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Protein

Zinc transporter 5

Gene

SLC30A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.5 Publications

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB
  • zinc ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • cellular zinc ion homeostasis Source: UniProtKB
  • cobalt ion transport Source: MGI
  • regulation of proton transport Source: UniProtKB
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: UniProtKB
  • zinc II ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145740-MONOMER.
ReactomeiR-HSA-264876. Insulin processing.
R-HSA-435368. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.4.3. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 5
Short name:
ZnT-5
Alternative name(s):
Solute carrier family 30 member 5
ZnT-like transporter 1
Short name:
hZTL1
Gene namesi
Name:SLC30A5
Synonyms:ZNT5, ZNTL1, ZTL1
ORF Names:UNQ863/PRO1879
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19089. SLC30A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 56ExtracellularSequence analysis3
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 98CytoplasmicSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120ExtracellularSequence analysis1
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 152CytoplasmicSequence analysisAdd BLAST11
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 193ExtracellularSequence analysisAdd BLAST20
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 238CytoplasmicSequence analysisAdd BLAST24
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 303CytoplasmicSequence analysisAdd BLAST15
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 342ExtracellularSequence analysisAdd BLAST18
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 418CytoplasmicSequence analysisAdd BLAST55
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 448ExtracellularSequence analysis9
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 483CytoplasmicSequence analysisAdd BLAST14
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 520ExtracellularSequence analysisAdd BLAST16
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 592CytoplasmicSequence analysisAdd BLAST51
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Topological domaini614 – 617ExtracellularSequence analysis4
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Topological domaini639 – 765CytoplasmicSequence analysisAdd BLAST127

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • Golgi apparatus Source: BHF-UCL
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: MGI
  • nucleolus Source: HPA
  • nucleus Source: HPA
  • secretory granule Source: MGI
  • secretory granule membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64924.
OpenTargetsiENSG00000145740.
PharmGKBiPA134865113.

Polymorphism and mutation databases

BioMutaiSLC30A5.
DMDMi74723898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142931 – 765Zinc transporter 5Add BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TAD4.
MaxQBiQ8TAD4.
PaxDbiQ8TAD4.
PeptideAtlasiQ8TAD4.
PRIDEiQ8TAD4.

PTM databases

iPTMnetiQ8TAD4.
PhosphoSitePlusiQ8TAD4.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.2 Publications

Inductioni

Down-regulated by ZNF658 in response to zinc.2 Publications

Gene expression databases

BgeeiENSG00000145740.
CleanExiHS_SLC30A5.
ExpressionAtlasiQ8TAD4. baseline and differential.
GenevisibleiQ8TAD4. HS.

Organism-specific databases

HPAiHPA035373.

Interactioni

Subunit structurei

Heterooligomer. Interacts with ZNT6.1 Publication

Protein-protein interaction databases

BioGridi122346. 33 interactors.
IntActiQ8TAD4. 3 interactors.
STRINGi9606.ENSP00000379836.

Structurei

3D structure databases

ProteinModelPortaliQ8TAD4.
SMRiQ8TAD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni542 – 578His-rich loopAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 20Poly-Gly9

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000082502.
HOVERGENiHBG056637.
InParanoidiQ8TAD4.
KOiK14692.
OMAiICSVKME.
OrthoDBiEOG091G030D.
PhylomeDBiQ8TAD4.
TreeFamiTF315217.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKYGGDVL AGPGGGGGLG PVDVPSARLT KYIVLLCFTK FLKAVGLFES
60 70 80 90 100
YDLLKAVHIV QFIFILKLGT AFFMVLFQKP FSSGKTITKH QWIKIFKHAV
110 120 130 140 150
AGCIISLLWF FGLTLCGPLR TLLLFEHSDI VVISLLSVLF TSSGGGPAKT
160 170 180 190 200
RGAAFFIIAV ICLLLFDNDD LMAKMAEHPE GHHDSALTHM LYTAIAFLGV
210 220 230 240 250
ADHKGGVLLL VLALCCKVGF HTASRKLSVD VGGAKRLQAL SHLVSVLLLC
260 270 280 290 300
PWVIVLSVTT ESKVESWFSL IMPFATVIFF VMILDFYVDS ICSVKMEVSK
310 320 330 340 350
CARYGSFPIF ISALLFGNFW THPITDQLRA MNKAAHQEST EHVLSGGVVV
360 370 380 390 400
SAIFFILSAN ILSSPSKRGQ KGTLIGYSPE GTPLYNFMGD AFQHSSQSIP
410 420 430 440 450
RFIKESLKQI LEESDSRQIF YFLCLNLLFT FVELFYGVLT NSLGLISDGF
460 470 480 490 500
HMLFDCSALV MGLFAALMSR WKATRIFSYG YGRIEILSGF INGLFLIVIA
510 520 530 540 550
FFVFMESVAR LIDPPELDTH MLTPVSVGGL IVNLIGICAF SHAHSHAHGA
560 570 580 590 600
SQGSCHSSDH SHSHHMHGHS DHGHGHSHGS AGGGMNANMR GVFLHVLADT
610 620 630 640 650
LGSIGVIVST VLIEQFGWFI ADPLCSLFIA ILIFLSVVPL IKDACQVLLL
660 670 680 690 700
RLPPEYEKEL HIALEKIQKI EGLISYRDPH FWRHSASIVA GTIHIQVTSD
710 720 730 740 750
VLEQRIVQQV TGILKDAGVN NLTIQVEKEA YFQHMSGLST GFHDVLAMTK
760
QMESMKYCKD GTYIM
Length:765
Mass (Da):84,047
Last modified:June 1, 2002 - v1
Checksum:iCD96BB6D710DF42D
GO
Isoform 2 (identifier: Q8TAD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     667-694: IQKIEGLISYRDPHFWRHSASIVAGTIH → VLYVISSLLSSLKITFLKSLLEVKQTTK
     695-765: Missing.

Show »
Length:523
Mass (Da):57,399
Checksum:i836F358FAE631286
GO
Isoform 3 (identifier: Q8TAD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-118: WIKIFKHAVAGCIISLLWFFGLTLCGP → IIGSLKIPGRKEFKDKKLNDPRKLVGN
     119-765: Missing.

Note: No experimental confirmation available.
Show »
Length:118
Mass (Da):12,944
Checksum:i30E74D490B02E939
GO
Isoform 4 (identifier: Q8TAD4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-69: Missing.
     92-118: WIKIFKHAVAGCIISLLWFFGLTLCGP → IIGSLKIPGRKEFKDKKLNDPRKLVGN
     119-765: Missing.

Show »
Length:77
Mass (Da):8,216
Checksum:i92097FCAD51728A7
GO

Sequence cautioni

The sequence BAB14258 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303R → C in BAB14258 (PubMed:14702039).Curated1
Sequence conflicti321T → A in AAL84188 (PubMed:11937503).Curated1
Sequence conflicti328L → P in AAL84188 (PubMed:11937503).Curated1
Sequence conflicti483R → Q in BAB14258 (PubMed:14702039).Curated1
Sequence conflicti628 – 629FI → ST in AAQ88869 (PubMed:12975309).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0302541 – 171Missing in isoform 2. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_04511529 – 69Missing in isoform 4. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_04367392 – 118WIKIF…TLCGP → IIGSLKIPGRKEFKDKKLND PRKLVGN in isoform 3 and isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_043674119 – 765Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST647
Alternative sequenceiVSP_030255667 – 694IQKIE…AGTIH → VLYVISSLLSSLKITFLKSL LEVKQTTK in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_030256695 – 765Missing in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461760 mRNA. Translation: AAL96437.1.
AF439324 mRNA. Translation: AAL84188.1.
AY089991 mRNA. Translation: AAM09099.1.
AY358505 mRNA. Translation: AAQ88869.1.
AK022818 mRNA. Translation: BAB14258.1. Different initiation.
AK292925 mRNA. Translation: BAF85614.1.
BX537394 mRNA. Translation: CAD97636.1.
AC010273 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51307.1.
CH471137 Genomic DNA. Translation: EAW51309.1.
BC000808 mRNA. Translation: AAH00808.1.
BC008198 mRNA. Translation: AAH08198.2.
BC017441 mRNA. Translation: AAH17441.1.
BC130452 mRNA. Translation: AAI30453.1.
BC130454 mRNA. Translation: AAI30455.1.
BC144349 mRNA. Translation: AAI44350.1.
CCDSiCCDS34173.1. [Q8TAD4-3]
CCDS3996.1. [Q8TAD4-1]
CCDS58955.1. [Q8TAD4-4]
RefSeqiNP_001238898.1. NM_001251969.1. [Q8TAD4-4]
NP_075053.2. NM_022902.4. [Q8TAD4-1]
NP_076960.1. NM_024055.4. [Q8TAD4-3]
UniGeneiHs.631975.

Genome annotation databases

EnsembliENST00000380860; ENSP00000370241; ENSG00000145740. [Q8TAD4-3]
ENST00000396591; ENSP00000379836; ENSG00000145740. [Q8TAD4-1]
ENST00000502979; ENSP00000421251; ENSG00000145740. [Q8TAD4-4]
GeneIDi64924.
KEGGihsa:64924.
UCSCiuc003jvg.4. human. [Q8TAD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461760 mRNA. Translation: AAL96437.1.
AF439324 mRNA. Translation: AAL84188.1.
AY089991 mRNA. Translation: AAM09099.1.
AY358505 mRNA. Translation: AAQ88869.1.
AK022818 mRNA. Translation: BAB14258.1. Different initiation.
AK292925 mRNA. Translation: BAF85614.1.
BX537394 mRNA. Translation: CAD97636.1.
AC010273 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51307.1.
CH471137 Genomic DNA. Translation: EAW51309.1.
BC000808 mRNA. Translation: AAH00808.1.
BC008198 mRNA. Translation: AAH08198.2.
BC017441 mRNA. Translation: AAH17441.1.
BC130452 mRNA. Translation: AAI30453.1.
BC130454 mRNA. Translation: AAI30455.1.
BC144349 mRNA. Translation: AAI44350.1.
CCDSiCCDS34173.1. [Q8TAD4-3]
CCDS3996.1. [Q8TAD4-1]
CCDS58955.1. [Q8TAD4-4]
RefSeqiNP_001238898.1. NM_001251969.1. [Q8TAD4-4]
NP_075053.2. NM_022902.4. [Q8TAD4-1]
NP_076960.1. NM_024055.4. [Q8TAD4-3]
UniGeneiHs.631975.

3D structure databases

ProteinModelPortaliQ8TAD4.
SMRiQ8TAD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122346. 33 interactors.
IntActiQ8TAD4. 3 interactors.
STRINGi9606.ENSP00000379836.

Protein family/group databases

TCDBi2.A.4.4.3. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiQ8TAD4.
PhosphoSitePlusiQ8TAD4.

Polymorphism and mutation databases

BioMutaiSLC30A5.
DMDMi74723898.

Proteomic databases

EPDiQ8TAD4.
MaxQBiQ8TAD4.
PaxDbiQ8TAD4.
PeptideAtlasiQ8TAD4.
PRIDEiQ8TAD4.

Protocols and materials databases

DNASUi64924.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380860; ENSP00000370241; ENSG00000145740. [Q8TAD4-3]
ENST00000396591; ENSP00000379836; ENSG00000145740. [Q8TAD4-1]
ENST00000502979; ENSP00000421251; ENSG00000145740. [Q8TAD4-4]
GeneIDi64924.
KEGGihsa:64924.
UCSCiuc003jvg.4. human. [Q8TAD4-1]

Organism-specific databases

CTDi64924.
DisGeNETi64924.
GeneCardsiSLC30A5.
HGNCiHGNC:19089. SLC30A5.
HPAiHPA035373.
MIMi607819. gene.
neXtProtiNX_Q8TAD4.
OpenTargetsiENSG00000145740.
PharmGKBiPA134865113.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000082502.
HOVERGENiHBG056637.
InParanoidiQ8TAD4.
KOiK14692.
OMAiICSVKME.
OrthoDBiEOG091G030D.
PhylomeDBiQ8TAD4.
TreeFamiTF315217.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145740-MONOMER.
ReactomeiR-HSA-264876. Insulin processing.
R-HSA-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

ChiTaRSiSLC30A5. human.
GenomeRNAii64924.
PROiQ8TAD4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145740.
CleanExiHS_SLC30A5.
ExpressionAtlasiQ8TAD4. baseline and differential.
GenevisibleiQ8TAD4. HS.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT5_HUMAN
AccessioniPrimary (citable) accession number: Q8TAD4
Secondary accession number(s): B7ZM89
, Q6UX54, Q7L4M4, Q8TDG3, Q9BVY8, Q9H9H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.