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Protein

Overexpressed in colon carcinoma 1 protein

Gene

OCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Overexpressed in colon carcinoma 1 protein
Short name:
OCC-1
Alternative name(s):
AGD3
Gene namesi
Name:OCC1
Synonyms:C12orf75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:35164. C12orf75.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716815.

Polymorphism and mutation databases

BioMutaiOCC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6363Overexpressed in colon carcinoma 1 proteinPRO_0000368221Add
BLAST

Proteomic databases

EPDiQ8TAD7.
MaxQBiQ8TAD7.
PaxDbiQ8TAD7.
PRIDEiQ8TAD7.
TopDownProteomicsiQ8TAD7.

PTM databases

iPTMnetiQ8TAD7.
PhosphoSiteiQ8TAD7.

Expressioni

Tissue specificityi

High expression in placenta, skeletal muscle, kidney and pancreas tissues. Absent or very faint expression in heart, brain, lung and liver. Expressed during adipogenic differentiation of mesenchymal stem cells (at protein level).2 Publications

Gene expression databases

BgeeiQ8TAD7.
ExpressionAtlasiQ8TAD7. baseline and differential.
GenevisibleiQ8TAD7. HS.

Organism-specific databases

HPAiHPA065311.

Interactioni

Protein-protein interaction databases

BioGridi132482. 11 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the OCC1 family.Curated

Phylogenomic databases

eggNOGiENOG410JMVI. Eukaryota.
ENOG41115A6. LUCA.
GeneTreeiENSGT00610000087444.
InParanoidiQ8TAD7.
OrthoDBiEOG738083.
PhylomeDBiQ8TAD7.

Family and domain databases

InterProiIPR029133. OCC1.
[Graphical view]
PfamiPF15506. OCC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGNSTATS AGAGQGPAGA AKDVTEESVT EDDKRRNYGG VYVGLPSEAV
60
NMVSSQTKTV RKN
Length:63
Mass (Da):6,407
Last modified:April 14, 2009 - v2
Checksum:i60F992759DB5FCCD
GO

Sequence cautioni

The sequence AAH13920.2 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAH45812.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAH61920.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAH67897.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAC85391.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAC85392.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311378 mRNA. Translation: CAC85391.1. Sequence problems.
AJ311377 mRNA. Translation: CAC85392.1. Sequence problems.
AK056999 mRNA. No translation available.
AC011313 Genomic DNA. No translation available.
BC013920 mRNA. Translation: AAH13920.2. Sequence problems.
BC045812 mRNA. Translation: AAH45812.1. Sequence problems.
BC061920 mRNA. Translation: AAH61920.1. Sequence problems.
BC067897 mRNA. Translation: AAH67897.1. Sequence problems.
CCDSiCCDS55879.1.
RefSeqiNP_001138671.1. NM_001145199.1.
UniGeneiHs.368938.

Genome annotation databases

EnsembliENST00000443585; ENSP00000448536; ENSG00000235162.
GeneIDi387882.
KEGGihsa:387882.
UCSCiuc001tlh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311378 mRNA. Translation: CAC85391.1. Sequence problems.
AJ311377 mRNA. Translation: CAC85392.1. Sequence problems.
AK056999 mRNA. No translation available.
AC011313 Genomic DNA. No translation available.
BC013920 mRNA. Translation: AAH13920.2. Sequence problems.
BC045812 mRNA. Translation: AAH45812.1. Sequence problems.
BC061920 mRNA. Translation: AAH61920.1. Sequence problems.
BC067897 mRNA. Translation: AAH67897.1. Sequence problems.
CCDSiCCDS55879.1.
RefSeqiNP_001138671.1. NM_001145199.1.
UniGeneiHs.368938.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132482. 11 interactions.

PTM databases

iPTMnetiQ8TAD7.
PhosphoSiteiQ8TAD7.

Polymorphism and mutation databases

BioMutaiOCC1.

Proteomic databases

EPDiQ8TAD7.
MaxQBiQ8TAD7.
PaxDbiQ8TAD7.
PRIDEiQ8TAD7.
TopDownProteomicsiQ8TAD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443585; ENSP00000448536; ENSG00000235162.
GeneIDi387882.
KEGGihsa:387882.
UCSCiuc001tlh.4. human.

Organism-specific databases

CTDi387882.
GeneCardsiC12orf75.
H-InvDBHIX0019089.
HGNCiHGNC:35164. C12orf75.
HPAiHPA065311.
neXtProtiNX_Q8TAD7.
PharmGKBiPA164716815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JMVI. Eukaryota.
ENOG41115A6. LUCA.
GeneTreeiENSGT00610000087444.
InParanoidiQ8TAD7.
OrthoDBiEOG738083.
PhylomeDBiQ8TAD7.

Miscellaneous databases

ChiTaRSiC12orf75. human.
GenomeRNAii387882.
PROiQ8TAD7.

Gene expression databases

BgeeiQ8TAD7.
ExpressionAtlasiQ8TAD7. baseline and differential.
GenevisibleiQ8TAD7. HS.

Family and domain databases

InterProiIPR029133. OCC1.
[Graphical view]
PfamiPF15506. OCC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas."
    Pibouin L., Villaudy J., Ferbus D., Muleris M., Prosperi M.T., Remvikos Y., Goubin G.
    Cancer Genet. Cytogenet. 133:55-60(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Liver and Testis.
  5. "Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation."
    Kikuchi K., Fukuda M., Ito T., Inoue M., Yokoi T., Chiku S., Mitsuyama T., Asai K., Hirose T., Aizawa Y.
    Nucleic Acids Res. 37:4987-5000(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiOCC1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: June 8, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was reported to be transcribed but not translated (PubMed:11890990). However, it was later shown that it is expressed at protein level (PubMed:19531736).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.