name:
SLP-3
Gene namesi
Name:STOML3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000133115.11.
HGNCiHGNC:19420. STOML3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini50 – 291CytoplasmicSequence analysisAdd BLAST242

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi161003.
OpenTargetsiENSG00000133115.
PharmGKBiPA134939552.

Polymorphism and mutation databases

BioMutaiSTOML3.
DMDMi60415939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940331 – 291Stomatin-like protein 3Add BLAST291

Proteomic databases

EPDiQ8TAV4.
MaxQBiQ8TAV4.
PaxDbiQ8TAV4.
PeptideAtlasiQ8TAV4.
PRIDEiQ8TAV4.

PTM databases

iPTMnetiQ8TAV4.
PhosphoSitePlusiQ8TAV4.
SwissPalmiQ8TAV4.

Expressioni

Gene expression databases

BgeeiENSG00000133115.
CleanExiHS_STOML3.
GenevisibleiQ8TAV4. HS.

Organism-specific databases

HPAiCAB014880.
HPA012892.

Interactioni

Subunit structurei

Homodimer. Interacts with PIEZO1 and PIEZO2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
UPK2O005264EBI-12900395,EBI-10179682

Protein-protein interaction databases

BioGridi127771. 1 interactor.
IntActiQ8TAV4. 6 interactors.
STRINGi9606.ENSP00000368952.

Structurei

3D structure databases

ProteinModelPortaliQ8TAV4.
SMRiQ8TAV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000217040.
HOVERGENiHBG004815.
InParanoidiQ8TAV4.
KOiK17286.
OMAiYYRIHSA.
OrthoDBiEOG091G0G9K.
PhylomeDBiQ8TAV4.
TreeFamiTF105750.

Family and domain databases

InterProiView protein in InterPro
IPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR028519. SLP3.
IPR001972. Stomatin_fam.
PANTHERiPTHR10264:SF101. PTHR10264:SF101. 1 hit.
PfamiView protein in Pfam
PF01145. Band_7. 1 hit.
PRINTSiPR00721. STOMATIN.
SMARTiView protein in SMART
SM00244. PHB. 1 hit.
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiView protein in PROSITE
PS01270. BAND_7. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSRVSSPEK QDKENFVGVN NKRLGVCGWI LFSLSFLLVI ITFPISIWMC
60 70 80 90 100
LKIIKEYERA VVFRLGRIQA DKAKGPGLIL VLPCIDVFVK VDLRTVTCNI
110 120 130 140 150
PPQEILTRDS VTTQVDGVVY YRIYSAVSAV ANVNDVHQAT FLLAQTTLRN
160 170 180 190 200
VLGTQTLSQI LAGREEIAHS IQTLLDDATE LWGIRVARVE IKDVRIPVQL
210 220 230 240 250
QRSMAAEAEA TREARAKVLA AEGEMNASKS LKSASMVLAE SPIALQLRYL
260 270 280 290
QTLSTVATEK NSTIVFPLPM NILEGIGGVS YDNHKKLPNK A
Length:291
Mass (Da):32,135
Last modified:June 1, 2002 - v1
Checksum:iB51A7DD5E96E1935
GO
Isoform 2 (identifier: Q8TAV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MDSRVSSPEKQDKENF → MNSRGEL

Note: No experimental confirmation available.
Show »
Length:282
Mass (Da):31,044
Checksum:i28522DDC2A2D6627
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0429371 – 16MDSRV…DKENF → MNSRGEL in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304159 mRNA. Translation: BAG65047.1.
AL445590 Genomic DNA. No translation available.
BC025760 mRNA. Translation: AAH25760.1.
CCDSiCCDS45040.1. [Q8TAV4-2]
CCDS9367.1. [Q8TAV4-1]
RefSeqiNP_001137505.1. NM_001144033.1. [Q8TAV4-2]
NP_660329.1. NM_145286.2. [Q8TAV4-1]
UniGeneiHs.327794.

Genome annotation databases

EnsembliENST00000379631; ENSP00000368952; ENSG00000133115. [Q8TAV4-1]
ENST00000423210; ENSP00000401989; ENSG00000133115. [Q8TAV4-2]
GeneIDi161003.
KEGGihsa:161003.
UCSCiuc001uwx.4. human. [Q8TAV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTML3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAV4
Secondary accession number(s): B4E285, Q5JS35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families