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Protein

Ermin

Gene

ERMN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).By similarity

GO - Biological processi

  • actin filament organization Source: UniProtKB
  • morphogenesis of a branching structure Source: Ensembl
  • regulation of cell projection organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ermin
Alternative name(s):
Juxtanodin
Short name:
JN
Gene namesi
Name:ERMN
Synonyms:KIAA1189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29208. ERMN.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • filopodium Source: Ensembl
  • internode region of axon Source: UniProtKB
  • myelin sheath Source: Ensembl
  • neuronal cell body Source: Ensembl
  • paranode region of axon Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385355.

Polymorphism and mutation databases

BioMutaiERMN.
DMDMi74730370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284ErminPRO_0000314748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei214 – 2141PhosphoserineBy similarity
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei230 – 2301PhosphoserineBy similarity
Modified residuei233 – 2331PhosphoserineBy similarity
Modified residuei237 – 2371PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TAM6.
PaxDbiQ8TAM6.
PeptideAtlasiQ8TAM6.
PRIDEiQ8TAM6.

PTM databases

iPTMnetiQ8TAM6.
PhosphoSiteiQ8TAM6.

Expressioni

Tissue specificityi

Highly expressed in adult and fetal brain. Expressed at intermediate levels in the lung and liver.1 Publication

Gene expression databases

BgeeiQ8TAM6.
CleanExiHS_ERMN.
ExpressionAtlasiQ8TAM6. baseline and differential.
GenevisibleiQ8TAM6. HS.

Organism-specific databases

HPAiHPA038295.
HPA038296.

Interactioni

Subunit structurei

Binds actin.By similarity

Protein-protein interaction databases

BioGridi121541. 3 interactions.
IntActiQ8TAM6. 1 interaction.
STRINGi9606.ENSP00000380453.

Structurei

3D structure databases

ProteinModelPortaliQ8TAM6.
SMRiQ8TAM6. Positions 194-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 28420Binds actinBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 1926Poly-Asp

Phylogenomic databases

eggNOGiKOG2030. Eukaryota.
COG1293. LUCA.
GeneTreeiENSGT00390000005845.
HOGENOMiHOG000069967.
HOVERGENiHBG102710.
InParanoidiQ8TAM6.
OMAiWLGFRKP.
OrthoDBiEOG73805R.
PhylomeDBiQ8TAM6.
TreeFamiTF337225.

Family and domain databases

InterProiIPR008954. Moesin_tail.
[Graphical view]
SUPFAMiSSF48678. SSF48678. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDVPATFTQ AECNGDKPPE NGQQTITKIS EELTDVDSPL PHYRVEPSLE
60 70 80 90 100
GALTKGSQEE RRKLQGNMLL NSSMEDKMLK ENPEEKLFIV HKAITDLSLQ
110 120 130 140 150
ETSADEMTFR EGHQWEKIPL SGSNQEIRRQ KERITEQPLK EEEDEDRKNK
160 170 180 190 200
GHQAAEIEWL GFRKPSQADM LHSKHDEEQK VWDEEIDDDD DDNCNNDEDE
210 220 230 240 250
VRVIEFKKKH EEVSQFKEEG DASEDSPLSS ASSQAVTPDE QPTLGKKSDI
260 270 280
SRNAYSRYNT ISYRKIRKGN TKQRIDEFES MMHL
Length:284
Mass (Da):32,783
Last modified:June 1, 2002 - v1
Checksum:i7A0589BED3682BED
GO
Isoform 2 (identifier: Q8TAM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKTLSPDRIQPHIM

Show »
Length:297
Mass (Da):34,301
Checksum:i98446B1F76604416
GO

Sequence cautioni

The sequence BAA86503.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MKTLSPDRIQPHIM in isoform 2. 1 PublicationVSP_036982

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ334271 mRNA. Translation: ABC67251.1.
AB033015 mRNA. Translation: BAA86503.1. Different initiation.
AK296477 mRNA. Translation: BAG59118.1.
AC016732 Genomic DNA. Translation: AAY14889.1.
CH471058 Genomic DNA. Translation: EAX11448.1.
BC026345 mRNA. Translation: AAH26345.1.
CCDSiCCDS42764.1. [Q8TAM6-2]
CCDS46431.1. [Q8TAM6-1]
RefSeqiNP_001009959.1. NM_001009959.2. [Q8TAM6-2]
NP_001291273.1. NM_001304344.1. [Q8TAM6-1]
NP_001291274.1. NM_001304345.1. [Q8TAM6-1]
NP_001291275.1. NM_001304346.1.
NP_065762.1. NM_020711.2. [Q8TAM6-1]
UniGeneiHs.443894.
Hs.707957.

Genome annotation databases

EnsembliENST00000397283; ENSP00000380453; ENSG00000136541. [Q8TAM6-2]
ENST00000410096; ENSP00000387047; ENSG00000136541. [Q8TAM6-1]
GeneIDi57471.
KEGGihsa:57471.
UCSCiuc002tzh.4. human. [Q8TAM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ334271 mRNA. Translation: ABC67251.1.
AB033015 mRNA. Translation: BAA86503.1. Different initiation.
AK296477 mRNA. Translation: BAG59118.1.
AC016732 Genomic DNA. Translation: AAY14889.1.
CH471058 Genomic DNA. Translation: EAX11448.1.
BC026345 mRNA. Translation: AAH26345.1.
CCDSiCCDS42764.1. [Q8TAM6-2]
CCDS46431.1. [Q8TAM6-1]
RefSeqiNP_001009959.1. NM_001009959.2. [Q8TAM6-2]
NP_001291273.1. NM_001304344.1. [Q8TAM6-1]
NP_001291274.1. NM_001304345.1. [Q8TAM6-1]
NP_001291275.1. NM_001304346.1.
NP_065762.1. NM_020711.2. [Q8TAM6-1]
UniGeneiHs.443894.
Hs.707957.

3D structure databases

ProteinModelPortaliQ8TAM6.
SMRiQ8TAM6. Positions 194-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121541. 3 interactions.
IntActiQ8TAM6. 1 interaction.
STRINGi9606.ENSP00000380453.

PTM databases

iPTMnetiQ8TAM6.
PhosphoSiteiQ8TAM6.

Polymorphism and mutation databases

BioMutaiERMN.
DMDMi74730370.

Proteomic databases

EPDiQ8TAM6.
PaxDbiQ8TAM6.
PeptideAtlasiQ8TAM6.
PRIDEiQ8TAM6.

Protocols and materials databases

DNASUi57471.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397283; ENSP00000380453; ENSG00000136541. [Q8TAM6-2]
ENST00000410096; ENSP00000387047; ENSG00000136541. [Q8TAM6-1]
GeneIDi57471.
KEGGihsa:57471.
UCSCiuc002tzh.4. human. [Q8TAM6-1]

Organism-specific databases

CTDi57471.
GeneCardsiERMN.
HGNCiHGNC:29208. ERMN.
HPAiHPA038295.
HPA038296.
MIMi610072. gene.
neXtProtiNX_Q8TAM6.
PharmGKBiPA162385355.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2030. Eukaryota.
COG1293. LUCA.
GeneTreeiENSGT00390000005845.
HOGENOMiHOG000069967.
HOVERGENiHBG102710.
InParanoidiQ8TAM6.
OMAiWLGFRKP.
OrthoDBiEOG73805R.
PhylomeDBiQ8TAM6.
TreeFamiTF337225.

Miscellaneous databases

ChiTaRSiERMN. human.
GenomeRNAii57471.
PROiQ8TAM6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAM6.
CleanExiHS_ERMN.
ExpressionAtlasiQ8TAM6. baseline and differential.
GenevisibleiQ8TAM6. HS.

Family and domain databases

InterProiIPR008954. Moesin_tail.
[Graphical view]
SUPFAMiSSF48678. SSF48678. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology."
    Brockschnieder D., Sabanay H., Riethmacher D., Peles E.
    J. Neurosci. 26:757-762(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiERMIN_HUMAN
AccessioniPrimary (citable) accession number: Q8TAM6
Secondary accession number(s): B4DKA6, Q9ULN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.