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Protein

Homeobox protein Nkx-2.3

Gene

NKX2-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi148 – 20760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  2. gland morphogenesis Source: Ensembl
  3. leukocyte homeostasis Source: Ensembl
  4. leukocyte migration Source: Ensembl
  5. lymph node development Source: Ensembl
  6. macrophage differentiation Source: Ensembl
  7. odontogenesis of dentin-containing tooth Source: Ensembl
  8. Peyer's patch development Source: Ensembl
  9. plasma cell differentiation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. post-embryonic digestive tract morphogenesis Source: Ensembl
  12. regulation of cell proliferation Source: Ensembl
  13. spleen development Source: Ensembl
  14. transcription, DNA-templated Source: UniProtKB-KW
  15. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.3
Alternative name(s):
Homeobox protein NK-2 homolog C
Gene namesi
Name:NKX2-3
Synonyms:NKX23, NKX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:7836. NKX2-3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Homeobox protein Nkx-2.3PRO_0000048933Add
BLAST

Proteomic databases

PaxDbiQ8TAU0.
PeptideAtlasiQ8TAU0.
PRIDEiQ8TAU0.

PTM databases

PhosphoSiteiQ8TAU0.

Expressioni

Gene expression databases

BgeeiQ8TAU0.
CleanExiHS_NKX2-3.
GenevestigatoriQ8TAU0.

Organism-specific databases

HPAiHPA047561.

Interactioni

Protein-protein interaction databases

BioGridi127740. 2 interactions.
IntActiQ8TAU0. 1 interaction.
STRINGi9606.ENSP00000342828.

Structurei

3D structure databases

ProteinModelPortaliQ8TAU0.
SMRiQ8TAU0. Positions 148-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2235Poly-Pro
Compositional biasi271 – 28616Poly-AlaAdd
BLAST
Compositional biasi298 – 3058Poly-Gly

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG310976.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ8TAU0.
KOiK09343.
OMAiPCVTPSA.
OrthoDBiEOG769ZK0.
PhylomeDBiQ8TAU0.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA
60 70 80 90 100
EGTQFSDGGE EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS
110 120 130 140 150
CSEPKEHEEE PEVVRDRSQK SCQLKKSLET AGDCKAAEES ERPKPRSRRK
160 170 180 190 200
PRVLFSQAQV FELERRFKQQ RYLSAPEREH LASSLKLTST QVKIWFQNRR
210 220 230 240 250
YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT PSAQAYGAPY
260 270 280 290 300
SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG
310 320 330 340 350
GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG
360
AACAQGTLQG IRAW
Length:364
Mass (Da):38,406
Last modified:January 27, 2003 - v2
Checksum:i10A279CFA3C8A6DB
GO

Sequence cautioni

The sequence AAH25788.1 differs from that shown.The lack of 97 nucleotides within coding exon 2 produces a frameshift and results in a truncated protein.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300856 mRNA. Translation: BAG62506.1.
AL353719 Genomic DNA. Translation: CAI16899.1.
BC025788 mRNA. Translation: AAH25788.1. Sequence problems.
AH009193 Genomic DNA. Translation: AAF44651.1.
CCDSiCCDS41558.1.
RefSeqiNP_660328.2. NM_145285.2.
UniGeneiHs.243272.

Genome annotation databases

EnsembliENST00000344586; ENSP00000342828; ENSG00000119919.
GeneIDi159296.
KEGGihsa:159296.
UCSCiuc009xwj.3. human.

Polymorphism databases

DMDMi27923815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300856 mRNA. Translation: BAG62506.1.
AL353719 Genomic DNA. Translation: CAI16899.1.
BC025788 mRNA. Translation: AAH25788.1. Sequence problems.
AH009193 Genomic DNA. Translation: AAF44651.1.
CCDSiCCDS41558.1.
RefSeqiNP_660328.2. NM_145285.2.
UniGeneiHs.243272.

3D structure databases

ProteinModelPortaliQ8TAU0.
SMRiQ8TAU0. Positions 148-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127740. 2 interactions.
IntActiQ8TAU0. 1 interaction.
STRINGi9606.ENSP00000342828.

PTM databases

PhosphoSiteiQ8TAU0.

Polymorphism databases

DMDMi27923815.

Proteomic databases

PaxDbiQ8TAU0.
PeptideAtlasiQ8TAU0.
PRIDEiQ8TAU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344586; ENSP00000342828; ENSG00000119919.
GeneIDi159296.
KEGGihsa:159296.
UCSCiuc009xwj.3. human.

Organism-specific databases

CTDi159296.
GeneCardsiGC10P101292.
HGNCiHGNC:7836. NKX2-3.
HPAiHPA047561.
MIMi606727. gene.
neXtProtiNX_Q8TAU0.
PharmGKBiPA31643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG310976.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ8TAU0.
KOiK09343.
OMAiPCVTPSA.
OrthoDBiEOG769ZK0.
PhylomeDBiQ8TAU0.
TreeFamiTF351204.

Miscellaneous databases

GeneWikiiNKX2-3.
GenomeRNAii159296.
NextBioi87898.
PROiQ8TAU0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAU0.
CleanExiHS_NKX2-3.
GenevestigatoriQ8TAU0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.
  4. "Homeobox gene Nkx2-3 is critical for normal development of the gut, spleen and gut-associated lymphoid tissue."
    Wang C.-C., Brodnicki T., Harvey R.P.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-211.

Entry informationi

Entry nameiNKX23_HUMAN
AccessioniPrimary (citable) accession number: Q8TAU0
Secondary accession number(s): B4DUZ4, Q9NYS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: January 7, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.