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Protein

SWI/SNF complex subunit SMARCC2

Gene

SMARCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity).2 PublicationsBy similarity3 Publications

GO - Molecular functioni

  • DNA binding Source: InterPro
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: UniProtKB
  • chromatin remodeling Source: UniProtKB
  • covalent chromatin modification Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nervous system development Source: UniProtKB-KW
  • nucleosome disassembly Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
R-HSA-8939243. RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
SIGNORiQ8TAQ2.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF complex subunit SMARCC2
Alternative name(s):
BRG1-associated factor 170
Short name:
BAF170
SWI/SNF complex 170 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
Gene namesi
Name:SMARCC2
Synonyms:BAF170
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139613.11.
HGNCiHGNC:11105. SMARCC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6601.
OpenTargetsiENSG00000139613.
PharmGKBiPA35955.

Polymorphism and mutation databases

BioMutaiSMARCC2.
DMDMi57012959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971171 – 1214SWI/SNF complex subunit SMARCC2Add BLAST1214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei326N6-acetyllysineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei387PhosphoserineBy similarity1
Modified residuei548PhosphothreonineCombined sources1
Cross-linki564Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki566Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki568Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki592Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki787Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei813PhosphoserineCombined sources1
Cross-linki848Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TAQ2.
MaxQBiQ8TAQ2.
PaxDbiQ8TAQ2.
PeptideAtlasiQ8TAQ2.
PRIDEiQ8TAQ2.

PTM databases

iPTMnetiQ8TAQ2.
PhosphoSitePlusiQ8TAQ2.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000139613.
CleanExiHS_SMARCC2.
ExpressionAtlasiQ8TAQ2. baseline and differential.
GenevisibleiQ8TAQ2. HS.

Organism-specific databases

HPAiCAB004321.
HPA021213.
HPA061788.

Interactioni

Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204). May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4 (PubMed:11238380). Interacts with SMARD1 (PubMed:12917342). Interacts with KDM6B (By similarity). Interaction with RCOR1 (PubMed:12192000).2 PublicationsBy similarity4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112485. 149 interactors.
CORUMiQ8TAQ2.
DIPiDIP-27611N.
IntActiQ8TAQ2. 59 interactors.
MINTiMINT-1151033.
STRINGi9606.ENSP00000267064.

Structurei

3D structure databases

ProteinModelPortaliQ8TAQ2.
SMRiQ8TAQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 521SWIRMPROSITE-ProRule annotationAdd BLAST98
Domaini596 – 647SANTPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili907 – 934Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 189Poly-Glu4
Compositional biasi747 – 855Glu-richAdd BLAST109
Compositional biasi861 – 870Poly-Ala10
Compositional biasi956 – 960Poly-Gln5
Compositional biasi961 – 1213Pro-richAdd BLAST253

Sequence similaritiesi

Belongs to the SMARCC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1279. Eukaryota.
COG5259. LUCA.
GeneTreeiENSGT00390000018166.
HOGENOMiHOG000047736.
HOVERGENiHBG054849.
InParanoidiQ8TAQ2.
KOiK11649.
PhylomeDBiQ8TAQ2.
TreeFamiTF314710.

Family and domain databases

CDDicd00024. CHROMO. 1 hit.
cd00167. SANT. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiView protein in InterPro
IPR036420. BRCT_dom_sf.
IPR000953. Chromo/chromo_shadow_dom.
IPR009057. Homeobox-like_sf.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR032451. SMARCC_C.
IPR032450. SMARCC_N.
IPR007526. SWIRM.
IPR032448. SWIRM-assoc.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
PF16495. SWIRM-assoc_1. 1 hit.
PF16496. SWIRM-assoc_2. 1 hit.
PF16498. SWIRM-assoc_3. 1 hit.
SMARTiView protein in SMART
SM00298. CHROMO. 1 hit.
SM00717. SANT. 1 hit.
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF52113. SSF52113. 2 hits.
PROSITEiView protein in PROSITE
PS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAQ2-1) [UniParc]FASTAAdd to basket
Also known as: SMARCC2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS
60 70 80 90 100
SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGSL CHILAAAYKF
110 120 130 140 150
KSDQGWRRYD FQNPSRMDRN VEMFMTIEKS LVQNNCLSRP NIFLCPEIEP
160 170 180 190 200
KLLGKLKDII KRHQGTVTED KNNASHVVYP VPGNLEEEEW VRPVMKRDKQ
210 220 230 240 250
VLLHWGYYPD SYDTWIPASE IEASVEDAPT PEKPRKVHAK WILDTDTFNE
260 270 280 290 300
WMNEEDYEVN DDKNPVSRRK KISAKTLTDE VNSPDSDRRD KKGGNYKKRK
310 320 330 340 350
RSPSPSPTPE AKKKNAKKGP STPYTKSKRG HREEEQEDLT KDMDEPSPVP
360 370 380 390 400
NVEEVTLPKT VNTKKDSESA PVKGGTMTDL DEQEDESMET TGKDEDENST
410 420 430 440 450
GNKGEQTKNP DLHEDNVTEQ THHIIIPSYA AWFDYNSVHA IERRALPEFF
460 470 480 490 500
NGKNKSKTPE IYLAYRNFMI DTYRLNPQEY LTSTACRRNL AGDVCAIMRV
510 520 530 540 550
HAFLEQWGLI NYQVDAESRP TPMGPPPTSH FHVLADTPSG LVPLQPKTPQ
560 570 580 590 600
QTSASQQMLN FPDKGKEKPT DMQNFGLRTD MYTKKNVPSK SKAAASATRE
610 620 630 640 650
WTEQETLLLL EALEMYKDDW NKVSEHVGSR TQDECILHFL RLPIEDPYLE
660 670 680 690 700
DSEASLGPLA YQPIPFSQSG NPVMSTVAFL ASVVDPRVAS AAAKSALEEF
710 720 730 740 750
SKMKEEVPTA LVEAHVRKVE EAAKVTGKAD PAFGLESSGI AGTTSDEPER
760 770 780 790 800
IEESGNDEAR VEGQATDEKK EPKEPREGGG AIEEEAKEKT SEAPKKDEEK
810 820 830 840 850
GKEGDSEKES EKSDGDPIVD PEKEKEPKEG QEEVLKEVVE SEGERKTKVE
860 870 880 890 900
RDIGEGNLST AAAAALAAAA VKAKHLAAVE ERKIKSLVAL LVETQMKKLE
910 920 930 940 950
IKLRHFEELE TIMDREREAL EYQRQQLLAD RQAFHMEQLK YAEMRARQQH
960 970 980 990 1000
FQQMHQQQQQ PPPALPPGSQ PIPPTGAAGP PAVHGLAVAP ASVVPAPAGS
1010 1020 1030 1040 1050
GAPPGSLGPS EQIGQAGSTA GPQQQQPAGA PQPGAVPPGV PPPGPHGPSP
1060 1070 1080 1090 1100
FPNQQTPPSM MPGAVPGSGH PGVAGNAPLG LPFGMPPPPP PPAPSIIPFG
1110 1120 1130 1140 1150
SLADSISINL PAPPNLHGHH HHLPFAPGTL PPPNLPVSMA NPLHPNLPAT
1160 1170 1180 1190 1200
TTMPSSLPLG PGLGSAAAQS PAIVAAVQGN LLPSASPLPD PGTPLPPDPT
1210
APSPGTVTPV PPPQ
Length:1,214
Mass (Da):132,879
Last modified:June 1, 2002 - v1
Checksum:iEEFC1042A9296320
GO
Isoform 2 (identifier: Q8TAQ2-2) [UniParc]FASTAAdd to basket
Also known as: SMARCC2b

The sequence of this isoform differs from the canonical sequence as follows:
     550-550: Q → QGRQVDADTKAGRKGKELDDLVPETAKGKPEL
     1075-1189: Missing.

Show »
Length:1,130
Mass (Da):124,841
Checksum:i30107786CB04BC1E
GO
Isoform 3 (identifier: Q8TAQ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-550: Q → QGRQVDADTKAGRKGKELDDLVPETAKGKPEL
     1075-1167: Missing.

Note: No experimental confirmation available.
Show »
Length:1,152
Mass (Da):126,924
Checksum:i70504763A7CA887C
GO

Sequence cautioni

The sequence BAD92243 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311 – 316AKKKNA → VKEEKC in AAC50694 (PubMed:8804307).Curated6
Sequence conflicti498M → S in AAC50694 (PubMed:8804307).Curated1
Sequence conflicti587V → A in AAC50694 (PubMed:8804307).Curated1
Sequence conflicti876L → F in AAP88926 (Ref. 2) Curated1
Sequence conflicti876L → F in AAH13045 (PubMed:15489334).Curated1
Sequence conflicti942A → P in AAC50694 (PubMed:8804307).Curated1
Sequence conflicti1020A → R in AAC50694 (PubMed:8804307).Curated1
Sequence conflicti1117 – 1126HGHHHHLPFA → MGSPPSPVR in AAC50694 (PubMed:8804307).Curated10

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012490550Q → QGRQVDADTKAGRKGKELDD LVPETAKGKPEL in isoform 2 and isoform 3. 3 Publications1
Alternative sequenceiVSP_0124911075 – 1189Missing in isoform 2. 2 PublicationsAdd BLAST115
Alternative sequenceiVSP_0446471075 – 1167Missing in isoform 3. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66616 mRNA. Translation: AAC50694.1.
BT009924 mRNA. Translation: AAP88926.1.
AB209006 mRNA. Translation: BAD92243.1. Different initiation.
AC073896 Genomic DNA. No translation available.
BC009067 mRNA. Translation: AAH09067.1.
BC013045 mRNA. Translation: AAH13045.1.
BC026222 mRNA. Translation: AAH26222.1.
CCDSiCCDS55835.1. [Q8TAQ2-3]
CCDS8907.1. [Q8TAQ2-1]
CCDS8908.1. [Q8TAQ2-2]
RefSeqiNP_001123892.1. NM_001130420.2. [Q8TAQ2-3]
NP_001317217.1. NM_001330288.1.
NP_003066.2. NM_003075.4. [Q8TAQ2-1]
NP_620706.1. NM_139067.3. [Q8TAQ2-2]
UniGeneiHs.236030.
Hs.632717.

Genome annotation databases

EnsembliENST00000267064; ENSP00000267064; ENSG00000139613. [Q8TAQ2-1]
ENST00000347471; ENSP00000302919; ENSG00000139613. [Q8TAQ2-2]
ENST00000394023; ENSP00000377591; ENSG00000139613. [Q8TAQ2-3]
GeneIDi6601.
KEGGihsa:6601.
UCSCiuc001ska.4. human. [Q8TAQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMRC2_HUMAN
AccessioniPrimary (citable) accession number: Q8TAQ2
Secondary accession number(s): F8VTJ5
, Q59GV3, Q92923, Q96E12, Q96GY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families