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Protein

Oligodendrocyte transcription factor 1

Gene

OLIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ8TAK6
SIGNORiQ8TAK6

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 1
Short name:
Oligo1
Alternative name(s):
Class B basic helix-loop-helix protein 6
Short name:
bHLHb6
Class E basic helix-loop-helix protein 21
Short name:
bHLHe21
Gene namesi
Name:OLIG1
Synonyms:BHLHB6, BHLHE21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000184221.12
HGNCiHGNC:16983 OLIG1
MIMi606385 gene
neXtProtiNX_Q8TAK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi116448
OpenTargetsiENSG00000184221
PharmGKBiPA31918

Polymorphism and mutation databases

DMDMi22653884

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274111 – 271Oligodendrocyte transcription factor 1Add BLAST271

Proteomic databases

PaxDbiQ8TAK6
PeptideAtlasiQ8TAK6
PRIDEiQ8TAK6
TopDownProteomicsiQ8TAK6

PTM databases

iPTMnetiQ8TAK6
PhosphoSitePlusiQ8TAK6

Expressioni

Tissue specificityi

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.1 Publication

Gene expression databases

BgeeiENSG00000184221
CleanExiHS_OLIG1
ExpressionAtlasiQ8TAK6 baseline and differential
GenevisibleiQ8TAK6 HS

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125511, 21 interactors
IntActiQ8TAK6, 22 interactors
MINTiQ8TAK6
STRINGi9606.ENSP00000371785

Structurei

3D structure databases

ProteinModelPortaliQ8TAK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 164bHLHPROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 59Ser-richAdd BLAST17
Compositional biasi102 – 105Poly-Gln4

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00530000063239
HOVERGENiHBG053369
InParanoidiQ8TAK6
KOiK09085
OMAiGTMLRPQ
OrthoDBiEOG091G0IHI
PhylomeDBiQ8TAK6
TreeFamiTF322733

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032657 Olig1
PANTHERiPTHR19290:SF7 PTHR19290:SF7, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TAK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS
60 70 80 90 100
STSSTSSSST TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE
110 120 130 140 150
EQQQQLRRKI NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK
160 170 180 190 200
IATLLLARNY ILLLGSSLQE LRRALGEGAG PAAPRLLLAG LPLLAAAPGS
210 220 230 240 250
VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG GPGLCTCAVC
260 270
KFPHLVPASL GLAAVQAQFS K
Length:271
Mass (Da):27,905
Last modified:August 30, 2002 - v2
Checksum:i7CB9D8DD9CBA0DF5
GO

Sequence cautioni

The sequence AAH26989 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence DAA01058 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834450 mRNA Translation: CAD39110.1
AP000289 Genomic DNA No translation available.
BC026989 mRNA Translation: AAH26989.1 Different initiation.
BC033290 mRNA Translation: AAH33290.1
BK000278 mRNA Translation: DAA01058.1 Different initiation.
CCDSiCCDS42920.2
RefSeqiNP_620450.2, NM_138983.2
UniGeneiHs.56663

Genome annotation databases

EnsembliENST00000382348; ENSP00000371785; ENSG00000184221
GeneIDi116448
KEGGihsa:116448
UCSCiuc002yqz.4 human

Similar proteinsi

Entry informationi

Entry nameiOLIG1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAK6
Secondary accession number(s): Q7RTS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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