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Protein

Zinc finger protein 420

Gene

ZNF420

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 16123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri167 – 18923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri643 – 66523C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 420
Gene namesi
Name:ZNF420
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20649. ZNF420.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688Zinc finger protein 420PRO_0000047575Add
BLAST

Proteomic databases

PaxDbiQ8TAQ5.
PRIDEiQ8TAQ5.

PTM databases

PhosphoSiteiQ8TAQ5.

Expressioni

Gene expression databases

BgeeiQ8TAQ5.
CleanExiHS_ZNF420.
ExpressionAtlasiQ8TAQ5. baseline and differential.
GenevestigatoriQ8TAQ5.

Organism-specific databases

HPAiHPA053022.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN2AQ8N7268EBI-3923307,EBI-625922
TP53P046374EBI-3923307,EBI-366083

Protein-protein interaction databases

BioGridi127098. 11 interactions.
IntActiQ8TAQ5. 9 interactions.
MINTiMINT-7989567.
STRINGi9606.ENSP00000338770.

Structurei

3D structure databases

ProteinModelPortaliQ8TAQ5.
SMRiQ8TAQ5. Positions 6-45, 136-665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8681KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 16123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri167 – 18923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri643 – 66523C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121848.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAQ5.
KOiK09228.
OMAiYFSQGMI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TAQ5.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 20 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TAQ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKLVMFRD VAIDFSQEEW ECLDSAQRDL YRDVMLENYS NLVSLDLPSR
60 70 80 90 100
CASKDLSPEK NTYETELSQW EMSDRLENCD LEESNSRDYL EAKGKMEKQQ
110 120 130 140 150
ENQKEYFRQG MIIYDKMSIF NQHTYLSQHS RCHSTEKPYK CKECGKAFRR
160 170 180 190 200
ASHLTQHQSI HTGEKPYECK QCGKAFSRDS QLSLHQRLHT GEKPYACKEC
210 220 230 240 250
GKAFTQSSQL ILHHRIHTGE KPYKCEECGK AFIRSSQLTR HQKVHTGEKP
260 270 280 290 300
YECKECGKAF TQNSQLTLHQ RLHTGEKLYE CKECRKVFTQ LSQLILHKRI
310 320 330 340 350
HTGEKPYECK ECGKAFICGS QLSQHQKIHN GEKPYECKEC GRAFIRGSLL
360 370 380 390 400
MQHQRIHTGE KPYKCEECGK AFIRGSQLTQ HQRIHTNEKP YECKECGKMF
410 420 430 440 450
SHGSQLTQHQ RIHTGEKPYQ CKECGKAFNR GSLLTRHQRI HTGEKPYECK
460 470 480 490 500
ECGKTFSRGS ELTQHERIHT GEKPYECKEC GKSFIRGSQL TQHQRIHTGE
510 520 530 540 550
KPYECKECRM AFTQSSHLSQ HQRLHTGEKP YVCNECGKAF ARGLLLIQHQ
560 570 580 590 600
RIHTGEKPYQ CKECGKAFIR GSQLTQHQRI HTGEKPYECK ECGKAFSHGS
610 620 630 640 650
QLTLHQRIHT GEKPYECREC RKAFTQSSHL SRHQRIHTGE KPYQCKECGK
660 670 680
AFTRGSQLTQ HQRIHISEKS FEYKECGIDF SHGSQVYM
Length:688
Mass (Da):80,247
Last modified:June 1, 2002 - v1
Checksum:i70E984F166F8A975
GO
Isoform 2 (identifier: Q8TAQ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-536: GEKPYECKEC...GEKPYVCNEC → AFLAGQQDRS...EQKYRRSLQP
     537-688: Missing.

Note: No experimental confirmation available.

Show »
Length:536
Mass (Da):62,957
Checksum:iF98B57D73A99A255
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei471 – 53666GEKPY…VCNEC → AFLAGQQDRSDIYMSRRFTK SIFPVFFSVPTMWTSKLELR YSHGDFENGIWVLWIMEQKY RRSLQP in isoform 2. 1 PublicationVSP_055951Add
BLAST
Alternative sequencei537 – 688152Missing in isoform 2. 1 PublicationVSP_055952Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056753 mRNA. Translation: BAB71272.1.
AK315728 mRNA. Translation: BAG38083.1.
AC008733 Genomic DNA. No translation available.
AC010632 Genomic DNA. No translation available.
AC012309 Genomic DNA. No translation available.
BC026210 mRNA. Translation: AAH26210.1.
CCDSiCCDS12498.1. [Q8TAQ5-1]
RefSeqiNP_653290.2. NM_144689.3. [Q8TAQ5-1]
XP_006723104.1. XM_006723041.1. [Q8TAQ5-2]
UniGeneiHs.444992.

Genome annotation databases

EnsembliENST00000304239; ENSP00000306102; ENSG00000197050. [Q8TAQ5-2]
ENST00000337995; ENSP00000338770; ENSG00000197050. [Q8TAQ5-1]
GeneIDi147923.
KEGGihsa:147923.
UCSCiuc002ofl.3. human. [Q8TAQ5-1]

Polymorphism databases

DMDMi71153480.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056753 mRNA. Translation: BAB71272.1.
AK315728 mRNA. Translation: BAG38083.1.
AC008733 Genomic DNA. No translation available.
AC010632 Genomic DNA. No translation available.
AC012309 Genomic DNA. No translation available.
BC026210 mRNA. Translation: AAH26210.1.
CCDSiCCDS12498.1. [Q8TAQ5-1]
RefSeqiNP_653290.2. NM_144689.3. [Q8TAQ5-1]
XP_006723104.1. XM_006723041.1. [Q8TAQ5-2]
UniGeneiHs.444992.

3D structure databases

ProteinModelPortaliQ8TAQ5.
SMRiQ8TAQ5. Positions 6-45, 136-665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127098. 11 interactions.
IntActiQ8TAQ5. 9 interactions.
MINTiMINT-7989567.
STRINGi9606.ENSP00000338770.

PTM databases

PhosphoSiteiQ8TAQ5.

Polymorphism databases

DMDMi71153480.

Proteomic databases

PaxDbiQ8TAQ5.
PRIDEiQ8TAQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304239; ENSP00000306102; ENSG00000197050. [Q8TAQ5-2]
ENST00000337995; ENSP00000338770; ENSG00000197050. [Q8TAQ5-1]
GeneIDi147923.
KEGGihsa:147923.
UCSCiuc002ofl.3. human. [Q8TAQ5-1]

Organism-specific databases

CTDi147923.
GeneCardsiGC19P037498.
HGNCiHGNC:20649. ZNF420.
HPAiHPA053022.
neXtProtiNX_Q8TAQ5.
PharmGKBiPA134958420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121848.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAQ5.
KOiK09228.
OMAiYFSQGMI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TAQ5.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii147923.
NextBioi85766.
PROiQ8TAQ5.

Gene expression databases

BgeeiQ8TAQ5.
CleanExiHS_ZNF420.
ExpressionAtlasiQ8TAQ5. baseline and differential.
GenevestigatoriQ8TAQ5.

Family and domain databases

Gene3Di3.30.160.60. 20 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.

Entry informationi

Entry nameiZN420_HUMAN
AccessioniPrimary (citable) accession number: Q8TAQ5
Secondary accession number(s): B2RDY6, Q96ML5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.