ID   OLIG1_HUMAN             Reviewed;         271 AA.
AC   Q8TAK6; Q7RTS0;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   27-MAR-2024, entry version 163.
DE   RecName: Full=Oligodendrocyte transcription factor 1;
DE            Short=Oligo1;
DE   AltName: Full=Class B basic helix-loop-helix protein 6;
DE            Short=bHLHb6;
DE   AltName: Full=Class E basic helix-loop-helix protein 21;
DE            Short=bHLHe21;
GN   Name=OLIG1; Synonyms=BHLHB6, BHLHE21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14516699; DOI=10.1016/s0925-4773(03)00130-8;
RA   McLellan A.S., Langlands K., Kealey T.;
RT   "Exhaustive identification of human class II basic helix-loop-helix
RT   proteins by virtual library screening.";
RL   Mech. Dev. 119:S285-S291(2002).
RN   [5]
RP   FUNCTION.
RX   PubMed=10719889; DOI=10.1016/s0896-6273(00)80898-3;
RA   Zhou Q., Wang S., Anderson D.J.;
RT   "Identification of a novel family of oligodendrocyte lineage-specific basic
RT   helix-loop-helix transcription factors.";
RL   Neuron 25:331-343(2000).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=11526205; DOI=10.1073/pnas.181340798;
RA   Lu Q.R., Park J.K., Noll E., Chan J.A., Alberta J.A., Yuk D.-I.,
RA   Alzamora M.G., Louis D.N., Stiles C.D., Rowitch D.H., Black P.M.;
RT   "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial
RT   brain tumors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001).
CC   -!- FUNCTION: Promotes formation and maturation of oligodendrocytes,
CC       especially within the brain. Cooperates with OLIG2 to establish the pMN
CC       domain of the embryonic neural tube (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:10719889}.
CC   -!- INTERACTION:
CC       Q8TAK6; Q14451: GRB7; NbExp=3; IntAct=EBI-3867416, EBI-970191;
CC       Q8TAK6; P08631-2: HCK; NbExp=2; IntAct=EBI-3867416, EBI-9834454;
CC       Q8TAK6; Q92569: PIK3R3; NbExp=2; IntAct=EBI-3867416, EBI-79893;
CC       Q8TAK6; O14796: SH2D1B; NbExp=2; IntAct=EBI-3867416, EBI-3923013;
CC       Q8TAK6; Q15796: SMAD2; NbExp=2; IntAct=EBI-3867416, EBI-1040141;
CC       Q8TAK6; P07947: YES1; NbExp=3; IntAct=EBI-3867416, EBI-515331;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes.
CC       Strongly expressed in oligodendrogliomas, while expression is weak to
CC       moderate in astrocytomas. Expression in glioblastomas is highly
CC       variable. {ECO:0000269|PubMed:11526205}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH26989.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=DAA01058.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL834450; CAD39110.1; -; mRNA.
DR   EMBL; AP000289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC026989; AAH26989.1; ALT_INIT; mRNA.
DR   EMBL; BC033290; AAH33290.1; -; mRNA.
DR   EMBL; BK000278; DAA01058.1; ALT_INIT; mRNA.
DR   CCDS; CCDS42920.2; -.
DR   RefSeq; NP_620450.2; NM_138983.2.
DR   AlphaFoldDB; Q8TAK6; -.
DR   SMR; Q8TAK6; -.
DR   BioGRID; 125511; 28.
DR   IntAct; Q8TAK6; 22.
DR   MINT; Q8TAK6; -.
DR   STRING; 9606.ENSP00000371785; -.
DR   iPTMnet; Q8TAK6; -.
DR   PhosphoSitePlus; Q8TAK6; -.
DR   BioMuta; OLIG1; -.
DR   DMDM; 22653884; -.
DR   MassIVE; Q8TAK6; -.
DR   PaxDb; 9606-ENSP00000371785; -.
DR   PeptideAtlas; Q8TAK6; -.
DR   ProteomicsDB; 73889; -.
DR   TopDownProteomics; Q8TAK6; -.
DR   Antibodypedia; 22667; 394 antibodies from 40 providers.
DR   DNASU; 116448; -.
DR   Ensembl; ENST00000382348.2; ENSP00000371785.1; ENSG00000184221.13.
DR   GeneID; 116448; -.
DR   KEGG; hsa:116448; -.
DR   MANE-Select; ENST00000382348.2; ENSP00000371785.1; NM_138983.3; NP_620450.2.
DR   UCSC; uc002yqz.4; human.
DR   AGR; HGNC:16983; -.
DR   CTD; 116448; -.
DR   DisGeNET; 116448; -.
DR   GeneCards; OLIG1; -.
DR   HGNC; HGNC:16983; OLIG1.
DR   HPA; ENSG00000184221; Tissue enriched (brain).
DR   MIM; 606385; gene.
DR   neXtProt; NX_Q8TAK6; -.
DR   OpenTargets; ENSG00000184221; -.
DR   PharmGKB; PA31918; -.
DR   VEuPathDB; HostDB:ENSG00000184221; -.
DR   eggNOG; KOG3898; Eukaryota.
DR   GeneTree; ENSGT00940000162722; -.
DR   HOGENOM; CLU_060337_0_0_1; -.
DR   InParanoid; Q8TAK6; -.
DR   OMA; CKFPHFI; -.
DR   OrthoDB; 5324482at2759; -.
DR   PhylomeDB; Q8TAK6; -.
DR   TreeFam; TF322733; -.
DR   PathwayCommons; Q8TAK6; -.
DR   SignaLink; Q8TAK6; -.
DR   SIGNOR; Q8TAK6; -.
DR   BioGRID-ORCS; 116448; 13 hits in 1169 CRISPR screens.
DR   GeneWiki; OLIG1; -.
DR   GenomeRNAi; 116448; -.
DR   Pharos; Q8TAK6; Tbio.
DR   PRO; PR:Q8TAK6; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q8TAK6; Protein.
DR   Bgee; ENSG00000184221; Expressed in inferior vagus X ganglion and 122 other cell types or tissues.
DR   ExpressionAtlas; Q8TAK6; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0070888; F:E-box binding; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0061564; P:axon development; IBA:GO_Central.
DR   GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
DR   GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007423; P:sensory organ development; IBA:GO_Central.
DR   CDD; cd18942; bHLH_TS_OLIG1; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR032657; Olig1_bHLH.
DR   PANTHER; PTHR19290; BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED; 1.
DR   PANTHER; PTHR19290:SF7; OLIGODENDROCYTE TRANSCRIPTION FACTOR 1; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   Genevisible; Q8TAK6; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..271
FT                   /note="Oligodendrocyte transcription factor 1"
FT                   /id="PRO_0000127411"
FT   DOMAIN          105..164
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          38..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  27905 MW;  7CB9D8DD9CBA0DF5 CRC64;
     MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS STSSTSSSST
     TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE EQQQQLRRKI NSRERKRMQD
     LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY ILLLGSSLQE LRRALGEGAG
     PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG
     GPGLCTCAVC KFPHLVPASL GLAAVQAQFS K
//