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Protein

Zinc finger protein 461

Gene

ZNF461

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 267C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri273 – 295C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 461
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 1
Short name:
GIOT-1
Gene namesi
Name:ZNF461
Synonyms:GIOT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000197808.11
HGNCiHGNC:21629 ZNF461
MIMi608640 gene
neXtProtiNX_Q8TAF7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197808
PharmGKBiPA145149895

Polymorphism and mutation databases

BioMutaiZNF461
DMDMi51338811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471961 – 563Zinc finger protein 461Add BLAST563

Proteomic databases

EPDiQ8TAF7
MaxQBiQ8TAF7
PaxDbiQ8TAF7
PeptideAtlasiQ8TAF7
PRIDEiQ8TAF7

PTM databases

iPTMnetiQ8TAF7
PhosphoSitePlusiQ8TAF7

Expressioni

Tissue specificityi

Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000197808
CleanExiHS_ZNF461
ExpressionAtlasiQ8TAF7 baseline and differential
GenevisibleiQ8TAF7 HS

Organism-specific databases

HPAiHPA021139

Interactioni

Protein-protein interaction databases

BioGridi124926, 3 interactors
IntActiQ8TAF7, 1 interactor
STRINGi9606.ENSP00000467931

Structurei

3D structure databases

ProteinModelPortaliQ8TAF7
SMRiQ8TAF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 267C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri273 – 295C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TAF7
KOiK09228
PhylomeDBiQ8TAF7

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS
60 70 80 90 100
KPAVISSLEQ GKEPWMVVRE ETGRWCPGTW KTWGFHNNFL DNNEATDINA
110 120 130 140 150
DLASRDEPQK LSPKRDIYET ELSQWVNMEE FKSHSPERSI FSAIWEGNCH
160 170 180 190 200
FEQHQGQEEG YFRQLMINHE NMPIFSQHTL LTQEFYDREK ISECKKCRKI
210 220 230 240 250
FSYHLFFSHH KRTHSKELSE CKECTEIVNT PCLFKQQTIQ NGDKCNECKE
260 270 280 290 300
CWKAFVHCSQ LKHLRIHNGE KRYECNECGK AFNYGSELTL HQRIHTGEKP
310 320 330 340 350
YECKECGKAF RQRSQLTQHQ RLHTGEKPYE CKQCGKAFIR GFQLTEHLRL
360 370 380 390 400
HTGEKPYECK ECGKTFRHRS HLTIHQRIHT GEKPYECREC GKAFSYHSSF
410 420 430 440 450
SHHQKIHSGK KPYECHECGK AFCDGLQLTL HQRIHTGEKP YECKECGKTF
460 470 480 490 500
RQCSHLKRHQ RIHTGEKPHE CMICGKAFRL HSHLIQHQRI HTGEKPYECK
510 520 530 540 550
ECGKAFSYHS SFSHHQRIHS GKKPYQCGKA FNHRLQLNLH QTLHTGEKPV
560
RFPLLPPHPS LAS
Length:563
Mass (Da):66,214
Last modified:August 16, 2004 - v2
Checksum:i7530043A4940F028
GO
Isoform 2 (identifier: Q8TAF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.
Show »
Length:436
Mass (Da):51,516
Checksum:i57674438DDC06395
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05283487N → S. Corresponds to variant dbSNP:rs10419469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0113961 – 127Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY329493 mRNA Translation: AAR00226.1
AK292834 mRNA Translation: BAF85523.1
BC028631 mRNA Translation: AAH28631.1
AB021641 mRNA Translation: BAA86987.1
CCDSiCCDS54257.1 [Q8TAF7-1]
RefSeqiNP_001284552.1, NM_001297623.2
NP_694989.2, NM_153257.4 [Q8TAF7-1]
XP_011525788.1, XM_011527486.2 [Q8TAF7-2]
UniGeneiHs.590972

Genome annotation databases

EnsembliENST00000588268; ENSP00000467931; ENSG00000197808 [Q8TAF7-1]
GeneIDi92283
KEGGihsa:92283
UCSCiuc002oem.4 human [Q8TAF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiZN461_HUMAN
AccessioniPrimary (citable) accession number: Q8TAF7
Secondary accession number(s): A8K9W9, Q6VSF7, Q9ULZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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