Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor-binding protein 3

Gene

FGFBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

  • positive regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  • positive regulation of vascular permeability Source: MGI

Keywordsi

Molecular functionGrowth factor binding, Heparin-binding

Enzyme and pathway databases

ReactomeiR-HSA-190377 FGFR2b ligand binding and activation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor-binding protein 3
Short name:
FGF-BP3
Short name:
FGF-binding protein 3
Short name:
FGFBP-3
Gene namesi
Name:FGFBP3
Synonyms:C10orf13
ORF Names:PSEC0101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000174721.9
HGNCiHGNC:23428 FGFBP3
neXtProtiNX_Q8TAT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi143282
OpenTargetsiENSG00000174721
PharmGKBiPA162388444

Polymorphism and mutation databases

BioMutaiFGFBP3
DMDMi74751362

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000024426427 – 258Fibroblast growth factor-binding protein 3Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 80By similarity
Disulfide bondi90 ↔ 124By similarity
Disulfide bondi241 ↔ 249By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8TAT2
PaxDbiQ8TAT2
PeptideAtlasiQ8TAT2
PRIDEiQ8TAT2

PTM databases

iPTMnetiQ8TAT2
PhosphoSitePlusiQ8TAT2

Expressioni

Gene expression databases

BgeeiENSG00000174721
CleanExiHS_FGFBP3
GenevisibleiQ8TAT2 HS

Organism-specific databases

HPAiHPA053943

Interactioni

Subunit structurei

Interacts with FGF2.1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: MGI

Protein-protein interaction databases

STRINGi9606.ENSP00000339067

Structurei

3D structure databases

ProteinModelPortaliQ8TAT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J22M Eukaryota
ENOG4112ARC LUCA
GeneTreeiENSGT00680000100139
HOGENOMiHOG000059653
HOVERGENiHBG066419
InParanoidiQ8TAT2
OMAiKRRPCHD
OrthoDBiEOG091G0RWC
PhylomeDBiQ8TAT2
TreeFamiTF335877

Family and domain databases

InterProiView protein in InterPro
IPR010510 FGF1-bd
PANTHERiPTHR15258 PTHR15258, 1 hit
PfamiView protein in Pfam
PF06473 FGF-BP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TAT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPKLRASL SPSLLLLLSG CLLAAARREK GAASNVAEPV PGPTGGSSGR
60 70 80 90 100
FLSPEQHACS WQLLLPAPEA AAGSELALRC QSPDGARHQC AYRGHPERCA
110 120 130 140 150
AYAARRAHFW KQVLGGLRKK RRPCHDPAPL QARLCAGKKG HGAELRLVPR
160 170 180 190 200
ASPPARPTVA GFAGESKPRA RNRGRTRERA SGPAAGTPPP QSAPPKENPS
210 220 230 240 250
ERKTNEGKRK AALVPNEERP MGTGPDPDGL DGNAELTETY CAEKWHSLCN

FFVNFWNG
Length:258
Mass (Da):27,590
Last modified:June 1, 2002 - v1
Checksum:iC6290744F0AB9DEF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059288107A → T. Corresponds to variant dbSNP:rs10881994Ensembl.1
Natural variantiVAR_026888206E → V1 PublicationCorresponds to variant dbSNP:rs1107947Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ503576 mRNA Translation: ABF56582.1
AK075410 mRNA Translation: BAC11602.1
AK315427 mRNA Translation: BAG37815.1
AL359198 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50104.1
BC025966 mRNA Translation: AAH25966.1
CCDSiCCDS7418.1
RefSeqiNP_689642.3, NM_152429.4
UniGeneiHs.466120

Genome annotation databases

EnsembliENST00000311575; ENSP00000339067; ENSG00000174721
GeneIDi143282
KEGGihsa:143282
UCSCiuc001khq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFGFP3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAT2
Secondary accession number(s): B2RD68, Q8NBN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health