Q8TAV3 (CP2W1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 2W1
EC=1.14.14.-

Alternative name(s):
CYPIIW1

Gene names

Name:

CYP2W1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein Potential. Endoplasmic reticulum membrane Potential.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	xenobiotic metabolic process Traceable author statement. Source: Reactome
Cellular component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Cytochrome P450 2W1		PRO_0000051782
Sites
	Metal binding	433	1	Iron (heme axial ligand) By similarity
Natural variations
	Natural variant	181	1	A → T. Corresponds to variant rs3735684 [ dbSNP | Ensembl ].		VAR_027413

Sequences

	Sequence		Length	Mass (Da)
	Q8TAV3 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: BB84B2F1FEFEF5BC	FASTA	490	53,844
	10 20 30 40 50 60 MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS QQDRSLMELS 70 80 90 100 110 120 ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP PIAIFQLIQR GGGIFFSSGA 130 140 150 160 170 180 RWRAARQFTV RALHSLGVGR EPVADKILQE LKCLSGQLDG YRGRPFPLAL LGWAPSNITF 190 200 210 220 230 240 ALLFGRRFDY RDPVFVSLLG LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV 250 260 270 280 290 300 RAILRTLLEA RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET 310 320 330 340 350 360 TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV LHEVQRFITL 370 380 390 400 410 420 LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ TPGQFNPGHF LDANGHFVKR 430 440 450 460 470 480 EAFLPFSAGR RVCVGERLAR TELFLLFAGL LQRYRLLPPP GVSPASLDTT PARAFTMRPR 490 AQALCAVPRP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC025761 mRNA. Translation: AAH25761.2.
IPI	IPI00183606.
RefSeq	NP_060251.2. NM_017781.2.
UniGene	Hs.272795.
3D structure databases
ProteinModelPortal	Q8TAV3.
SMR	Q8TAV3. Positions 32-489.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TAV3. 2 interactions.
STRING	Q8TAV3.
Polymorphism databases
DMDM	114152790.
Proteomic databases
PRIDE	Q8TAV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308919; ENSP00000310149; ENSG00000073067.
GeneID	54905.
KEGG	hsa:54905.
UCSC	uc003sjq.1. human.
Organism-specific databases
CTD	54905.
GeneCards	GC07P001022.
HGNC	HGNC:20243. CYP2W1.
HPA	HPA012753.
neXtProt	NX_Q8TAV3.
PharmGKB	PA134992665.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07547.
GeneTree	ENSGT00600000084382.
HOGENOM	HBG749920.
HOVERGEN	HBG015789.
InParanoid	Q8TAV3.
OMA	ILQELKC.
OrthoDB	EOG418BNP.
PhylomeDB	Q8TAV3.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q8TAV3.
Bgee	Q8TAV3.
CleanEx	HS_CYP2W1.
Genevestigator	Q8TAV3.
GermOnline	ENSG00000073067. Homo sapiens.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
KO	K07423.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	57946.

Entry information

Entry name

CP2W1_HUMAN

Accession

Primary (citable) accession number: Q8TAV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.