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Protein

Oligodendrocyte transcription factor 1

Gene

OLIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. neuron fate commitment Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ8TAK6.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 1
Short name:
Oligo1
Alternative name(s):
Class B basic helix-loop-helix protein 6
Short name:
bHLHb6
Class E basic helix-loop-helix protein 21
Short name:
bHLHe21
Gene namesi
Name:OLIG1
Synonyms:BHLHB6, BHLHE21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:16983. OLIG1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Oligodendrocyte transcription factor 1PRO_0000127411Add
BLAST

Proteomic databases

PaxDbiQ8TAK6.
PRIDEiQ8TAK6.

PTM databases

PhosphoSiteiQ8TAK6.

Expressioni

Tissue specificityi

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.1 Publication

Gene expression databases

BgeeiQ8TAK6.
CleanExiHS_OLIG1.
ExpressionAtlasiQ8TAK6. baseline and differential.
GenevestigatoriQ8TAK6.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SMAD2Q157962EBI-3867416,EBI-1040141

Protein-protein interaction databases

BioGridi125511. 4 interactions.
IntActiQ8TAK6. 5 interactions.
MINTiMINT-7295465.
STRINGi9606.ENSP00000331066.

Structurei

3D structure databases

ProteinModelPortaliQ8TAK6.
SMRiQ8TAK6. Positions 107-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 16460bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 5917Ser-richAdd
BLAST
Compositional biasi102 – 1054Poly-Gln

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG256163.
GeneTreeiENSGT00530000063239.
HOVERGENiHBG053369.
InParanoidiQ8TAK6.
KOiK09085.
OMAiGTMLRPQ.
OrthoDBiEOG7HF1KN.
PhylomeDBiQ8TAK6.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS
60 70 80 90 100
STSSTSSSST TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE
110 120 130 140 150
EQQQQLRRKI NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK
160 170 180 190 200
IATLLLARNY ILLLGSSLQE LRRALGEGAG PAAPRLLLAG LPLLAAAPGS
210 220 230 240 250
VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG GPGLCTCAVC
260 270
KFPHLVPASL GLAAVQAQFS K
Length:271
Mass (Da):27,905
Last modified:August 30, 2002 - v2
Checksum:i7CB9D8DD9CBA0DF5
GO

Sequence cautioni

The sequence AAH26989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence DAA01058.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834450 mRNA. Translation: CAD39110.1.
AP000289 Genomic DNA. No translation available.
BC026989 mRNA. Translation: AAH26989.1. Different initiation.
BC033290 mRNA. Translation: AAH33290.1.
BK000278 mRNA. Translation: DAA01058.1. Different initiation.
CCDSiCCDS42920.2.
RefSeqiNP_620450.2. NM_138983.2.
UniGeneiHs.56663.

Genome annotation databases

EnsembliENST00000382348; ENSP00000371785; ENSG00000184221.
GeneIDi116448.
KEGGihsa:116448.
UCSCiuc002yqz.3. human.

Polymorphism databases

DMDMi22653884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834450 mRNA. Translation: CAD39110.1.
AP000289 Genomic DNA. No translation available.
BC026989 mRNA. Translation: AAH26989.1. Different initiation.
BC033290 mRNA. Translation: AAH33290.1.
BK000278 mRNA. Translation: DAA01058.1. Different initiation.
CCDSiCCDS42920.2.
RefSeqiNP_620450.2. NM_138983.2.
UniGeneiHs.56663.

3D structure databases

ProteinModelPortaliQ8TAK6.
SMRiQ8TAK6. Positions 107-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125511. 4 interactions.
IntActiQ8TAK6. 5 interactions.
MINTiMINT-7295465.
STRINGi9606.ENSP00000331066.

PTM databases

PhosphoSiteiQ8TAK6.

Polymorphism databases

DMDMi22653884.

Proteomic databases

PaxDbiQ8TAK6.
PRIDEiQ8TAK6.

Protocols and materials databases

DNASUi116448.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382348; ENSP00000371785; ENSG00000184221.
GeneIDi116448.
KEGGihsa:116448.
UCSCiuc002yqz.3. human.

Organism-specific databases

CTDi116448.
GeneCardsiGC21P034442.
HGNCiHGNC:16983. OLIG1.
MIMi606385. gene.
neXtProtiNX_Q8TAK6.
PharmGKBiPA31918.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256163.
GeneTreeiENSGT00530000063239.
HOVERGENiHBG053369.
InParanoidiQ8TAK6.
KOiK09085.
OMAiGTMLRPQ.
OrthoDBiEOG7HF1KN.
PhylomeDBiQ8TAK6.
TreeFamiTF322733.

Enzyme and pathway databases

SignaLinkiQ8TAK6.

Miscellaneous databases

GeneWikiiOLIG1.
GenomeRNAii116448.
NextBioi79933.
PROiQ8TAK6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAK6.
CleanExiHS_OLIG1.
ExpressionAtlasiQ8TAK6. baseline and differential.
GenevestigatoriQ8TAK6.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
    McLellan A.S., Langlands K., Kealey T.
    Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors."
    Zhou Q., Wang S., Anderson D.J.
    Neuron 25:331-343(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiOLIG1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAK6
Secondary accession number(s): Q7RTS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: January 7, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.