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Protein

GTPase RhebL1

Gene

RHEBL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38MagnesiumBy similarity1
Binding sitei63GTP; via amide nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 21GTP1 Publication6
Nucleotide bindingi32 – 38GTP1 Publication7
Nucleotide bindingi119 – 122GTP1 Publication4
Nucleotide bindingi149 – 150GTP1 Publication2

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • TOR signaling Source: UniProtKB

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.2 2681

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase RhebL1
Alternative name(s):
Ras homolog enriched in brain like-1 c
Short name:
RhebL1c
Ras homolog enriched in brain-like protein 1
Short name:
Rheb-like protein 1
Rheb2
Gene namesi
Name:RHEBL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167550.10
HGNCiHGNC:21166 RHEBL1
neXtProtiNX_Q8TAI7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41N → A: Partially impaired in RPS6K1 activation. 1 Publication1
Mutagenesisi54F → A: Partially deficient in guanine nucleotide binding. 1 Publication1
Mutagenesisi56L → A: Partially deficient in guanine nucleotide binding. 1 Publication1
Mutagenesisi60D → K: Significant decrease in NF-kappa B activation. 1 Publication1
Mutagenesisi64Q → L: Constitutively active. 1 Publication1

Organism-specific databases

DisGeNETi121268
OpenTargetsiENSG00000167550
PharmGKBiPA134984759

Polymorphism and mutation databases

BioMutaiRHEBL1
DMDMi74730357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003242921 – 180GTPase RhebL1Add BLAST180
PropeptideiPRO_0000324293181 – 183Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180Cysteine methyl esterBy similarity1
Lipidationi180S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ8TAI7
PeptideAtlasiQ8TAI7
PRIDEiQ8TAI7

PTM databases

iPTMnetiQ8TAI7
PhosphoSitePlusiQ8TAI7

Expressioni

Tissue specificityi

Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines.2 Publications

Gene expression databases

BgeeiENSG00000167550
CleanExiHS_RHEBL1
ExpressionAtlasiQ8TAI7 baseline and differential
GenevisibleiQ8TAI7 HS

Organism-specific databases

HPAiHPA053111
HPA061001

Interactioni

Subunit structurei

Interacts with MTOR.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125715, 9 interactors
IntActiQ8TAI7, 8 interactors
MINTiQ8TAI7
STRINGi9606.ENSP00000301068

Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 14Combined sources9
Helixi19 – 28Combined sources10
Beta strandi39 – 47Combined sources9
Beta strandi54 – 61Combined sources8
Helixi72 – 74Combined sources3
Turni75 – 77Combined sources3
Beta strandi80 – 86Combined sources7
Helixi90 – 104Combined sources15
Beta strandi114 – 119Combined sources6
Helixi124 – 126Combined sources3
Helixi131 – 141Combined sources11
Beta strandi144 – 147Combined sources4
Helixi153 – 169Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OESX-ray2.30A1-183[»]
ProteinModelPortaliQ8TAI7
SMRiQ8TAI7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TAI7

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133696
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ8TAI7
KOiK07849
OMAiGKTRMPV
OrthoDBiEOG091G0ONO
PhylomeDBiQ8TAI7
TreeFamiTF314986

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLVRYRKVV ILGYRCVGKT SLAHQFVEGE FSEGYDPTVE NTYSKIVTLG
60 70 80 90 100
KDEFHLHLVD TAGQDEYSIL PYSFIIGVHG YVLVYSVTSL HSFQVIESLY
110 120 130 140 150
QKLHEGHGKT RVPVVLVGNK ADLSPEREVQ AVEGKKLAES WGATFMESSA
160 170 180
RENQLTQGIF TKVIQEIARV ENSYGQERRC HLM
Length:183
Mass (Da):20,682
Last modified:June 1, 2002 - v1
Checksum:i0C5408800B61DD62
GO
Isoform 2 (identifier: Q8TAI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-68: GKTSLAHQFV...VDTAGQDEYS → VRKDRGCECG...ILQWRILTAR
     69-183: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:68
Mass (Da):8,176
Checksum:i5412A25D63C02FB8
GO

Sequence cautioni

The sequence AAS80166 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04085118 – 68GKTSL…QDEYS → VRKDRGCECGWMIWIQLSHC SPQGRHLWHINLWKASSRKA TILQWRILTAR in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_04085269 – 183Missing in isoform 2. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327412 mRNA Translation: AAP92804.1
AY509932 mRNA Translation: AAS80166.1 Sequence problems.
AK098663 mRNA Translation: BAC05370.1
CH471111 Genomic DNA Translation: EAW58038.1
BC027482 mRNA Translation: AAH27482.1
CCDSiCCDS8778.1 [Q8TAI7-1]
RefSeqiNP_001290055.1, NM_001303126.1
NP_653194.1, NM_144593.2 [Q8TAI7-1]
UniGeneiHs.159013

Genome annotation databases

EnsembliENST00000301068; ENSP00000301068; ENSG00000167550 [Q8TAI7-1]
ENST00000550797; ENSP00000446726; ENSG00000167550 [Q8TAI7-2]
GeneIDi121268
KEGGihsa:121268
UCSCiuc001rtc.2 human [Q8TAI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiREBL1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAI7
Secondary accession number(s): Q56VH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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