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Q8TAP9

- MPLKI_HUMAN

UniProt

Q8TAP9 - MPLKI_HUMAN

Protein

M-phase-specific PLK1-interacting protein

Gene

MPLKIP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase-specific PLK1-interacting protein
    Alternative name(s):
    TTD non-photosensitive 1 protein
    Gene namesi
    Name:MPLKIP
    Synonyms:C7orf11, TTDN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16002. MPLKIP.

    Subcellular locationi

    Nucleus. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
    Note: The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. midbody Source: UniProtKB
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Trichothiodystrophy non-photosensitive 1 (TTDN1) [MIM:234050]: TTDN1 is an autosomal recessive disease characterized by sulfur-deficient brittle hair, intellectual impairment, decreased male fertility and no cutaneous photosensitivity.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441M → V in TTDN1. 1 Publication
    VAR_022940

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi93 – 931S → A: Partially prevents phosphorylation. 1 Publication
    Mutagenesisi104 – 1041S → A: Has no effect on interaction with PLK1 in mitosis. Partially prevents phosphorylation. 1 Publication
    Mutagenesisi120 – 1201T → A: Abolishes interaction with PLK1 in mitosis. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi234050. phenotype.
    Orphaneti33364. Trichothiodystrophy.
    PharmGKBiPA25943.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179M-phase-specific PLK1-interacting proteinPRO_0000065674Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471Phosphoserine1 Publication
    Modified residuei51 – 511Phosphothreonine1 Publication
    Modified residuei72 – 721Phosphoserine2 Publications
    Modified residuei80 – 801Phosphoserine2 Publications
    Modified residuei82 – 821Phosphoserine1 Publication
    Modified residuei93 – 931Phosphoserine2 Publications
    Modified residuei104 – 1041Phosphoserine2 Publications
    Modified residuei120 – 1201Phosphothreonine1 Publication
    Modified residuei124 – 1241Phosphoserine1 Publication
    Modified residuei133 – 1331Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylated during mitosis in the cell cycle probably by CDK1.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TAP9.
    PaxDbiQ8TAP9.
    PRIDEiQ8TAP9.

    PTM databases

    PhosphoSiteiQ8TAP9.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles.2 Publications

    Gene expression databases

    ArrayExpressiQ8TAP9.
    BgeeiQ8TAP9.
    CleanExiHS_C7orf11.
    GenevestigatoriQ8TAP9.

    Organism-specific databases

    HPAiHPA058457.

    Interactioni

    Subunit structurei

    Interacts with PLK1; phosphorylation-dependent.1 Publication

    Protein-protein interaction databases

    BioGridi126463. 14 interactions.
    STRINGi9606.ENSP00000304553.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAP9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45065.
    HOGENOMiHOG000252982.
    HOVERGENiHBG073319.
    InParanoidiQ8TAP9.
    OMAiHRPNFRP.
    OrthoDBiEOG7BP84Z.
    PhylomeDBiQ8TAP9.
    TreeFamiTF335586.

    Family and domain databases

    InterProiIPR028265. MPLKIP-like.
    IPR026618. MPLKIP_like_vertebrate.
    [Graphical view]
    PANTHERiPTHR22446. PTHR22446. 1 hit.
    PfamiPF15502. MPLKIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRQNFRPPT PPYPGPGGGG WGSGSSFRGT PGGGGPRPPS PRDGYGSPHH    50
    TPPYGPRSRP YGSSHSPRHG GSFPGGRFGS PSPGGYPGSY SRSPAGSQQQ 100
    FGYSPGQQQT HPQGSPRTST PFGSGRVREK RMSNELENYF KPSMLEDPWA 150
    GLEPVSVVDI SQQYSNTQTF TGKKGRYFC 179
    Length:179
    Mass (Da):19,147
    Last modified:June 1, 2002 - v1
    Checksum:i77DBA4FBDF9C70CC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291G → E in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036273
    Natural varianti144 – 1441M → V in TTDN1. 1 Publication
    VAR_022940

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC026265 mRNA. Translation: AAH26265.1.
    CCDSiCCDS5463.1.
    RefSeqiNP_619646.1. NM_138701.3.
    UniGeneiHs.654989.

    Genome annotation databases

    EnsembliENST00000306984; ENSP00000304553; ENSG00000168303.
    GeneIDi136647.
    KEGGihsa:136647.
    UCSCiuc003thl.4. human.

    Polymorphism databases

    DMDMi71153365.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC026265 mRNA. Translation: AAH26265.1 .
    CCDSi CCDS5463.1.
    RefSeqi NP_619646.1. NM_138701.3.
    UniGenei Hs.654989.

    3D structure databases

    ProteinModelPortali Q8TAP9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126463. 14 interactions.
    STRINGi 9606.ENSP00000304553.

    PTM databases

    PhosphoSitei Q8TAP9.

    Polymorphism databases

    DMDMi 71153365.

    Proteomic databases

    MaxQBi Q8TAP9.
    PaxDbi Q8TAP9.
    PRIDEi Q8TAP9.

    Protocols and materials databases

    DNASUi 136647.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306984 ; ENSP00000304553 ; ENSG00000168303 .
    GeneIDi 136647.
    KEGGi hsa:136647.
    UCSCi uc003thl.4. human.

    Organism-specific databases

    CTDi 136647.
    GeneCardsi GC07M040172.
    HGNCi HGNC:16002. MPLKIP.
    HPAi HPA058457.
    MIMi 234050. phenotype.
    609188. gene.
    neXtProti NX_Q8TAP9.
    Orphaneti 33364. Trichothiodystrophy.
    PharmGKBi PA25943.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45065.
    HOGENOMi HOG000252982.
    HOVERGENi HBG073319.
    InParanoidi Q8TAP9.
    OMAi HRPNFRP.
    OrthoDBi EOG7BP84Z.
    PhylomeDBi Q8TAP9.
    TreeFami TF335586.

    Miscellaneous databases

    ChiTaRSi MPLKIP. human.
    GeneWikii C7orf11.
    MPLKIP.
    GenomeRNAii 136647.
    NextBioi 83599.
    PROi Q8TAP9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TAP9.
    Bgeei Q8TAP9.
    CleanExi HS_C7orf11.
    Genevestigatori Q8TAP9.

    Family and domain databases

    InterProi IPR028265. MPLKIP-like.
    IPR026618. MPLKIP_like_vertebrate.
    [Graphical view ]
    PANTHERi PTHR22446. PTHR22446. 1 hit.
    Pfami PF15502. MPLKIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity."
      Zhang Y., Tian Y., Chen Q., Chen D., Zhai Z., Shu H.-B.
      Cell. Mol. Life Sci. 64:632-640(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PLK1, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-93; SER-104 AND THR-120, PHOSPHORYLATION AT SER-93 AND SER-104.
    5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72 AND SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; THR-51; SER-80; SER-93; SER-104; THR-120 AND SER-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-80; SER-82 AND SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: VARIANT TTDN1 VAL-144, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-29.

    Entry informationi

    Entry nameiMPLKI_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3