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Q8TAU3 (ZN417_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 417
Gene names
Name:ZNF417
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 13 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 575575Zinc finger protein 417
PRO_0000233985

Regions

Domain15 – 8874KRAB
Zinc finger92 – 11423C2H2-type 1
Zinc finger240 – 26223C2H2-type 2
Zinc finger268 – 29023C2H2-type 3
Zinc finger296 – 31823C2H2-type 4
Zinc finger324 – 34623C2H2-type 5; degenerate
Zinc finger352 – 37423C2H2-type 6
Zinc finger380 – 40223C2H2-type 7
Zinc finger408 – 43023C2H2-type 8
Zinc finger436 – 45823C2H2-type 9
Zinc finger464 – 48623C2H2-type 10
Zinc finger492 – 51423C2H2-type 11
Zinc finger520 – 54223C2H2-type 12
Zinc finger548 – 57023C2H2-type 13

Natural variations

Natural variant4951N → S. Ref.2
Corresponds to variant rs10416584 [ dbSNP | Ensembl ].
VAR_060275

Experimental info

Sequence conflict1731R → H in AAH25783. Ref.2
Sequence conflict3161R → L in AAH25783. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8TAU3 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 8CE2FB25CBE474F5

FASTA57565,733
        10         20         30         40         50         60 
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL ISSLGCWCGS 

        70         80         90        100        110        120 
KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI LEDVFHFADH QETHHKQKLN 

       130        140        150        160        170        180 
RSGACGKNLD DTAYLHQHQK QHIGEKFYRK SVREASFVKK RKLRVSQEPF VFREFGKDVL 

       190        200        210        220        230        240 
PSSGLCQEAA AVEKTDSETM HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY 

       250        260        270        280        290        300 
VCSDCGKSFS RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE 

       310        320        330        340        350        360 
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER AYHCGECGKS 

       370        380        390        400        410        420 
FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR GHTGERPYEC KECGKSFRYR 

       430        440        450        460        470        480 
SHLTEHQRLH TGERPYNCRE CGKLFNRKYH LLVHERVHTG ERPYACEVCG KLFGNKNCVT 

       490        500        510        520        530        540 
IHQRIHTGER PYECNECGKS FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR 

       550        560        570 
IHTGERPYEC TKCGKTFQRS STLLHHQSSH RRKAL 

« Hide

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-495.
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010326 Genomic DNA. No translation available.
BC025783 mRNA. Translation: AAH25783.1.
CCDSCCDS12965.1.
RefSeqNP_689688.2. NM_152475.2.
UniGeneHs.567710.

3D structure databases

ProteinModelPortalQ8TAU3.
SMRQ8TAU3. Positions 106-573.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127075. 7 interactions.
IntActQ8TAU3. 14 interactions.
MINTMINT-1483592.
STRING9606.ENSP00000311319.

PTM databases

PhosphoSiteQ8TAU3.

Polymorphism databases

DMDM296453053.

Proteomic databases

MaxQBQ8TAU3.
PaxDbQ8TAU3.
PRIDEQ8TAU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312026; ENSP00000311319; ENSG00000173480.
GeneID147687.
KEGGhsa:147687.
UCSCuc002qqq.3. human.

Organism-specific databases

CTD147687.
GeneCardsGC19M058417.
HGNCHGNC:20646. ZNF417.
HPAHPA042125.
HPA043288.
HPA056213.
neXtProtNX_Q8TAU3.
PharmGKBPA134863699.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8TAU3.
KOK09228.
OMADHPETHH.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8TAU3.
TreeFamTF339848.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ8TAU3.
CleanExHS_ZNF417.
GenevestigatorQ8TAU3.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi147687.
NextBio85683.
PROQ8TAU3.

Entry information

Entry nameZN417_HUMAN
AccessionPrimary (citable) accession number: Q8TAU3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM