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Q8TAU3

- ZN417_HUMAN

UniProt

Q8TAU3 - ZN417_HUMAN

Protein

Zinc finger protein 417

Gene

ZNF417

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 417
    Gene namesi
    Name:ZNF417
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20646. ZNF417.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134863699.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 575575Zinc finger protein 417PRO_0000233985Add
    BLAST

    Proteomic databases

    MaxQBiQ8TAU3.
    PaxDbiQ8TAU3.
    PRIDEiQ8TAU3.

    PTM databases

    PhosphoSiteiQ8TAU3.

    Expressioni

    Gene expression databases

    BgeeiQ8TAU3.
    CleanExiHS_ZNF417.
    GenevestigatoriQ8TAU3.

    Organism-specific databases

    HPAiHPA042125.
    HPA043288.
    HPA056213.

    Interactioni

    Protein-protein interaction databases

    BioGridi127075. 7 interactions.
    IntActiQ8TAU3. 14 interactions.
    MINTiMINT-1483592.
    STRINGi9606.ENSP00000311319.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAU3.
    SMRiQ8TAU3. Positions 106-573.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 8874KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8TAU3.
    KOiK09228.
    OMAiDHPETHH.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8TAU3.
    TreeFamiTF339848.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TAU3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL    50
    ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI 100
    LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK 150
    SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEAA AVEKTDSETM 200
    HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS 250
    RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE 300
    CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER 350
    AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR 400
    GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH 450
    LLVHERVHTG ERPYACEVCG KLFGNKNCVT IHQRIHTGER PYECNECGKS 500
    FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR IHTGERPYEC 550
    TKCGKTFQRS STLLHHQSSH RRKAL 575
    Length:575
    Mass (Da):65,733
    Last modified:May 18, 2010 - v2
    Checksum:i8CE2FB25CBE474F5
    GO
    Isoform 2 (identifier: Q8TAU3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-199: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:376
    Mass (Da):43,212
    Checksum:i9E787AC7E84A2898
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731R → H in AAH25783. (PubMed:15489334)Curated
    Sequence conflicti316 – 3161R → L in AAH25783. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti495 – 4951N → S.1 Publication
    Corresponds to variant rs10416584 [ dbSNP | Ensembl ].
    VAR_060275

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 199199Missing in isoform 2. 1 PublicationVSP_055950Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK293789 mRNA. Translation: BAG57202.1.
    AC010326 Genomic DNA. No translation available.
    BC025783 mRNA. Translation: AAH25783.1.
    CCDSiCCDS12965.1.
    RefSeqiNP_689688.2. NM_152475.2.
    UniGeneiHs.567710.

    Genome annotation databases

    EnsembliENST00000312026; ENSP00000311319; ENSG00000173480.
    ENST00000536263; ENSP00000442760; ENSG00000173480.
    GeneIDi147687.
    KEGGihsa:147687.
    UCSCiuc002qqq.3. human.

    Polymorphism databases

    DMDMi296453053.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK293789 mRNA. Translation: BAG57202.1 .
    AC010326 Genomic DNA. No translation available.
    BC025783 mRNA. Translation: AAH25783.1 .
    CCDSi CCDS12965.1.
    RefSeqi NP_689688.2. NM_152475.2.
    UniGenei Hs.567710.

    3D structure databases

    ProteinModelPortali Q8TAU3.
    SMRi Q8TAU3. Positions 106-573.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127075. 7 interactions.
    IntActi Q8TAU3. 14 interactions.
    MINTi MINT-1483592.
    STRINGi 9606.ENSP00000311319.

    PTM databases

    PhosphoSitei Q8TAU3.

    Polymorphism databases

    DMDMi 296453053.

    Proteomic databases

    MaxQBi Q8TAU3.
    PaxDbi Q8TAU3.
    PRIDEi Q8TAU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312026 ; ENSP00000311319 ; ENSG00000173480 .
    ENST00000536263 ; ENSP00000442760 ; ENSG00000173480 .
    GeneIDi 147687.
    KEGGi hsa:147687.
    UCSCi uc002qqq.3. human.

    Organism-specific databases

    CTDi 147687.
    GeneCardsi GC19M058417.
    HGNCi HGNC:20646. ZNF417.
    HPAi HPA042125.
    HPA043288.
    HPA056213.
    neXtProti NX_Q8TAU3.
    PharmGKBi PA134863699.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8TAU3.
    KOi K09228.
    OMAi DHPETHH.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8TAU3.
    TreeFami TF339848.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 147687.
    NextBioi 85683.
    PROi Q8TAU3.

    Gene expression databases

    Bgeei Q8TAU3.
    CleanExi HS_ZNF417.
    Genevestigatori Q8TAU3.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-495.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiZN417_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAU3
    Secondary accession number(s): B4DEU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3