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Q8TAE7

- KCNG3_HUMAN

UniProt

Q8TAE7 - KCNG3_HUMAN

Protein

Potassium voltage-gated channel subfamily G member 3

Gene

KCNG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily G member 3
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv10.1
    Voltage-gated potassium channel subunit Kv6.3
    Gene namesi
    Name:KCNG3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:18306. KCNG3.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
    Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. plasma membrane Source: UniProtKB
    3. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30036.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Potassium voltage-gated channel subfamily G member 3PRO_0000054077Add
    BLAST

    Proteomic databases

    PaxDbiQ8TAE7.
    PRIDEiQ8TAE7.

    PTM databases

    PhosphoSiteiQ8TAE7.

    Expressioni

    Tissue specificityi

    Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord.

    Gene expression databases

    BgeeiQ8TAE7.
    CleanExiHS_KCNG3.
    GenevestigatoriQ8TAE7.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.

    Protein-protein interaction databases

    BioGridi128090. 4 interactions.
    IntActiQ8TAE7. 1 interaction.
    STRINGi9606.ENSP00000304127.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAE7.
    SMRiQ8TAE7. Positions 11-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 167167CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini243 – 25513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 32215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini414 – 43623CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei361 – 38121Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei168 – 18821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei388 – 41326Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi373 – 3786Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231014.
    HOVERGENiHBG100172.
    InParanoidiQ8TAE7.
    KOiK04902.
    OMAiHMCELSF.
    OrthoDBiEOG7VB2F7.
    PhylomeDBiQ8TAE7.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TAE7-1) [UniParc]FASTAAdd to Basket

    Also known as: Kv10.1b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV    50
    CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY 100
    WGLEGAHLEY CCQRRLDDRM SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS 150
    RRWLERMRRT FEEPTSSLAA QILASVSVVF VIVSMVVLCA STLPDWRNAA 200
    ADNRSLDDRS RYSAGPGREP SGIIEAICIG WFTAECIVRF IVSKNKCEFV 250
    KRPLNIIDLL AITPYYISVL MTVFTGENSQ LQRAGVTLRV LRMMRIFWVI 300
    KLARHFIGLQ TLGLTLKRCY REMVMLLVFI CVAMAIFSAL SQLLEHGLDL 350
    ETSNKDFTSI PAACWWVIIS MTTVGYGDMY PITVPGRILG GVCVVSGIVL 400
    LALPITFIYH SFVQCYHELK FRSARYSRSL STEFLN 436
    Length:436
    Mass (Da):49,593
    Last modified:June 1, 2002 - v1
    Checksum:i3C289CFF0B462513
    GO
    Isoform 2 (identifier: Q8TAE7-2) [UniParc]FASTAAdd to Basket

    Also known as: Kv10.1a

    The sequence of this isoform differs from the canonical sequence as follows:
         212-222: Missing.

    Show »
    Length:425
    Mass (Da):48,534
    Checksum:iFA14B477CFD01604
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei212 – 22211Missing in isoform 2. 1 PublicationVSP_001026Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070604 mRNA. Translation: BAB85520.1.
    AF348982 mRNA. Translation: AAL83909.1.
    AF454547 mRNA. Translation: AAM93548.1.
    AF454548 mRNA. Translation: AAM93549.1.
    AC025750 Genomic DNA. Translation: AAY24039.1.
    CH471053 Genomic DNA. Translation: EAX00319.1.
    BC071558 mRNA. Translation: AAH71558.1.
    CCDSiCCDS1809.1. [Q8TAE7-1]
    CCDS42674.1. [Q8TAE7-2]
    RefSeqiNP_579875.1. NM_133329.5. [Q8TAE7-1]
    NP_758847.1. NM_172344.2. [Q8TAE7-2]
    UniGeneiHs.352633.

    Genome annotation databases

    EnsembliENST00000306078; ENSP00000304127; ENSG00000171126. [Q8TAE7-1]
    ENST00000394973; ENSP00000378424; ENSG00000171126. [Q8TAE7-2]
    GeneIDi170850.
    KEGGihsa:170850.
    UCSCiuc002rsm.3. human. [Q8TAE7-2]
    uc002rsn.3. human. [Q8TAE7-1]

    Polymorphism databases

    DMDMi24418472.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070604 mRNA. Translation: BAB85520.1 .
    AF348982 mRNA. Translation: AAL83909.1 .
    AF454547 mRNA. Translation: AAM93548.1 .
    AF454548 mRNA. Translation: AAM93549.1 .
    AC025750 Genomic DNA. Translation: AAY24039.1 .
    CH471053 Genomic DNA. Translation: EAX00319.1 .
    BC071558 mRNA. Translation: AAH71558.1 .
    CCDSi CCDS1809.1. [Q8TAE7-1 ]
    CCDS42674.1. [Q8TAE7-2 ]
    RefSeqi NP_579875.1. NM_133329.5. [Q8TAE7-1 ]
    NP_758847.1. NM_172344.2. [Q8TAE7-2 ]
    UniGenei Hs.352633.

    3D structure databases

    ProteinModelPortali Q8TAE7.
    SMRi Q8TAE7. Positions 11-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128090. 4 interactions.
    IntActi Q8TAE7. 1 interaction.
    STRINGi 9606.ENSP00000304127.

    Chemistry

    ChEMBLi CHEMBL2362996.

    PTM databases

    PhosphoSitei Q8TAE7.

    Polymorphism databases

    DMDMi 24418472.

    Proteomic databases

    PaxDbi Q8TAE7.
    PRIDEi Q8TAE7.

    Protocols and materials databases

    DNASUi 170850.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306078 ; ENSP00000304127 ; ENSG00000171126 . [Q8TAE7-1 ]
    ENST00000394973 ; ENSP00000378424 ; ENSG00000171126 . [Q8TAE7-2 ]
    GeneIDi 170850.
    KEGGi hsa:170850.
    UCSCi uc002rsm.3. human. [Q8TAE7-2 ]
    uc002rsn.3. human. [Q8TAE7-1 ]

    Organism-specific databases

    CTDi 170850.
    GeneCardsi GC02M042669.
    HGNCi HGNC:18306. KCNG3.
    MIMi 606767. gene.
    neXtProti NX_Q8TAE7.
    PharmGKBi PA30036.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231014.
    HOVERGENi HBG100172.
    InParanoidi Q8TAE7.
    KOi K04902.
    OMAi HMCELSF.
    OrthoDBi EOG7VB2F7.
    PhylomeDBi Q8TAE7.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNG3.
    GenomeRNAii 170850.
    NextBioi 89126.
    PROi Q8TAE7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TAE7.
    CleanExi HS_KCNG3.
    Genevestigatori Q8TAE7.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1."
      Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K.
      FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome."
      Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J.
      Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
      Vega-Saenz de Miera E.C., Rudy B.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNG3_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAE7
    Secondary accession number(s): Q53SC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3