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Q8TAP8

- PPR35_HUMAN

UniProt

Q8TAP8 - PPR35_HUMAN

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Protein

Protein phosphatase 1 regulatory subunit 35

Gene

PPP1R35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits PPP1CA phosphatase activity.1 Publication

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB
  2. protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 35
Gene namesi
Name:PPP1R35
Synonyms:C7orf47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28320. PPP1R35.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Protein phosphatase 1 regulatory subunit 35PRO_0000271356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471Phosphoserine1 Publication
Modified residuei52 – 521Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TAP8.
PaxDbiQ8TAP8.
PRIDEiQ8TAP8.

PTM databases

PhosphoSiteiQ8TAP8.

Expressioni

Gene expression databases

BgeeiQ8TAP8.
CleanExiHS_C7orf47.
GenevestigatoriQ8TAP8.

Organism-specific databases

HPAiHPA051607.

Interactioni

Subunit structurei

Interacts with PPP1CA.1 Publication

Protein-protein interaction databases

BioGridi128765. 2 interactions.
IntActiQ8TAP8. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8TAP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 6039Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PPP1R35 family.Curated

Phylogenomic databases

eggNOGiNOG45984.
GeneTreeiENSGT00390000004198.
HOGENOMiHOG000111594.
HOVERGENiHBG073318.
InParanoidiQ8TAP8.
KOiK17574.
OMAiQIRCGLE.
OrthoDBiEOG7D85XT.
PhylomeDBiQ8TAP8.
TreeFamiTF337101.

Family and domain databases

InterProiIPR029135. PPP1R35_C.
[Graphical view]
PfamiPF15503. PPP1R35_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMMGCGESEL KSADGEEAAA VPGPPPEPQV PQLRAPVPEP GLDLSLSPRP
60 70 80 90 100
DSPQPRHGSP GRRKGRAERR GAARQRRQVR FRLTPPSPVR SEPQPAVPQE
110 120 130 140 150
LEMPVLKSSL ALGLELRAAA GSHFDAAKAV EEQLRKSFQI RCGLEESVSE
160 170 180 190 200
GLNVPRSKRL FRDLVSLQVP EEQVLNAALR EKLALLPPQA RAPHPKEPPG
210 220 230 240 250
PGPDMTILCD PETLFYESPH LTLDGLPPLR LQLRPRPSED TFLMHRTLRR

WEA
Length:253
Mass (Da):27,953
Last modified:June 1, 2002 - v1
Checksum:i9DE5142EDD2150B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092849 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23833.1.
CH471091 Genomic DNA. Translation: EAW76532.1.
BC026269 mRNA. Translation: AAH26269.1.
CCDSiCCDS5694.1.
RefSeqiNP_659467.1. NM_145030.2.
UniGeneiHs.413359.

Genome annotation databases

EnsembliENST00000292330; ENSP00000292330; ENSG00000160813.
GeneIDi221908.
KEGGihsa:221908.
UCSCiuc003uuy.1. human.

Polymorphism databases

DMDMi74730374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092849 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23833.1 .
CH471091 Genomic DNA. Translation: EAW76532.1 .
BC026269 mRNA. Translation: AAH26269.1 .
CCDSi CCDS5694.1.
RefSeqi NP_659467.1. NM_145030.2.
UniGenei Hs.413359.

3D structure databases

ProteinModelPortali Q8TAP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128765. 2 interactions.
IntActi Q8TAP8. 2 interactions.

PTM databases

PhosphoSitei Q8TAP8.

Polymorphism databases

DMDMi 74730374.

Proteomic databases

MaxQBi Q8TAP8.
PaxDbi Q8TAP8.
PRIDEi Q8TAP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292330 ; ENSP00000292330 ; ENSG00000160813 .
GeneIDi 221908.
KEGGi hsa:221908.
UCSCi uc003uuy.1. human.

Organism-specific databases

CTDi 221908.
GeneCardsi GC07M100034.
H-InvDB HIX0006921.
HGNCi HGNC:28320. PPP1R35.
HPAi HPA051607.
neXtProti NX_Q8TAP8.
PharmGKBi PA162380520.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45984.
GeneTreei ENSGT00390000004198.
HOGENOMi HOG000111594.
HOVERGENi HBG073318.
InParanoidi Q8TAP8.
KOi K17574.
OMAi QIRCGLE.
OrthoDBi EOG7D85XT.
PhylomeDBi Q8TAP8.
TreeFami TF337101.

Miscellaneous databases

ChiTaRSi PPP1R35. human.
GenomeRNAii 221908.
NextBioi 91486.
PROi Q8TAP8.

Gene expression databases

Bgeei Q8TAP8.
CleanExi HS_C7orf47.
Genevestigatori Q8TAP8.

Family and domain databases

InterProi IPR029135. PPP1R35_C.
[Graphical view ]
Pfami PF15503. PPP1R35_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Docking motif-guided mapping of the interactome of protein phosphatase-1."
    Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M.
    Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PPP1CA.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47 AND SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiPPR35_HUMAN
AccessioniPrimary (citable) accession number: Q8TAP8
Secondary accession number(s): A4D2C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3