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Q8TAV3

- CP2W1_HUMAN

UniProt

Q8TAV3 - CP2W1_HUMAN

Protein

Cytochrome P450 2W1

Gene

CYP2W1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi433 – 4331Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    GO - Biological processi

    1. small molecule metabolic process Source: Reactome
    2. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13425. Miscellaneous substrates.
    REACT_13543. Xenobiotics.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2W1 (EC:1.14.14.-)
    Alternative name(s):
    CYPIIW1
    Gene namesi
    Name:CYP2W1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:20243. CYP2W1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134992665.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2W1PRO_0000051782Add
    BLAST

    Proteomic databases

    MaxQBiQ8TAV3.
    PaxDbiQ8TAV3.
    PRIDEiQ8TAV3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TAV3.
    BgeeiQ8TAV3.
    CleanExiHS_CYP2W1.
    GenevestigatoriQ8TAV3.

    Organism-specific databases

    HPAiHPA012753.

    Interactioni

    Protein-protein interaction databases

    BioGridi120251. 2 interactions.
    IntActiQ8TAV3. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAV3.
    SMRiQ8TAV3. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiQ8TAV3.
    KOiK07423.
    OMAiPARAFTM.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ8TAV3.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS    50
    QQDRSLMELS ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP 100
    PIAIFQLIQR GGGIFFSSGA RWRAARQFTV RALHSLGVGR EPVADKILQE 150
    LKCLSGQLDG YRGRPFPLAL LGWAPSNITF ALLFGRRFDY RDPVFVSLLG 200
    LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV RAILRTLLEA 250
    RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET 300
    TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV 350
    LHEVQRFITL LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ 400
    TPGQFNPGHF LDANGHFVKR EAFLPFSAGR RVCVGERLAR TELFLLFAGL 450
    LQRYRLLPPP GVSPASLDTT PARAFTMRPR AQALCAVPRP 490
    Length:490
    Mass (Da):53,844
    Last modified:September 5, 2006 - v2
    Checksum:iBB84B2F1FEFEF5BC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti181 – 1811A → T.
    Corresponds to variant rs3735684 [ dbSNP | Ensembl ].
    VAR_027413

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC025761 mRNA. Translation: AAH25761.2.
    CCDSiCCDS5319.2.
    RefSeqiNP_060251.2. NM_017781.2.
    XP_005249849.1. XM_005249792.1.
    UniGeneiHs.272795.

    Genome annotation databases

    EnsembliENST00000308919; ENSP00000310149; ENSG00000073067.
    GeneIDi54905.
    KEGGihsa:54905.
    UCSCiuc003sjq.1. human.

    Polymorphism databases

    DMDMi114152790.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC025761 mRNA. Translation: AAH25761.2 .
    CCDSi CCDS5319.2.
    RefSeqi NP_060251.2. NM_017781.2.
    XP_005249849.1. XM_005249792.1.
    UniGenei Hs.272795.

    3D structure databases

    ProteinModelPortali Q8TAV3.
    SMRi Q8TAV3. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120251. 2 interactions.
    IntActi Q8TAV3. 2 interactions.

    Chemistry

    ChEMBLi CHEMBL2406897.

    Polymorphism databases

    DMDMi 114152790.

    Proteomic databases

    MaxQBi Q8TAV3.
    PaxDbi Q8TAV3.
    PRIDEi Q8TAV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308919 ; ENSP00000310149 ; ENSG00000073067 .
    GeneIDi 54905.
    KEGGi hsa:54905.
    UCSCi uc003sjq.1. human.

    Organism-specific databases

    CTDi 54905.
    GeneCardsi GC07P001022.
    HGNCi HGNC:20243. CYP2W1.
    HPAi HPA012753.
    neXtProti NX_Q8TAV3.
    PharmGKBi PA134992665.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi Q8TAV3.
    KOi K07423.
    OMAi PARAFTM.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q8TAV3.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_13425. Miscellaneous substrates.
    REACT_13543. Xenobiotics.

    Miscellaneous databases

    GeneWikii CYP2W1.
    GenomeRNAii 54905.
    NextBioi 57946.
    PROi Q8TAV3.

    Gene expression databases

    ArrayExpressi Q8TAV3.
    Bgeei Q8TAV3.
    CleanExi HS_CYP2W1.
    Genevestigatori Q8TAV3.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCP2W1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3