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Protein

Zinc finger protein 417

Gene

ZNF417

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173480-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 417
Gene namesi
Name:ZNF417
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20646. ZNF417.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173480.
PharmGKBiPA134863699.

Polymorphism and mutation databases

BioMutaiZNF417.
DMDMi296453053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339851 – 575Zinc finger protein 417Add BLAST575

Proteomic databases

EPDiQ8TAU3.
MaxQBiQ8TAU3.
PaxDbiQ8TAU3.
PeptideAtlasiQ8TAU3.
PRIDEiQ8TAU3.

PTM databases

iPTMnetiQ8TAU3.
PhosphoSitePlusiQ8TAU3.

Expressioni

Gene expression databases

BgeeiENSG00000173480.
CleanExiHS_ZNF417.
ExpressionAtlasiQ8TAU3. baseline and differential.
GenevisibleiQ8TAU3. HS.

Organism-specific databases

HPAiHPA042125.
HPA043288.
HPA056213.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-35EBI-740727,EBI-10173507
BEND5Q7L4P63EBI-740727,EBI-724373
CARD9Q9H2573EBI-740727,EBI-751319
CCDC136Q96JN2-23EBI-740727,EBI-10171416
CCDC57Q2TAC23EBI-740727,EBI-2808286
CCNDBP1O952733EBI-740727,EBI-748961
CEP44Q9C0F14EBI-740727,EBI-744115
CEP70Q8NHQ15EBI-740727,EBI-739624
CSRNP1Q96S653EBI-740727,EBI-4311573
EFSO432813EBI-740727,EBI-718488
FHL2Q141923EBI-740727,EBI-701903
FHL3Q136433EBI-740727,EBI-741101
FSD2A1L4K15EBI-740727,EBI-5661036
GOLGA2Q083793EBI-740727,EBI-618309
HMBOX1Q6NT765EBI-740727,EBI-2549423
IKZF1Q134223EBI-740727,EBI-745305
KLC3Q6P5973EBI-740727,EBI-1643885
KRT15P190123EBI-740727,EBI-739566
KRT38O760153EBI-740727,EBI-1047263
KRT40Q6A1625EBI-740727,EBI-10171697
KRTAP10-5P603705EBI-740727,EBI-10172150
KRTAP10-7P604093EBI-740727,EBI-10172290
KRTAP10-8P604105EBI-740727,EBI-10171774
KRTAP10-9P604113EBI-740727,EBI-10172052
KRTAP4-2Q9BYR53EBI-740727,EBI-10172511
KRTAP5-9P263715EBI-740727,EBI-3958099
KXD1Q9BQD35EBI-740727,EBI-739657
LURAP1Q96LR23EBI-740727,EBI-741355
LZTS2Q9BRK45EBI-740727,EBI-741037
MDFIQ997506EBI-740727,EBI-724076
MEOX2A4D1275EBI-740727,EBI-10172134
MID2Q9UJV3-25EBI-740727,EBI-10172526
MTUS2Q5JR593EBI-740727,EBI-742948
NDEL1Q9GZM83EBI-740727,EBI-928842
NINLQ9Y2I64EBI-740727,EBI-719716
NOTCH2NLQ7Z3S95EBI-740727,EBI-945833
PHC2Q8IXK03EBI-740727,EBI-713786
PLSCR1O151623EBI-740727,EBI-740019
PNMA2Q9UL424EBI-740727,EBI-302355
RELQ048643EBI-740727,EBI-307352
RPGRIP1Q96KN73EBI-740727,EBI-1050213
RUNDC3AQ59EK93EBI-740727,EBI-747225
SPRY2O435973EBI-740727,EBI-742487
SSX2IPQ9Y2D83EBI-740727,EBI-2212028
STX11O755583EBI-740727,EBI-714135
TCF4P158843EBI-740727,EBI-533224
TFIP11Q9UBB94EBI-740727,EBI-1105213
TMCC2Q7Z6C63EBI-740727,EBI-10177480
TNS2Q63HR25EBI-740727,EBI-949753
TRAF1Q130773EBI-740727,EBI-359224
TRIM27P143736EBI-740727,EBI-719493
TRIM36Q9NQ863EBI-740727,EBI-2341518
TRIM37O949724EBI-740727,EBI-741602
TRIM41Q8WV445EBI-740727,EBI-725997
TRIM54Q9BYV25EBI-740727,EBI-2130429
TSGA10Q9BZW73EBI-740727,EBI-744794
ZBTB1Q9Y2K13EBI-740727,EBI-2682961
ZBTB10Q96DT73EBI-740727,EBI-10235384
ZBTB43O432983EBI-740727,EBI-740718
ZBTB8AQ96BR95EBI-740727,EBI-742740
ZNF587Q96SQ53EBI-740727,EBI-6427977

Protein-protein interaction databases

BioGridi127075. 67 interactors.
IntActiQ8TAU3. 104 interactors.
MINTiMINT-1483592.
STRINGi9606.ENSP00000311319.

Structurei

3D structure databases

ProteinModelPortaliQ8TAU3.
SMRiQ8TAU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 88KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAU3.
KOiK09228.
OMAiDHPETHH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TAU3.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEAA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKNCVT IHQRIHTGER PYECNECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,733
Last modified:May 18, 2010 - v2
Checksum:i8CE2FB25CBE474F5
GO
Isoform 2 (identifier: Q8TAU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-199: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):43,212
Checksum:i9E787AC7E84A2898
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173R → H in AAH25783 (PubMed:15489334).Curated1
Sequence conflicti316R → L in AAH25783 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060275495N → S.1 PublicationCorresponds to variant rs10416584dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559501 – 199Missing in isoform 2. 1 PublicationAdd BLAST199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293789 mRNA. Translation: BAG57202.1.
AC010326 Genomic DNA. No translation available.
BC025783 mRNA. Translation: AAH25783.1.
CCDSiCCDS12965.1. [Q8TAU3-1]
RefSeqiNP_689688.2. NM_152475.2. [Q8TAU3-1]
UniGeneiHs.567710.

Genome annotation databases

EnsembliENST00000312026; ENSP00000311319; ENSG00000173480. [Q8TAU3-1]
GeneIDi147687.
KEGGihsa:147687.
UCSCiuc002qqq.4. human. [Q8TAU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293789 mRNA. Translation: BAG57202.1.
AC010326 Genomic DNA. No translation available.
BC025783 mRNA. Translation: AAH25783.1.
CCDSiCCDS12965.1. [Q8TAU3-1]
RefSeqiNP_689688.2. NM_152475.2. [Q8TAU3-1]
UniGeneiHs.567710.

3D structure databases

ProteinModelPortaliQ8TAU3.
SMRiQ8TAU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127075. 67 interactors.
IntActiQ8TAU3. 104 interactors.
MINTiMINT-1483592.
STRINGi9606.ENSP00000311319.

PTM databases

iPTMnetiQ8TAU3.
PhosphoSitePlusiQ8TAU3.

Polymorphism and mutation databases

BioMutaiZNF417.
DMDMi296453053.

Proteomic databases

EPDiQ8TAU3.
MaxQBiQ8TAU3.
PaxDbiQ8TAU3.
PeptideAtlasiQ8TAU3.
PRIDEiQ8TAU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312026; ENSP00000311319; ENSG00000173480. [Q8TAU3-1]
GeneIDi147687.
KEGGihsa:147687.
UCSCiuc002qqq.4. human. [Q8TAU3-1]

Organism-specific databases

CTDi147687.
GeneCardsiZNF417.
HGNCiHGNC:20646. ZNF417.
HPAiHPA042125.
HPA043288.
HPA056213.
neXtProtiNX_Q8TAU3.
OpenTargetsiENSG00000173480.
PharmGKBiPA134863699.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAU3.
KOiK09228.
OMAiDHPETHH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TAU3.
TreeFamiTF339848.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173480-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii147687.
PROiQ8TAU3.

Gene expression databases

BgeeiENSG00000173480.
CleanExiHS_ZNF417.
ExpressionAtlasiQ8TAU3. baseline and differential.
GenevisibleiQ8TAU3. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN417_HUMAN
AccessioniPrimary (citable) accession number: Q8TAU3
Secondary accession number(s): B4DEU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.