SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8TAE7

- KCNG3_HUMAN

UniProt

Q8TAE7 - KCNG3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Potassium voltage-gated channel subfamily G member 3

Gene
KCNG3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. protein homooligomerization Source: InterPro
  2. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene namesi
Name:KCNG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:18306. KCNG3.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 167167Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei168 – 18821Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Transmembranei222 – 24221Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Topological domaini243 – 25513Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei256 – 27621Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Transmembranei287 – 30721Helical; Voltage-sensor; Name=Segment S4; Reviewed predictionAdd
BLAST
Topological domaini308 – 32215Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Intramembranei361 – 38121Pore-forming; Name=Segment H5; Reviewed predictionAdd
BLAST
Transmembranei388 – 41326Helical; Name=Segment S6; Reviewed predictionAdd
BLAST
Topological domaini414 – 43623Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. plasma membrane Source: UniProtKB
  3. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Potassium voltage-gated channel subfamily G member 3PRO_0000054077Add
BLAST

Proteomic databases

PaxDbiQ8TAE7.
PRIDEiQ8TAE7.

PTM databases

PhosphoSiteiQ8TAE7.

Expressioni

Tissue specificityi

Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord.

Gene expression databases

BgeeiQ8TAE7.
CleanExiHS_KCNG3.
GenevestigatoriQ8TAE7.

Interactioni

Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.

Protein-protein interaction databases

BioGridi128090. 4 interactions.
IntActiQ8TAE7. 1 interaction.
STRINGi9606.ENSP00000304127.

Structurei

3D structure databases

ProteinModelPortaliQ8TAE7.
SMRiQ8TAE7. Positions 11-417.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi373 – 3786Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ8TAE7.
KOiK04902.
OMAiHMCELSF.
OrthoDBiEOG7VB2F7.
PhylomeDBiQ8TAE7.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TAE7-1) [UniParc]FASTAAdd to Basket

Also known as: Kv10.1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV    50
CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY 100
WGLEGAHLEY CCQRRLDDRM SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS 150
RRWLERMRRT FEEPTSSLAA QILASVSVVF VIVSMVVLCA STLPDWRNAA 200
ADNRSLDDRS RYSAGPGREP SGIIEAICIG WFTAECIVRF IVSKNKCEFV 250
KRPLNIIDLL AITPYYISVL MTVFTGENSQ LQRAGVTLRV LRMMRIFWVI 300
KLARHFIGLQ TLGLTLKRCY REMVMLLVFI CVAMAIFSAL SQLLEHGLDL 350
ETSNKDFTSI PAACWWVIIS MTTVGYGDMY PITVPGRILG GVCVVSGIVL 400
LALPITFIYH SFVQCYHELK FRSARYSRSL STEFLN 436
Length:436
Mass (Da):49,593
Last modified:June 1, 2002 - v1
Checksum:i3C289CFF0B462513
GO
Isoform 2 (identifier: Q8TAE7-2) [UniParc]FASTAAdd to Basket

Also known as: Kv10.1a

The sequence of this isoform differs from the canonical sequence as follows:
     212-222: Missing.

Show »
Length:425
Mass (Da):48,534
Checksum:iFA14B477CFD01604
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei212 – 22211Missing in isoform 2. VSP_001026Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070604 mRNA. Translation: BAB85520.1.
AF348982 mRNA. Translation: AAL83909.1.
AF454547 mRNA. Translation: AAM93548.1.
AF454548 mRNA. Translation: AAM93549.1.
AC025750 Genomic DNA. Translation: AAY24039.1.
CH471053 Genomic DNA. Translation: EAX00319.1.
BC071558 mRNA. Translation: AAH71558.1.
CCDSiCCDS1809.1. [Q8TAE7-1]
CCDS42674.1. [Q8TAE7-2]
RefSeqiNP_579875.1. NM_133329.5. [Q8TAE7-1]
NP_758847.1. NM_172344.2. [Q8TAE7-2]
UniGeneiHs.352633.

Genome annotation databases

EnsembliENST00000306078; ENSP00000304127; ENSG00000171126. [Q8TAE7-1]
ENST00000394973; ENSP00000378424; ENSG00000171126. [Q8TAE7-2]
GeneIDi170850.
KEGGihsa:170850.
UCSCiuc002rsm.3. human. [Q8TAE7-2]
uc002rsn.3. human. [Q8TAE7-1]

Polymorphism databases

DMDMi24418472.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070604 mRNA. Translation: BAB85520.1 .
AF348982 mRNA. Translation: AAL83909.1 .
AF454547 mRNA. Translation: AAM93548.1 .
AF454548 mRNA. Translation: AAM93549.1 .
AC025750 Genomic DNA. Translation: AAY24039.1 .
CH471053 Genomic DNA. Translation: EAX00319.1 .
BC071558 mRNA. Translation: AAH71558.1 .
CCDSi CCDS1809.1. [Q8TAE7-1 ]
CCDS42674.1. [Q8TAE7-2 ]
RefSeqi NP_579875.1. NM_133329.5. [Q8TAE7-1 ]
NP_758847.1. NM_172344.2. [Q8TAE7-2 ]
UniGenei Hs.352633.

3D structure databases

ProteinModelPortali Q8TAE7.
SMRi Q8TAE7. Positions 11-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128090. 4 interactions.
IntActi Q8TAE7. 1 interaction.
STRINGi 9606.ENSP00000304127.

Chemistry

ChEMBLi CHEMBL2362996.

PTM databases

PhosphoSitei Q8TAE7.

Polymorphism databases

DMDMi 24418472.

Proteomic databases

PaxDbi Q8TAE7.
PRIDEi Q8TAE7.

Protocols and materials databases

DNASUi 170850.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306078 ; ENSP00000304127 ; ENSG00000171126 . [Q8TAE7-1 ]
ENST00000394973 ; ENSP00000378424 ; ENSG00000171126 . [Q8TAE7-2 ]
GeneIDi 170850.
KEGGi hsa:170850.
UCSCi uc002rsm.3. human. [Q8TAE7-2 ]
uc002rsn.3. human. [Q8TAE7-1 ]

Organism-specific databases

CTDi 170850.
GeneCardsi GC02M042669.
HGNCi HGNC:18306. KCNG3.
MIMi 606767. gene.
neXtProti NX_Q8TAE7.
PharmGKBi PA30036.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231014.
HOVERGENi HBG100172.
InParanoidi Q8TAE7.
KOi K04902.
OMAi HMCELSF.
OrthoDBi EOG7VB2F7.
PhylomeDBi Q8TAE7.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNG3.
GenomeRNAii 170850.
NextBioi 89126.
PROi Q8TAE7.
SOURCEi Search...

Gene expression databases

Bgeei Q8TAE7.
CleanExi HS_KCNG3.
Genevestigatori Q8TAE7.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1."
    Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K.
    FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome."
    Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J.
    Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
    Vega-Saenz de Miera E.C., Rudy B.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiKCNG3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAE7
Secondary accession number(s): Q53SC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi