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Q8TAS1

- UHMK1_HUMAN

UniProt

Q8TAS1 - UHMK1_HUMAN

Protein

Serine/threonine-protein kinase Kist

Gene

UHMK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (19 Oct 2002)
      Previous versions | rss
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    Functioni

    Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541ATPPROSITE-ProRule annotation
    Active sitei158 – 1581Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: HGNC
    2. protein binding Source: HGNC
    3. protein serine/threonine kinase activity Source: HGNC
    4. ribonucleoprotein complex binding Source: BHF-UCL
    5. RNA binding Source: UniProtKB-KW
    6. transferase activity Source: HGNC

    GO - Biological processi

    1. cell cycle arrest Source: HGNC
    2. neuron projection development Source: BHF-UCL
    3. peptidyl-serine phosphorylation Source: UniProtKB
    4. positive regulation of translational initiation Source: BHF-UCL
    5. protein autophosphorylation Source: HGNC
    6. regulation of protein export from nucleus Source: HGNC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Enzyme and pathway databases

    SignaLinkiQ8TAS1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase Kist (EC:2.7.11.1)
    Alternative name(s):
    Kinase interacting with stathmin
    PAM COOH-terminal interactor protein 2
    Short name:
    P-CIP2
    U2AF homology motif kinase 1
    Gene namesi
    Name:UHMK1
    Synonyms:KIS, KIST
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19683. UHMK1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. axon Source: BHF-UCL
    2. dendrite cytoplasm Source: BHF-UCL
    3. neuronal ribonucleoprotein granule Source: BHF-UCL
    4. nucleus Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi54 – 541K → A: Loss of kinase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134974001.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Serine/threonine-protein kinase KistPRO_0000086777Add
    BLAST

    Proteomic databases

    PaxDbiQ8TAS1.
    PRIDEiQ8TAS1.

    PTM databases

    PhosphoSiteiQ8TAS1.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.1 Publication

    Developmental stagei

    Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level).1 Publication

    Gene expression databases

    BgeeiQ8TAS1.
    CleanExiHS_UHMK1.
    GenevestigatoriQ8TAS1.

    Interactioni

    Subunit structurei

    Interacts with stathmin and CDKN1B/p27Kip1 By similarity. Interacts with PAM.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi126088. 2 interactions.
    IntActiQ8TAS1. 1 interaction.
    MINTiMINT-7241640.
    STRINGi9606.ENSP00000420270.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAS1.
    SMRiQ8TAS1. Positions 23-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 304282Protein kinaseCuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini324 – 40683RRMCuratedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000013166.
    HOVERGENiHBG056149.
    InParanoidiQ8TAS1.
    KOiK08877.
    OMAiYGVFTNH.
    OrthoDBiEOG7S4X5Z.
    PhylomeDBiQ8TAS1.
    TreeFamiTF331856.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000719. Prot_kinase_dom.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TAS1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP    50
    GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF 100
    SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH 150
    HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP 200
    EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW 250
    KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC 300
    SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE 350
    CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV 400
    ATFYPLSAYK RGYLYQTLL 419
    Length:419
    Mass (Da):46,546
    Last modified:October 19, 2002 - v2
    Checksum:i903E982EE12A8CF8
    GO
    Isoform 2 (identifier: Q8TAS1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         342-344: DVV → GLC
         345-419: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:344
    Mass (Da):38,130
    Checksum:iF17050CA387CCA9B
    GO
    Isoform 3 (identifier: Q8TAS1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-89: MAGSGCAWGA...LEQLQGHRNI → MFLTRPKVCVDLNRR

    Note: No experimental confirmation available.

    Show »
    Length:345
    Mass (Da):39,044
    Checksum:i2D542DC30505CF01
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti159 – 1591L → V.1 Publication
    Corresponds to variant rs34466082 [ dbSNP | Ensembl ].
    VAR_041272
    Natural varianti197 – 1971Y → D.1 Publication
    Corresponds to variant rs56201055 [ dbSNP | Ensembl ].
    VAR_041273

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8989MAGSG…GHRNI → MFLTRPKVCVDLNRR in isoform 3. 1 PublicationVSP_046145Add
    BLAST
    Alternative sequencei342 – 3443DVV → GLC in isoform 2. 1 PublicationVSP_004908
    Alternative sequencei345 – 41975Missing in isoform 2. 1 PublicationVSP_004909Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ536197 mRNA. Translation: CAD60192.1.
    AK058195 mRNA. No translation available.
    AK292369 mRNA. Translation: BAF85058.1.
    AL359699 Genomic DNA. Translation: CAH70392.1.
    CH471067 Genomic DNA. Translation: EAW90706.1.
    CH471067 Genomic DNA. Translation: EAW90707.1.
    BC014917 mRNA. Translation: AAH14917.1.
    BC026046 mRNA. Translation: AAH26046.1.
    CCDSiCCDS1239.1. [Q8TAS1-1]
    CCDS53423.1. [Q8TAS1-3]
    CCDS53424.1. [Q8TAS1-2]
    RefSeqiNP_001171692.1. NM_001184763.1. [Q8TAS1-3]
    NP_653225.2. NM_144624.2. [Q8TAS1-2]
    NP_787062.1. NM_175866.4. [Q8TAS1-1]
    UniGeneiHs.127310.

    Genome annotation databases

    EnsembliENST00000489294; ENSP00000420270; ENSG00000152332. [Q8TAS1-1]
    ENST00000538489; ENSP00000446416; ENSG00000152332. [Q8TAS1-2]
    ENST00000545294; ENSP00000441226; ENSG00000152332. [Q8TAS1-3]
    GeneIDi127933.
    KEGGihsa:127933.
    UCSCiuc001gcc.2. human. [Q8TAS1-1]
    uc001gcd.3. human.
    uc009wuu.2. human. [Q8TAS1-2]

    Polymorphism databases

    DMDMi24211880.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ536197 mRNA. Translation: CAD60192.1 .
    AK058195 mRNA. No translation available.
    AK292369 mRNA. Translation: BAF85058.1 .
    AL359699 Genomic DNA. Translation: CAH70392.1 .
    CH471067 Genomic DNA. Translation: EAW90706.1 .
    CH471067 Genomic DNA. Translation: EAW90707.1 .
    BC014917 mRNA. Translation: AAH14917.1 .
    BC026046 mRNA. Translation: AAH26046.1 .
    CCDSi CCDS1239.1. [Q8TAS1-1 ]
    CCDS53423.1. [Q8TAS1-3 ]
    CCDS53424.1. [Q8TAS1-2 ]
    RefSeqi NP_001171692.1. NM_001184763.1. [Q8TAS1-3 ]
    NP_653225.2. NM_144624.2. [Q8TAS1-2 ]
    NP_787062.1. NM_175866.4. [Q8TAS1-1 ]
    UniGenei Hs.127310.

    3D structure databases

    ProteinModelPortali Q8TAS1.
    SMRi Q8TAS1. Positions 23-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126088. 2 interactions.
    IntActi Q8TAS1. 1 interaction.
    MINTi MINT-7241640.
    STRINGi 9606.ENSP00000420270.

    PTM databases

    PhosphoSitei Q8TAS1.

    Polymorphism databases

    DMDMi 24211880.

    Proteomic databases

    PaxDbi Q8TAS1.
    PRIDEi Q8TAS1.

    Protocols and materials databases

    DNASUi 127933.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000489294 ; ENSP00000420270 ; ENSG00000152332 . [Q8TAS1-1 ]
    ENST00000538489 ; ENSP00000446416 ; ENSG00000152332 . [Q8TAS1-2 ]
    ENST00000545294 ; ENSP00000441226 ; ENSG00000152332 . [Q8TAS1-3 ]
    GeneIDi 127933.
    KEGGi hsa:127933.
    UCSCi uc001gcc.2. human. [Q8TAS1-1 ]
    uc001gcd.3. human.
    uc009wuu.2. human. [Q8TAS1-2 ]

    Organism-specific databases

    CTDi 127933.
    GeneCardsi GC01P162467.
    HGNCi HGNC:19683. UHMK1.
    MIMi 608849. gene.
    neXtProti NX_Q8TAS1.
    PharmGKBi PA134974001.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000013166.
    HOVERGENi HBG056149.
    InParanoidi Q8TAS1.
    KOi K08877.
    OMAi YGVFTNH.
    OrthoDBi EOG7S4X5Z.
    PhylomeDBi Q8TAS1.
    TreeFami TF331856.

    Enzyme and pathway databases

    SignaLinki Q8TAS1.

    Miscellaneous databases

    ChiTaRSi UHMK1. human.
    GeneWikii UHMK1.
    GenomeRNAii 127933.
    NextBioi 82204.
    PROi Q8TAS1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TAS1.
    CleanExi HS_UHMK1.
    Genevestigatori Q8TAS1.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000719. Prot_kinase_dom.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human."
      Bieche I., Manceau V., Curmi P.A., Laurendeau I., Lachkar S., Leroy K., Vidaud D., Sobel A., Maucuer A.
      Brain Res. Mol. Brain Res. 114:55-64(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye and Skin.
    6. "The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase."
      Caldwell B.D., Darlington D.N., Penzes P., Johnson R.C., Eipper B.A., Mains R.E.
      J. Biol. Chem. 274:34646-34656(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PAM.
    7. "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression."
      Boehm M., Yoshimoto T., Crook M.F., Nallamshetty S., True A., Nabel G.J., Nabel E.G.
      EMBO J. 21:3390-3401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDKN1B, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-54.
    8. Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    9. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-159 AND ASP-197.

    Entry informationi

    Entry nameiUHMK1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAS1
    Secondary accession number(s): A8K8K4, G3V1M1, Q96C22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3