UniProtKB - Q8TAP4 (LMO3_HUMAN)
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Protein
LIM domain only protein 3
Gene
LMO3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of glucocorticoid receptor signaling pathway Source: UniProtKB
- positive regulation of peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SIGNORi | Q8TAP4 |
Names & Taxonomyi
Protein namesi | Recommended name: LIM domain only protein 3Short name: LMO-3 Alternative name(s): Neuronal-specific transcription factor DAT1 Rhombotin-3 |
Gene namesi | Name:LMO3 Synonyms:RBTN3, RBTNL2, RHOM3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000048540.14 |
HGNCi | HGNC:6643 LMO3 |
MIMi | 180386 gene |
neXtProti | NX_Q8TAP4 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55885 |
OpenTargetsi | ENSG00000048540 |
PharmGKBi | PA30409 |
Polymorphism and mutation databases
BioMutai | LMO3 |
DMDMi | 34098603 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075817 | 1 – 145 | LIM domain only protein 3Add BLAST | 145 |
Proteomic databases
MaxQBi | Q8TAP4 |
PaxDbi | Q8TAP4 |
PeptideAtlasi | Q8TAP4 |
PRIDEi | Q8TAP4 |
PTM databases
iPTMneti | Q8TAP4 |
PhosphoSitePlusi | Q8TAP4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000048540 |
CleanExi | HS_LMO3 |
ExpressionAtlasi | Q8TAP4 baseline and differential |
Genevisiblei | Q8TAP4 HS |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 12097733 interactors. |
DIPi | DIP-50129N |
IntActi | Q8TAP4 86 interactors. |
MINTi | Q8TAP4 |
STRINGi | 9606.ENSP00000312856 |
Structurei
3D structure databases
ProteinModelPortali | Q8TAP4 |
SMRi | Q8TAP4 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 73 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 75 – 137 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 63 |
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG0490 Eukaryota ENOG410YIJ3 LUCA |
GeneTreei | ENSGT00760000118921 |
HOGENOMi | HOG000232175 |
HOVERGENi | HBG054231 |
InParanoidi | Q8TAP4 |
OMAi | XLFGVTG |
OrthoDBi | EOG091G0LKW |
PhylomeDBi | Q8TAP4 |
TreeFami | TF351071 |
Family and domain databases
InterProi | View protein in InterPro IPR001781 Znf_LIM |
Pfami | View protein in Pfam PF00412 LIM, 2 hits |
SMARTi | View protein in SMART SM00132 LIM, 2 hits |
PROSITEi | View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 2 hits |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TAP4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MLSVQPDTKP KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV
60 70 80 90 100
GSTLYTKANL ILCRRDYLRL FGVTGNCAAC SKLIPAFEMV MRAKDNVYHL
110 120 130 140
DCFACQLCNQ RFCVGDKFFL KNNMILCQTD YEEGLMKEGY APQVR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | L → P in BAC04582 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045312 | 1 | M → MQKKEKSFGIQM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_047379 | 1 | M → MLMEGGRAAAARNVSSIQM in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_045313 | 50 – 69 | VGSTL…RDYLR → HLKRCGSIYIHAAHTEIGIC VTLEWPLPFVIIDFSQQITI AW in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | LMO3_HUMAN | |
Accessioni | Q8TAP4Primary (citable) accession number: Q8TAP4 Secondary accession number(s): B4DG90 Q9UDD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |