SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8TAE8

- G45IP_HUMAN

UniProt

Q8TAE8 - G45IP_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Growth arrest and DNA damage-inducible proteins-interacting protein 1

Gene
GADD45GIP1, MRPL59, PLINP1, PRG6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible proteins-interacting protein 1
Alternative name(s):
39S ribosomal protein L59, mitochondrial
Short name:
MRP-L59
CKII beta-associating protein
CR6-interacting factor 1
Short name:
CRIF1
Papillomavirus L2-interacting nuclear protein 1
Short name:
PLINP
Short name:
PLINP-1
p53-responsive gene 6 protein
Gene namesi
Synonyms:MRPL59, PLINP1, PRG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29996. GADD45GIP1.

Subcellular locationi

Mitochondrion. Nucleus
Note: Using N-terminally tagged constructs, has been found in the nucleus (1 Publication). C-terminally tagged constructs are targeted exclusively to mitochondria (1 Publication). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (1 Publication).4 Publications

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Growth arrest and DNA damage-inducible proteins-interacting protein 1PRO_0000228620Add
BLAST

Proteomic databases

MaxQBiQ8TAE8.
PaxDbiQ8TAE8.
PeptideAtlasiQ8TAE8.
PRIDEiQ8TAE8.

PTM databases

PhosphoSiteiQ8TAE8.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.1 Publication

Inductioni

Down-regulated by p53/TP53 in apoptotic cells.1 Publication

Gene expression databases

ArrayExpressiQ8TAE8.
BgeeiQ8TAE8.
CleanExiHS_GADD45GIP1.
GenevestigatoriQ8TAE8.

Interactioni

Subunit structurei

Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Interacts with ATAD3A and ATAD3B. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GADD45AP245223EBI-372506,EBI-448167
Gadd45bP223393EBI-372506,EBI-2266938From a different organism.
GADD45GO952574EBI-372506,EBI-448202
STAT3P407634EBI-372506,EBI-518675

Protein-protein interaction databases

BioGridi124721. 25 interactions.
IntActiQ8TAE8. 8 interactions.
MINTiMINT-253595.
STRINGi9606.ENSP00000323065.

Structurei

3D structure databases

ProteinModelPortaliQ8TAE8.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili99 – 212114 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi184 – 20017Nuclear localization signal Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 1394Poly-Gln

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG285057.
HOGENOMiHOG000112686.
HOVERGENiHBG068845.
InParanoidiQ8TAE8.
OMAiMPQMIEN.
OrthoDBiEOG7ZKSDX.
PhylomeDBiQ8TAE8.
TreeFamiTF323794.

Family and domain databases

InterProiIPR018472. Damage-induce-interacting_prot.
[Graphical view]
PfamiPF10147. CR6_interact. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAE8-1 [UniParc]FASTAAdd to Basket

« Hide

MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW    50
QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEER EWYPSLATMQ 100
ESLRVKQLAE EQKRREREQH IAECMAKMPQ MIVNWQQQQR ENWEKAQADK 150
ERRARLQAEA QELLGYQVDP RSARFQELLQ DLEKKERKRL KEEKQKRKKE 200
ARAAALAAAV AQDPAASGAP SS 222
Length:222
Mass (Da):25,384
Last modified:June 1, 2002 - v1
Checksum:i304C397AEC958804
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 104QARS → KALN in CAD22344. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ429498 mRNA. Translation: CAD22344.1.
AF479749 mRNA. Translation: AAL85877.1.
AF475095 mRNA. Translation: AAM10639.1.
BC004944 mRNA. Translation: AAH04944.1.
BC013039 mRNA. Translation: AAH13039.2.
BC013027 mRNA. Translation: AAH13027.2.
BC069200 mRNA. Translation: AAH69200.1.
AJ295986 mRNA. Translation: CAC82499.1.
AF147080 mRNA. No translation available.
CCDSiCCDS12290.1.
RefSeqiNP_443082.2. NM_052850.3.
UniGeneiHs.515164.

Genome annotation databases

EnsembliENST00000316939; ENSP00000323065; ENSG00000179271.
GeneIDi90480.
KEGGihsa:90480.
UCSCiuc002mwb.4. human.

Polymorphism databases

DMDMi74730346.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ429498 mRNA. Translation: CAD22344.1 .
AF479749 mRNA. Translation: AAL85877.1 .
AF475095 mRNA. Translation: AAM10639.1 .
BC004944 mRNA. Translation: AAH04944.1 .
BC013039 mRNA. Translation: AAH13039.2 .
BC013027 mRNA. Translation: AAH13027.2 .
BC069200 mRNA. Translation: AAH69200.1 .
AJ295986 mRNA. Translation: CAC82499.1 .
AF147080 mRNA. No translation available.
CCDSi CCDS12290.1.
RefSeqi NP_443082.2. NM_052850.3.
UniGenei Hs.515164.

3D structure databases

ProteinModelPortali Q8TAE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124721. 25 interactions.
IntActi Q8TAE8. 8 interactions.
MINTi MINT-253595.
STRINGi 9606.ENSP00000323065.

PTM databases

PhosphoSitei Q8TAE8.

Polymorphism databases

DMDMi 74730346.

Proteomic databases

MaxQBi Q8TAE8.
PaxDbi Q8TAE8.
PeptideAtlasi Q8TAE8.
PRIDEi Q8TAE8.

Protocols and materials databases

DNASUi 90480.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316939 ; ENSP00000323065 ; ENSG00000179271 .
GeneIDi 90480.
KEGGi hsa:90480.
UCSCi uc002mwb.4. human.

Organism-specific databases

CTDi 90480.
GeneCardsi GC19M013065.
HGNCi HGNC:29996. GADD45GIP1.
MIMi 605162. gene.
neXtProti NX_Q8TAE8.
PharmGKBi PA134954784.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285057.
HOGENOMi HOG000112686.
HOVERGENi HBG068845.
InParanoidi Q8TAE8.
OMAi MPQMIEN.
OrthoDBi EOG7ZKSDX.
PhylomeDBi Q8TAE8.
TreeFami TF323794.

Miscellaneous databases

GeneWikii GADD45GIP1.
GenomeRNAii 90480.
NextBioi 76780.
PROi Q8TAE8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TAE8.
Bgeei Q8TAE8.
CleanExi HS_GADD45GIP1.
Genevestigatori Q8TAE8.

Family and domain databases

InterProi IPR018472. Damage-induce-interacting_prot.
[Graphical view ]
Pfami PF10147. CR6_interact. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins."
    Goernemann J., Hofmann T.G., Will H., Mueller M.
    Virology 303:69-78(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH HPV16 L2.
    Tissue: Keratinocyte.
  2. "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."
    Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M.
    J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH GADD45A; GADD45B AND GADD45G, TISSUE SPECIFICITY.
    Tissue: Colon carcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Muscle and Skin.
  4. "Full length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)."
    Frigimelica E., Lanfranchi G.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-222.
  5. "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene."
    Horikoshi N., Cong J., Kley N., Shenk T.
    Biochem. Biophys. Res. Commun. 261:864-869(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-122, INDUCTION.
  6. "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation."
    Park K.C., Song K.-H., Chung H.K., Kim H., Kim D.W., Song J.H., Hwang E.S., Jung H.S., Park S.-H., Bae I., Lee I.K., Choi H.-S., Shong M.
    Mol. Endocrinol. 19:12-24(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NR4A1/NUR77.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: INTERACTION WITH ATAD3A AND ATAD3B, SUBCELLULAR LOCATION.
  11. "Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome."
    Koc E.C., Cimen H., Kumcuoglu B., Abu N., Akpinar G., Haque M.E., Spremulli L.L., Koc H.
    Front. Physiol. 4:183-183(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiG45IP_HUMAN
AccessioniPrimary (citable) accession number: Q8TAE8
Secondary accession number(s): Q8IVM3
, Q8TE51, Q969P9, Q9BSM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi