Q8TAE7 (KCNG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily G member 3

Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3

Gene names

Name:

KCNG3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potassium channel subunit. Modulates channel activity.
Subunit structure	Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.
Subcellular location	Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
Tissue specificity	Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum Inferred from direct assay Ref.2. Source: UniProtKB plasma membrane Inferred from direct assay Ref.2. Source: UniProtKB voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TAE7-1)

Also known as: Kv10.1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TAE7-2)

Also known as: Kv10.1a;

The sequence of this isoform differs from the canonical sequence as follows:
     212-222: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Potassium voltage-gated channel subfamily G member 3		PRO_0000054077
Regions
	Topological domain	1 – 167	167	Cytoplasmic Potential
	Transmembrane	168 – 188	21	Helical; Name=Segment S1; Potential
	Transmembrane	222 – 242	21	Helical; Name=Segment S2; Potential
	Topological domain	243 – 255	13	Cytoplasmic Potential
	Transmembrane	256 – 276	21	Helical; Name=Segment S3; Potential
	Transmembrane	287 – 307	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	308 – 322	15	Cytoplasmic Potential
	Transmembrane	323 – 343	21	Helical; Name=Segment S5; Potential
	Intramembrane	361 – 381	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	388 – 413	26	Helical; Name=Segment S6; Potential
	Topological domain	414 – 436	23	Cytoplasmic Potential
	Motif	373 – 378	6	Selectivity filter By similarity
Natural variations
	Alternative sequence	212 – 222	11	Missing in isoform 2.		VSP_001026

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Kv10.1b) [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 3C289CFF0B462513	FASTA	436	49,593
	10 20 30 40 50 60 MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV CDDYDRERNE 70 80 90 100 110 120 YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY WGLEGAHLEY CCQRRLDDRM 130 140 150 160 170 180 SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS RRWLERMRRT FEEPTSSLAA QILASVSVVF 190 200 210 220 230 240 VIVSMVVLCA STLPDWRNAA ADNRSLDDRS RYSAGPGREP SGIIEAICIG WFTAECIVRF 250 260 270 280 290 300 IVSKNKCEFV KRPLNIIDLL AITPYYISVL MTVFTGENSQ LQRAGVTLRV LRMMRIFWVI 310 320 330 340 350 360 KLARHFIGLQ TLGLTLKRCY REMVMLLVFI CVAMAIFSAL SQLLEHGLDL ETSNKDFTSI 370 380 390 400 410 420 PAACWWVIIS MTTVGYGDMY PITVPGRILG GVCVVSGIVL LALPITFIYH SFVQCYHELK 430 FRSARYSRSL STEFLN
	Isoform 2 (Kv10.1a) [UniParc]. Checksum: FA14B477CFD01604	FASTA	425	48,534
	10 20 30 40 50 60 MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV CDDYDRERNE 70 80 90 100 110 120 YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY WGLEGAHLEY CCQRRLDDRM 130 140 150 160 170 180 SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS RRWLERMRRT FEEPTSSLAA QILASVSVVF 190 200 210 220 230 240 VIVSMVVLCA STLPDWRNAA ADNRSLDDRS RIIEAICIGW FTAECIVRFI VSKNKCEFVK 250 260 270 280 290 300 RPLNIIDLLA ITPYYISVLM TVFTGENSQL QRAGVTLRVL RMMRIFWVIK LARHFIGLQT 310 320 330 340 350 360 LGLTLKRCYR EMVMLLVFIC VAMAIFSALS QLLEHGLDLE TSNKDFTSIP AACWWVIISM 370 380 390 400 410 420 TTVGYGDMYP ITVPGRILGG VCVVSGIVLL ALPITFIYHS FVQCYHELKF RSARYSRSLS TEFLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1." Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K. FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome." Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J. Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits." Vega-Saenz de Miera E.C., Rudy B. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB070604 mRNA. Translation: BAB85520.1. AF348982 mRNA. Translation: AAL83909.1. AF454547 mRNA. Translation: AAM93548.1. AF454548 mRNA. Translation: AAM93549.1. AC025750 Genomic DNA. Translation: AAY24039.1. CH471053 Genomic DNA. Translation: EAX00319.1. BC071558 mRNA. Translation: AAH71558.1.
IPI	IPI00152048. IPI00172429.
RefSeq	NP_579875.1. NM_133329.5. NP_758847.1. NM_172344.2.
UniGene	Hs.352633.
3D structure databases
ProteinModelPortal	Q8TAE7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TAE7. 1 interaction.
STRING	9606.ENSP00000304127.
PTM databases
PhosphoSite	Q8TAE7.
Polymorphism databases
DMDM	24418472.
Proteomic databases
PaxDb	Q8TAE7.
PRIDE	Q8TAE7.
Protocols and materials databases
DNASU	170850.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306078; ENSP00000304127; ENSG00000171126. ENST00000394973; ENSP00000378424; ENSG00000171126.
GeneID	170850.
KEGG	hsa:170850.
UCSC	uc002rsm.3. human. uc002rsn.3. human.
Organism-specific databases
CTD	170850.
GeneCards	GC02M042669.
HGNC	HGNC:18306. KCNG3.
MIM	606767. gene.
neXtProt	NX_Q8TAE7.
PharmGKB	PA30036.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231014.
HOVERGEN	HBG100172.
InParanoid	Q8TAE7.
KO	K04902.
OMA	HMCELSF.
OrthoDB	EOG4BK544.
PhylomeDB	Q8TAE7.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q8TAE7.
CleanEx	HS_KCNG3.
Genevestigator	Q8TAE7.
GermOnline	ENSG00000171126. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003971. K_chnl_volt-dep_Kv9. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01494. KV9CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	170850.
NextBio	89126.
SOURCE	Search...

Entry information

Entry name

KCNG3_HUMAN

Accession

Primary (citable) accession number: Q8TAE7
Secondary accession number(s): Q53SC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.