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Q8TAQ5 (ZN420_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Zinc finger protein 420
Gene names
Name:ZNF420
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length688 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 19 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 688688Zinc finger protein 420
PRO_0000047575

Regions

Domain6 – 8681KRAB
Zinc finger139 – 16123C2H2-type 1
Zinc finger167 – 18923C2H2-type 2
Zinc finger195 – 21723C2H2-type 3
Zinc finger223 – 24523C2H2-type 4
Zinc finger251 – 27323C2H2-type 5
Zinc finger279 – 30123C2H2-type 6
Zinc finger307 – 32923C2H2-type 7
Zinc finger335 – 35723C2H2-type 8
Zinc finger363 – 38523C2H2-type 9
Zinc finger391 – 41323C2H2-type 10
Zinc finger419 – 44123C2H2-type 11
Zinc finger447 – 46923C2H2-type 12
Zinc finger475 – 49723C2H2-type 13
Zinc finger503 – 52523C2H2-type 14
Zinc finger531 – 55323C2H2-type 15
Zinc finger559 – 58123C2H2-type 16
Zinc finger587 – 60923C2H2-type 17
Zinc finger615 – 63723C2H2-type 18
Zinc finger643 – 66523C2H2-type 19

Sequences

Sequence LengthMass (Da)Tools
Q8TAQ5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 70E984F166F8A975

FASTA68880,247
        10         20         30         40         50         60 
MARKLVMFRD VAIDFSQEEW ECLDSAQRDL YRDVMLENYS NLVSLDLPSR CASKDLSPEK 

        70         80         90        100        110        120 
NTYETELSQW EMSDRLENCD LEESNSRDYL EAKGKMEKQQ ENQKEYFRQG MIIYDKMSIF 

       130        140        150        160        170        180 
NQHTYLSQHS RCHSTEKPYK CKECGKAFRR ASHLTQHQSI HTGEKPYECK QCGKAFSRDS 

       190        200        210        220        230        240 
QLSLHQRLHT GEKPYACKEC GKAFTQSSQL ILHHRIHTGE KPYKCEECGK AFIRSSQLTR 

       250        260        270        280        290        300 
HQKVHTGEKP YECKECGKAF TQNSQLTLHQ RLHTGEKLYE CKECRKVFTQ LSQLILHKRI 

       310        320        330        340        350        360 
HTGEKPYECK ECGKAFICGS QLSQHQKIHN GEKPYECKEC GRAFIRGSLL MQHQRIHTGE 

       370        380        390        400        410        420 
KPYKCEECGK AFIRGSQLTQ HQRIHTNEKP YECKECGKMF SHGSQLTQHQ RIHTGEKPYQ 

       430        440        450        460        470        480 
CKECGKAFNR GSLLTRHQRI HTGEKPYECK ECGKTFSRGS ELTQHERIHT GEKPYECKEC 

       490        500        510        520        530        540 
GKSFIRGSQL TQHQRIHTGE KPYECKECRM AFTQSSHLSQ HQRLHTGEKP YVCNECGKAF 

       550        560        570        580        590        600 
ARGLLLIQHQ RIHTGEKPYQ CKECGKAFIR GSQLTQHQRI HTGEKPYECK ECGKAFSHGS 

       610        620        630        640        650        660 
QLTLHQRIHT GEKPYECREC RKAFTQSSHL SRHQRIHTGE KPYQCKECGK AFTRGSQLTQ 

       670        680 
HQRIHISEKS FEYKECGIDF SHGSQVYM

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK315728 mRNA. Translation: BAG38083.1.
BC026210 mRNA. Translation: AAH26210.1.
IPIIPI00154558.
RefSeqNP_653290.2. NM_144689.3.
UniGeneHs.444992.

3D structure databases

ProteinModelPortalQ8TAQ5.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8TAQ5. 7 interactions.
MINTMINT-7989567.
STRING9606.ENSP00000338770.

PTM databases

PhosphoSiteQ8TAQ5.

Polymorphism databases

DMDM71153480.

Proteomic databases

PaxDbQ8TAQ5.
PRIDEQ8TAQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000337995; ENSP00000338770; ENSG00000197050.
GeneID147923.
KEGGhsa:147923.
UCSCuc002ofl.3. human.

Organism-specific databases

CTD147923.
GeneCardsGC19P037569.
HGNCHGNC:20649. ZNF420.
HPAHPA053022.
neXtProtNX_Q8TAQ5.
PharmGKBPA134958420.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8TAQ5.
KOK09228.
OMAWEMSARL.
OrthoDBEOG4J9MZ8.
PhylomeDBQ8TAQ5.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8TAQ5.
BgeeQ8TAQ5.
CleanExHS_ZNF420.
GenevestigatorQ8TAQ5.
GermOnlineENSG00000197050. Homo sapiens.

Family and domain databases

Gene3D3.30.160.60. 20 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMSSF109640. Krueppel-associated_box. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi147923.
NextBio85766.

Entry information

Entry nameZN420_HUMAN
AccessionPrimary (citable) accession number: Q8TAQ5
Secondary accession number(s): B2RDY6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: May 29, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents