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Protein

Serine/threonine-protein kinase Kist

Gene

UHMK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei158 – 1581Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: HGNC
  2. protein serine/threonine kinase activity Source: HGNC
  3. ribonucleoprotein complex binding Source: BHF-UCL
  4. RNA binding Source: UniProtKB-KW
  5. transferase activity Source: HGNC

GO - Biological processi

  1. cell cycle arrest Source: HGNC
  2. neuron projection development Source: BHF-UCL
  3. peptidyl-serine phosphorylation Source: UniProtKB
  4. positive regulation of translational initiation Source: BHF-UCL
  5. protein autophosphorylation Source: HGNC
  6. regulation of protein export from nucleus Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

SignaLinkiQ8TAS1.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Kist (EC:2.7.11.1)
Alternative name(s):
Kinase interacting with stathmin
PAM COOH-terminal interactor protein 2
Short name:
P-CIP2
U2AF homology motif kinase 1
Gene namesi
Name:UHMK1
Synonyms:KIS, KIST
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19683. UHMK1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. axon Source: BHF-UCL
  2. dendrite cytoplasm Source: BHF-UCL
  3. neuronal ribonucleoprotein granule Source: BHF-UCL
  4. nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541K → A: Loss of kinase activity. 1 Publication

Organism-specific databases

PharmGKBiPA134974001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Serine/threonine-protein kinase KistPRO_0000086777Add
BLAST

Proteomic databases

PaxDbiQ8TAS1.
PRIDEiQ8TAS1.

PTM databases

PhosphoSiteiQ8TAS1.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.1 Publication

Developmental stagei

Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level).1 Publication

Gene expression databases

BgeeiQ8TAS1.
CleanExiHS_UHMK1.
GenevestigatoriQ8TAS1.

Interactioni

Subunit structurei

Interacts with stathmin and CDKN1B/p27Kip1 (By similarity). Interacts with PAM.By similarity2 Publications

Protein-protein interaction databases

BioGridi126088. 2 interactions.
IntActiQ8TAS1. 1 interaction.
MINTiMINT-7241640.
STRINGi9606.ENSP00000420270.

Structurei

3D structure databases

ProteinModelPortaliQ8TAS1.
SMRiQ8TAS1. Positions 20-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 304282Protein kinaseCuratedPROSITE-ProRule annotationAdd
BLAST
Domaini324 – 40683RRMCuratedPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000013166.
HOVERGENiHBG056149.
InParanoidiQ8TAS1.
KOiK08877.
OMAiDMKEECQ.
OrthoDBiEOG7S4X5Z.
PhylomeDBiQ8TAS1.
TreeFamiTF331856.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000719. Prot_kinase_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TAS1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP
60 70 80 90 100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF
110 120 130 140 150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH
160 170 180 190 200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP
210 220 230 240 250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW
260 270 280 290 300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC
310 320 330 340 350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE
360 370 380 390 400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV
410
ATFYPLSAYK RGYLYQTLL
Length:419
Mass (Da):46,546
Last modified:October 19, 2002 - v2
Checksum:i903E982EE12A8CF8
GO
Isoform 2 (identifier: Q8TAS1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-344: DVV → GLC
     345-419: Missing.

Note: No experimental confirmation available.

Show »
Length:344
Mass (Da):38,130
Checksum:iF17050CA387CCA9B
GO
Isoform 3 (identifier: Q8TAS1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAGSGCAWGA...LEQLQGHRNI → MFLTRPKVCVDLNRR

Note: No experimental confirmation available.

Show »
Length:345
Mass (Da):39,044
Checksum:i2D542DC30505CF01
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591L → V.1 Publication
Corresponds to variant rs34466082 [ dbSNP | Ensembl ].
VAR_041272
Natural varianti197 – 1971Y → D.1 Publication
Corresponds to variant rs56201055 [ dbSNP | Ensembl ].
VAR_041273

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989MAGSG…GHRNI → MFLTRPKVCVDLNRR in isoform 3. 1 PublicationVSP_046145Add
BLAST
Alternative sequencei342 – 3443DVV → GLC in isoform 2. 1 PublicationVSP_004908
Alternative sequencei345 – 41975Missing in isoform 2. 1 PublicationVSP_004909Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536197 mRNA. Translation: CAD60192.1.
AK058195 mRNA. No translation available.
AK292369 mRNA. Translation: BAF85058.1.
AL359699 Genomic DNA. Translation: CAH70392.1.
CH471067 Genomic DNA. Translation: EAW90706.1.
CH471067 Genomic DNA. Translation: EAW90707.1.
BC014917 mRNA. Translation: AAH14917.1.
BC026046 mRNA. Translation: AAH26046.1.
CCDSiCCDS1239.1. [Q8TAS1-1]
CCDS53423.1. [Q8TAS1-3]
CCDS53424.1. [Q8TAS1-2]
RefSeqiNP_001171692.1. NM_001184763.1. [Q8TAS1-3]
NP_653225.2. NM_144624.2. [Q8TAS1-2]
NP_787062.1. NM_175866.4. [Q8TAS1-1]
UniGeneiHs.127310.

Genome annotation databases

GeneIDi127933.
KEGGihsa:127933.
UCSCiuc001gcc.2. human. [Q8TAS1-1]
uc001gcd.3. human.
uc009wuu.2. human. [Q8TAS1-2]

Polymorphism databases

DMDMi24211880.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536197 mRNA. Translation: CAD60192.1.
AK058195 mRNA. No translation available.
AK292369 mRNA. Translation: BAF85058.1.
AL359699 Genomic DNA. Translation: CAH70392.1.
CH471067 Genomic DNA. Translation: EAW90706.1.
CH471067 Genomic DNA. Translation: EAW90707.1.
BC014917 mRNA. Translation: AAH14917.1.
BC026046 mRNA. Translation: AAH26046.1.
CCDSiCCDS1239.1. [Q8TAS1-1]
CCDS53423.1. [Q8TAS1-3]
CCDS53424.1. [Q8TAS1-2]
RefSeqiNP_001171692.1. NM_001184763.1. [Q8TAS1-3]
NP_653225.2. NM_144624.2. [Q8TAS1-2]
NP_787062.1. NM_175866.4. [Q8TAS1-1]
UniGeneiHs.127310.

3D structure databases

ProteinModelPortaliQ8TAS1.
SMRiQ8TAS1. Positions 20-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126088. 2 interactions.
IntActiQ8TAS1. 1 interaction.
MINTiMINT-7241640.
STRINGi9606.ENSP00000420270.

PTM databases

PhosphoSiteiQ8TAS1.

Polymorphism databases

DMDMi24211880.

Proteomic databases

PaxDbiQ8TAS1.
PRIDEiQ8TAS1.

Protocols and materials databases

DNASUi127933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi127933.
KEGGihsa:127933.
UCSCiuc001gcc.2. human. [Q8TAS1-1]
uc001gcd.3. human.
uc009wuu.2. human. [Q8TAS1-2]

Organism-specific databases

CTDi127933.
GeneCardsiGC01P162467.
HGNCiHGNC:19683. UHMK1.
MIMi608849. gene.
neXtProtiNX_Q8TAS1.
PharmGKBiPA134974001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000013166.
HOVERGENiHBG056149.
InParanoidiQ8TAS1.
KOiK08877.
OMAiDMKEECQ.
OrthoDBiEOG7S4X5Z.
PhylomeDBiQ8TAS1.
TreeFamiTF331856.

Enzyme and pathway databases

SignaLinkiQ8TAS1.

Miscellaneous databases

ChiTaRSiUHMK1. human.
GeneWikiiUHMK1.
GenomeRNAii127933.
NextBioi82204.
PROiQ8TAS1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAS1.
CleanExiHS_UHMK1.
GenevestigatoriQ8TAS1.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000719. Prot_kinase_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human."
    Bieche I., Manceau V., Curmi P.A., Laurendeau I., Lachkar S., Leroy K., Vidaud D., Sobel A., Maucuer A.
    Brain Res. Mol. Brain Res. 114:55-64(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Skin.
  6. "The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase."
    Caldwell B.D., Darlington D.N., Penzes P., Johnson R.C., Eipper B.A., Mains R.E.
    J. Biol. Chem. 274:34646-34656(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PAM.
  7. "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression."
    Boehm M., Yoshimoto T., Crook M.F., Nallamshetty S., True A., Nabel G.J., Nabel E.G.
    EMBO J. 21:3390-3401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDKN1B, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-54.
  8. Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  9. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-159 AND ASP-197.

Entry informationi

Entry nameiUHMK1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAS1
Secondary accession number(s): A8K8K4, G3V1M1, Q96C22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: February 4, 2015
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.