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Protein

Cytochrome P450 2W1

Gene

CYP2W1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).4 Publications

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi433Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • aflatoxin B1 metabolic process Source: UniProtKB
  • epoxygenase P450 pathway Source: GO_Central
  • xenobiotic metabolic process Source: UniProtKB

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-211958. Miscellaneous substrates.
R-HSA-211981. Xenobiotics.

Chemistry databases

SwissLipidsiSLP:000001619.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2W1 (EC:1.14.14.-)
Alternative name(s):
CYPIIW1
Gene namesi
Name:CYP2W1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000073067.13.
HGNCiHGNC:20243. CYP2W1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi177N → A: Loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi54905.
OpenTargetsiENSG00000073067.
PharmGKBiPA134992665.

Chemistry databases

ChEMBLiCHEMBL2406897.

Polymorphism and mutation databases

BioMutaiCYP2W1.
DMDMi114152790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000005178223 – 490Cytochrome P450 2W1Sequence analysisAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi177N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8TAV3.
PaxDbiQ8TAV3.
PeptideAtlasiQ8TAV3.
PRIDEiQ8TAV3.

PTM databases

iPTMnetiQ8TAV3.
PhosphoSitePlusiQ8TAV3.

Expressioni

Tissue specificityi

Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors.1 Publication

Gene expression databases

BgeeiENSG00000073067.
CleanExiHS_CYP2W1.
ExpressionAtlasiQ8TAV3. baseline and differential.
GenevisibleiQ8TAV3. HS.

Organism-specific databases

HPAiHPA012753.

Interactioni

Protein-protein interaction databases

BioGridi120251. 5 interactors.
IntActiQ8TAV3. 2 interactors.
STRINGi9606.ENSP00000310149.

Structurei

3D structure databases

ProteinModelPortaliQ8TAV3.
SMRiQ8TAV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00900000140799.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ8TAV3.
KOiK07423.
OMAiDYRDPVF.
OrthoDBiEOG091G0BT8.
PhylomeDBiQ8TAV3.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TAV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS
60 70 80 90 100
QQDRSLMELS ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP
110 120 130 140 150
PIAIFQLIQR GGGIFFSSGA RWRAARQFTV RALHSLGVGR EPVADKILQE
160 170 180 190 200
LKCLSGQLDG YRGRPFPLAL LGWAPSNITF ALLFGRRFDY RDPVFVSLLG
210 220 230 240 250
LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV RAILRTLLEA
260 270 280 290 300
RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET
310 320 330 340 350
TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV
360 370 380 390 400
LHEVQRFITL LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ
410 420 430 440 450
TPGQFNPGHF LDANGHFVKR EAFLPFSAGR RVCVGERLAR TELFLLFAGL
460 470 480 490
LQRYRLLPPP GVSPASLDTT PARAFTMRPR AQALCAVPRP
Length:490
Mass (Da):53,844
Last modified:September 5, 2006 - v2
Checksum:iBB84B2F1FEFEF5BC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07191258E → A1 Publication1
Natural variantiVAR_027413181A → T Associated with increased colorectal cancer risk. 1 PublicationCorresponds to variant dbSNP:rs3735684Ensembl.1
Natural variantiVAR_071913432V → I1 PublicationCorresponds to variant dbSNP:rs78873069Ensembl.1
Natural variantiVAR_071914482Q → H1 PublicationCorresponds to variant dbSNP:rs773499447Ensembl.1
Natural variantiVAR_071915488P → L1 PublicationCorresponds to variant dbSNP:rs3808348Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073957 Genomic DNA. No translation available.
BC025761 mRNA. Translation: AAH25761.2.
CCDSiCCDS5319.2.
RefSeqiNP_060251.2. NM_017781.2.
UniGeneiHs.272795.

Genome annotation databases

EnsembliENST00000308919; ENSP00000310149; ENSG00000073067.
GeneIDi54905.
KEGGihsa:54905.
UCSCiuc003sjq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCP2W1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 5, 2006
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families