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Protein

Exocyst complex component 6

Gene

EXOC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-264876. Insulin processing.
R-HSA-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 6
Alternative name(s):
Exocyst complex component Sec15A
SEC15-like protein 1
Gene namesi
Name:EXOC6
Synonyms:SEC15A, SEC15L, SEC15L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23196. EXOC6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908462.

Polymorphism and mutation databases

BioMutaiEXOC6.
DMDMi212287926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Exocyst complex component 6PRO_0000118951Add
BLAST

Proteomic databases

EPDiQ8TAG9.
MaxQBiQ8TAG9.
PaxDbiQ8TAG9.
PRIDEiQ8TAG9.

PTM databases

iPTMnetiQ8TAG9.
PhosphoSiteiQ8TAG9.

Expressioni

Gene expression databases

BgeeiQ8TAG9.
CleanExiHS_EXOC6.
ExpressionAtlasiQ8TAG9. baseline and differential.
GenevisibleiQ8TAG9. HS.

Organism-specific databases

HPAiHPA036285.
HPA059111.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with CNTRL. Interacts with RAB11A in a GTP-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi120023. 40 interactions.
IntActiQ8TAG9. 13 interactions.
STRINGi9606.ENSP00000260762.

Structurei

3D structure databases

ProteinModelPortaliQ8TAG9.
SMRiQ8TAG9. Positions 411-730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC15 family.Curated

Phylogenomic databases

eggNOGiKOG2176. Eukaryota.
ENOG410XQAE. LUCA.
GeneTreeiENSGT00390000005739.
HOGENOMiHOG000290640.
HOVERGENiHBG057543.
InParanoidiQ8TAG9.
KOiK19985.
OMAiINHDRIP.
OrthoDBiEOG7MD4PG.
PhylomeDBiQ8TAG9.
TreeFamiTF315199.

Family and domain databases

InterProiIPR007225. Sec15.
[Graphical view]
PANTHERiPTHR12702. PTHR12702. 1 hit.
PfamiPF04091. Sec15. 1 hit.
[Graphical view]
PIRSFiPIRSF025007. Sec15. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENSESLGT VPEHERILQE IESTDTACVG PTLRSVYDDQ PNAHKKFMEK
60 70 80 90 100
LDACIRNHDK EIEKMCNFHH QGFVDAITEL LKVRTDAEKL KVQVTDTNRR
110 120 130 140 150
FQDAGKEVIV HTEDIIRCRI QQRNITTVVE KLQLCLPVLE MYSKLKEQMS
160 170 180 190 200
AKRYYSALKT MEQLENVYFP WVSQYRFCQL MIENLPKLRE DIKEISMSDL
210 220 230 240 250
KDFLESIRKH SDKIGETAMK QAQHQKTFSV SLQKQNKMKF GKNMYINRDR
260 270 280 290 300
IPEERNETVL KHSLEEEDEN EEEILTVQDL VDFSPVYRCL HIYSVLGDEE
310 320 330 340 350
TFENYYRKQR KKQARLVLQP QSNMHETVDG YRRYFTQIVG FFVVEDHILH
360 370 380 390 400
VTQGLVTRAY TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLTVIFA
410 420 430 440 450
DTLQGYGFPV NRLFDLLFEI RDQYNETLLK KWAGVFRDIF EEDNYSPIPV
460 470 480 490 500
VNEEEYKIVI SKFPFQDPDL EKQSFPKKFP MSQSVPHIYI QVKEFIYASL
510 520 530 540 550
KFSESLHRSS TEIDDMLRKS TNLLLTRTLS SCLLNLIRKP HIGLTELVQI
560 570 580 590 600
IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE
610 620 630 640 650
IYTKLNQKID EFVQLADYDW TMSEPDGRAS GYLMDLINFL RSIFQVFTHL
660 670 680 690 700
PGKVAQTACM SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF
710 720 730 740 750
ASSEPVPGFQ GDTLQLAFID LRQLLDLFMV WDWSTYLADY GQPASKYLRV
760 770 780 790 800
NPNTALTLLE KMKDTSKKNN IFAQFRKNDR DKQKLIETVV KQLRSLVNGM

SQHM
Length:804
Mass (Da):93,722
Last modified:July 22, 2008 - v3
Checksum:i413251A5BA6543C4
GO
Isoform 2 (identifier: Q8TAG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-31: AENSESLGTVPEHERILQEIESTDTACVGP → LEEETDQTYENVLAEIQSFELPVEA

Note: Gene prediction based on EST data.
Show »
Length:799
Mass (Da):93,407
Checksum:i8A90434F0409E992
GO

Sequence cautioni

The sequence AAF37262.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti776 – 7761R → G in AAH28395 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti396 – 3961T → I.1 Publication
Corresponds to variant rs1326331 [ dbSNP | Ensembl ].
VAR_044522
Natural varianti523 – 5231L → V.
Corresponds to variant rs11187225 [ dbSNP | Ensembl ].
VAR_044523
Natural varianti578 – 5781T → I.
Corresponds to variant rs35647717 [ dbSNP | Ensembl ].
VAR_044524

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 3130AENSE…ACVGP → LEEETDQTYENVLAEIQSFE LPVEA in isoform 2. CuratedVSP_047160Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL358613
, AL157705, AL392103, AL590080 Genomic DNA. Translation: CAH72805.2.
AL590080
, AL157705, AL358613, AL392103 Genomic DNA. Translation: CAH74087.1.
AL392103
, AL157705, AL358613, AL590080 Genomic DNA. Translation: CAI40847.2.
CH471066 Genomic DNA. Translation: EAW50083.1.
BC028395 mRNA. Translation: AAH28395.2.
AF220217 mRNA. Translation: AAF37262.1. Different initiation.
CCDSiCCDS31247.1. [Q8TAG9-2]
CCDS7424.2. [Q8TAG9-1]
RefSeqiNP_001013870.1. NM_001013848.3. [Q8TAG9-2]
NP_001306123.1. NM_001319194.1.
NP_001306124.1. NM_001319195.1.
NP_001306129.1. NM_001319200.1.
NP_061926.3. NM_019053.5. [Q8TAG9-1]
UniGeneiHs.655657.

Genome annotation databases

EnsembliENST00000260762; ENSP00000260762; ENSG00000138190. [Q8TAG9-1]
ENST00000371552; ENSP00000360607; ENSG00000138190. [Q8TAG9-2]
GeneIDi54536.
KEGGihsa:54536.
UCSCiuc001kie.4. human. [Q8TAG9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL358613
, AL157705, AL392103, AL590080 Genomic DNA. Translation: CAH72805.2.
AL590080
, AL157705, AL358613, AL392103 Genomic DNA. Translation: CAH74087.1.
AL392103
, AL157705, AL358613, AL590080 Genomic DNA. Translation: CAI40847.2.
CH471066 Genomic DNA. Translation: EAW50083.1.
BC028395 mRNA. Translation: AAH28395.2.
AF220217 mRNA. Translation: AAF37262.1. Different initiation.
CCDSiCCDS31247.1. [Q8TAG9-2]
CCDS7424.2. [Q8TAG9-1]
RefSeqiNP_001013870.1. NM_001013848.3. [Q8TAG9-2]
NP_001306123.1. NM_001319194.1.
NP_001306124.1. NM_001319195.1.
NP_001306129.1. NM_001319200.1.
NP_061926.3. NM_019053.5. [Q8TAG9-1]
UniGeneiHs.655657.

3D structure databases

ProteinModelPortaliQ8TAG9.
SMRiQ8TAG9. Positions 411-730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120023. 40 interactions.
IntActiQ8TAG9. 13 interactions.
STRINGi9606.ENSP00000260762.

PTM databases

iPTMnetiQ8TAG9.
PhosphoSiteiQ8TAG9.

Polymorphism and mutation databases

BioMutaiEXOC6.
DMDMi212287926.

Proteomic databases

EPDiQ8TAG9.
MaxQBiQ8TAG9.
PaxDbiQ8TAG9.
PRIDEiQ8TAG9.

Protocols and materials databases

DNASUi54536.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260762; ENSP00000260762; ENSG00000138190. [Q8TAG9-1]
ENST00000371552; ENSP00000360607; ENSG00000138190. [Q8TAG9-2]
GeneIDi54536.
KEGGihsa:54536.
UCSCiuc001kie.4. human. [Q8TAG9-1]

Organism-specific databases

CTDi54536.
GeneCardsiEXOC6.
H-InvDBHIX0009044.
HGNCiHGNC:23196. EXOC6.
HPAiHPA036285.
HPA059111.
MIMi609672. gene.
neXtProtiNX_Q8TAG9.
PharmGKBiPA134908462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2176. Eukaryota.
ENOG410XQAE. LUCA.
GeneTreeiENSGT00390000005739.
HOGENOMiHOG000290640.
HOVERGENiHBG057543.
InParanoidiQ8TAG9.
KOiK19985.
OMAiINHDRIP.
OrthoDBiEOG7MD4PG.
PhylomeDBiQ8TAG9.
TreeFamiTF315199.

Enzyme and pathway databases

ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-264876. Insulin processing.
R-HSA-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

GenomeRNAii54536.
NextBioi56960.
PROiQ8TAG9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAG9.
CleanExiHS_EXOC6.
ExpressionAtlasiQ8TAG9. baseline and differential.
GenevisibleiQ8TAG9. HS.

Family and domain databases

InterProiIPR007225. Sec15.
[Graphical view]
PANTHERiPTHR12702. PTHR12702. 1 hit.
PfamiPF04091. Sec15. 1 hit.
[Graphical view]
PIRSFiPIRSF025007. Sec15. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-396.
    Tissue: Brain.
  4. "Subunit structure of the human exocyst complex."
    Li C., Rodriguez M., Banerjee D.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-153 (ISOFORM 1).
  5. "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission."
    Gromley A., Yeaman C., Rosa J., Redick S., Chen C.-T., Mirabelle S., Guha M., Sillibourne J., Doxsey S.J.
    Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNTRL.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEXOC6_HUMAN
AccessioniPrimary (citable) accession number: Q8TAG9
Secondary accession number(s): E9PHI3, Q5VXH8, Q9NZ24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 22, 2008
Last modified: May 11, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.