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Protein

Potassium voltage-gated channel subfamily G member 3

Gene

KCNG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).2 Publications

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene namesi
Name:KCNG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171126.7
HGNCiHGNC:18306 KCNG3
MIMi606767 gene
neXtProtiNX_Q8TAE7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 168CytoplasmicBy similarityAdd BLAST168
Transmembranei169 – 190Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini191 – 220ExtracellularBy similarityAdd BLAST30
Transmembranei221 – 242Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini243 – 253CytoplasmicBy similarityAdd BLAST11
Transmembranei254 – 274Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini275 – 284ExtracellularBy similarity10
Transmembranei285 – 305Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini306 – 320CytoplasmicBy similarityAdd BLAST15
Transmembranei321 – 342Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini343 – 360ExtracellularBy similarityAdd BLAST18
Intramembranei361 – 372Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei373 – 380By similarity8
Topological domaini381 – 387ExtracellularBy similarity7
Transmembranei388 – 416Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini417 – 436CytoplasmicBy similarityAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi170850
OpenTargetsiENSG00000171126
PharmGKBiPA30036

Chemistry databases

ChEMBLiCHEMBL2362996

Polymorphism and mutation databases

BioMutaiKCNG3
DMDMi24418472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540771 – 436Potassium voltage-gated channel subfamily G member 3Add BLAST436

Proteomic databases

PaxDbiQ8TAE7
PeptideAtlasiQ8TAE7
PRIDEiQ8TAE7

PTM databases

iPTMnetiQ8TAE7
PhosphoSitePlusiQ8TAE7

Expressioni

Tissue specificityi

Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745).2 Publications

Gene expression databases

BgeeiENSG00000171126
CleanExiHS_KCNG3
GenevisibleiQ8TAE7 HS

Organism-specific databases

HPAiHPA041625

Interactioni

Subunit structurei

Heterotetramer with KCNB1 (PubMed:11852086, PubMed:12060745, PubMed:19074135). Does not form homomultimers (PubMed:12060745).3 Publications

Protein-protein interaction databases

BioGridi128090, 5 interactors
IntActiQ8TAE7, 1 interactor
STRINGi9606.ENSP00000304127

Structurei

3D structure databases

ProteinModelPortaliQ8TAE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi373 – 378Selectivity filterBy similarity6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231014
HOVERGENiHBG100172
InParanoidiQ8TAE7
KOiK04902
OMAiHMCELSF
OrthoDBiEOG091G09VX
PhylomeDBiQ8TAE7
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAE7-1) [UniParc]FASTAAdd to basket
Also known as: Kv10.1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV
60 70 80 90 100
CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY
110 120 130 140 150
WGLEGAHLEY CCQRRLDDRM SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS
160 170 180 190 200
RRWLERMRRT FEEPTSSLAA QILASVSVVF VIVSMVVLCA STLPDWRNAA
210 220 230 240 250
ADNRSLDDRS RYSAGPGREP SGIIEAICIG WFTAECIVRF IVSKNKCEFV
260 270 280 290 300
KRPLNIIDLL AITPYYISVL MTVFTGENSQ LQRAGVTLRV LRMMRIFWVI
310 320 330 340 350
KLARHFIGLQ TLGLTLKRCY REMVMLLVFI CVAMAIFSAL SQLLEHGLDL
360 370 380 390 400
ETSNKDFTSI PAACWWVIIS MTTVGYGDMY PITVPGRILG GVCVVSGIVL
410 420 430
LALPITFIYH SFVQCYHELK FRSARYSRSL STEFLN
Length:436
Mass (Da):49,593
Last modified:June 1, 2002 - v1
Checksum:i3C289CFF0B462513
GO
Isoform 2 (identifier: Q8TAE7-2) [UniParc]FASTAAdd to basket
Also known as: Kv10.1a

The sequence of this isoform differs from the canonical sequence as follows:
     212-222: Missing.

Show »
Length:425
Mass (Da):48,534
Checksum:iFA14B477CFD01604
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001026212 – 222Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070604 mRNA Translation: BAB85520.1
AF348982 mRNA Translation: AAL83909.1
AF454547 mRNA Translation: AAM93548.1
AF454548 mRNA Translation: AAM93549.1
AC025750 Genomic DNA Translation: AAY24039.1
CH471053 Genomic DNA Translation: EAX00319.1
BC071558 mRNA Translation: AAH71558.1
CCDSiCCDS1809.1 [Q8TAE7-1]
CCDS42674.1 [Q8TAE7-2]
RefSeqiNP_579875.1, NM_133329.5 [Q8TAE7-1]
NP_758847.1, NM_172344.2 [Q8TAE7-2]
UniGeneiHs.352633

Genome annotation databases

EnsembliENST00000306078; ENSP00000304127; ENSG00000171126 [Q8TAE7-1]
ENST00000394973; ENSP00000378424; ENSG00000171126 [Q8TAE7-2]
GeneIDi170850
KEGGihsa:170850
UCSCiuc002rsm.4 human [Q8TAE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKCNG3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAE7
Secondary accession number(s): Q53SC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health