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Q8TAU3

- ZN417_HUMAN

UniProt

Q8TAU3 - ZN417_HUMAN

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Protein

Zinc finger protein 417

Gene

ZNF417

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 417
Gene namesi
Name:ZNF417
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20646. ZNF417.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Zinc finger protein 417PRO_0000233985Add
BLAST

Proteomic databases

MaxQBiQ8TAU3.
PaxDbiQ8TAU3.
PRIDEiQ8TAU3.

PTM databases

PhosphoSiteiQ8TAU3.

Expressioni

Gene expression databases

BgeeiQ8TAU3.
CleanExiHS_ZNF417.
ExpressionAtlasiQ8TAU3. baseline.
GenevestigatoriQ8TAU3.

Organism-specific databases

HPAiHPA042125.
HPA043288.
HPA056213.

Interactioni

Protein-protein interaction databases

BioGridi127075. 7 interactions.
IntActiQ8TAU3. 14 interactions.
MINTiMINT-1483592.
STRINGi9606.ENSP00000311319.

Structurei

3D structure databases

ProteinModelPortaliQ8TAU3.
SMRiQ8TAU3. Positions 106-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8874KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAU3.
KOiK09228.
OMAiDHPETHH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TAU3.
TreeFamiTF339848.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TAU3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEAA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKNCVT IHQRIHTGER PYECNECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,733
Last modified:May 18, 2010 - v2
Checksum:i8CE2FB25CBE474F5
GO
Isoform 2 (identifier: Q8TAU3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-199: Missing.

Note: No experimental confirmation available.

Show »
Length:376
Mass (Da):43,212
Checksum:i9E787AC7E84A2898
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731R → H in AAH25783. (PubMed:15489334)Curated
Sequence conflicti316 – 3161R → L in AAH25783. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti495 – 4951N → S.1 Publication
Corresponds to variant rs10416584 [ dbSNP | Ensembl ].
VAR_060275

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 199199Missing in isoform 2. 1 PublicationVSP_055950Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293789 mRNA. Translation: BAG57202.1.
AC010326 Genomic DNA. No translation available.
BC025783 mRNA. Translation: AAH25783.1.
CCDSiCCDS12965.1. [Q8TAU3-1]
RefSeqiNP_689688.2. NM_152475.2.
UniGeneiHs.567710.

Genome annotation databases

EnsembliENST00000312026; ENSP00000311319; ENSG00000173480. [Q8TAU3-1]
GeneIDi147687.
KEGGihsa:147687.
UCSCiuc002qqq.3. human. [Q8TAU3-1]

Polymorphism databases

DMDMi296453053.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293789 mRNA. Translation: BAG57202.1 .
AC010326 Genomic DNA. No translation available.
BC025783 mRNA. Translation: AAH25783.1 .
CCDSi CCDS12965.1. [Q8TAU3-1 ]
RefSeqi NP_689688.2. NM_152475.2.
UniGenei Hs.567710.

3D structure databases

ProteinModelPortali Q8TAU3.
SMRi Q8TAU3. Positions 106-573.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127075. 7 interactions.
IntActi Q8TAU3. 14 interactions.
MINTi MINT-1483592.
STRINGi 9606.ENSP00000311319.

PTM databases

PhosphoSitei Q8TAU3.

Polymorphism databases

DMDMi 296453053.

Proteomic databases

MaxQBi Q8TAU3.
PaxDbi Q8TAU3.
PRIDEi Q8TAU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312026 ; ENSP00000311319 ; ENSG00000173480 . [Q8TAU3-1 ]
GeneIDi 147687.
KEGGi hsa:147687.
UCSCi uc002qqq.3. human. [Q8TAU3-1 ]

Organism-specific databases

CTDi 147687.
GeneCardsi GC19M058417.
HGNCi HGNC:20646. ZNF417.
HPAi HPA042125.
HPA043288.
HPA056213.
neXtProti NX_Q8TAU3.
PharmGKBi PA134863699.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119107.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8TAU3.
KOi K09228.
OMAi DHPETHH.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8TAU3.
TreeFami TF339848.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 147687.
NextBioi 35471316.
PROi Q8TAU3.

Gene expression databases

Bgeei Q8TAU3.
CleanExi HS_ZNF417.
ExpressionAtlasi Q8TAU3. baseline.
Genevestigatori Q8TAU3.

Family and domain databases

Gene3Di 3.30.160.60. 13 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-495.
    Tissue: Pancreas.

Entry informationi

Entry nameiZN417_HUMAN
AccessioniPrimary (citable) accession number: Q8TAU3
Secondary accession number(s): B4DEU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3