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Protein

Potassium voltage-gated channel subfamily G member 3

Gene

KCNG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).2 Publications

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene namesi
Name:KCNG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18306. KCNG3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 168168CytoplasmicBy similarityAdd
BLAST
Transmembranei169 – 19022Helical; Name=Segment S1By similarityAdd
BLAST
Topological domaini191 – 22030ExtracellularBy similarityAdd
BLAST
Transmembranei221 – 24222Helical; Name=Segment S2By similarityAdd
BLAST
Topological domaini243 – 25311CytoplasmicBy similarityAdd
BLAST
Transmembranei254 – 27421Helical; Name=Segment S3By similarityAdd
BLAST
Topological domaini275 – 28410ExtracellularBy similarity
Transmembranei285 – 30521Helical; Voltage-sensor; Name=Segment S4By similarityAdd
BLAST
Topological domaini306 – 32015CytoplasmicBy similarityAdd
BLAST
Transmembranei321 – 34222Helical; Name=Segment S5By similarityAdd
BLAST
Topological domaini343 – 36018ExtracellularBy similarityAdd
BLAST
Intramembranei361 – 37212Helical; Name=Pore helixBy similarityAdd
BLAST
Intramembranei373 – 3808By similarity
Topological domaini381 – 3877ExtracellularBy similarity
Transmembranei388 – 41629Helical; Name=Segment S6By similarityAdd
BLAST
Topological domaini417 – 43620CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
  • voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30036.

Polymorphism and mutation databases

BioMutaiKCNG3.
DMDMi24418472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Potassium voltage-gated channel subfamily G member 3PRO_0000054077Add
BLAST

Proteomic databases

PaxDbiQ8TAE7.
PRIDEiQ8TAE7.

PTM databases

PhosphoSiteiQ8TAE7.

Expressioni

Tissue specificityi

Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745).2 Publications

Gene expression databases

BgeeiQ8TAE7.
CleanExiHS_KCNG3.
GenevisibleiQ8TAE7. HS.

Interactioni

Subunit structurei

Heterotetramer with KCNB1 (PubMed:11852086, PubMed:12060745, PubMed:19074135). Does not form homomultimers (PubMed:12060745).3 Publications

Protein-protein interaction databases

BioGridi128090. 4 interactions.
IntActiQ8TAE7. 1 interaction.
STRINGi9606.ENSP00000304127.

Structurei

3D structure databases

ProteinModelPortaliQ8TAE7.
SMRiQ8TAE7. Positions 11-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi373 – 3786Selectivity filterBy similarity

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ8TAE7.
KOiK04902.
OMAiDMYPITM.
OrthoDBiEOG7VB2F7.
PhylomeDBiQ8TAE7.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAE7-1) [UniParc]FASTAAdd to basket

Also known as: Kv10.1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV
60 70 80 90 100
CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY
110 120 130 140 150
WGLEGAHLEY CCQRRLDDRM SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS
160 170 180 190 200
RRWLERMRRT FEEPTSSLAA QILASVSVVF VIVSMVVLCA STLPDWRNAA
210 220 230 240 250
ADNRSLDDRS RYSAGPGREP SGIIEAICIG WFTAECIVRF IVSKNKCEFV
260 270 280 290 300
KRPLNIIDLL AITPYYISVL MTVFTGENSQ LQRAGVTLRV LRMMRIFWVI
310 320 330 340 350
KLARHFIGLQ TLGLTLKRCY REMVMLLVFI CVAMAIFSAL SQLLEHGLDL
360 370 380 390 400
ETSNKDFTSI PAACWWVIIS MTTVGYGDMY PITVPGRILG GVCVVSGIVL
410 420 430
LALPITFIYH SFVQCYHELK FRSARYSRSL STEFLN
Length:436
Mass (Da):49,593
Last modified:June 1, 2002 - v1
Checksum:i3C289CFF0B462513
GO
Isoform 2 (identifier: Q8TAE7-2) [UniParc]FASTAAdd to basket

Also known as: Kv10.1a

The sequence of this isoform differs from the canonical sequence as follows:
     212-222: Missing.

Show »
Length:425
Mass (Da):48,534
Checksum:iFA14B477CFD01604
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei212 – 22211Missing in isoform 2. 1 PublicationVSP_001026Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070604 mRNA. Translation: BAB85520.1.
AF348982 mRNA. Translation: AAL83909.1.
AF454547 mRNA. Translation: AAM93548.1.
AF454548 mRNA. Translation: AAM93549.1.
AC025750 Genomic DNA. Translation: AAY24039.1.
CH471053 Genomic DNA. Translation: EAX00319.1.
BC071558 mRNA. Translation: AAH71558.1.
CCDSiCCDS1809.1. [Q8TAE7-1]
CCDS42674.1. [Q8TAE7-2]
RefSeqiNP_579875.1. NM_133329.5. [Q8TAE7-1]
NP_758847.1. NM_172344.2. [Q8TAE7-2]
UniGeneiHs.352633.

Genome annotation databases

EnsembliENST00000306078; ENSP00000304127; ENSG00000171126.
ENST00000394973; ENSP00000378424; ENSG00000171126. [Q8TAE7-2]
GeneIDi170850.
KEGGihsa:170850.
UCSCiuc002rsm.3. human. [Q8TAE7-2]
uc002rsn.3. human. [Q8TAE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070604 mRNA. Translation: BAB85520.1.
AF348982 mRNA. Translation: AAL83909.1.
AF454547 mRNA. Translation: AAM93548.1.
AF454548 mRNA. Translation: AAM93549.1.
AC025750 Genomic DNA. Translation: AAY24039.1.
CH471053 Genomic DNA. Translation: EAX00319.1.
BC071558 mRNA. Translation: AAH71558.1.
CCDSiCCDS1809.1. [Q8TAE7-1]
CCDS42674.1. [Q8TAE7-2]
RefSeqiNP_579875.1. NM_133329.5. [Q8TAE7-1]
NP_758847.1. NM_172344.2. [Q8TAE7-2]
UniGeneiHs.352633.

3D structure databases

ProteinModelPortaliQ8TAE7.
SMRiQ8TAE7. Positions 11-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128090. 4 interactions.
IntActiQ8TAE7. 1 interaction.
STRINGi9606.ENSP00000304127.

Chemistry

ChEMBLiCHEMBL2362996.

PTM databases

PhosphoSiteiQ8TAE7.

Polymorphism and mutation databases

BioMutaiKCNG3.
DMDMi24418472.

Proteomic databases

PaxDbiQ8TAE7.
PRIDEiQ8TAE7.

Protocols and materials databases

DNASUi170850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306078; ENSP00000304127; ENSG00000171126.
ENST00000394973; ENSP00000378424; ENSG00000171126. [Q8TAE7-2]
GeneIDi170850.
KEGGihsa:170850.
UCSCiuc002rsm.3. human. [Q8TAE7-2]
uc002rsn.3. human. [Q8TAE7-1]

Organism-specific databases

CTDi170850.
GeneCardsiGC02M042669.
HGNCiHGNC:18306. KCNG3.
MIMi606767. gene.
neXtProtiNX_Q8TAE7.
PharmGKBiPA30036.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ8TAE7.
KOiK04902.
OMAiDMYPITM.
OrthoDBiEOG7VB2F7.
PhylomeDBiQ8TAE7.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNG3.
GenomeRNAii170850.
NextBioi89126.
PROiQ8TAE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAE7.
CleanExiHS_KCNG3.
GenevisibleiQ8TAE7. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1."
    Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K.
    FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, INTERACTION WITH KCNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome."
    Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J.
    Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, INTERACTION WITH KCNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
    Vega-Saenz de Miera E.C., Rudy B.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4."
    Mederos y Schnitzler M., Rinne S., Skrobek L., Renigunta V., Schlichthorl G., Derst C., Gudermann T., Daut J., Preisig-Muller R.
    J. Biol. Chem. 284:4695-4704(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiKCNG3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAE7
Secondary accession number(s): Q53SC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.