Q8TAK6 (OLIG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oligodendrocyte transcription factor 1
Short name=Oligo1

Alternative name(s):
Class B basic helix-loop-helix protein 6
Short name=bHLHb6
Class E basic helix-loop-helix protein 21
Short name=bHLHe21

Gene names

Name:	OLIG1
Synonyms:	BHLHB6, BHLHE21

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube By similarity. Ref.5
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable. Ref.6
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.
Sequence caution	The sequence AAH26989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence DAA01058.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Oligodendrocyte transcription factor 1		PRO_0000127411
Regions
	Domain	116 – 164	49	Helix-loop-helix motif
	DNA binding	106 – 115	10	Basic motif
	Compositional bias	43 – 59	17	Ser-rich
	Compositional bias	102 – 105	4	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q8TAK6 [UniParc]. Last modified August 30, 2002. Version 2. Checksum: 7CB9D8DD9CBA0DF5	FASTA	271	27,905
	10 20 30 40 50 60 MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS STSSTSSSST 70 80 90 100 110 120 TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE EQQQQLRRKI NSRERKRMQD 130 140 150 160 170 180 LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY ILLLGSSLQE LRRALGEGAG 190 200 210 220 230 240 PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG 250 260 270 GPGLCTCAVC KFPHLVPASL GLAAVQAQFS K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening." McLellan A.S., Langlands K., Kealey T. Mech. Dev. 119:S285-S291(2002) [PubMed: 14516699] [Abstract] Cited for: IDENTIFICATION.
[5]	"Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors." Zhou Q., Wang S., Anderson D.J. Neuron 25:331-343(2000) [PubMed: 10719889] [Abstract] Cited for: FUNCTION.
[6]	"Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors." Lu Q.R., Park J.K., Noll E., Chan J.A., Alberta J.A., Yuk D.-I., Alzamora M.G., Louis D.N., Stiles C.D., Rowitch D.H., Black P.M. Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001) [PubMed: 11526205] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL834450 mRNA. Translation: CAD39110.1. AP000289 Genomic DNA. No translation available. BC026989 mRNA. Translation: AAH26989.1. Different initiation. BC033290 mRNA. Translation: AAH33290.1. BK000278 mRNA. Translation: DAA01058.1. Different initiation.
IPI	IPI00152068.
RefSeq	NP_620450.2. NM_138983.2.
UniGene	Hs.56663.
3D structure databases
ProteinModelPortal	Q8TAK6.
SMR	Q8TAK6. Positions 106-169.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TAK6. 2 interactions.
STRING	Q8TAK6.
Polymorphism databases
DMDM	22653884.
Proteomic databases
PRIDE	Q8TAK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382348; ENSP00000371785; ENSG00000184221.
GeneID	116448.
KEGG	hsa:116448.
UCSC	uc002yqz.1. human.
Organism-specific databases
CTD	116448.
GeneCards	GC21P034442.
H-InvDB	HIX0016072.
HGNC	HGNC:16983. OLIG1.
HPA	CAB025474.
MIM	606385. gene.
neXtProt	NX_Q8TAK6.
PharmGKB	PA31918.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063239.
HOVERGEN	HBG053369.
InParanoid	Q8TAK6.
OMA	LYELVGY.
OrthoDB	EOG4BP1CW.
PhylomeDB	Q8TAK6.
Gene expression databases
ArrayExpress	Q8TAK6.
Bgee	Q8TAK6.
CleanEx	HS_OLIG1.
Genevestigator	Q8TAK6.
GermOnline	ENSG00000184221. Homo sapiens.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
KO	K09085.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	79933.
SOURCE	Search...

Entry information

Entry name

OLIG1_HUMAN

Accession

Primary (citable) accession number: Q8TAK6
Secondary accession number(s): Q7RTS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	August 30, 2002
Last modified:	January 25, 2012
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.