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Protein

GA-binding protein subunit beta-2

Gene

GABPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as transcription factor capable of interacting with purine rich repeats (GA repeats).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ8TAK5.

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein subunit beta-2
Short name:
GABP subunit beta-2
Short name:
GABPB-2
Gene namesi
Name:GABPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143458.11.
HGNCiHGNC:28441. GABPB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi126626.
OpenTargetsiENSG00000143458.
PharmGKBiPA164741559.

Polymorphism and mutation databases

BioMutaiGABPB2.
DMDMi74751355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259081 – 448GA-binding protein subunit beta-2Add BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TAK5.
MaxQBiQ8TAK5.
PaxDbiQ8TAK5.
PeptideAtlasiQ8TAK5.
PRIDEiQ8TAK5.

PTM databases

iPTMnetiQ8TAK5.
PhosphoSitePlusiQ8TAK5.

Expressioni

Gene expression databases

BgeeiENSG00000143458.
CleanExiHS_GABPB2.
ExpressionAtlasiQ8TAK5. baseline and differential.
GenevisibleiQ8TAK5. HS.

Organism-specific databases

HPAiHPA028471.
HPA058483.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits. The C-terminal is necessary for the formation of a heterotetrameric GABP-alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: Ensembl

Protein-protein interaction databases

BioGridi126004. 7 interactors.
CORUMiQ8TAK5.
IntActiQ8TAK5. 10 interactors.
MINTiMINT-6778891.
STRINGi9606.ENSP00000357914.

Structurei

3D structure databases

ProteinModelPortaliQ8TAK5.
SMRiQ8TAK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 34ANK 1Add BLAST30
Repeati37 – 66ANK 2Add BLAST30
Repeati70 – 99ANK 3Add BLAST30
Repeati103 – 132ANK 4Add BLAST30
Repeati136 – 166ANK 5Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili345 – 395Sequence analysisAdd BLAST51

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IE1V. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00900000140840.
HOGENOMiHOG000231772.
HOVERGENiHBG051686.
InParanoidiQ8TAK5.
KOiK09454.
OMAiQVAEETI.
OrthoDBiEOG091G0AIM.
PhylomeDBiQ8TAK5.
TreeFamiTF326036.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 4 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8TAK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH
60 70 80 90 100
YSTAEVLLRA GVSRDARTKV DRTPLHMAAA DGHAHIVELL VRNGADVNAK
110 120 130 140 150
DMLKMTALHW ATERHHRDVV ELLIKYGADV HAFSKFDKSA FDIALEKNNA
160 170 180 190 200
EILVILQEAM QNQVNVNPER ANPVTDPVSM AAPFIFTSGE VVNLASLISS
210 220 230 240 250
TNTKTTSGDP HASTVQFSNS TTSVLATLAA LAEASVPLSN SHRATANTEE
260 270 280 290 300
IIEGNSVDSS IQQVMGSGGQ RVITIVTDGV PLGNIQTSIP TGGIGQPFIV
310 320 330 340 350
TVQDGQQVLT VPAGKVAEET VIKEEEEEKL PLTKKPRIGE KTNSVEESKE
360 370 380 390 400
GNERELLQQQ LQEANRRAQE YRHQLLKKEQ EAEQYRLKLE AIARQQPNGV
410 420 430 440
DFTMVEEVAE VDAVVVTEGE LEERETKVTG SAGTTEPHTR VSMATVSS
Length:448
Mass (Da):48,650
Last modified:June 1, 2002 - v1
Checksum:iDB0940BDDBF499C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13A → S in BAC03833 (PubMed:14702039).Curated1
Sequence conflicti144A → S in BAC03833 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03995062V → I. Corresponds to variant dbSNP:rs11204774Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092230 mRNA. Translation: BAC03833.1.
AL691467 Genomic DNA. No translation available.
AL590133 Genomic DNA. No translation available.
AL592424 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53474.1.
CH471121 Genomic DNA. Translation: EAW53475.1.
BC027033 mRNA. Translation: AAH27033.1.
CCDSiCCDS983.1.
RefSeqiNP_001310837.1. NM_001323908.1.
NP_653219.1. NM_144618.2.
XP_016855738.1. XM_017000249.1.
UniGeneiHs.15671.
Hs.654699.

Genome annotation databases

EnsembliENST00000368918; ENSP00000357914; ENSG00000143458.
GeneIDi126626.
KEGGihsa:126626.
UCSCiuc001ewr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGABP2_HUMAN
AccessioniPrimary (citable) accession number: Q8TAK5
Secondary accession number(s): B1AVJ8, D3DV14, Q8NAR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations