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Q8TAP8

- PPR35_HUMAN

UniProt

Q8TAP8 - PPR35_HUMAN

Protein

Protein phosphatase 1 regulatory subunit 35

Gene

PPP1R35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Inhibits PPP1CA phosphatase activity.1 Publication

    GO - Molecular functioni

    1. phosphatase binding Source: UniProtKB
    2. protein phosphatase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of phosphatase activity Source: UniProtKB

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 35
    Gene namesi
    Name:PPP1R35
    Synonyms:C7orf47
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:28320. PPP1R35.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162380520.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Protein phosphatase 1 regulatory subunit 35PRO_0000271356Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471Phosphoserine1 Publication
    Modified residuei52 – 521Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TAP8.
    PaxDbiQ8TAP8.
    PRIDEiQ8TAP8.

    PTM databases

    PhosphoSiteiQ8TAP8.

    Expressioni

    Gene expression databases

    BgeeiQ8TAP8.
    CleanExiHS_C7orf47.
    GenevestigatoriQ8TAP8.

    Organism-specific databases

    HPAiHPA051607.

    Interactioni

    Subunit structurei

    Interacts with PPP1CA.1 Publication

    Protein-protein interaction databases

    BioGridi128765. 2 interactions.
    IntActiQ8TAP8. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 6039Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PPP1R35 family.Curated

    Phylogenomic databases

    eggNOGiNOG45984.
    HOGENOMiHOG000111594.
    HOVERGENiHBG073318.
    InParanoidiQ8TAP8.
    KOiK17574.
    OMAiQIRCGLE.
    OrthoDBiEOG7D85XT.
    PhylomeDBiQ8TAP8.
    TreeFamiTF337101.

    Family and domain databases

    InterProiIPR029135. PPP1R35_C.
    [Graphical view]
    PfamiPF15503. PPP1R35_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMMGCGESEL KSADGEEAAA VPGPPPEPQV PQLRAPVPEP GLDLSLSPRP    50
    DSPQPRHGSP GRRKGRAERR GAARQRRQVR FRLTPPSPVR SEPQPAVPQE 100
    LEMPVLKSSL ALGLELRAAA GSHFDAAKAV EEQLRKSFQI RCGLEESVSE 150
    GLNVPRSKRL FRDLVSLQVP EEQVLNAALR EKLALLPPQA RAPHPKEPPG 200
    PGPDMTILCD PETLFYESPH LTLDGLPPLR LQLRPRPSED TFLMHRTLRR 250
    WEA 253
    Length:253
    Mass (Da):27,953
    Last modified:June 1, 2002 - v1
    Checksum:i9DE5142EDD2150B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092849 Genomic DNA. No translation available.
    CH236956 Genomic DNA. Translation: EAL23833.1.
    CH471091 Genomic DNA. Translation: EAW76532.1.
    BC026269 mRNA. Translation: AAH26269.1.
    CCDSiCCDS5694.1.
    RefSeqiNP_659467.1. NM_145030.2.
    UniGeneiHs.413359.

    Genome annotation databases

    EnsembliENST00000292330; ENSP00000292330; ENSG00000160813.
    GeneIDi221908.
    KEGGihsa:221908.
    UCSCiuc003uuy.1. human.

    Polymorphism databases

    DMDMi74730374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092849 Genomic DNA. No translation available.
    CH236956 Genomic DNA. Translation: EAL23833.1 .
    CH471091 Genomic DNA. Translation: EAW76532.1 .
    BC026269 mRNA. Translation: AAH26269.1 .
    CCDSi CCDS5694.1.
    RefSeqi NP_659467.1. NM_145030.2.
    UniGenei Hs.413359.

    3D structure databases

    ProteinModelPortali Q8TAP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128765. 2 interactions.
    IntActi Q8TAP8. 2 interactions.

    PTM databases

    PhosphoSitei Q8TAP8.

    Polymorphism databases

    DMDMi 74730374.

    Proteomic databases

    MaxQBi Q8TAP8.
    PaxDbi Q8TAP8.
    PRIDEi Q8TAP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292330 ; ENSP00000292330 ; ENSG00000160813 .
    GeneIDi 221908.
    KEGGi hsa:221908.
    UCSCi uc003uuy.1. human.

    Organism-specific databases

    CTDi 221908.
    GeneCardsi GC07M100034.
    H-InvDB HIX0006921.
    HGNCi HGNC:28320. PPP1R35.
    HPAi HPA051607.
    neXtProti NX_Q8TAP8.
    PharmGKBi PA162380520.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45984.
    HOGENOMi HOG000111594.
    HOVERGENi HBG073318.
    InParanoidi Q8TAP8.
    KOi K17574.
    OMAi QIRCGLE.
    OrthoDBi EOG7D85XT.
    PhylomeDBi Q8TAP8.
    TreeFami TF337101.

    Miscellaneous databases

    GenomeRNAii 221908.
    NextBioi 91486.
    PROi Q8TAP8.

    Gene expression databases

    Bgeei Q8TAP8.
    CleanExi HS_C7orf47.
    Genevestigatori Q8TAP8.

    Family and domain databases

    InterProi IPR029135. PPP1R35_C.
    [Graphical view ]
    Pfami PF15503. PPP1R35_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Docking motif-guided mapping of the interactome of protein phosphatase-1."
      Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M.
      Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PPP1CA.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47 AND SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiPPR35_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAP8
    Secondary accession number(s): A4D2C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3