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Protein

Exocyst complex component 6

Gene

EXOC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).By similarity

Caution

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 6
Alternative name(s):
Exocyst complex component Sec15A
SEC15-like protein 1
Gene namesi
Name:EXOC6
Synonyms:SEC15A, SEC15L, SEC15L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138190.16
HGNCiHGNC:23196 EXOC6
MIMi609672 gene
neXtProtiNX_Q8TAG9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi54536
OpenTargetsiENSG00000138190
PharmGKBiPA134908462

Polymorphism and mutation databases

BioMutaiEXOC6
DMDMi212287926

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189511 – 804Exocyst complex component 6Add BLAST804

Proteomic databases

EPDiQ8TAG9
MaxQBiQ8TAG9
PaxDbiQ8TAG9
PeptideAtlasiQ8TAG9
PRIDEiQ8TAG9

PTM databases

iPTMnetiQ8TAG9
PhosphoSitePlusiQ8TAG9

Expressioni

Gene expression databases

BgeeiENSG00000138190
CleanExiHS_EXOC6
ExpressionAtlasiQ8TAG9 baseline and differential
GenevisibleiQ8TAG9 HS

Organism-specific databases

HPAiHPA036285
HPA059111

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with CNTRL. Interacts with RAB11A in a GTP-dependent manner (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12002354 interactors.
CORUMiQ8TAG9
IntActiQ8TAG9 22 interactors.
STRINGi9606.ENSP00000260762

Structurei

3D structure databases

ProteinModelPortaliQ8TAG9
SMRiQ8TAG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC15 family.Curated

Phylogenomic databases

eggNOGiKOG2176 Eukaryota
ENOG410XQAE LUCA
GeneTreeiENSGT00390000005739
HOGENOMiHOG000290640
HOVERGENiHBG057543
InParanoidiQ8TAG9
KOiK19985
OMAiRDHYNEV
OrthoDBiEOG091G04HR
PhylomeDBiQ8TAG9
TreeFamiTF315199

Family and domain databases

InterProiView protein in InterPro
IPR007225 EXOC6/Sec15
PANTHERiPTHR12702 PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091 Sec15, 1 hit
PIRSFiPIRSF025007 Sec15, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENSESLGT VPEHERILQE IESTDTACVG PTLRSVYDDQ PNAHKKFMEK
60 70 80 90 100
LDACIRNHDK EIEKMCNFHH QGFVDAITEL LKVRTDAEKL KVQVTDTNRR
110 120 130 140 150
FQDAGKEVIV HTEDIIRCRI QQRNITTVVE KLQLCLPVLE MYSKLKEQMS
160 170 180 190 200
AKRYYSALKT MEQLENVYFP WVSQYRFCQL MIENLPKLRE DIKEISMSDL
210 220 230 240 250
KDFLESIRKH SDKIGETAMK QAQHQKTFSV SLQKQNKMKF GKNMYINRDR
260 270 280 290 300
IPEERNETVL KHSLEEEDEN EEEILTVQDL VDFSPVYRCL HIYSVLGDEE
310 320 330 340 350
TFENYYRKQR KKQARLVLQP QSNMHETVDG YRRYFTQIVG FFVVEDHILH
360 370 380 390 400
VTQGLVTRAY TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLTVIFA
410 420 430 440 450
DTLQGYGFPV NRLFDLLFEI RDQYNETLLK KWAGVFRDIF EEDNYSPIPV
460 470 480 490 500
VNEEEYKIVI SKFPFQDPDL EKQSFPKKFP MSQSVPHIYI QVKEFIYASL
510 520 530 540 550
KFSESLHRSS TEIDDMLRKS TNLLLTRTLS SCLLNLIRKP HIGLTELVQI
560 570 580 590 600
IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE
610 620 630 640 650
IYTKLNQKID EFVQLADYDW TMSEPDGRAS GYLMDLINFL RSIFQVFTHL
660 670 680 690 700
PGKVAQTACM SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF
710 720 730 740 750
ASSEPVPGFQ GDTLQLAFID LRQLLDLFMV WDWSTYLADY GQPASKYLRV
760 770 780 790 800
NPNTALTLLE KMKDTSKKNN IFAQFRKNDR DKQKLIETVV KQLRSLVNGM

SQHM
Length:804
Mass (Da):93,722
Last modified:July 22, 2008 - v3
Checksum:i413251A5BA6543C4
GO
Isoform 2 (identifier: Q8TAG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-31: AENSESLGTVPEHERILQEIESTDTACVGP → LEEETDQTYENVLAEIQSFELPVEA

Note: Gene prediction based on EST data.
Show »
Length:799
Mass (Da):93,407
Checksum:i8A90434F0409E992
GO

Sequence cautioni

The sequence AAF37262 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti776R → G in AAH28395 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044522396T → I1 PublicationCorresponds to variant dbSNP:rs1326331Ensembl.1
Natural variantiVAR_044523523L → V. Corresponds to variant dbSNP:rs11187225Ensembl.1
Natural variantiVAR_044524578T → I. Corresponds to variant dbSNP:rs35647717Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471602 – 31AENSE…ACVGP → LEEETDQTYENVLAEIQSFE LPVEA in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL358613
, AL157705, AL392103, AL590080 Genomic DNA Translation: CAH72805.2
AL590080
, AL157705, AL358613, AL392103 Genomic DNA Translation: CAH74087.1
AL392103
, AL157705, AL358613, AL590080 Genomic DNA Translation: CAI40847.2
CH471066 Genomic DNA Translation: EAW50083.1
BC028395 mRNA Translation: AAH28395.2
AF220217 mRNA Translation: AAF37262.1 Different initiation.
CCDSiCCDS31247.1 [Q8TAG9-2]
CCDS7424.2 [Q8TAG9-1]
RefSeqiNP_001013870.1, NM_001013848.3 [Q8TAG9-2]
NP_001306123.1, NM_001319194.1
NP_001306124.1, NM_001319195.1
NP_001306129.1, NM_001319200.1
NP_061926.3, NM_019053.5 [Q8TAG9-1]
XP_016871834.1, XM_017016345.1 [Q8TAG9-2]
UniGeneiHs.655657

Genome annotation databases

EnsembliENST00000260762; ENSP00000260762; ENSG00000138190 [Q8TAG9-1]
ENST00000371552; ENSP00000360607; ENSG00000138190 [Q8TAG9-2]
GeneIDi54536
KEGGihsa:54536
UCSCiuc001kie.4 human [Q8TAG9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEXOC6_HUMAN
AccessioniPrimary (citable) accession number: Q8TAG9
Secondary accession number(s): E9PHI3, Q5VXH8, Q9NZ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 22, 2008
Last modified: March 28, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome