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Protein

SUN domain-containing protein 3

Gene

SUN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164744-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 3
Alternative name(s):
Sad1/unc-84 domain-containing protein 1
Gene namesi
Name:SUN3
Synonyms:SUNC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22429. SUN3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 64HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi256979.
OpenTargetsiENSG00000164744.
PharmGKBiPA165618375.

Polymorphism and mutation databases

BioMutaiSUN3.
DMDMi162416243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122201 – 357SUN domain-containing protein 3Add BLAST357

Proteomic databases

PaxDbiQ8TAQ9.
PeptideAtlasiQ8TAQ9.
PRIDEiQ8TAQ9.

PTM databases

iPTMnetiQ8TAQ9.
PhosphoSitePlusiQ8TAQ9.

Expressioni

Gene expression databases

BgeeiENSG00000164744.
CleanExiHS_SUNC1.
ExpressionAtlasiQ8TAQ9. baseline and differential.
GenevisibleiQ8TAQ9. HS.

Organism-specific databases

HPAiHPA008344.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297325.

Structurei

3D structure databases

ProteinModelPortaliQ8TAQ9.
SMRiQ8TAQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 354SUNPROSITE-ProRule annotationAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 146Sequence analysisAdd BLAST49

Sequence similaritiesi

Contains 1 SUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000007503.
HOVERGENiHBG108520.
InParanoidiQ8TAQ9.
OMAiCVKLNIF.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ8TAQ9.
TreeFamiTF323915.

Family and domain databases

InterProiIPR030274. SUN3.
IPR012919. SUN_dom.
[Graphical view]
PANTHERiPTHR12911:SF24. PTHR12911:SF24. 1 hit.
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGKTKARRA AMFFRRCSED ASGSASGNAL LSEDENPDAN GVTRSWKIIL
60 70 80 90 100
STMLTLTFLL VGLLNHQWLK ETDVPQKSRQ LYAIIAEYGS RLYKYQARLR
110 120 130 140 150
MPKEQLELLK KESQNLENNF RQILFLIEQI DVLKALLRDM KDGMDNNHNW
160 170 180 190 200
NTHGDPVEDP DHTEEVSNLV NYVLKKLRED QVEMADYALK SAGASIIEAG
210 220 230 240 250
TSESYKNNKA KLYWHGIGFL NHEMPPDIIL QPDVYPGKCW AFPGSQGHTL
260 270 280 290 300
IKLATKIIPT AVTMEHISEK VSPSGNISSA PKEFSVYGIT KKCEGEEIFL
310 320 330 340 350
GQFIYNKTGT TVQTFELQHA VSEYLLCVKL NIFSNWGHPK YTCLYRFRVH

GTPGKHI
Length:357
Mass (Da):40,503
Last modified:December 4, 2007 - v4
Checksum:i5E63D57F1806753B
GO
Isoform 2 (identifier: Q8TAQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     287-287: Y → YVQRYMCRFVIQA

Show »
Length:269
Mass (Da):30,703
Checksum:i57908C8B09119E5D
GO
Isoform 3 (identifier: Q8TAQ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-61: SGKTKARRAA...TMLTLTFLLV → EDYSKYNAYT...ASASRVAGTT

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):39,079
Checksum:i712063DFF09C7F05
GO

Sequence cautioni

The sequence AAP97300 differs from that shown. Reason: Frameshift at positions 233 and 242.Curated
The sequence EAL23808 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231 – 232Missing in AAP97300 (Ref. 1) Curated2
Sequence conflicti292K → R in BAG63413 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037458127I → V.1 PublicationCorresponds to variant rs17852360dbSNPEnsembl.1
Natural variantiVAR_037459177L → V.Corresponds to variant rs7797657dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297481 – 100Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_0556242 – 61SGKTK…TFLLV → EDYSKYNAYTDFSSCRLECS GAILAHCNLHLLGSSISPAS ASRVAGTT in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_029749287Y → YVQRYMCRFVIQA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF429967 mRNA. Translation: AAP97300.1. Frameshift.
AK302011 mRNA. Translation: BAG63413.1.
DQ099386 mRNA. Translation: AAZ13762.1.
AC069279 Genomic DNA. No translation available.
CH236958 Genomic DNA. Translation: EAL23808.1. Sequence problems.
CH471128 Genomic DNA. Translation: EAW60999.1.
CH471128 Genomic DNA. Translation: EAW61000.1.
BC026189 mRNA. Translation: AAH26189.3.
CCDSiCCDS34636.1. [Q8TAQ9-1]
CCDS64647.1. [Q8TAQ9-3]
RefSeqiNP_001025190.1. NM_001030019.1. [Q8TAQ9-1]
NP_001271279.1. NM_001284350.1. [Q8TAQ9-3]
NP_689995.3. NM_152782.3. [Q8TAQ9-1]
XP_016867419.1. XM_017011930.1. [Q8TAQ9-1]
UniGeneiHs.406741.

Genome annotation databases

EnsembliENST00000297325; ENSP00000297325; ENSG00000164744. [Q8TAQ9-1]
ENST00000395572; ENSP00000378939; ENSG00000164744. [Q8TAQ9-1]
ENST00000412142; ENSP00000410204; ENSG00000164744. [Q8TAQ9-3]
ENST00000438771; ENSP00000409077; ENSG00000164744. [Q8TAQ9-2]
GeneIDi256979.
KEGGihsa:256979.
UCSCiuc003tof.4. human. [Q8TAQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF429967 mRNA. Translation: AAP97300.1. Frameshift.
AK302011 mRNA. Translation: BAG63413.1.
DQ099386 mRNA. Translation: AAZ13762.1.
AC069279 Genomic DNA. No translation available.
CH236958 Genomic DNA. Translation: EAL23808.1. Sequence problems.
CH471128 Genomic DNA. Translation: EAW60999.1.
CH471128 Genomic DNA. Translation: EAW61000.1.
BC026189 mRNA. Translation: AAH26189.3.
CCDSiCCDS34636.1. [Q8TAQ9-1]
CCDS64647.1. [Q8TAQ9-3]
RefSeqiNP_001025190.1. NM_001030019.1. [Q8TAQ9-1]
NP_001271279.1. NM_001284350.1. [Q8TAQ9-3]
NP_689995.3. NM_152782.3. [Q8TAQ9-1]
XP_016867419.1. XM_017011930.1. [Q8TAQ9-1]
UniGeneiHs.406741.

3D structure databases

ProteinModelPortaliQ8TAQ9.
SMRiQ8TAQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297325.

PTM databases

iPTMnetiQ8TAQ9.
PhosphoSitePlusiQ8TAQ9.

Polymorphism and mutation databases

BioMutaiSUN3.
DMDMi162416243.

Proteomic databases

PaxDbiQ8TAQ9.
PeptideAtlasiQ8TAQ9.
PRIDEiQ8TAQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297325; ENSP00000297325; ENSG00000164744. [Q8TAQ9-1]
ENST00000395572; ENSP00000378939; ENSG00000164744. [Q8TAQ9-1]
ENST00000412142; ENSP00000410204; ENSG00000164744. [Q8TAQ9-3]
ENST00000438771; ENSP00000409077; ENSG00000164744. [Q8TAQ9-2]
GeneIDi256979.
KEGGihsa:256979.
UCSCiuc003tof.4. human. [Q8TAQ9-1]

Organism-specific databases

CTDi256979.
DisGeNETi256979.
GeneCardsiSUN3.
HGNCiHGNC:22429. SUN3.
HPAiHPA008344.
neXtProtiNX_Q8TAQ9.
OpenTargetsiENSG00000164744.
PharmGKBiPA165618375.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000007503.
HOVERGENiHBG108520.
InParanoidiQ8TAQ9.
OMAiCVKLNIF.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ8TAQ9.
TreeFamiTF323915.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164744-MONOMER.

Miscellaneous databases

GenomeRNAii256979.
PROiQ8TAQ9.

Gene expression databases

BgeeiENSG00000164744.
CleanExiHS_SUNC1.
ExpressionAtlasiQ8TAQ9. baseline and differential.
GenevisibleiQ8TAQ9. HS.

Family and domain databases

InterProiIPR030274. SUN3.
IPR012919. SUN_dom.
[Graphical view]
PANTHERiPTHR12911:SF24. PTHR12911:SF24. 1 hit.
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUN3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAQ9
Secondary accession number(s): A4D2F3
, B4DXK1, D3DVM3, E7EWC8, Q4F965, Q7Z4U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.