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Q8TAE8

- G45IP_HUMAN

UniProt

Q8TAE8 - G45IP_HUMAN

Protein

Growth arrest and DNA damage-inducible proteins-interacting protein 1

Gene

GADD45GIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth arrest and DNA damage-inducible proteins-interacting protein 1
    Alternative name(s):
    39S ribosomal protein L59, mitochondrial
    Short name:
    MRP-L59
    CKII beta-associating protein
    CR6-interacting factor 1
    Short name:
    CRIF1
    Papillomavirus L2-interacting nuclear protein 1
    Short name:
    PLINP
    Short name:
    PLINP-1
    p53-responsive gene 6 protein
    Gene namesi
    Name:GADD45GIP1
    Synonyms:MRPL59, PLINP1, PRG6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29996. GADD45GIP1.

    Subcellular locationi

    Mitochondrion. Nucleus
    Note: Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).2 Publications

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134954784.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Growth arrest and DNA damage-inducible proteins-interacting protein 1PRO_0000228620Add
    BLAST

    Proteomic databases

    MaxQBiQ8TAE8.
    PaxDbiQ8TAE8.
    PeptideAtlasiQ8TAE8.
    PRIDEiQ8TAE8.

    PTM databases

    PhosphoSiteiQ8TAE8.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.1 Publication

    Inductioni

    Down-regulated by p53/TP53 in apoptotic cells.1 Publication

    Gene expression databases

    ArrayExpressiQ8TAE8.
    BgeeiQ8TAE8.
    CleanExiHS_GADD45GIP1.
    GenevestigatoriQ8TAE8.

    Interactioni

    Subunit structurei

    Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Interacts with ATAD3A and ATAD3B. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GADD45AP245223EBI-372506,EBI-448167
    Gadd45bP223393EBI-372506,EBI-2266938From a different organism.
    GADD45GO952574EBI-372506,EBI-448202
    STAT3P407633EBI-372506,EBI-518675
    Stat3P422273EBI-372506,EBI-602878From a different organism.

    Protein-protein interaction databases

    BioGridi124721. 25 interactions.
    IntActiQ8TAE8. 8 interactions.
    MINTiMINT-253595.
    STRINGi9606.ENSP00000323065.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili99 – 212114Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi184 – 20017Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi136 – 1394Poly-Gln

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG285057.
    HOGENOMiHOG000112686.
    HOVERGENiHBG068845.
    InParanoidiQ8TAE8.
    OMAiMPQMIEN.
    OrthoDBiEOG7ZKSDX.
    PhylomeDBiQ8TAE8.
    TreeFamiTF323794.

    Family and domain databases

    InterProiIPR018472. Damage-induce-interacting_prot.
    [Graphical view]
    PfamiPF10147. CR6_interact. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW    50
    QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEER EWYPSLATMQ 100
    ESLRVKQLAE EQKRREREQH IAECMAKMPQ MIVNWQQQQR ENWEKAQADK 150
    ERRARLQAEA QELLGYQVDP RSARFQELLQ DLEKKERKRL KEEKQKRKKE 200
    ARAAALAAAV AQDPAASGAP SS 222
    Length:222
    Mass (Da):25,384
    Last modified:June 1, 2002 - v1
    Checksum:i304C397AEC958804
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 104QARS → KALN in CAD22344. (PubMed:12482659)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ429498 mRNA. Translation: CAD22344.1.
    AF479749 mRNA. Translation: AAL85877.1.
    AF475095 mRNA. Translation: AAM10639.1.
    BC004944 mRNA. Translation: AAH04944.1.
    BC013039 mRNA. Translation: AAH13039.2.
    BC013027 mRNA. Translation: AAH13027.2.
    BC069200 mRNA. Translation: AAH69200.1.
    AJ295986 mRNA. Translation: CAC82499.1.
    AF147080 mRNA. No translation available.
    CCDSiCCDS12290.1.
    RefSeqiNP_443082.2. NM_052850.3.
    UniGeneiHs.515164.

    Genome annotation databases

    EnsembliENST00000316939; ENSP00000323065; ENSG00000179271.
    GeneIDi90480.
    KEGGihsa:90480.
    UCSCiuc002mwb.4. human.

    Polymorphism databases

    DMDMi74730346.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ429498 mRNA. Translation: CAD22344.1 .
    AF479749 mRNA. Translation: AAL85877.1 .
    AF475095 mRNA. Translation: AAM10639.1 .
    BC004944 mRNA. Translation: AAH04944.1 .
    BC013039 mRNA. Translation: AAH13039.2 .
    BC013027 mRNA. Translation: AAH13027.2 .
    BC069200 mRNA. Translation: AAH69200.1 .
    AJ295986 mRNA. Translation: CAC82499.1 .
    AF147080 mRNA. No translation available.
    CCDSi CCDS12290.1.
    RefSeqi NP_443082.2. NM_052850.3.
    UniGenei Hs.515164.

    3D structure databases

    ProteinModelPortali Q8TAE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124721. 25 interactions.
    IntActi Q8TAE8. 8 interactions.
    MINTi MINT-253595.
    STRINGi 9606.ENSP00000323065.

    PTM databases

    PhosphoSitei Q8TAE8.

    Polymorphism databases

    DMDMi 74730346.

    Proteomic databases

    MaxQBi Q8TAE8.
    PaxDbi Q8TAE8.
    PeptideAtlasi Q8TAE8.
    PRIDEi Q8TAE8.

    Protocols and materials databases

    DNASUi 90480.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316939 ; ENSP00000323065 ; ENSG00000179271 .
    GeneIDi 90480.
    KEGGi hsa:90480.
    UCSCi uc002mwb.4. human.

    Organism-specific databases

    CTDi 90480.
    GeneCardsi GC19M013065.
    HGNCi HGNC:29996. GADD45GIP1.
    MIMi 605162. gene.
    neXtProti NX_Q8TAE8.
    PharmGKBi PA134954784.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285057.
    HOGENOMi HOG000112686.
    HOVERGENi HBG068845.
    InParanoidi Q8TAE8.
    OMAi MPQMIEN.
    OrthoDBi EOG7ZKSDX.
    PhylomeDBi Q8TAE8.
    TreeFami TF323794.

    Miscellaneous databases

    GeneWikii GADD45GIP1.
    GenomeRNAii 90480.
    NextBioi 76780.
    PROi Q8TAE8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TAE8.
    Bgeei Q8TAE8.
    CleanExi HS_GADD45GIP1.
    Genevestigatori Q8TAE8.

    Family and domain databases

    InterProi IPR018472. Damage-induce-interacting_prot.
    [Graphical view ]
    Pfami PF10147. CR6_interact. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins."
      Goernemann J., Hofmann T.G., Will H., Mueller M.
      Virology 303:69-78(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH HPV16 L2.
      Tissue: Keratinocyte.
    2. "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."
      Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M.
      J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH GADD45A; GADD45B AND GADD45G, TISSUE SPECIFICITY.
      Tissue: Colon carcinoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung, Muscle and Skin.
    4. "Full length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)."
      Frigimelica E., Lanfranchi G.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-222.
    5. "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene."
      Horikoshi N., Cong J., Kley N., Shenk T.
      Biochem. Biophys. Res. Commun. 261:864-869(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-122, INDUCTION.
    6. "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation."
      Park K.C., Song K.-H., Chung H.K., Kim H., Kim D.W., Song J.H., Hwang E.S., Jung H.S., Park S.-H., Bae I., Lee I.K., Choi H.-S., Shong M.
      Mol. Endocrinol. 19:12-24(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NR4A1/NUR77.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: INTERACTION WITH ATAD3A AND ATAD3B, SUBCELLULAR LOCATION.
    11. "Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome."
      Koc E.C., Cimen H., Kumcuoglu B., Abu N., Akpinar G., Haque M.E., Spremulli L.L., Koc H.
      Front. Physiol. 4:183-183(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiG45IP_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAE8
    Secondary accession number(s): Q8IVM3
    , Q8TE51, Q969P9, Q9BSM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3