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Q8TAK6 (OLIG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oligodendrocyte transcription factor 1

Short name=Oligo1
Alternative name(s):
Class B basic helix-loop-helix protein 6
Short name=bHLHb6
Class E basic helix-loop-helix protein 21
Short name=bHLHe21
Gene names
Name:OLIG1
Synonyms:BHLHB6, BHLHE21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube By similarity. Ref.5

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable. Ref.6

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence caution

The sequence AAH26989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence DAA01058.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuron fate commitment

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 18923419. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SMAD2Q157962EBI-3867416,EBI-1040141

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Oligodendrocyte transcription factor 1
PRO_0000127411

Regions

Domain105 – 16460bHLH
Compositional bias43 – 5917Ser-rich
Compositional bias102 – 1054Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
Q8TAK6 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: 7CB9D8DD9CBA0DF5

FASTA27127,905
        10         20         30         40         50         60 
MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS STSSTSSSST 

        70         80         90        100        110        120 
TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE EQQQQLRRKI NSRERKRMQD 

       130        140        150        160        170        180 
LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY ILLLGSSLQE LRRALGEGAG 

       190        200        210        220        230        240 
PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG 

       250        260        270 
GPGLCTCAVC KFPHLVPASL GLAAVQAQFS K 

« Hide

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
McLellan A.S., Langlands K., Kealey T.
Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors."
Zhou Q., Wang S., Anderson D.J.
Neuron 25:331-343(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors."
Lu Q.R., Park J.K., Noll E., Chan J.A., Alberta J.A., Yuk D.-I., Alzamora M.G., Louis D.N., Stiles C.D., Rowitch D.H., Black P.M.
Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL834450 mRNA. Translation: CAD39110.1.
AP000289 Genomic DNA. No translation available.
BC026989 mRNA. Translation: AAH26989.1. Different initiation.
BC033290 mRNA. Translation: AAH33290.1.
BK000278 mRNA. Translation: DAA01058.1. Different initiation.
CCDSCCDS42920.2.
RefSeqNP_620450.2. NM_138983.2.
UniGeneHs.56663.

3D structure databases

ProteinModelPortalQ8TAK6.
SMRQ8TAK6. Positions 107-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125511. 4 interactions.
IntActQ8TAK6. 5 interactions.
MINTMINT-7295465.
STRING9606.ENSP00000331066.

PTM databases

PhosphoSiteQ8TAK6.

Polymorphism databases

DMDM22653884.

Proteomic databases

PaxDbQ8TAK6.
PRIDEQ8TAK6.

Protocols and materials databases

DNASU116448.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333063; ENSP00000331066; ENSG00000184221.
ENST00000382348; ENSP00000371785; ENSG00000184221.
GeneID116448.
KEGGhsa:116448.
UCSCuc002yqz.3. human.

Organism-specific databases

CTD116448.
GeneCardsGC21P034442.
HGNCHGNC:16983. OLIG1.
MIM606385. gene.
neXtProtNX_Q8TAK6.
PharmGKBPA31918.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256163.
HOVERGENHBG053369.
InParanoidQ8TAK6.
KOK09085.
OMAGSPGLCT.
OrthoDBEOG7HF1KN.
PhylomeDBQ8TAK6.
TreeFamTF322733.

Enzyme and pathway databases

SignaLinkQ8TAK6.

Gene expression databases

ArrayExpressQ8TAK6.
BgeeQ8TAK6.
CleanExHS_OLIG1.
GenevestigatorQ8TAK6.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOLIG1.
GenomeRNAi116448.
NextBio79933.
PROQ8TAK6.
SOURCESearch...

Entry information

Entry nameOLIG1_HUMAN
AccessionPrimary (citable) accession number: Q8TAK6
Secondary accession number(s): Q7RTS0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM