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Protein

GA-binding protein subunit beta-2

Gene

GABPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as transcription factor capable of interacting with purine rich repeats (GA repeats).By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ8TAK5.

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein subunit beta-2
Short name:
GABP subunit beta-2
Short name:
GABPB-2
Gene namesi
Name:GABPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28441. GABPB2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164741559.

Polymorphism and mutation databases

BioMutaiGABPB2.
DMDMi74751355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448GA-binding protein subunit beta-2PRO_0000325908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei256 – 2561PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TAK5.
MaxQBiQ8TAK5.
PaxDbiQ8TAK5.
PeptideAtlasiQ8TAK5.
PRIDEiQ8TAK5.

PTM databases

iPTMnetiQ8TAK5.
PhosphoSiteiQ8TAK5.

Expressioni

Gene expression databases

BgeeiQ8TAK5.
CleanExiHS_GABPB2.
ExpressionAtlasiQ8TAK5. baseline and differential.
GenevisibleiQ8TAK5. HS.

Organism-specific databases

HPAiHPA028471.
HPA058483.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits. The C-terminal is necessary for the formation of a heterotetrameric GABP-alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GORASP2Q9H8Y83EBI-8468945,EBI-739467

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi126004. 7 interactions.
IntActiQ8TAK5. 6 interactions.
MINTiMINT-6778891.
STRINGi9606.ENSP00000357914.

Structurei

3D structure databases

ProteinModelPortaliQ8TAK5.
SMRiQ8TAK5. Positions 5-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 3430ANK 1Add
BLAST
Repeati37 – 6630ANK 2Add
BLAST
Repeati70 – 9930ANK 3Add
BLAST
Repeati103 – 13230ANK 4Add
BLAST
Repeati136 – 16631ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili345 – 39551Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IE1V. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129826.
HOGENOMiHOG000231772.
HOVERGENiHBG051686.
InParanoidiQ8TAK5.
KOiK09454.
OMAiQVAEETI.
OrthoDBiEOG7ZD1W2.
PhylomeDBiQ8TAK5.
TreeFamiTF326036.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH
60 70 80 90 100
YSTAEVLLRA GVSRDARTKV DRTPLHMAAA DGHAHIVELL VRNGADVNAK
110 120 130 140 150
DMLKMTALHW ATERHHRDVV ELLIKYGADV HAFSKFDKSA FDIALEKNNA
160 170 180 190 200
EILVILQEAM QNQVNVNPER ANPVTDPVSM AAPFIFTSGE VVNLASLISS
210 220 230 240 250
TNTKTTSGDP HASTVQFSNS TTSVLATLAA LAEASVPLSN SHRATANTEE
260 270 280 290 300
IIEGNSVDSS IQQVMGSGGQ RVITIVTDGV PLGNIQTSIP TGGIGQPFIV
310 320 330 340 350
TVQDGQQVLT VPAGKVAEET VIKEEEEEKL PLTKKPRIGE KTNSVEESKE
360 370 380 390 400
GNERELLQQQ LQEANRRAQE YRHQLLKKEQ EAEQYRLKLE AIARQQPNGV
410 420 430 440
DFTMVEEVAE VDAVVVTEGE LEERETKVTG SAGTTEPHTR VSMATVSS
Length:448
Mass (Da):48,650
Last modified:June 1, 2002 - v1
Checksum:iDB0940BDDBF499C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131A → S in BAC03833 (PubMed:14702039).Curated
Sequence conflicti144 – 1441A → S in BAC03833 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621V → I.
Corresponds to variant rs11204774 [ dbSNP | Ensembl ].
VAR_039950

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092230 mRNA. Translation: BAC03833.1.
AL691467, AL590133, AL592424 Genomic DNA. Translation: CAH73759.1.
AL590133, AL592424, AL691467 Genomic DNA. Translation: CAI13351.1.
AL592424, AL590133, AL691467 Genomic DNA. Translation: CAI16392.1.
CH471121 Genomic DNA. Translation: EAW53474.1.
CH471121 Genomic DNA. Translation: EAW53475.1.
BC027033 mRNA. Translation: AAH27033.1.
CCDSiCCDS983.1.
RefSeqiNP_001310837.1. NM_001323908.1.
NP_653219.1. NM_144618.2.
UniGeneiHs.654699.

Genome annotation databases

EnsembliENST00000368918; ENSP00000357914; ENSG00000143458.
GeneIDi126626.
KEGGihsa:126626.
UCSCiuc001ewr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092230 mRNA. Translation: BAC03833.1.
AL691467, AL590133, AL592424 Genomic DNA. Translation: CAH73759.1.
AL590133, AL592424, AL691467 Genomic DNA. Translation: CAI13351.1.
AL592424, AL590133, AL691467 Genomic DNA. Translation: CAI16392.1.
CH471121 Genomic DNA. Translation: EAW53474.1.
CH471121 Genomic DNA. Translation: EAW53475.1.
BC027033 mRNA. Translation: AAH27033.1.
CCDSiCCDS983.1.
RefSeqiNP_001310837.1. NM_001323908.1.
NP_653219.1. NM_144618.2.
UniGeneiHs.654699.

3D structure databases

ProteinModelPortaliQ8TAK5.
SMRiQ8TAK5. Positions 5-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126004. 7 interactions.
IntActiQ8TAK5. 6 interactions.
MINTiMINT-6778891.
STRINGi9606.ENSP00000357914.

PTM databases

iPTMnetiQ8TAK5.
PhosphoSiteiQ8TAK5.

Polymorphism and mutation databases

BioMutaiGABPB2.
DMDMi74751355.

Proteomic databases

EPDiQ8TAK5.
MaxQBiQ8TAK5.
PaxDbiQ8TAK5.
PeptideAtlasiQ8TAK5.
PRIDEiQ8TAK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368918; ENSP00000357914; ENSG00000143458.
GeneIDi126626.
KEGGihsa:126626.
UCSCiuc001ewr.3. human.

Organism-specific databases

CTDi126626.
GeneCardsiGABPB2.
HGNCiHGNC:28441. GABPB2.
HPAiHPA028471.
HPA058483.
neXtProtiNX_Q8TAK5.
PharmGKBiPA164741559.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE1V. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129826.
HOGENOMiHOG000231772.
HOVERGENiHBG051686.
InParanoidiQ8TAK5.
KOiK09454.
OMAiQVAEETI.
OrthoDBiEOG7ZD1W2.
PhylomeDBiQ8TAK5.
TreeFamiTF326036.

Enzyme and pathway databases

SIGNORiQ8TAK5.

Miscellaneous databases

GenomeRNAii126626.
PROiQ8TAK5.

Gene expression databases

BgeeiQ8TAK5.
CleanExiHS_GABPB2.
ExpressionAtlasiQ8TAK5. baseline and differential.
GenevisibleiQ8TAK5. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiGABP2_HUMAN
AccessioniPrimary (citable) accession number: Q8TAK5
Secondary accession number(s): B1AVJ8, D3DV14, Q8NAR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.