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Protein

Serine/threonine-protein kinase Kist

Gene

UHMK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: HGNC
  • mRNA binding Source: GO_Central
  • protein serine/threonine kinase activity Source: HGNC
  • ribonucleoprotein complex binding Source: BHF-UCL
  • transferase activity Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:HS07808-MONOMER.
SignaLinkiQ8TAS1.
SIGNORiQ8TAS1.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Kist (EC:2.7.11.1)
Alternative name(s):
Kinase interacting with stathmin
PAM COOH-terminal interactor protein 2
Short name:
P-CIP2
U2AF homology motif kinase 1
Gene namesi
Name:UHMK1
Synonyms:KIS, KIST
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19683. UHMK1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54K → A: Loss of kinase activity. 1 Publication1

Organism-specific databases

DisGeNETi127933.
OpenTargetsiENSG00000152332.
PharmGKBiPA134974001.

Polymorphism and mutation databases

BioMutaiUHMK1.
DMDMi24211880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867771 – 419Serine/threonine-protein kinase KistAdd BLAST419

Proteomic databases

PaxDbiQ8TAS1.
PeptideAtlasiQ8TAS1.
PRIDEiQ8TAS1.

PTM databases

iPTMnetiQ8TAS1.
PhosphoSitePlusiQ8TAS1.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.1 Publication

Developmental stagei

Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000152332.
CleanExiHS_UHMK1.
GenevisibleiQ8TAS1. HS.

Interactioni

Subunit structurei

Interacts with stathmin and CDKN1B/p27Kip1 (By similarity). Interacts with PAM.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156374EBI-1753608,EBI-744603

Protein-protein interaction databases

BioGridi126088. 2 interactors.
IntActiQ8TAS1. 5 interactors.
MINTiMINT-7241640.
STRINGi9606.ENSP00000420270.

Structurei

3D structure databases

ProteinModelPortaliQ8TAS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 304Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST282
Domaini324 – 406RRMPROSITE-ProRule annotationCuratedAdd BLAST83

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00790000123065.
HOGENOMiHOG000013166.
HOVERGENiHBG056149.
InParanoidiQ8TAS1.
KOiK08877.
OMAiDMKEECQ.
OrthoDBiEOG091G08EY.
PhylomeDBiQ8TAS1.
TreeFamiTF331856.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000719. Prot_kinase_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP
60 70 80 90 100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF
110 120 130 140 150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH
160 170 180 190 200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP
210 220 230 240 250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW
260 270 280 290 300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC
310 320 330 340 350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE
360 370 380 390 400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV
410
ATFYPLSAYK RGYLYQTLL
Length:419
Mass (Da):46,546
Last modified:October 19, 2002 - v2
Checksum:i903E982EE12A8CF8
GO
Isoform 2 (identifier: Q8TAS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-344: DVV → GLC
     345-419: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):38,130
Checksum:iF17050CA387CCA9B
GO
Isoform 3 (identifier: Q8TAS1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAGSGCAWGA...LEQLQGHRNI → MFLTRPKVCVDLNRR

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):39,044
Checksum:i2D542DC30505CF01
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041272159L → V.1 PublicationCorresponds to variant rs34466082dbSNPEnsembl.1
Natural variantiVAR_041273197Y → D.1 PublicationCorresponds to variant rs56201055dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0461451 – 89MAGSG…GHRNI → MFLTRPKVCVDLNRR in isoform 3. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_004908342 – 344DVV → GLC in isoform 2. 1 Publication3
Alternative sequenceiVSP_004909345 – 419Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536197 mRNA. Translation: CAD60192.1.
AK058195 mRNA. No translation available.
AK292369 mRNA. Translation: BAF85058.1.
AL359699 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90706.1.
CH471067 Genomic DNA. Translation: EAW90707.1.
BC014917 mRNA. Translation: AAH14917.1.
BC026046 mRNA. Translation: AAH26046.1.
CCDSiCCDS1239.1. [Q8TAS1-1]
CCDS53423.1. [Q8TAS1-3]
CCDS53424.1. [Q8TAS1-2]
RefSeqiNP_001171692.1. NM_001184763.1. [Q8TAS1-3]
NP_653225.2. NM_144624.2. [Q8TAS1-2]
NP_787062.1. NM_175866.4. [Q8TAS1-1]
UniGeneiHs.127310.

Genome annotation databases

EnsembliENST00000489294; ENSP00000420270; ENSG00000152332. [Q8TAS1-1]
ENST00000538489; ENSP00000446416; ENSG00000152332. [Q8TAS1-2]
ENST00000545294; ENSP00000441226; ENSG00000152332. [Q8TAS1-3]
GeneIDi127933.
KEGGihsa:127933.
UCSCiuc001gcc.3. human. [Q8TAS1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536197 mRNA. Translation: CAD60192.1.
AK058195 mRNA. No translation available.
AK292369 mRNA. Translation: BAF85058.1.
AL359699 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90706.1.
CH471067 Genomic DNA. Translation: EAW90707.1.
BC014917 mRNA. Translation: AAH14917.1.
BC026046 mRNA. Translation: AAH26046.1.
CCDSiCCDS1239.1. [Q8TAS1-1]
CCDS53423.1. [Q8TAS1-3]
CCDS53424.1. [Q8TAS1-2]
RefSeqiNP_001171692.1. NM_001184763.1. [Q8TAS1-3]
NP_653225.2. NM_144624.2. [Q8TAS1-2]
NP_787062.1. NM_175866.4. [Q8TAS1-1]
UniGeneiHs.127310.

3D structure databases

ProteinModelPortaliQ8TAS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126088. 2 interactors.
IntActiQ8TAS1. 5 interactors.
MINTiMINT-7241640.
STRINGi9606.ENSP00000420270.

PTM databases

iPTMnetiQ8TAS1.
PhosphoSitePlusiQ8TAS1.

Polymorphism and mutation databases

BioMutaiUHMK1.
DMDMi24211880.

Proteomic databases

PaxDbiQ8TAS1.
PeptideAtlasiQ8TAS1.
PRIDEiQ8TAS1.

Protocols and materials databases

DNASUi127933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000489294; ENSP00000420270; ENSG00000152332. [Q8TAS1-1]
ENST00000538489; ENSP00000446416; ENSG00000152332. [Q8TAS1-2]
ENST00000545294; ENSP00000441226; ENSG00000152332. [Q8TAS1-3]
GeneIDi127933.
KEGGihsa:127933.
UCSCiuc001gcc.3. human. [Q8TAS1-1]

Organism-specific databases

CTDi127933.
DisGeNETi127933.
GeneCardsiUHMK1.
HGNCiHGNC:19683. UHMK1.
MIMi608849. gene.
neXtProtiNX_Q8TAS1.
OpenTargetsiENSG00000152332.
PharmGKBiPA134974001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00790000123065.
HOGENOMiHOG000013166.
HOVERGENiHBG056149.
InParanoidiQ8TAS1.
KOiK08877.
OMAiDMKEECQ.
OrthoDBiEOG091G08EY.
PhylomeDBiQ8TAS1.
TreeFamiTF331856.

Enzyme and pathway databases

BioCyciZFISH:HS07808-MONOMER.
SignaLinkiQ8TAS1.
SIGNORiQ8TAS1.

Miscellaneous databases

ChiTaRSiUHMK1. human.
GeneWikiiUHMK1.
GenomeRNAii127933.
PROiQ8TAS1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152332.
CleanExiHS_UHMK1.
GenevisibleiQ8TAS1. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000719. Prot_kinase_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUHMK1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAS1
Secondary accession number(s): A0A0A6YYC2
, A8K8K4, G3V1M1, Q96C22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.