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Q8TAU0

- NKX23_HUMAN

UniProt

Q8TAU0 - NKX23_HUMAN

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Protein

Homeobox protein Nkx-2.3

Gene
NKX2-3, NKX23, NKX2C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi148 – 20760HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  2. gland morphogenesis Source: Ensembl
  3. leukocyte homeostasis Source: Ensembl
  4. leukocyte migration Source: Ensembl
  5. lymph node development Source: Ensembl
  6. macrophage differentiation Source: Ensembl
  7. odontogenesis of dentin-containing tooth Source: Ensembl
  8. Peyer's patch development Source: Ensembl
  9. plasma cell differentiation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. post-embryonic digestive tract morphogenesis Source: Ensembl
  12. regulation of cell proliferation Source: Ensembl
  13. spleen development Source: Ensembl
  14. transcription, DNA-templated Source: UniProtKB-KW
  15. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.3
Alternative name(s):
Homeobox protein NK-2 homolog C
Gene namesi
Name:NKX2-3
Synonyms:NKX23, NKX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:7836. NKX2-3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Homeobox protein Nkx-2.3PRO_0000048933Add
BLAST

Proteomic databases

PaxDbiQ8TAU0.
PeptideAtlasiQ8TAU0.
PRIDEiQ8TAU0.

PTM databases

PhosphoSiteiQ8TAU0.

Expressioni

Gene expression databases

BgeeiQ8TAU0.
CleanExiHS_NKX2-3.
GenevestigatoriQ8TAU0.

Organism-specific databases

HPAiHPA047561.

Interactioni

Protein-protein interaction databases

BioGridi127740. 2 interactions.
IntActiQ8TAU0. 1 interaction.
STRINGi9606.ENSP00000342828.

Structurei

3D structure databases

ProteinModelPortaliQ8TAU0.
SMRiQ8TAU0. Positions 148-202.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2235Poly-Pro
Compositional biasi271 – 28616Poly-AlaAdd
BLAST
Compositional biasi298 – 3058Poly-Gly

Sequence similaritiesi

Belongs to the NK-2 homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG310976.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ8TAU0.
KOiK09343.
OMAiPCVTPSA.
OrthoDBiEOG769ZK0.
PhylomeDBiQ8TAU0.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAU0-1 [UniParc]FASTAAdd to Basket

« Hide

MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA    50
EGTQFSDGGE EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS 100
CSEPKEHEEE PEVVRDRSQK SCQLKKSLET AGDCKAAEES ERPKPRSRRK 150
PRVLFSQAQV FELERRFKQQ RYLSAPEREH LASSLKLTST QVKIWFQNRR 200
YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT PSAQAYGAPY 250
SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG 300
GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG 350
AACAQGTLQG IRAW 364
Length:364
Mass (Da):38,406
Last modified:January 27, 2003 - v2
Checksum:i10A279CFA3C8A6DB
GO

Sequence cautioni

The sequence AAH25788.1 differs from that shown. Reason: Frameshift at position 273. This frameshift is potential, but if it is real then the sequence of residues 274-302 are lacking from the translated cDNA while this region does not seem to correspond to an exon.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK300856 mRNA. Translation: BAG62506.1.
AL353719 Genomic DNA. Translation: CAI16899.1.
BC025788 mRNA. Translation: AAH25788.1. Frameshift.
AH009193 Genomic DNA. Translation: AAF44651.1.
CCDSiCCDS41558.1.
RefSeqiNP_660328.2. NM_145285.2.
UniGeneiHs.243272.

Genome annotation databases

EnsembliENST00000344586; ENSP00000342828; ENSG00000119919.
GeneIDi159296.
KEGGihsa:159296.
UCSCiuc009xwj.3. human.

Polymorphism databases

DMDMi27923815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK300856 mRNA. Translation: BAG62506.1 .
AL353719 Genomic DNA. Translation: CAI16899.1 .
BC025788 mRNA. Translation: AAH25788.1 . Frameshift.
AH009193 Genomic DNA. Translation: AAF44651.1 .
CCDSi CCDS41558.1.
RefSeqi NP_660328.2. NM_145285.2.
UniGenei Hs.243272.

3D structure databases

ProteinModelPortali Q8TAU0.
SMRi Q8TAU0. Positions 148-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127740. 2 interactions.
IntActi Q8TAU0. 1 interaction.
STRINGi 9606.ENSP00000342828.

PTM databases

PhosphoSitei Q8TAU0.

Polymorphism databases

DMDMi 27923815.

Proteomic databases

PaxDbi Q8TAU0.
PeptideAtlasi Q8TAU0.
PRIDEi Q8TAU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344586 ; ENSP00000342828 ; ENSG00000119919 .
GeneIDi 159296.
KEGGi hsa:159296.
UCSCi uc009xwj.3. human.

Organism-specific databases

CTDi 159296.
GeneCardsi GC10P101292.
HGNCi HGNC:7836. NKX2-3.
HPAi HPA047561.
MIMi 606727. gene.
neXtProti NX_Q8TAU0.
PharmGKBi PA31643.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310976.
HOGENOMi HOG000231923.
HOVERGENi HBG006689.
InParanoidi Q8TAU0.
KOi K09343.
OMAi PCVTPSA.
OrthoDBi EOG769ZK0.
PhylomeDBi Q8TAU0.
TreeFami TF351204.

Miscellaneous databases

GeneWikii NKX2-3.
GenomeRNAii 159296.
NextBioi 87898.
PROi Q8TAU0.
SOURCEi Search...

Gene expression databases

Bgeei Q8TAU0.
CleanExi HS_NKX2-3.
Genevestigatori Q8TAU0.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.
  4. "Homeobox gene Nkx2-3 is critical for normal development of the gut, spleen and gut-associated lymphoid tissue."
    Wang C.-C., Brodnicki T., Harvey R.P.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-211.

Entry informationi

Entry nameiNKX23_HUMAN
AccessioniPrimary (citable) accession number: Q8TAU0
Secondary accession number(s): B4DUZ4, Q9NYS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi