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Q8TAV3

- CP2W1_HUMAN

UniProt

Q8TAV3 - CP2W1_HUMAN

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Protein

Cytochrome P450 2W1

Gene

CYP2W1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi433 – 4331Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

GO - Biological processi

  1. small molecule metabolic process Source: Reactome
  2. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13425. Miscellaneous substrates.
REACT_13543. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2W1 (EC:1.14.14.-)
Alternative name(s):
CYPIIW1
Gene namesi
Name:CYP2W1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:20243. CYP2W1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2W1PRO_0000051782Add
BLAST

Proteomic databases

MaxQBiQ8TAV3.
PaxDbiQ8TAV3.
PRIDEiQ8TAV3.

Expressioni

Gene expression databases

BgeeiQ8TAV3.
CleanExiHS_CYP2W1.
ExpressionAtlasiQ8TAV3. baseline and differential.
GenevestigatoriQ8TAV3.

Organism-specific databases

HPAiHPA012753.

Interactioni

Protein-protein interaction databases

BioGridi120251. 4 interactions.
IntActiQ8TAV3. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8TAV3.
SMRiQ8TAV3. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ8TAV3.
KOiK07423.
OMAiPARAFTM.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ8TAV3.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS
60 70 80 90 100
QQDRSLMELS ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP
110 120 130 140 150
PIAIFQLIQR GGGIFFSSGA RWRAARQFTV RALHSLGVGR EPVADKILQE
160 170 180 190 200
LKCLSGQLDG YRGRPFPLAL LGWAPSNITF ALLFGRRFDY RDPVFVSLLG
210 220 230 240 250
LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV RAILRTLLEA
260 270 280 290 300
RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET
310 320 330 340 350
TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV
360 370 380 390 400
LHEVQRFITL LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ
410 420 430 440 450
TPGQFNPGHF LDANGHFVKR EAFLPFSAGR RVCVGERLAR TELFLLFAGL
460 470 480 490
LQRYRLLPPP GVSPASLDTT PARAFTMRPR AQALCAVPRP
Length:490
Mass (Da):53,844
Last modified:September 5, 2006 - v2
Checksum:iBB84B2F1FEFEF5BC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811A → T.
Corresponds to variant rs3735684 [ dbSNP | Ensembl ].
VAR_027413

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC025761 mRNA. Translation: AAH25761.2.
CCDSiCCDS5319.2.
RefSeqiNP_060251.2. NM_017781.2.
XP_005249849.1. XM_005249792.1.
UniGeneiHs.272795.

Genome annotation databases

EnsembliENST00000308919; ENSP00000310149; ENSG00000073067.
GeneIDi54905.
KEGGihsa:54905.
UCSCiuc003sjq.1. human.

Polymorphism databases

DMDMi114152790.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC025761 mRNA. Translation: AAH25761.2 .
CCDSi CCDS5319.2.
RefSeqi NP_060251.2. NM_017781.2.
XP_005249849.1. XM_005249792.1.
UniGenei Hs.272795.

3D structure databases

ProteinModelPortali Q8TAV3.
SMRi Q8TAV3. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120251. 4 interactions.
IntActi Q8TAV3. 2 interactions.

Chemistry

ChEMBLi CHEMBL2406897.

Polymorphism databases

DMDMi 114152790.

Proteomic databases

MaxQBi Q8TAV3.
PaxDbi Q8TAV3.
PRIDEi Q8TAV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308919 ; ENSP00000310149 ; ENSG00000073067 .
GeneIDi 54905.
KEGGi hsa:54905.
UCSCi uc003sjq.1. human.

Organism-specific databases

CTDi 54905.
GeneCardsi GC07P001022.
HGNCi HGNC:20243. CYP2W1.
HPAi HPA012753.
neXtProti NX_Q8TAV3.
PharmGKBi PA134992665.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi Q8TAV3.
KOi K07423.
OMAi PARAFTM.
OrthoDBi EOG7RBZ85.
PhylomeDBi Q8TAV3.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_13425. Miscellaneous substrates.
REACT_13543. Xenobiotics.

Miscellaneous databases

GeneWikii CYP2W1.
GenomeRNAii 54905.
NextBioi 57946.
PROi Q8TAV3.

Gene expression databases

Bgeei Q8TAV3.
CleanExi HS_CYP2W1.
ExpressionAtlasi Q8TAV3. baseline and differential.
Genevestigatori Q8TAV3.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCP2W1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3