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Protein

Zinc finger protein 461

Gene

ZNF461

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri192 – 21423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26722C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 461
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 1
Short name:
GIOT-1
Gene namesi
Name:ZNF461
Synonyms:GIOT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21629. ZNF461.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149895.

Polymorphism and mutation databases

BioMutaiZNF461.
DMDMi51338811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Zinc finger protein 461PRO_0000047196Add
BLAST

Proteomic databases

EPDiQ8TAF7.
PaxDbiQ8TAF7.
PRIDEiQ8TAF7.

PTM databases

iPTMnetiQ8TAF7.
PhosphoSiteiQ8TAF7.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine.1 Publication

Gene expression databases

BgeeiQ8TAF7.
CleanExiHS_ZNF461.
ExpressionAtlasiQ8TAF7. baseline and differential.
GenevisibleiQ8TAF7. HS.

Organism-specific databases

HPAiHPA021139.

Interactioni

Protein-protein interaction databases

BioGridi124926. 3 interactions.
STRINGi9606.ENSP00000467931.

Structurei

3D structure databases

ProteinModelPortaliQ8TAF7.
SMRiQ8TAF7. Positions 194-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri192 – 21423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26722C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAF7.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TAF7.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS
60 70 80 90 100
KPAVISSLEQ GKEPWMVVRE ETGRWCPGTW KTWGFHNNFL DNNEATDINA
110 120 130 140 150
DLASRDEPQK LSPKRDIYET ELSQWVNMEE FKSHSPERSI FSAIWEGNCH
160 170 180 190 200
FEQHQGQEEG YFRQLMINHE NMPIFSQHTL LTQEFYDREK ISECKKCRKI
210 220 230 240 250
FSYHLFFSHH KRTHSKELSE CKECTEIVNT PCLFKQQTIQ NGDKCNECKE
260 270 280 290 300
CWKAFVHCSQ LKHLRIHNGE KRYECNECGK AFNYGSELTL HQRIHTGEKP
310 320 330 340 350
YECKECGKAF RQRSQLTQHQ RLHTGEKPYE CKQCGKAFIR GFQLTEHLRL
360 370 380 390 400
HTGEKPYECK ECGKTFRHRS HLTIHQRIHT GEKPYECREC GKAFSYHSSF
410 420 430 440 450
SHHQKIHSGK KPYECHECGK AFCDGLQLTL HQRIHTGEKP YECKECGKTF
460 470 480 490 500
RQCSHLKRHQ RIHTGEKPHE CMICGKAFRL HSHLIQHQRI HTGEKPYECK
510 520 530 540 550
ECGKAFSYHS SFSHHQRIHS GKKPYQCGKA FNHRLQLNLH QTLHTGEKPV
560
RFPLLPPHPS LAS
Length:563
Mass (Da):66,214
Last modified:August 16, 2004 - v2
Checksum:i7530043A4940F028
GO
Isoform 2 (identifier: Q8TAF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.
Show »
Length:436
Mass (Da):51,516
Checksum:i57674438DDC06395
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871N → S.
Corresponds to variant rs10419469 [ dbSNP | Ensembl ].
VAR_052834

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 127127Missing in isoform 2. 1 PublicationVSP_011396Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY329493 mRNA. Translation: AAR00226.1.
AK292834 mRNA. Translation: BAF85523.1.
BC028631 mRNA. Translation: AAH28631.1.
AB021641 mRNA. Translation: BAA86987.1.
CCDSiCCDS54257.1. [Q8TAF7-1]
RefSeqiNP_694989.2. NM_153257.4. [Q8TAF7-1]
XP_011525788.1. XM_011527486.1. [Q8TAF7-2]
XP_011525789.1. XM_011527487.1. [Q8TAF7-2]
XP_011525790.1. XM_011527488.1. [Q8TAF7-2]
UniGeneiHs.590972.

Genome annotation databases

EnsembliENST00000588268; ENSP00000467931; ENSG00000197808. [Q8TAF7-1]
GeneIDi92283.
KEGGihsa:92283.
UCSCiuc002oem.4. human. [Q8TAF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY329493 mRNA. Translation: AAR00226.1.
AK292834 mRNA. Translation: BAF85523.1.
BC028631 mRNA. Translation: AAH28631.1.
AB021641 mRNA. Translation: BAA86987.1.
CCDSiCCDS54257.1. [Q8TAF7-1]
RefSeqiNP_694989.2. NM_153257.4. [Q8TAF7-1]
XP_011525788.1. XM_011527486.1. [Q8TAF7-2]
XP_011525789.1. XM_011527487.1. [Q8TAF7-2]
XP_011525790.1. XM_011527488.1. [Q8TAF7-2]
UniGeneiHs.590972.

3D structure databases

ProteinModelPortaliQ8TAF7.
SMRiQ8TAF7. Positions 194-553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124926. 3 interactions.
STRINGi9606.ENSP00000467931.

PTM databases

iPTMnetiQ8TAF7.
PhosphoSiteiQ8TAF7.

Polymorphism and mutation databases

BioMutaiZNF461.
DMDMi51338811.

Proteomic databases

EPDiQ8TAF7.
PaxDbiQ8TAF7.
PRIDEiQ8TAF7.

Protocols and materials databases

DNASUi92283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588268; ENSP00000467931; ENSG00000197808. [Q8TAF7-1]
GeneIDi92283.
KEGGihsa:92283.
UCSCiuc002oem.4. human. [Q8TAF7-1]

Organism-specific databases

CTDi92283.
GeneCardsiZNF461.
HGNCiHGNC:21629. ZNF461.
HPAiHPA021139.
MIMi608640. gene.
neXtProtiNX_Q8TAF7.
PharmGKBiPA145149895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TAF7.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TAF7.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF461. human.
GenomeRNAii92283.
PROiQ8TAF7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAF7.
CleanExiHS_ZNF461.
ExpressionAtlasiQ8TAF7. baseline and differential.
GenevisibleiQ8TAF7. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4."
    Dai J., Li Y., Ji C., Jin F., Zheng Z., Wang X., Sun X., Xu X., Gu S., Xie Y., Mao Y.
    Cytogenet. Genome Res. 103:74-78(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Identification and characterization of novel zinc finger proteins in the human ovary."
    Okada T., Mizutani T., Miyamoto K.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-563.
    Tissue: Ovary.

Entry informationi

Entry nameiZN461_HUMAN
AccessioniPrimary (citable) accession number: Q8TAF7
Secondary accession number(s): A8K9W9, Q6VSF7, Q9ULZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.