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Q8TAQ5

- ZN420_HUMAN

UniProt

Q8TAQ5 - ZN420_HUMAN

Protein

Zinc finger protein 420

Gene

ZNF420

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri139 – 16123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri167 – 18923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri195 – 21723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri223 – 24523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri251 – 27323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 30123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri307 – 32923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri391 – 41323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri559 – 58123C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri587 – 60923C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri615 – 63723C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri643 – 66523C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 420
    Gene namesi
    Name:ZNF420
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20649. ZNF420.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134958420.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 688688Zinc finger protein 420PRO_0000047575Add
    BLAST

    Proteomic databases

    PaxDbiQ8TAQ5.
    PRIDEiQ8TAQ5.

    PTM databases

    PhosphoSiteiQ8TAQ5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TAQ5.
    BgeeiQ8TAQ5.
    CleanExiHS_ZNF420.
    GenevestigatoriQ8TAQ5.

    Organism-specific databases

    HPAiHPA053022.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDKN2AQ8N7268EBI-3923307,EBI-625922
    TP53P046374EBI-3923307,EBI-366083

    Protein-protein interaction databases

    BioGridi127098. 11 interactions.
    IntActiQ8TAQ5. 9 interactions.
    MINTiMINT-7989567.
    STRINGi9606.ENSP00000338770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAQ5.
    SMRiQ8TAQ5. Positions 6-45, 136-665.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 8681KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri139 – 16123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri167 – 18923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri195 – 21723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri223 – 24523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri251 – 27323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 30123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri307 – 32923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri391 – 41323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri559 – 58123C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri587 – 60923C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri615 – 63723C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri643 – 66523C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8TAQ5.
    KOiK09228.
    OMAiEDTYETE.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8TAQ5.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 20 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 19 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 19 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TAQ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARKLVMFRD VAIDFSQEEW ECLDSAQRDL YRDVMLENYS NLVSLDLPSR    50
    CASKDLSPEK NTYETELSQW EMSDRLENCD LEESNSRDYL EAKGKMEKQQ 100
    ENQKEYFRQG MIIYDKMSIF NQHTYLSQHS RCHSTEKPYK CKECGKAFRR 150
    ASHLTQHQSI HTGEKPYECK QCGKAFSRDS QLSLHQRLHT GEKPYACKEC 200
    GKAFTQSSQL ILHHRIHTGE KPYKCEECGK AFIRSSQLTR HQKVHTGEKP 250
    YECKECGKAF TQNSQLTLHQ RLHTGEKLYE CKECRKVFTQ LSQLILHKRI 300
    HTGEKPYECK ECGKAFICGS QLSQHQKIHN GEKPYECKEC GRAFIRGSLL 350
    MQHQRIHTGE KPYKCEECGK AFIRGSQLTQ HQRIHTNEKP YECKECGKMF 400
    SHGSQLTQHQ RIHTGEKPYQ CKECGKAFNR GSLLTRHQRI HTGEKPYECK 450
    ECGKTFSRGS ELTQHERIHT GEKPYECKEC GKSFIRGSQL TQHQRIHTGE 500
    KPYECKECRM AFTQSSHLSQ HQRLHTGEKP YVCNECGKAF ARGLLLIQHQ 550
    RIHTGEKPYQ CKECGKAFIR GSQLTQHQRI HTGEKPYECK ECGKAFSHGS 600
    QLTLHQRIHT GEKPYECREC RKAFTQSSHL SRHQRIHTGE KPYQCKECGK 650
    AFTRGSQLTQ HQRIHISEKS FEYKECGIDF SHGSQVYM 688
    Length:688
    Mass (Da):80,247
    Last modified:June 1, 2002 - v1
    Checksum:i70E984F166F8A975
    GO
    Isoform 2 (identifier: Q8TAQ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         471-536: GEKPYECKEC...GEKPYVCNEC → AFLAGQQDRS...EQKYRRSLQP
         537-688: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:536
    Mass (Da):62,957
    Checksum:iF98B57D73A99A255
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei471 – 53666GEKPY…VCNEC → AFLAGQQDRSDIYMSRRFTK SIFPVFFSVPTMWTSKLELR YSHGDFENGIWVLWIMEQKY RRSLQP in isoform 2. 1 PublicationVSP_055951Add
    BLAST
    Alternative sequencei537 – 688152Missing in isoform 2. 1 PublicationVSP_055952Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056753 mRNA. Translation: BAB71272.1.
    AK315728 mRNA. Translation: BAG38083.1.
    AC008733 Genomic DNA. No translation available.
    AC010632 Genomic DNA. No translation available.
    AC012309 Genomic DNA. No translation available.
    BC026210 mRNA. Translation: AAH26210.1.
    CCDSiCCDS12498.1.
    RefSeqiNP_653290.2. NM_144689.3.
    XP_006723104.1. XM_006723041.1.
    UniGeneiHs.444992.

    Genome annotation databases

    EnsembliENST00000304239; ENSP00000306102; ENSG00000197050.
    ENST00000337995; ENSP00000338770; ENSG00000197050.
    GeneIDi147923.
    KEGGihsa:147923.
    UCSCiuc002ofl.3. human.

    Polymorphism databases

    DMDMi71153480.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056753 mRNA. Translation: BAB71272.1 .
    AK315728 mRNA. Translation: BAG38083.1 .
    AC008733 Genomic DNA. No translation available.
    AC010632 Genomic DNA. No translation available.
    AC012309 Genomic DNA. No translation available.
    BC026210 mRNA. Translation: AAH26210.1 .
    CCDSi CCDS12498.1.
    RefSeqi NP_653290.2. NM_144689.3.
    XP_006723104.1. XM_006723041.1.
    UniGenei Hs.444992.

    3D structure databases

    ProteinModelPortali Q8TAQ5.
    SMRi Q8TAQ5. Positions 6-45, 136-665.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127098. 11 interactions.
    IntActi Q8TAQ5. 9 interactions.
    MINTi MINT-7989567.
    STRINGi 9606.ENSP00000338770.

    PTM databases

    PhosphoSitei Q8TAQ5.

    Polymorphism databases

    DMDMi 71153480.

    Proteomic databases

    PaxDbi Q8TAQ5.
    PRIDEi Q8TAQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304239 ; ENSP00000306102 ; ENSG00000197050 .
    ENST00000337995 ; ENSP00000338770 ; ENSG00000197050 .
    GeneIDi 147923.
    KEGGi hsa:147923.
    UCSCi uc002ofl.3. human.

    Organism-specific databases

    CTDi 147923.
    GeneCardsi GC19P037498.
    HGNCi HGNC:20649. ZNF420.
    HPAi HPA053022.
    neXtProti NX_Q8TAQ5.
    PharmGKBi PA134958420.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8TAQ5.
    KOi K09228.
    OMAi EDTYETE.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8TAQ5.
    TreeFami TF341817.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 147923.
    NextBioi 85766.
    PROi Q8TAQ5.

    Gene expression databases

    ArrayExpressi Q8TAQ5.
    Bgeei Q8TAQ5.
    CleanExi HS_ZNF420.
    Genevestigatori Q8TAQ5.

    Family and domain databases

    Gene3Di 3.30.160.60. 20 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 19 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 19 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Testis.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.

    Entry informationi

    Entry nameiZN420_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAQ5
    Secondary accession number(s): B2RDY6, Q96ML5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3