Reviewed, UniProtKB/Swiss-Prot Q8TAV3 (CP2W1_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2W1
    EC=1.14.14.-
Alternative name(s):
    CYPIIW1

Gene names

Name:

CYP2W1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein Potential. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Cytochrome P450 2W1		PRO_0000051782
Sites
	Metal binding	433	1	Iron (heme axial ligand) By similarity
Natural variations
	Natural variant	181	1	A → T: dbSNP rs3735684.		VAR_027413

Sequences

	Sequence		Length	Mass (Da)
	Q8TAV3-1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: BB84B2F1FEFEF5BC	FASTA	490	53,844
	10 20 30 40 50 60 MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS QQDRSLMELS 70 80 90 100 110 120 ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP PIAIFQLIQR GGGIFFSSGA 130 140 150 160 170 180 RWRAARQFTV RALHSLGVGR EPVADKILQE LKCLSGQLDG YRGRPFPLAL LGWAPSNITF 190 200 210 220 230 240 ALLFGRRFDY RDPVFVSLLG LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV 250 260 270 280 290 300 RAILRTLLEA RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET 310 320 330 340 350 360 TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV LHEVQRFITL 370 380 390 400 410 420 LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ TPGQFNPGHF LDANGHFVKR 430 440 450 460 470 480 EAFLPFSAGR RVCVGERLAR TELFLLFAGL LQRYRLLPPP GVSPASLDTT PARAFTMRPR 490 AQALCAVPRP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC025761 mRNA. Translation: AAH25761.2.
IPI	IPI00183606.
RefSeq	NP_060251.2.
UniGene	Hs.272795
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBase	Search...
Proteomic databases
PRIDE	Q8TAV3.
Genome annotation databases
Ensembl	ENSG00000073067. Homo sapiens. [Contig view]
GeneID	54905.
KEGG	hsa:54905.
Organism-specific databases
GeneCards	GC07P000989.
HGNC	HGNC:20243. CYP2W1.
HPA	HPA012753.
PharmGKB	PA134992665.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8TAV3.
HOVERGEN	Q8TAV3.
OMA	Q8TAV3. DVQGRVQ.
Enzyme and pathway databases
Reactome	REACT_13433. Biological oxidations.
Gene expression databases
ArrayExpress	Q8TAV3.
Bgee	Q8TAV3.
CleanEx	HS_CYP2W1.
GermOnline	ENSG00000073067. Homo sapiens.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	57946.

Entry information

Entry name

CP2W1_HUMAN

Accession

Primary (citable) accession number: Q8TAV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)