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Protein

Interleukin-17D

Gene

IL17D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17D
Short name:
IL-17D
Alternative name(s):
Interleukin-27
Short name:
IL-27
Gene namesi
Name:IL17D
Synonyms:IL27
ORF Names:UNQ3096/PRO21175
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:5984. IL17D.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29798.

Polymorphism and mutation databases

BioMutaiIL17D.
DMDMi46576614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 202187Interleukin-17DPRO_0000015430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TAD2.
PRIDEiQ8TAD2.

PTM databases

PhosphoSiteiQ8TAD2.

Expressioni

Tissue specificityi

Expressed preferentially in adipose, skeletal muscle and CNS.1 Publication

Gene expression databases

BgeeiQ8TAD2.
CleanExiHS_IL17D.
HS_IL27.
ExpressionAtlasiQ8TAD2. baseline and differential.
GenevisibleiQ8TAD2. HS.

Organism-specific databases

HPAiHPA060475.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302924.

Structurei

3D structure databases

ProteinModelPortaliQ8TAD2.
SMRiQ8TAD2. Positions 89-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42020.
GeneTreeiENSGT00730000110983.
HOGENOMiHOG000049074.
HOVERGENiHBG058772.
InParanoidiQ8TAD2.
KOiK05492.
OMAiGGRHSYT.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ8TAD2.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TAD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV
60 70 80 90 100
LSAFHHTLQL GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY
110 120 130 140 150
DPARYPRYLP EAYCLCRGCL TGLFGEEDVR FRSAPVYMPT VVLRRTPACA
160 170 180 190 200
GGRSVYTEAY VTIPVGCTCV PEPEKDADSI NSSIDKQGAK LLLGPNDAPA

GP
Length:202
Mass (Da):21,893
Last modified:June 1, 2002 - v1
Checksum:iD171C5FB2DD039C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781A → G in AAQ89471 (PubMed:12975309).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078238 mRNA. Translation: AAL86911.1.
AF479775 mRNA. Translation: AAM12734.1.
AF458062 mRNA. Translation: AAM77566.1.
AY359113 mRNA. Translation: AAQ89471.1.
AL161772, AL512652 Genomic DNA. Translation: CAH70875.1.
AL512652, AL161772 Genomic DNA. Translation: CAH71796.1.
CH471075 Genomic DNA. Translation: EAX08276.1.
BC036243 mRNA. Translation: AAH36243.1.
CCDSiCCDS9292.1.
RefSeqiNP_612141.1. NM_138284.1.
UniGeneiHs.655142.

Genome annotation databases

EnsembliENST00000304920; ENSP00000302924; ENSG00000172458.
GeneIDi53342.
KEGGihsa:53342.
UCSCiuc001unm.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078238 mRNA. Translation: AAL86911.1.
AF479775 mRNA. Translation: AAM12734.1.
AF458062 mRNA. Translation: AAM77566.1.
AY359113 mRNA. Translation: AAQ89471.1.
AL161772, AL512652 Genomic DNA. Translation: CAH70875.1.
AL512652, AL161772 Genomic DNA. Translation: CAH71796.1.
CH471075 Genomic DNA. Translation: EAX08276.1.
BC036243 mRNA. Translation: AAH36243.1.
CCDSiCCDS9292.1.
RefSeqiNP_612141.1. NM_138284.1.
UniGeneiHs.655142.

3D structure databases

ProteinModelPortaliQ8TAD2.
SMRiQ8TAD2. Positions 89-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302924.

PTM databases

PhosphoSiteiQ8TAD2.

Polymorphism and mutation databases

BioMutaiIL17D.
DMDMi46576614.

Proteomic databases

PaxDbiQ8TAD2.
PRIDEiQ8TAD2.

Protocols and materials databases

DNASUi53342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304920; ENSP00000302924; ENSG00000172458.
GeneIDi53342.
KEGGihsa:53342.
UCSCiuc001unm.3. human.

Organism-specific databases

CTDi53342.
GeneCardsiGC13P021276.
HGNCiHGNC:5984. IL17D.
HPAiHPA060475.
MIMi607587. gene.
neXtProtiNX_Q8TAD2.
PharmGKBiPA29798.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42020.
GeneTreeiENSGT00730000110983.
HOGENOMiHOG000049074.
HOVERGENiHBG058772.
InParanoidiQ8TAD2.
KOiK05492.
OMAiGGRHSYT.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ8TAD2.
TreeFamiTF314701.

Miscellaneous databases

GenomeRNAii53342.
NextBioi55976.
PROiQ8TAD2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAD2.
CleanExiHS_IL17D.
HS_IL27.
ExpressionAtlasiQ8TAD2. baseline and differential.
GenevisibleiQ8TAD2. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interleukin 27 (IL27): a newly identified cytokine."
    Hadj-Slimane R., Bobe P.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis."
    Starnes T., Broxmeyer H.E., Robertson M.J., Hromas R.
    J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 169:642-646(2002)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. Gilbert J.M., Gorman D.M.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiIL17D_HUMAN
AccessioniPrimary (citable) accession number: Q8TAD2
Secondary accession number(s): B1AM69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.