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Protein

Zinc transporter 5

Gene

SLC30A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.5 Publications

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB
  • zinc ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • cellular protein metabolic process Source: Reactome
  • cellular zinc ion homeostasis Source: UniProtKB
  • cobalt ion transport Source: MGI
  • regulation of proton transport Source: UniProtKB
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: UniProtKB
  • transmembrane transport Source: Reactome
  • zinc II ion transmembrane transport Source: GOC
  • zinc II ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-HSA-264876. Insulin processing.
R-HSA-435368. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.4.3. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 5
Short name:
ZnT-5
Alternative name(s):
Solute carrier family 30 member 5
ZnT-like transporter 1
Short name:
hZTL1
Gene namesi
Name:SLC30A5
Synonyms:ZNT5, ZNTL1, ZTL1
ORF Names:UNQ863/PRO1879
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19089. SLC30A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 563ExtracellularSequence analysis
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 9821CytoplasmicSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Topological domaini120 – 1201ExtracellularSequence analysis
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Topological domaini142 – 15211CytoplasmicSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Topological domaini174 – 19320ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence analysisAdd
BLAST
Topological domaini215 – 23824CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 2678ExtracellularSequence analysis
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Topological domaini289 – 30315CytoplasmicSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Topological domaini325 – 34218ExtracellularSequence analysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence analysisAdd
BLAST
Topological domaini364 – 41855CytoplasmicSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Topological domaini440 – 4489ExtracellularSequence analysis
Transmembranei449 – 46921HelicalSequence analysisAdd
BLAST
Topological domaini470 – 48314CytoplasmicSequence analysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence analysisAdd
BLAST
Topological domaini505 – 52016ExtracellularSequence analysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence analysisAdd
BLAST
Topological domaini542 – 59251CytoplasmicSequence analysisAdd
BLAST
Transmembranei593 – 61321HelicalSequence analysisAdd
BLAST
Topological domaini614 – 6174ExtracellularSequence analysis
Transmembranei618 – 63821HelicalSequence analysisAdd
BLAST
Topological domaini639 – 765127CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • Golgi apparatus Source: BHF-UCL
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: MGI
  • nucleolus Source: HPA
  • nucleus Source: HPA
  • secretory granule Source: MGI
  • secretory granule membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134865113.

Polymorphism and mutation databases

BioMutaiSLC30A5.
DMDMi74723898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Zinc transporter 5PRO_0000314293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TAD4.
MaxQBiQ8TAD4.
PaxDbiQ8TAD4.
PRIDEiQ8TAD4.

PTM databases

iPTMnetiQ8TAD4.
PhosphoSiteiQ8TAD4.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.2 Publications

Inductioni

Down-regulated by ZNF658 in response to zinc.2 Publications

Gene expression databases

BgeeiQ8TAD4.
CleanExiHS_SLC30A5.
ExpressionAtlasiQ8TAD4. baseline and differential.
GenevisibleiQ8TAD4. HS.

Organism-specific databases

HPAiHPA035373.

Interactioni

Subunit structurei

Heterooligomer. Interacts with ZNT6.1 Publication

Protein-protein interaction databases

BioGridi122346. 33 interactions.
IntActiQ8TAD4. 3 interactions.
STRINGi9606.ENSP00000379836.

Structurei

3D structure databases

ProteinModelPortaliQ8TAD4.
SMRiQ8TAD4. Positions 422-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni542 – 57837His-rich loopAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 209Poly-Gly

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000082502.
HOVERGENiHBG056637.
InParanoidiQ8TAD4.
KOiK14692.
OMAiICSVKME.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ8TAD4.
TreeFamiTF315217.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKYGGDVL AGPGGGGGLG PVDVPSARLT KYIVLLCFTK FLKAVGLFES
60 70 80 90 100
YDLLKAVHIV QFIFILKLGT AFFMVLFQKP FSSGKTITKH QWIKIFKHAV
110 120 130 140 150
AGCIISLLWF FGLTLCGPLR TLLLFEHSDI VVISLLSVLF TSSGGGPAKT
160 170 180 190 200
RGAAFFIIAV ICLLLFDNDD LMAKMAEHPE GHHDSALTHM LYTAIAFLGV
210 220 230 240 250
ADHKGGVLLL VLALCCKVGF HTASRKLSVD VGGAKRLQAL SHLVSVLLLC
260 270 280 290 300
PWVIVLSVTT ESKVESWFSL IMPFATVIFF VMILDFYVDS ICSVKMEVSK
310 320 330 340 350
CARYGSFPIF ISALLFGNFW THPITDQLRA MNKAAHQEST EHVLSGGVVV
360 370 380 390 400
SAIFFILSAN ILSSPSKRGQ KGTLIGYSPE GTPLYNFMGD AFQHSSQSIP
410 420 430 440 450
RFIKESLKQI LEESDSRQIF YFLCLNLLFT FVELFYGVLT NSLGLISDGF
460 470 480 490 500
HMLFDCSALV MGLFAALMSR WKATRIFSYG YGRIEILSGF INGLFLIVIA
510 520 530 540 550
FFVFMESVAR LIDPPELDTH MLTPVSVGGL IVNLIGICAF SHAHSHAHGA
560 570 580 590 600
SQGSCHSSDH SHSHHMHGHS DHGHGHSHGS AGGGMNANMR GVFLHVLADT
610 620 630 640 650
LGSIGVIVST VLIEQFGWFI ADPLCSLFIA ILIFLSVVPL IKDACQVLLL
660 670 680 690 700
RLPPEYEKEL HIALEKIQKI EGLISYRDPH FWRHSASIVA GTIHIQVTSD
710 720 730 740 750
VLEQRIVQQV TGILKDAGVN NLTIQVEKEA YFQHMSGLST GFHDVLAMTK
760
QMESMKYCKD GTYIM
Length:765
Mass (Da):84,047
Last modified:June 1, 2002 - v1
Checksum:iCD96BB6D710DF42D
GO
Isoform 2 (identifier: Q8TAD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     667-694: IQKIEGLISYRDPHFWRHSASIVAGTIH → VLYVISSLLSSLKITFLKSLLEVKQTTK
     695-765: Missing.

Show »
Length:523
Mass (Da):57,399
Checksum:i836F358FAE631286
GO
Isoform 3 (identifier: Q8TAD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-118: WIKIFKHAVAGCIISLLWFFGLTLCGP → IIGSLKIPGRKEFKDKKLNDPRKLVGN
     119-765: Missing.

Note: No experimental confirmation available.
Show »
Length:118
Mass (Da):12,944
Checksum:i30E74D490B02E939
GO
Isoform 4 (identifier: Q8TAD4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-69: Missing.
     92-118: WIKIFKHAVAGCIISLLWFFGLTLCGP → IIGSLKIPGRKEFKDKKLNDPRKLVGN
     119-765: Missing.

Show »
Length:77
Mass (Da):8,216
Checksum:i92097FCAD51728A7
GO

Sequence cautioni

The sequence BAB14258.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031R → C in BAB14258 (PubMed:14702039).Curated
Sequence conflicti321 – 3211T → A in AAL84188 (PubMed:11937503).Curated
Sequence conflicti328 – 3281L → P in AAL84188 (PubMed:11937503).Curated
Sequence conflicti483 – 4831R → Q in BAB14258 (PubMed:14702039).Curated
Sequence conflicti628 – 6292FI → ST in AAQ88869 (PubMed:12975309).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 2. 1 PublicationVSP_030254Add
BLAST
Alternative sequencei29 – 6941Missing in isoform 4. 1 PublicationVSP_045115Add
BLAST
Alternative sequencei92 – 11827WIKIF…TLCGP → IIGSLKIPGRKEFKDKKLND PRKLVGN in isoform 3 and isoform 4. 1 PublicationVSP_043673Add
BLAST
Alternative sequencei119 – 765647Missing in isoform 3 and isoform 4. 1 PublicationVSP_043674Add
BLAST
Alternative sequencei667 – 69428IQKIE…AGTIH → VLYVISSLLSSLKITFLKSL LEVKQTTK in isoform 2. 1 PublicationVSP_030255Add
BLAST
Alternative sequencei695 – 76571Missing in isoform 2. 1 PublicationVSP_030256Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461760 mRNA. Translation: AAL96437.1.
AF439324 mRNA. Translation: AAL84188.1.
AY089991 mRNA. Translation: AAM09099.1.
AY358505 mRNA. Translation: AAQ88869.1.
AK022818 mRNA. Translation: BAB14258.1. Different initiation.
AK292925 mRNA. Translation: BAF85614.1.
BX537394 mRNA. Translation: CAD97636.1.
AC010273 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51307.1.
CH471137 Genomic DNA. Translation: EAW51309.1.
BC000808 mRNA. Translation: AAH00808.1.
BC008198 mRNA. Translation: AAH08198.2.
BC017441 mRNA. Translation: AAH17441.1.
BC130452 mRNA. Translation: AAI30453.1.
BC130454 mRNA. Translation: AAI30455.1.
BC144349 mRNA. Translation: AAI44350.1.
CCDSiCCDS34173.1. [Q8TAD4-3]
CCDS3996.1. [Q8TAD4-1]
CCDS58955.1. [Q8TAD4-4]
RefSeqiNP_001238898.1. NM_001251969.1. [Q8TAD4-4]
NP_075053.2. NM_022902.4. [Q8TAD4-1]
NP_076960.1. NM_024055.4. [Q8TAD4-3]
UniGeneiHs.631975.

Genome annotation databases

EnsembliENST00000380860; ENSP00000370241; ENSG00000145740. [Q8TAD4-3]
ENST00000396591; ENSP00000379836; ENSG00000145740. [Q8TAD4-1]
ENST00000502979; ENSP00000421251; ENSG00000145740. [Q8TAD4-4]
GeneIDi64924.
KEGGihsa:64924.
UCSCiuc003jvg.4. human. [Q8TAD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461760 mRNA. Translation: AAL96437.1.
AF439324 mRNA. Translation: AAL84188.1.
AY089991 mRNA. Translation: AAM09099.1.
AY358505 mRNA. Translation: AAQ88869.1.
AK022818 mRNA. Translation: BAB14258.1. Different initiation.
AK292925 mRNA. Translation: BAF85614.1.
BX537394 mRNA. Translation: CAD97636.1.
AC010273 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51307.1.
CH471137 Genomic DNA. Translation: EAW51309.1.
BC000808 mRNA. Translation: AAH00808.1.
BC008198 mRNA. Translation: AAH08198.2.
BC017441 mRNA. Translation: AAH17441.1.
BC130452 mRNA. Translation: AAI30453.1.
BC130454 mRNA. Translation: AAI30455.1.
BC144349 mRNA. Translation: AAI44350.1.
CCDSiCCDS34173.1. [Q8TAD4-3]
CCDS3996.1. [Q8TAD4-1]
CCDS58955.1. [Q8TAD4-4]
RefSeqiNP_001238898.1. NM_001251969.1. [Q8TAD4-4]
NP_075053.2. NM_022902.4. [Q8TAD4-1]
NP_076960.1. NM_024055.4. [Q8TAD4-3]
UniGeneiHs.631975.

3D structure databases

ProteinModelPortaliQ8TAD4.
SMRiQ8TAD4. Positions 422-514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122346. 33 interactions.
IntActiQ8TAD4. 3 interactions.
STRINGi9606.ENSP00000379836.

Protein family/group databases

TCDBi2.A.4.4.3. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiQ8TAD4.
PhosphoSiteiQ8TAD4.

Polymorphism and mutation databases

BioMutaiSLC30A5.
DMDMi74723898.

Proteomic databases

EPDiQ8TAD4.
MaxQBiQ8TAD4.
PaxDbiQ8TAD4.
PRIDEiQ8TAD4.

Protocols and materials databases

DNASUi64924.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380860; ENSP00000370241; ENSG00000145740. [Q8TAD4-3]
ENST00000396591; ENSP00000379836; ENSG00000145740. [Q8TAD4-1]
ENST00000502979; ENSP00000421251; ENSG00000145740. [Q8TAD4-4]
GeneIDi64924.
KEGGihsa:64924.
UCSCiuc003jvg.4. human. [Q8TAD4-1]

Organism-specific databases

CTDi64924.
GeneCardsiSLC30A5.
HGNCiHGNC:19089. SLC30A5.
HPAiHPA035373.
MIMi607819. gene.
neXtProtiNX_Q8TAD4.
PharmGKBiPA134865113.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000082502.
HOVERGENiHBG056637.
InParanoidiQ8TAD4.
KOiK14692.
OMAiICSVKME.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ8TAD4.
TreeFamiTF315217.

Enzyme and pathway databases

ReactomeiR-HSA-264876. Insulin processing.
R-HSA-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

ChiTaRSiSLC30A5. human.
GenomeRNAii64924.
NextBioi67071.
PROiQ8TAD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAD4.
CleanExiHS_SLC30A5.
ExpressionAtlasiQ8TAD4. baseline and differential.
GenevisibleiQ8TAD4. HS.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells."
    Kambe T., Narita H., Yamaguchi-Iwai Y., Hirose J., Amano T., Sugiura N., Sasaki R., Mori K., Iwanaga T., Nagao M.
    J. Biol. Chem. 277:19049-19055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane."
    Cragg R.A., Christie G.R., Phillips S.R., Russi R.M., Kuery S., Mathers J.C., Taylor P.M., Ford D.
    J. Biol. Chem. 277:22789-22797(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  3. "Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study."
    Devergnas S., Chimienti F., Naud N., Pennequin A., Coquerel Y., Chantegrel J., Favier A., Seve M.
    Biochem. Pharmacol. 68:699-709(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INDUCTION.
    Tissue: Heart.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma and Trachea.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon endothelium.
  7. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 104-765 (ISOFORM 1).
    Tissue: Brain, Placenta and Uterus.
  10. "Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells."
    Suzuki T., Ishihara K., Migaki H., Ishihara K., Nagao M., Yamaguchi-Iwai Y., Kambe T.
    J. Biol. Chem. 280:30956-30962(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ZNT6.
  11. "Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane."
    Suzuki T., Ishihara K., Migaki H., Matsuura W., Kohda A., Okumura K., Nagao M., Yamaguchi-Iwai Y., Kambe T.
    J. Biol. Chem. 280:637-643(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "The zinc finger protein ZNF658 regulates the transcription of genes involved in zinc homeostasis and affects ribosome biogenesis through the zinc transcriptional regulatory element."
    Ogo O.A., Tyson J., Cockell S.J., Howard A., Valentine R.A., Ford D.
    Mol. Cell. Biol. 35:977-987(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiZNT5_HUMAN
AccessioniPrimary (citable) accession number: Q8TAD4
Secondary accession number(s): B7ZM89
, Q6UX54, Q7L4M4, Q8TDG3, Q9BVY8, Q9H9H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.