Q8TAG9 (EXOC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exocyst complex component 6

Alternative name(s):
Exocyst complex component Sec15A
SEC15-like protein 1

Gene names

Name:	EXOC6
Synonyms:	SEC15A, SEC15L, SEC15L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	804 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis By similarity.
Subunit structure	The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with CEP110. Interacts with RAB11A in a GTP-dependent manner By similarity. Ref.5
Sequence similarities	Belongs to the SEC15 family.
Sequence caution	The sequence AAF37262.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	erythrocyte differentiation Inferred from electronic annotation. Source: Compara protein transport Inferred from electronic annotation. Source: UniProtKB-KW vesicle docking involved in exocytosis Inferred from electronic annotation. Source: InterPro
Cellular_component	exocyst Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 804	804	Exocyst complex component 6		PRO_0000118951
Natural variations
	Natural variant	396	1	T → I. Ref.3 Corresponds to variant rs1326331 [ dbSNP | Ensembl ].		VAR_044522
	Natural variant	523	1	L → V. Corresponds to variant rs11187225 [ dbSNP | Ensembl ].		VAR_044523
	Natural variant	578	1	T → I. Corresponds to variant rs35647717 [ dbSNP | Ensembl ].		VAR_044524
Experimental info
	Sequence conflict	776	1	R → G in AAH28395. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8TAG9 [UniParc]. Last modified July 22, 2008. Version 3. Checksum: 413251A5BA6543C4	FASTA	804	93,722
	10 20 30 40 50 60 MAENSESLGT VPEHERILQE IESTDTACVG PTLRSVYDDQ PNAHKKFMEK LDACIRNHDK 70 80 90 100 110 120 EIEKMCNFHH QGFVDAITEL LKVRTDAEKL KVQVTDTNRR FQDAGKEVIV HTEDIIRCRI 130 140 150 160 170 180 QQRNITTVVE KLQLCLPVLE MYSKLKEQMS AKRYYSALKT MEQLENVYFP WVSQYRFCQL 190 200 210 220 230 240 MIENLPKLRE DIKEISMSDL KDFLESIRKH SDKIGETAMK QAQHQKTFSV SLQKQNKMKF 250 260 270 280 290 300 GKNMYINRDR IPEERNETVL KHSLEEEDEN EEEILTVQDL VDFSPVYRCL HIYSVLGDEE 310 320 330 340 350 360 TFENYYRKQR KKQARLVLQP QSNMHETVDG YRRYFTQIVG FFVVEDHILH VTQGLVTRAY 370 380 390 400 410 420 TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLTVIFA DTLQGYGFPV NRLFDLLFEI 430 440 450 460 470 480 RDQYNETLLK KWAGVFRDIF EEDNYSPIPV VNEEEYKIVI SKFPFQDPDL EKQSFPKKFP 490 500 510 520 530 540 MSQSVPHIYI QVKEFIYASL KFSESLHRSS TEIDDMLRKS TNLLLTRTLS SCLLNLIRKP 550 560 570 580 590 600 HIGLTELVQI IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE 610 620 630 640 650 660 IYTKLNQKID EFVQLADYDW TMSEPDGRAS GYLMDLINFL RSIFQVFTHL PGKVAQTACM 670 680 690 700 710 720 SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF ASSEPVPGFQ GDTLQLAFID 730 740 750 760 770 780 LRQLLDLFMV WDWSTYLADY GQPASKYLRV NPNTALTLLE KMKDTSKKNN IFAQFRKNDR 790 800 DKQKLIETVV KQLRSLVNGM SQHM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-396. Tissue: Brain.
[4]	"Subunit structure of the human exocyst complex." Li C., Rodriguez M., Banerjee D. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-153.
[5]	"Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission." Gromley A., Yeaman C., Rosa J., Redick S., Chen C.-T., Mirabelle S., Guha M., Sillibourne J., Doxsey S.J. Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CEP110.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL358613 , AL157705, AL392103, AL590080 Genomic DNA. Translation: CAH72805.2. AL590080 , AL157705, AL358613, AL392103 Genomic DNA. Translation: CAH74087.1. AL392103 , AL157705, AL358613, AL590080 Genomic DNA. Translation: CAI40847.2. CH471066 Genomic DNA. Translation: EAW50083.1. BC028395 mRNA. Translation: AAH28395.2. AF220217 mRNA. Translation: AAF37262.1. Different initiation.
IPI	IPI01013822.
RefSeq	NP_001013870.1. NM_001013848.2. NP_061926.3. NM_019053.4.
UniGene	Hs.655657.
3D structure databases
ProteinModelPortal	Q8TAG9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TAG9. 10 interactions.
STRING	9606.ENSP00000260762.
PTM databases
PhosphoSite	Q8TAG9.
Polymorphism databases
DMDM	212287926.
Proteomic databases
PaxDb	Q8TAG9.
PRIDE	Q8TAG9.
Protocols and materials databases
DNASU	54536.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260762; ENSP00000260762; ENSG00000138190.
GeneID	54536.
KEGG	hsa:54536.
UCSC	uc001kig.3. human.
Organism-specific databases
CTD	54536.
GeneCards	GC10P094599.
H-InvDB	HIX0009044.
HGNC	HGNC:23196. EXOC6.
HPA	HPA036285.
MIM	609672. gene.
neXtProt	NX_Q8TAG9.
PharmGKB	PA134908462.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322476.
HOGENOM	HOG000290640.
HOVERGEN	HBG057543.
InParanoid	Q8TAG9.
OrthoDB	EOG4DNF3S.
PhylomeDB	Q8TAG9.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6_traffickingpathway. Arf6 trafficking events. insulin_pathway. Insulin Pathway.
Reactome	REACT_11123. Membrane Trafficking. REACT_116125. Disease.
Gene expression databases
ArrayExpress	Q8TAG9.
Bgee	Q8TAG9.
CleanEx	HS_EXOC6.
Genevestigator	Q8TAG9.
GermOnline	ENSG00000138190. Homo sapiens.
Family and domain databases
InterPro	IPR007225. Sec15. [Graphical view]
PANTHER	PTHR12702. PTHR12702. 1 hit.
Pfam	PF04091. Sec15. 1 hit. [Graphical view]
PIRSF	PIRSF025007. Sec15. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	EXOC6. human.
GenomeRNAi	54536.
NextBio	56960.
SOURCE	Search...

Entry information

Entry name

EXOC6_HUMAN

Accession

Primary (citable) accession number: Q8TAG9
Secondary accession number(s): Q5VXH8, Q9NZ24

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.