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Q8TAU0

- NKX23_HUMAN

UniProt

Q8TAU0 - NKX23_HUMAN

Protein

Homeobox protein Nkx-2.3

Gene

NKX2-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (27 Jan 2003)
      Previous versions | rss
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    Functioni

    Transcription factor.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi148 – 20760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. CD4-positive, alpha-beta T cell differentiation Source: Ensembl
    2. gland morphogenesis Source: Ensembl
    3. leukocyte homeostasis Source: Ensembl
    4. leukocyte migration Source: Ensembl
    5. lymph node development Source: Ensembl
    6. macrophage differentiation Source: Ensembl
    7. odontogenesis of dentin-containing tooth Source: Ensembl
    8. Peyer's patch development Source: Ensembl
    9. plasma cell differentiation Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. post-embryonic digestive tract morphogenesis Source: Ensembl
    12. regulation of cell proliferation Source: Ensembl
    13. spleen development Source: Ensembl
    14. transcription, DNA-templated Source: UniProtKB-KW
    15. triglyceride metabolic process Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Nkx-2.3
    Alternative name(s):
    Homeobox protein NK-2 homolog C
    Gene namesi
    Name:NKX2-3
    Synonyms:NKX23, NKX2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:7836. NKX2-3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31643.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Homeobox protein Nkx-2.3PRO_0000048933Add
    BLAST

    Proteomic databases

    PaxDbiQ8TAU0.
    PeptideAtlasiQ8TAU0.
    PRIDEiQ8TAU0.

    PTM databases

    PhosphoSiteiQ8TAU0.

    Expressioni

    Gene expression databases

    BgeeiQ8TAU0.
    CleanExiHS_NKX2-3.
    GenevestigatoriQ8TAU0.

    Organism-specific databases

    HPAiHPA047561.

    Interactioni

    Protein-protein interaction databases

    BioGridi127740. 2 interactions.
    IntActiQ8TAU0. 1 interaction.
    STRINGi9606.ENSP00000342828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAU0.
    SMRiQ8TAU0. Positions 148-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 2235Poly-Pro
    Compositional biasi271 – 28616Poly-AlaAdd
    BLAST
    Compositional biasi298 – 3058Poly-Gly

    Sequence similaritiesi

    Belongs to the NK-2 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG310976.
    HOGENOMiHOG000231923.
    HOVERGENiHBG006689.
    InParanoidiQ8TAU0.
    KOiK09343.
    OMAiPCVTPSA.
    OrthoDBiEOG769ZK0.
    PhylomeDBiQ8TAU0.
    TreeFamiTF351204.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA    50
    EGTQFSDGGE EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS 100
    CSEPKEHEEE PEVVRDRSQK SCQLKKSLET AGDCKAAEES ERPKPRSRRK 150
    PRVLFSQAQV FELERRFKQQ RYLSAPEREH LASSLKLTST QVKIWFQNRR 200
    YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT PSAQAYGAPY 250
    SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG 300
    GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG 350
    AACAQGTLQG IRAW 364
    Length:364
    Mass (Da):38,406
    Last modified:January 27, 2003 - v2
    Checksum:i10A279CFA3C8A6DB
    GO

    Sequence cautioni

    The sequence AAH25788.1 differs from that shown. Reason: Frameshift at position 273. The lack of 97 nucleotides within coding exon 2 produces a frameshift and results in a truncated protein.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300856 mRNA. Translation: BAG62506.1.
    AL353719 Genomic DNA. Translation: CAI16899.1.
    BC025788 mRNA. Translation: AAH25788.1. Frameshift.
    AH009193 Genomic DNA. Translation: AAF44651.1.
    CCDSiCCDS41558.1.
    RefSeqiNP_660328.2. NM_145285.2.
    UniGeneiHs.243272.

    Genome annotation databases

    EnsembliENST00000344586; ENSP00000342828; ENSG00000119919.
    GeneIDi159296.
    KEGGihsa:159296.
    UCSCiuc009xwj.3. human.

    Polymorphism databases

    DMDMi27923815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300856 mRNA. Translation: BAG62506.1 .
    AL353719 Genomic DNA. Translation: CAI16899.1 .
    BC025788 mRNA. Translation: AAH25788.1 . Frameshift.
    AH009193 Genomic DNA. Translation: AAF44651.1 .
    CCDSi CCDS41558.1.
    RefSeqi NP_660328.2. NM_145285.2.
    UniGenei Hs.243272.

    3D structure databases

    ProteinModelPortali Q8TAU0.
    SMRi Q8TAU0. Positions 148-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127740. 2 interactions.
    IntActi Q8TAU0. 1 interaction.
    STRINGi 9606.ENSP00000342828.

    PTM databases

    PhosphoSitei Q8TAU0.

    Polymorphism databases

    DMDMi 27923815.

    Proteomic databases

    PaxDbi Q8TAU0.
    PeptideAtlasi Q8TAU0.
    PRIDEi Q8TAU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344586 ; ENSP00000342828 ; ENSG00000119919 .
    GeneIDi 159296.
    KEGGi hsa:159296.
    UCSCi uc009xwj.3. human.

    Organism-specific databases

    CTDi 159296.
    GeneCardsi GC10P101292.
    HGNCi HGNC:7836. NKX2-3.
    HPAi HPA047561.
    MIMi 606727. gene.
    neXtProti NX_Q8TAU0.
    PharmGKBi PA31643.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310976.
    HOGENOMi HOG000231923.
    HOVERGENi HBG006689.
    InParanoidi Q8TAU0.
    KOi K09343.
    OMAi PCVTPSA.
    OrthoDBi EOG769ZK0.
    PhylomeDBi Q8TAU0.
    TreeFami TF351204.

    Miscellaneous databases

    GeneWikii NKX2-3.
    GenomeRNAii 159296.
    NextBioi 87898.
    PROi Q8TAU0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TAU0.
    CleanExi HS_NKX2-3.
    Genevestigatori Q8TAU0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Spleen.
    4. "Homeobox gene Nkx2-3 is critical for normal development of the gut, spleen and gut-associated lymphoid tissue."
      Wang C.-C., Brodnicki T., Harvey R.P.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-211.

    Entry informationi

    Entry nameiNKX23_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAU0
    Secondary accession number(s): B4DUZ4, Q9NYS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: January 27, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3