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Q8TAD2

- IL17D_HUMAN

UniProt

Q8TAD2 - IL17D_HUMAN

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Protein

Interleukin-17D

Gene
IL17D, IL27, UNQ3096/PRO21175
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells.1 Publication

GO - Biological processi

  1. inflammatory response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17D
Short name:
IL-17D
Alternative name(s):
Interleukin-27
Short name:
IL-27
Gene namesi
Name:IL17D
Synonyms:IL27
ORF Names:UNQ3096/PRO21175
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:5984. IL17D.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed predictionAdd
BLAST
Chaini16 – 202187Interleukin-17DPRO_0000015430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TAD2.
PRIDEiQ8TAD2.

PTM databases

PhosphoSiteiQ8TAD2.

Expressioni

Tissue specificityi

Expressed preferentially in adipose, skeletal muscle and CNS.1 Publication

Gene expression databases

BgeeiQ8TAD2.
CleanExiHS_IL17D.
HS_IL27.
GenevestigatoriQ8TAD2.

Organism-specific databases

HPAiHPA060475.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302924.

Structurei

3D structure databases

ProteinModelPortaliQ8TAD2.
SMRiQ8TAD2. Positions 89-170.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42020.
HOGENOMiHOG000049074.
HOVERGENiHBG058772.
InParanoidiQ8TAD2.
KOiK05492.
OMAiISPWAYR.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ8TAD2.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TAD2-1 [UniParc]FASTAAdd to Basket

« Hide

MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV    50
LSAFHHTLQL GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY 100
DPARYPRYLP EAYCLCRGCL TGLFGEEDVR FRSAPVYMPT VVLRRTPACA 150
GGRSVYTEAY VTIPVGCTCV PEPEKDADSI NSSIDKQGAK LLLGPNDAPA 200
GP 202
Length:202
Mass (Da):21,893
Last modified:June 1, 2002 - v1
Checksum:iD171C5FB2DD039C3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781A → G in AAQ89471. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY078238 mRNA. Translation: AAL86911.1.
AF479775 mRNA. Translation: AAM12734.1.
AF458062 mRNA. Translation: AAM77566.1.
AY359113 mRNA. Translation: AAQ89471.1.
AL161772, AL512652 Genomic DNA. Translation: CAH70875.1.
AL512652, AL161772 Genomic DNA. Translation: CAH71796.1.
CH471075 Genomic DNA. Translation: EAX08276.1.
BC036243 mRNA. Translation: AAH36243.1.
CCDSiCCDS9292.1.
RefSeqiNP_612141.1. NM_138284.1.
UniGeneiHs.655142.

Genome annotation databases

EnsembliENST00000304920; ENSP00000302924; ENSG00000172458.
GeneIDi53342.
KEGGihsa:53342.
UCSCiuc001unm.3. human.

Polymorphism databases

DMDMi46576614.

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY078238 mRNA. Translation: AAL86911.1 .
AF479775 mRNA. Translation: AAM12734.1 .
AF458062 mRNA. Translation: AAM77566.1 .
AY359113 mRNA. Translation: AAQ89471.1 .
AL161772 , AL512652 Genomic DNA. Translation: CAH70875.1 .
AL512652 , AL161772 Genomic DNA. Translation: CAH71796.1 .
CH471075 Genomic DNA. Translation: EAX08276.1 .
BC036243 mRNA. Translation: AAH36243.1 .
CCDSi CCDS9292.1.
RefSeqi NP_612141.1. NM_138284.1.
UniGenei Hs.655142.

3D structure databases

ProteinModelPortali Q8TAD2.
SMRi Q8TAD2. Positions 89-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000302924.

PTM databases

PhosphoSitei Q8TAD2.

Polymorphism databases

DMDMi 46576614.

Proteomic databases

PaxDbi Q8TAD2.
PRIDEi Q8TAD2.

Protocols and materials databases

DNASUi 53342.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304920 ; ENSP00000302924 ; ENSG00000172458 .
GeneIDi 53342.
KEGGi hsa:53342.
UCSCi uc001unm.3. human.

Organism-specific databases

CTDi 53342.
GeneCardsi GC13P021276.
HGNCi HGNC:5984. IL17D.
HPAi HPA060475.
MIMi 607587. gene.
neXtProti NX_Q8TAD2.
PharmGKBi PA29798.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42020.
HOGENOMi HOG000049074.
HOVERGENi HBG058772.
InParanoidi Q8TAD2.
KOi K05492.
OMAi ISPWAYR.
OrthoDBi EOG7KSX9Z.
PhylomeDBi Q8TAD2.
TreeFami TF314701.

Miscellaneous databases

GenomeRNAii 53342.
NextBioi 55976.
PROi Q8TAD2.
SOURCEi Search...

Gene expression databases

Bgeei Q8TAD2.
CleanExi HS_IL17D.
HS_IL27.
Genevestigatori Q8TAD2.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view ]
PANTHERi PTHR21295. PTHR21295. 1 hit.
Pfami PF06083. IL17. 1 hit.
[Graphical view ]
PRINTSi PR01932. INTRLEUKIN17.
SUPFAMi SSF57501. SSF57501. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interleukin 27 (IL27): a newly identified cytokine."
    Hadj-Slimane R., Bobe P.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis."
    Starnes T., Broxmeyer H.E., Robertson M.J., Hromas R.
    J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 169:642-646(2002)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. Gilbert J.M., Gorman D.M.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiIL17D_HUMAN
AccessioniPrimary (citable) accession number: Q8TAD2
Secondary accession number(s): B1AM69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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