Q8TAE6 (PP14C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase 1 regulatory subunit 14C

Alternative name(s):
Kinase-enhanced PP1 inhibitor
PKC-potentiated PP1 inhibitory protein
Serologically defined breast cancer antigen NY-BR-81

Gene names

Name:	PPP1R14C
Synonyms:	KEPI

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Detected in breast cancer. Ref.1
Sequence similarities	Belongs to the PP1 inhibitor family.
Sequence caution	The sequence AAG48264.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Polymorphism
Molecular function	Protein phosphatase inhibitor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Protein phosphatase 1 regulatory subunit 14C		PRO_0000071494
Regions
	Compositional bias	51 – 56	6	Poly-Ala
	Compositional bias	58 – 64	7	Poly-Gln
	Compositional bias	102 – 105	4	Poly-Glu
Amino acid modifications
	Modified residue	73	1	Phosphothreonine By similarity
Natural variations
	Natural variant	10	1	T → A. Ref.1 Ref.4 Corresponds to variant rs2297672 [ dbSNP | Ensembl ].		VAR_025547

Sequences

	Sequence		Length	Mass (Da)
	Q8TAE6 [UniParc]. Last modified March 21, 2006. Version 3. Checksum: 514CB1EC4B15E5BB	FASTA	165	17,843
	10 20 30 40 50 60 MSVATGSSET AGGASGGGAR VFFQSPRGGA GGSPGSSSGS GSSREDSAPV ATAAAAGQVQ 70 80 90 100 110 120 QQQQRRHQQG KVTVKYDRKE LRKRLVLEEW IVEQLGQLYG CEEEEMPEVE IDIDDLLDAD 130 140 150 160 SDEERASKLQ EALVDCYKPT EEFIKELLSR IRGMRKLSPP QKKSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression." Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O., Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J. Cancer Immun. 1:4-4(2001) [PubMed: 12747765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ALA-10. Tissue: Mammary gland.
[2]	"KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine." Liu Q.-R., Zhang P.-W., Zhen Q., Walther D., Wang X.-B., Uhl G. J. Biol. Chem. 277:13312-13320(2002) [PubMed: 11812771] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-10. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF308297 mRNA. Translation: AAG48264.1. Different initiation. AF407165 mRNA. Translation: AAL83506.1. AF407166 Genomic DNA. Translation: AAL83507.1. AL355497, AL096708 Genomic DNA. Translation: CAH74129.1. AL096708, AL355497 Genomic DNA. Translation: CAI19346.1. BC015773 mRNA. Translation: AAH15773.1.
IPI	IPI00290397.
RefSeq	NP_112211.1. NM_030949.2.
UniGene	Hs.486798.
3D structure databases
ProteinModelPortal	Q8TAE6.
SMR	Q8TAE6. Positions 57-156.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TAE6.
PTM databases
PhosphoSite	Q8TAE6.
Polymorphism databases
DMDM	90110047.
Proteomic databases
PeptideAtlas	Q8TAE6.
PRIDE	Q8TAE6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361131; ENSP00000355260; ENSG00000198729.
GeneID	81706.
KEGG	hsa:81706.
UCSC	uc003qnt.1. human.
Organism-specific databases
CTD	81706.
GeneCards	GC06P150464.
H-InvDB	HIX0006291.
HGNC	HGNC:14952. PPP1R14C.
MIM	613242. gene.
neXtProt	NX_Q8TAE6.
PharmGKB	PA33630.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20600.
GeneTree	ENSGT00390000003608.
HOGENOM	HBG717795.
HOVERGEN	HBG054419.
InParanoid	Q8TAE6.
OMA	WIVEQLS.
OrthoDB	EOG4BVRW6.
Gene expression databases
ArrayExpress	Q8TAE6.
Bgee	Q8TAE6.
CleanEx	HS_PPP1R14C.
Genevestigator	Q8TAE6.
GermOnline	ENSG00000198729. Homo sapiens.
Family and domain databases
InterPro	IPR008025. PP1_inhibitor. [Graphical view]
Gene3D	G3DSA:1.10.150.220. PP1_inhibitor. 1 hit.
PANTHER	PTHR16188. PP1_inhibitor. 1 hit.
Pfam	PF05361. PP1_inhibitor. 1 hit. [Graphical view]
SUPFAM	SSF81790. PP1_inhibitor. 1 hit.
ProtoNet	Search...
Other
NextBio	72067.
SOURCE	Search...

Entry information

Entry name

PP14C_HUMAN

Accession

Primary (citable) accession number: Q8TAE6
Secondary accession number(s): Q5VY83, Q96BB1, Q9H277

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.