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Q8TAE7 (KCNG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene names
Name:KCNG3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity.

Subunit structure

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.

Subcellular location

Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

Tissue specificity

Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TAE7-1)

Also known as: Kv10.1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TAE7-2)

Also known as: Kv10.1a;

The sequence of this isoform differs from the canonical sequence as follows:
     212-222: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Potassium voltage-gated channel subfamily G member 3
PRO_0000054077

Regions

Topological domain1 – 167167Cytoplasmic Potential
Transmembrane168 – 18821Helical; Name=Segment S1; Potential
Transmembrane222 – 24221Helical; Name=Segment S2; Potential
Topological domain243 – 25513Cytoplasmic Potential
Transmembrane256 – 27621Helical; Name=Segment S3; Potential
Transmembrane287 – 30721Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain308 – 32215Cytoplasmic Potential
Transmembrane323 – 34321Helical; Name=Segment S5; Potential
Intramembrane361 – 38121Pore-forming; Name=Segment H5; Potential
Transmembrane388 – 41326Helical; Name=Segment S6; Potential
Topological domain414 – 43623Cytoplasmic Potential
Motif373 – 3786Selectivity filter By similarity

Natural variations

Alternative sequence212 – 22211Missing in isoform 2.
VSP_001026

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Kv10.1b) [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 3C289CFF0B462513

FASTA43649,593
        10         20         30         40         50         60 
MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV CDDYDRERNE 

        70         80         90        100        110        120 
YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY WGLEGAHLEY CCQRRLDDRM 

       130        140        150        160        170        180 
SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS RRWLERMRRT FEEPTSSLAA QILASVSVVF 

       190        200        210        220        230        240 
VIVSMVVLCA STLPDWRNAA ADNRSLDDRS RYSAGPGREP SGIIEAICIG WFTAECIVRF 

       250        260        270        280        290        300 
IVSKNKCEFV KRPLNIIDLL AITPYYISVL MTVFTGENSQ LQRAGVTLRV LRMMRIFWVI 

       310        320        330        340        350        360 
KLARHFIGLQ TLGLTLKRCY REMVMLLVFI CVAMAIFSAL SQLLEHGLDL ETSNKDFTSI 

       370        380        390        400        410        420 
PAACWWVIIS MTTVGYGDMY PITVPGRILG GVCVVSGIVL LALPITFIYH SFVQCYHELK 

       430 
FRSARYSRSL STEFLN 

« Hide

Isoform 2 (Kv10.1a) [UniParc].

Checksum: FA14B477CFD01604
Show »

FASTA42548,534

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1."
Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K.
FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome."
Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J.
Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
Vega-Saenz de Miera E.C., Rudy B.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB070604 mRNA. Translation: BAB85520.1.
AF348982 mRNA. Translation: AAL83909.1.
AF454547 mRNA. Translation: AAM93548.1.
AF454548 mRNA. Translation: AAM93549.1.
AC025750 Genomic DNA. Translation: AAY24039.1.
CH471053 Genomic DNA. Translation: EAX00319.1.
BC071558 mRNA. Translation: AAH71558.1.
RefSeqNP_579875.1. NM_133329.5.
NP_758847.1. NM_172344.2.
UniGeneHs.352633.

3D structure databases

ProteinModelPortalQ8TAE7.
SMRQ8TAE7. Positions 11-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128090. 4 interactions.
IntActQ8TAE7. 1 interaction.
STRING9606.ENSP00000304127.

Chemistry

ChEMBLCHEMBL2362996.

PTM databases

PhosphoSiteQ8TAE7.

Polymorphism databases

DMDM24418472.

Proteomic databases

PaxDbQ8TAE7.
PRIDEQ8TAE7.

Protocols and materials databases

DNASU170850.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306078; ENSP00000304127; ENSG00000171126. [Q8TAE7-1]
ENST00000394973; ENSP00000378424; ENSG00000171126. [Q8TAE7-2]
GeneID170850.
KEGGhsa:170850.
UCSCuc002rsm.3. human. [Q8TAE7-2]
uc002rsn.3. human. [Q8TAE7-1]

Organism-specific databases

CTD170850.
GeneCardsGC02M042669.
HGNCHGNC:18306. KCNG3.
MIM606767. gene.
neXtProtNX_Q8TAE7.
PharmGKBPA30036.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231014.
HOVERGENHBG100172.
InParanoidQ8TAE7.
KOK04902.
OMAHMCELSF.
OrthoDBEOG7VB2F7.
PhylomeDBQ8TAE7.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ8TAE7.
CleanExHS_KCNG3.
GenevestigatorQ8TAE7.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNG3.
GenomeRNAi170850.
NextBio89126.
PROQ8TAE7.
SOURCESearch...

Entry information

Entry nameKCNG3_HUMAN
AccessionPrimary (citable) accession number: Q8TAE7
Secondary accession number(s): Q53SC1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM