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Protein

Centrosomal protein of 76 kDa

Gene

CEP76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.1 Publication

GO - Biological processi

  • G2/M transition of mitotic cell cycle Source: Reactome
  • regulation of centriole replication Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 76 kDa
Short name:
Cep76
Gene namesi
Name:CEP76
Synonyms:C18orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:25727. CEP76.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytosol Source: Reactome
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916911.

Polymorphism and mutation databases

DMDMi59797956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659Centrosomal protein of 76 kDaPRO_0000089501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei83 – 831PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TAP6.
MaxQBiQ8TAP6.
PaxDbiQ8TAP6.
PeptideAtlasiQ8TAP6.
PRIDEiQ8TAP6.

PTM databases

iPTMnetiQ8TAP6.
PhosphoSiteiQ8TAP6.

Expressioni

Developmental stagei

Expressed at low level in G1 and is induced in S and G2 phase, during which point centrioles have already commenced duplication (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000101624.
CleanExiHS_CEP76.
ExpressionAtlasiQ8TAP6. baseline and differential.
GenevisibleiQ8TAP6. HS.

Organism-specific databases

HPAiHPA039395.

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP7O43687-23EBI-742887,EBI-10185182
BANPQ8N9N53EBI-742887,EBI-744695
C22orf39Q6P5X53EBI-742887,EBI-7317823
CABP5Q9NP863EBI-742887,EBI-10311131
CCDC92Q53HC03EBI-742887,EBI-719994
CIR1Q86X953EBI-742887,EBI-627102
CRYBA4P536735EBI-742887,EBI-7519711
CSNK1G1Q9HCP03EBI-742887,EBI-1383814
CUTCQ9NTM93EBI-742887,EBI-714918
DZIP1LQ8IYY43EBI-742887,EBI-10264440
EAF1Q96JC93EBI-742887,EBI-769261
EP400NLH9KV843EBI-742887,EBI-10178184
FAM90A1Q86YD73EBI-742887,EBI-6658203
GDAP2Q9NXN43EBI-742887,EBI-10316460
HSPB7Q9UBY93EBI-742887,EBI-739361
ILVBLA1L0T03EBI-742887,EBI-720553
KIAA1143Q96AT14EBI-742887,EBI-2548425
KLHDC4Q8TBB53EBI-742887,EBI-8472352
LATS1Q6PJG33EBI-742887,EBI-10253976
MBD3O959833EBI-742887,EBI-1783068
NHLRC2Q8NBF23EBI-742887,EBI-10269163
PARD6BQ9BYG53EBI-742887,EBI-295391
PIN1Q135263EBI-742887,EBI-714158
PLCB1Q9NQ663EBI-742887,EBI-3396023
POM121Q96HA13EBI-742887,EBI-739990
RADILQ96JH83EBI-742887,EBI-744267
RNF128Q8TEB73EBI-742887,EBI-2341619
RPL9P9P329693EBI-742887,EBI-358122
SALL2Q9Y4674EBI-742887,EBI-746180
SH2D4AQ9H7883EBI-742887,EBI-747035
TOB2Q141063EBI-742887,EBI-2562000
TSSC4Q9Y5U23EBI-742887,EBI-717229
TTC21AA0A0B4J1Y23EBI-742887,EBI-10220701
TUFT1Q9NNX13EBI-742887,EBI-2557363
TXNDC9O145303EBI-742887,EBI-707554
WDFY3Q8IZQ1-23EBI-742887,EBI-10264625
ZBTB24O431673EBI-742887,EBI-744471
ZMAT2Q96NC03EBI-742887,EBI-2682299
ZNF85Q03923-33EBI-742887,EBI-10223330

Protein-protein interaction databases

BioGridi123028. 153 interactions.
IntActiQ8TAP6. 58 interactions.
MINTiMINT-1478334.
STRINGi9606.ENSP00000262127.

Structurei

3D structure databases

ProteinModelPortaliQ8TAP6.
SMRiQ8TAP6. Positions 365-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CEP76 family.Curated

Phylogenomic databases

eggNOGiENOG410IFDB. Eukaryota.
ENOG410XWNZ. LUCA.
GeneTreeiENSGT00390000000781.
HOGENOMiHOG000008143.
HOVERGENiHBG050901.
InParanoidiQ8TAP6.
KOiK16457.
OMAiVHRESLG.
OrthoDBiEOG091G02SF.
PhylomeDBiQ8TAP6.
TreeFamiTF329324.

Family and domain databases

InterProiIPR028926. CEP76-C2.
[Graphical view]
PfamiPF15627. CEP76-C2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE
60 70 80 90 100
DLIKALRRRG IIDDVMKELN FVTDSVEQEL PSSPKQPICF DRQSTLKKTN
110 120 130 140 150
IDPTRRYLYL QVLGGKAFLE HLQEPEPLPG QVCSTFTLCL HYRNQRFRSK
160 170 180 190 200
PVPCACEPDF HDGFLLEVHR ESLGDGTRMA DSTTMLSISD PIHMVLIKTD
210 220 230 240 250
IFGETTLVAS YFLEWRSVLG SENGVTSLTV ELMGVGTESK VSVGILNIKL
260 270 280 290 300
EMYPPLNQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
310 320 330 340 350
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER
360 370 380 390 400
APVIGGGGKQ EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG
410 420 430 440 450
TKAKGVPHAW VMTCGTDGAI TFWESLTGHR YIHKPTNPDE PPVAEQPKPL
460 470 480 490 500
YPYRTIGCVF NHQMFLGNCQ PSDAVETCVF DLNDESKWKP MSEEAIKSVC
510 520 530 540 550
APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR KDLGLTTVWE
560 570 580 590 600
DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
610 620 630 640 650
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM

FACKYRSVL
Length:659
Mass (Da):74,413
Last modified:June 1, 2002 - v1
Checksum:i66EB85DCDCBEE518
GO
Isoform 2 (identifier: Q8TAP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-174: TNIDPTRRYL...LLEVHRESLG → S

Note: No experimental confirmation available.
Show »
Length:584
Mass (Da):65,733
Checksum:i32792B1A54D92636
GO
Isoform 3 (identifier: Q8TAP6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     431-445: YIHKPTNPDEPPVAE → LCFQPSDVPGKLSTL
     446-659: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,669
Checksum:i3DB77E46396240EF
GO

Sequence cautioni

The sequence BAG64223 differs from that shown. Reason: Erroneous termination at position 648. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti314 – 3141N → S in BAB14123 (PubMed:14702039).Curated
Sequence conflicti606 – 6061R → G in BAB14123 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 178178Missing in isoform 3. 1 PublicationVSP_037610Add
BLAST
Alternative sequencei99 – 17476TNIDP…RESLG → S in isoform 2. 1 PublicationVSP_037611Add
BLAST
Alternative sequencei431 – 44515YIHKP…PPVAE → LCFQPSDVPGKLSTL in isoform 3. 1 PublicationVSP_037612Add
BLAST
Alternative sequencei446 – 659214Missing in isoform 3. 1 PublicationVSP_037613Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022604 mRNA. Translation: BAB14123.1.
AK301964 mRNA. Translation: BAG63377.1.
AK303117 mRNA. Translation: BAG64223.1. Sequence problems.
EF445040 Genomic DNA. Translation: ACA06091.1.
AP005482 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01543.1.
BC026307 mRNA. Translation: AAH26307.1.
AL833727 mRNA. Translation: CAH56252.1.
CCDSiCCDS11861.1. [Q8TAP6-1]
CCDS62390.1. [Q8TAP6-2]
RefSeqiNP_001258918.1. NM_001271989.1. [Q8TAP6-2]
NP_079175.2. NM_024899.3. [Q8TAP6-1]
UniGeneiHs.236940.

Genome annotation databases

EnsembliENST00000262127; ENSP00000262127; ENSG00000101624. [Q8TAP6-1]
ENST00000423709; ENSP00000403074; ENSG00000101624. [Q8TAP6-2]
GeneIDi79959.
KEGGihsa:79959.
UCSCiuc002kri.5. human. [Q8TAP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022604 mRNA. Translation: BAB14123.1.
AK301964 mRNA. Translation: BAG63377.1.
AK303117 mRNA. Translation: BAG64223.1. Sequence problems.
EF445040 Genomic DNA. Translation: ACA06091.1.
AP005482 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01543.1.
BC026307 mRNA. Translation: AAH26307.1.
AL833727 mRNA. Translation: CAH56252.1.
CCDSiCCDS11861.1. [Q8TAP6-1]
CCDS62390.1. [Q8TAP6-2]
RefSeqiNP_001258918.1. NM_001271989.1. [Q8TAP6-2]
NP_079175.2. NM_024899.3. [Q8TAP6-1]
UniGeneiHs.236940.

3D structure databases

ProteinModelPortaliQ8TAP6.
SMRiQ8TAP6. Positions 365-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123028. 153 interactions.
IntActiQ8TAP6. 58 interactions.
MINTiMINT-1478334.
STRINGi9606.ENSP00000262127.

PTM databases

iPTMnetiQ8TAP6.
PhosphoSiteiQ8TAP6.

Polymorphism and mutation databases

DMDMi59797956.

Proteomic databases

EPDiQ8TAP6.
MaxQBiQ8TAP6.
PaxDbiQ8TAP6.
PeptideAtlasiQ8TAP6.
PRIDEiQ8TAP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262127; ENSP00000262127; ENSG00000101624. [Q8TAP6-1]
ENST00000423709; ENSP00000403074; ENSG00000101624. [Q8TAP6-2]
GeneIDi79959.
KEGGihsa:79959.
UCSCiuc002kri.5. human. [Q8TAP6-1]

Organism-specific databases

CTDi79959.
GeneCardsiCEP76.
HGNCiHGNC:25727. CEP76.
HPAiHPA039395.
neXtProtiNX_Q8TAP6.
PharmGKBiPA134916911.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFDB. Eukaryota.
ENOG410XWNZ. LUCA.
GeneTreeiENSGT00390000000781.
HOGENOMiHOG000008143.
HOVERGENiHBG050901.
InParanoidiQ8TAP6.
KOiK16457.
OMAiVHRESLG.
OrthoDBiEOG091G02SF.
PhylomeDBiQ8TAP6.
TreeFamiTF329324.

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

GeneWikiiCEP76.
GenomeRNAii79959.
PROiQ8TAP6.

Gene expression databases

BgeeiENSG00000101624.
CleanExiHS_CEP76.
ExpressionAtlasiQ8TAP6. baseline and differential.
GenevisibleiQ8TAP6. HS.

Family and domain databases

InterProiIPR028926. CEP76-C2.
[Graphical view]
PfamiPF15627. CEP76-C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEP76_HUMAN
AccessioniPrimary (citable) accession number: Q8TAP6
Secondary accession number(s): B0YJB2
, B4DXG5, B4DZW1, Q658N5, Q9H9U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.