Q8TAU0 (NKX23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Nkx-2.3

Alternative name(s):
Homeobox protein NK-2 homolog C

Gene names

Name:	NKX2-3
Synonyms:	NKX23, NKX2C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence AAH25788.1 differs from that shown. Reason: Frameshift at position 273. This frameshift is potential, but if it is real then the sequence of residues 274-302 are lacking from the translated cDNA while this region does not seem to correspond to an exon.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CD4-positive, alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara Peyer's patch development Inferred from electronic annotation. Source: Compara gland morphogenesis Inferred from electronic annotation. Source: Compara leukocyte homeostasis Inferred from electronic annotation. Source: Compara leukocyte migration Inferred from electronic annotation. Source: Compara lymph node development Inferred from electronic annotation. Source: Compara macrophage differentiation Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara plasma cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara post-embryonic digestive tract morphogenesis Inferred from electronic annotation. Source: Compara regulation of cell proliferation Inferred from electronic annotation. Source: Compara spleen development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW triglyceride metabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Homeobox protein Nkx-2.3		PRO_0000048933
Regions
	DNA binding	148 – 207	60	Homeobox
	Compositional bias	219 – 223	5	Poly-Pro
	Compositional bias	271 – 286	16	Poly-Ala
	Compositional bias	298 – 305	8	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q8TAU0 [UniParc]. Last modified January 27, 2003. Version 2. Checksum: 10A279CFA3C8A6DB	FASTA	364	38,406
	10 20 30 40 50 60 MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA EGTQFSDGGE 70 80 90 100 110 120 EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS CSEPKEHEEE PEVVRDRSQK 130 140 150 160 170 180 SCQLKKSLET AGDCKAAEES ERPKPRSRRK PRVLFSQAQV FELERRFKQQ RYLSAPEREH 190 200 210 220 230 240 LASSLKLTST QVKIWFQNRR YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT 250 260 270 280 290 300 PSAQAYGAPY SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG 310 320 330 340 350 360 GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG AACAQGTLQG IRAW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Spleen.
[4]	"Homeobox gene Nkx2-3 is critical for normal development of the gut, spleen and gut-associated lymphoid tissue." Wang C.-C., Brodnicki T., Harvey R.P. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-211.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK300856 mRNA. Translation: BAG62506.1. AL353719 Genomic DNA. Translation: CAI16899.1. BC025788 mRNA. Translation: AAH25788.1. Frameshift. AH009193 Genomic DNA. Translation: AAF44651.1.
IPI	IPI00152116.
RefSeq	NP_660328.2. NM_145285.2.
UniGene	Hs.243272.
3D structure databases
ProteinModelPortal	Q8TAU0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TAU0. 1 interaction.
STRING	9606.ENSP00000342828.
PTM databases
PhosphoSite	Q8TAU0.
Polymorphism databases
DMDM	27923815.
Proteomic databases
PaxDb	Q8TAU0.
PeptideAtlas	Q8TAU0.
PRIDE	Q8TAU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344586; ENSP00000342828; ENSG00000119919.
GeneID	159296.
KEGG	hsa:159296.
UCSC	uc009xwj.3. human.
Organism-specific databases
CTD	159296.
GeneCards	GC10P101292.
HGNC	HGNC:7836. NKX2-3.
HPA	HPA047561.
MIM	606727. gene.
neXtProt	NX_Q8TAU0.
PharmGKB	PA31643.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG310976.
HOGENOM	HOG000231923.
HOVERGEN	HBG006689.
InParanoid	Q8TAU0.
KO	K09343.
OMA	YGCAYPA.
OrthoDB	EOG4WM4WF.
Gene expression databases
Bgee	Q8TAU0.
CleanEx	HS_NKX2-3.
Genevestigator	Q8TAU0.
GermOnline	ENSG00000119919. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	159296.
NextBio	87898.
SOURCE	Search...

Entry information

Entry name

NKX23_HUMAN

Accession

Primary (citable) accession number: Q8TAU0
Secondary accession number(s): B4DUZ4, Q9NYS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	January 27, 2003
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.