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Q8TAK6

- OLIG1_HUMAN

UniProt

Q8TAK6 - OLIG1_HUMAN

Protein

Oligodendrocyte transcription factor 1

Gene

OLIG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. neuron fate commitment Source: Ensembl
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ8TAK6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligodendrocyte transcription factor 1
    Short name:
    Oligo1
    Alternative name(s):
    Class B basic helix-loop-helix protein 6
    Short name:
    bHLHb6
    Class E basic helix-loop-helix protein 21
    Short name:
    bHLHe21
    Gene namesi
    Name:OLIG1
    Synonyms:BHLHB6, BHLHE21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:16983. OLIG1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31918.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Oligodendrocyte transcription factor 1PRO_0000127411Add
    BLAST

    Proteomic databases

    PaxDbiQ8TAK6.
    PRIDEiQ8TAK6.

    PTM databases

    PhosphoSiteiQ8TAK6.

    Expressioni

    Tissue specificityi

    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.1 Publication

    Gene expression databases

    ArrayExpressiQ8TAK6.
    BgeeiQ8TAK6.
    CleanExiHS_OLIG1.
    GenevestigatoriQ8TAK6.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SMAD2Q157962EBI-3867416,EBI-1040141

    Protein-protein interaction databases

    BioGridi125511. 4 interactions.
    IntActiQ8TAK6. 5 interactions.
    MINTiMINT-7295465.
    STRINGi9606.ENSP00000331066.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAK6.
    SMRiQ8TAK6. Positions 107-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini105 – 16460bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi43 – 5917Ser-richAdd
    BLAST
    Compositional biasi102 – 1054Poly-Gln

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG256163.
    HOVERGENiHBG053369.
    InParanoidiQ8TAK6.
    KOiK09085.
    OMAiGSPGLCT.
    OrthoDBiEOG7HF1KN.
    PhylomeDBiQ8TAK6.
    TreeFamiTF322733.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS    50
    STSSTSSSST TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE 100
    EQQQQLRRKI NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK 150
    IATLLLARNY ILLLGSSLQE LRRALGEGAG PAAPRLLLAG LPLLAAAPGS 200
    VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG GPGLCTCAVC 250
    KFPHLVPASL GLAAVQAQFS K 271
    Length:271
    Mass (Da):27,905
    Last modified:August 30, 2002 - v2
    Checksum:i7CB9D8DD9CBA0DF5
    GO

    Sequence cautioni

    The sequence AAH26989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence DAA01058.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834450 mRNA. Translation: CAD39110.1.
    AP000289 Genomic DNA. No translation available.
    BC026989 mRNA. Translation: AAH26989.1. Different initiation.
    BC033290 mRNA. Translation: AAH33290.1.
    BK000278 mRNA. Translation: DAA01058.1. Different initiation.
    CCDSiCCDS42920.2.
    RefSeqiNP_620450.2. NM_138983.2.
    UniGeneiHs.56663.

    Genome annotation databases

    EnsembliENST00000382348; ENSP00000371785; ENSG00000184221.
    GeneIDi116448.
    KEGGihsa:116448.
    UCSCiuc002yqz.3. human.

    Polymorphism databases

    DMDMi22653884.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834450 mRNA. Translation: CAD39110.1 .
    AP000289 Genomic DNA. No translation available.
    BC026989 mRNA. Translation: AAH26989.1 . Different initiation.
    BC033290 mRNA. Translation: AAH33290.1 .
    BK000278 mRNA. Translation: DAA01058.1 . Different initiation.
    CCDSi CCDS42920.2.
    RefSeqi NP_620450.2. NM_138983.2.
    UniGenei Hs.56663.

    3D structure databases

    ProteinModelPortali Q8TAK6.
    SMRi Q8TAK6. Positions 107-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125511. 4 interactions.
    IntActi Q8TAK6. 5 interactions.
    MINTi MINT-7295465.
    STRINGi 9606.ENSP00000331066.

    PTM databases

    PhosphoSitei Q8TAK6.

    Polymorphism databases

    DMDMi 22653884.

    Proteomic databases

    PaxDbi Q8TAK6.
    PRIDEi Q8TAK6.

    Protocols and materials databases

    DNASUi 116448.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382348 ; ENSP00000371785 ; ENSG00000184221 .
    GeneIDi 116448.
    KEGGi hsa:116448.
    UCSCi uc002yqz.3. human.

    Organism-specific databases

    CTDi 116448.
    GeneCardsi GC21P034442.
    HGNCi HGNC:16983. OLIG1.
    MIMi 606385. gene.
    neXtProti NX_Q8TAK6.
    PharmGKBi PA31918.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256163.
    HOVERGENi HBG053369.
    InParanoidi Q8TAK6.
    KOi K09085.
    OMAi GSPGLCT.
    OrthoDBi EOG7HF1KN.
    PhylomeDBi Q8TAK6.
    TreeFami TF322733.

    Enzyme and pathway databases

    SignaLinki Q8TAK6.

    Miscellaneous databases

    GeneWikii OLIG1.
    GenomeRNAii 116448.
    NextBioi 79933.
    PROi Q8TAK6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TAK6.
    Bgeei Q8TAK6.
    CleanExi HS_OLIG1.
    Genevestigatori Q8TAK6.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
      McLellan A.S., Langlands K., Kealey T.
      Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors."
      Zhou Q., Wang S., Anderson D.J.
      Neuron 25:331-343(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiOLIG1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAK6
    Secondary accession number(s): Q7RTS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3