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Protein

M-phase-specific PLK1-interacting protein

Gene

MPLKIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168303-MONOMER.
SIGNORiQ8TAP9.

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase-specific PLK1-interacting protein
Alternative name(s):
TTD non-photosensitive 1 protein
Gene namesi
Name:MPLKIP
Synonyms:C7orf11, TTDN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16002. MPLKIP.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: HPA
  • midbody Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Trichothiodystrophy 4, non-photosensitive (TTD4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD4 patients do not manifest cutaneous photosensitivity.
See also OMIM:234050
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022940144M → V in TTD4. 1 PublicationCorresponds to variant rs137853117dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi93S → A: Partially prevents phosphorylation. 1 Publication1
Mutagenesisi104S → A: Has no effect on interaction with PLK1 in mitosis. Partially prevents phosphorylation. 1 Publication1
Mutagenesisi120T → A: Abolishes interaction with PLK1 in mitosis. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi136647.
MalaCardsiMPLKIP.
MIMi234050. phenotype.
OpenTargetsiENSG00000168303.
Orphaneti33364. Trichothiodystrophy.
PharmGKBiPA25943.

Polymorphism and mutation databases

BioMutaiMPLKIP.
DMDMi71153365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656741 – 179M-phase-specific PLK1-interacting proteinAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Asymmetric dimethylarginineBy similarity1
Modified residuei40PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei57Omega-N-methylarginineCombined sources1
Modified residuei59Asymmetric dimethylarginineCombined sources1
Modified residuei68Asymmetric dimethylarginineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei77Asymmetric dimethylarginineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1 Publication1
Modified residuei104PhosphoserineCombined sources1 Publication1
Modified residuei115PhosphoserineCombined sources1
Modified residuei117Omega-N-methylarginineCombined sources1
Modified residuei120PhosphothreonineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis in the cell cycle probably by CDK1.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8TAP9.
MaxQBiQ8TAP9.
PaxDbiQ8TAP9.
PeptideAtlasiQ8TAP9.
PRIDEiQ8TAP9.

PTM databases

iPTMnetiQ8TAP9.
PhosphoSitePlusiQ8TAP9.

Expressioni

Tissue specificityi

Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles.2 Publications

Gene expression databases

BgeeiENSG00000168303.
CleanExiHS_C7orf11.
ExpressionAtlasiQ8TAP9. baseline and differential.
GenevisibleiQ8TAP9. HS.

Organism-specific databases

HPAiHPA058457.
HPA065463.

Interactioni

Subunit structurei

Interacts with PLK1; phosphorylation-dependent.1 Publication

Protein-protein interaction databases

BioGridi126463. 18 interactors.
IntActiQ8TAP9. 1 interactor.
STRINGi9606.ENSP00000304553.

Structurei

3D structure databases

ProteinModelPortaliQ8TAP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J0XS. Eukaryota.
ENOG4111V2F. LUCA.
GeneTreeiENSGT00390000002582.
HOGENOMiHOG000252982.
HOVERGENiHBG073319.
InParanoidiQ8TAP9.
OMAiHRPNFRP.
OrthoDBiEOG091G13KW.
PhylomeDBiQ8TAP9.
TreeFamiTF335586.

Family and domain databases

InterProiIPR028265. MPLKIP-like.
IPR026618. MPLKIP-like_vertebrate.
[Graphical view]
PANTHERiPTHR22446. PTHR22446. 1 hit.
PfamiPF15502. MPLKIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRQNFRPPT PPYPGPGGGG WGSGSSFRGT PGGGGPRPPS PRDGYGSPHH
60 70 80 90 100
TPPYGPRSRP YGSSHSPRHG GSFPGGRFGS PSPGGYPGSY SRSPAGSQQQ
110 120 130 140 150
FGYSPGQQQT HPQGSPRTST PFGSGRVREK RMSNELENYF KPSMLEDPWA
160 170
GLEPVSVVDI SQQYSNTQTF TGKKGRYFC
Length:179
Mass (Da):19,147
Last modified:June 1, 2002 - v1
Checksum:i77DBA4FBDF9C70CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03627329G → E in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs565833937dbSNPEnsembl.1
Natural variantiVAR_022940144M → V in TTD4. 1 PublicationCorresponds to variant rs137853117dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026265 mRNA. Translation: AAH26265.1.
CCDSiCCDS5463.1.
RefSeqiNP_619646.1. NM_138701.3.
UniGeneiHs.654989.

Genome annotation databases

EnsembliENST00000306984; ENSP00000304553; ENSG00000168303.
GeneIDi136647.
KEGGihsa:136647.
UCSCiuc003thl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026265 mRNA. Translation: AAH26265.1.
CCDSiCCDS5463.1.
RefSeqiNP_619646.1. NM_138701.3.
UniGeneiHs.654989.

3D structure databases

ProteinModelPortaliQ8TAP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126463. 18 interactors.
IntActiQ8TAP9. 1 interactor.
STRINGi9606.ENSP00000304553.

PTM databases

iPTMnetiQ8TAP9.
PhosphoSitePlusiQ8TAP9.

Polymorphism and mutation databases

BioMutaiMPLKIP.
DMDMi71153365.

Proteomic databases

EPDiQ8TAP9.
MaxQBiQ8TAP9.
PaxDbiQ8TAP9.
PeptideAtlasiQ8TAP9.
PRIDEiQ8TAP9.

Protocols and materials databases

DNASUi136647.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306984; ENSP00000304553; ENSG00000168303.
GeneIDi136647.
KEGGihsa:136647.
UCSCiuc003thl.5. human.

Organism-specific databases

CTDi136647.
DisGeNETi136647.
GeneCardsiMPLKIP.
HGNCiHGNC:16002. MPLKIP.
HPAiHPA058457.
HPA065463.
MalaCardsiMPLKIP.
MIMi234050. phenotype.
609188. gene.
neXtProtiNX_Q8TAP9.
OpenTargetsiENSG00000168303.
Orphaneti33364. Trichothiodystrophy.
PharmGKBiPA25943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XS. Eukaryota.
ENOG4111V2F. LUCA.
GeneTreeiENSGT00390000002582.
HOGENOMiHOG000252982.
HOVERGENiHBG073319.
InParanoidiQ8TAP9.
OMAiHRPNFRP.
OrthoDBiEOG091G13KW.
PhylomeDBiQ8TAP9.
TreeFamiTF335586.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168303-MONOMER.
SIGNORiQ8TAP9.

Miscellaneous databases

GeneWikiiC7orf11.
MPLKIP.
GenomeRNAii136647.
PROiQ8TAP9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168303.
CleanExiHS_C7orf11.
ExpressionAtlasiQ8TAP9. baseline and differential.
GenevisibleiQ8TAP9. HS.

Family and domain databases

InterProiIPR028265. MPLKIP-like.
IPR026618. MPLKIP-like_vertebrate.
[Graphical view]
PANTHERiPTHR22446. PTHR22446. 1 hit.
PfamiPF15502. MPLKIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPLKI_HUMAN
AccessioniPrimary (citable) accession number: Q8TAP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.