Q8TAD2 (IL17D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17D
Short name=IL-17D

Alternative name(s):
Interleukin-27
Short name=IL-27

Gene names

Name:	IL17D
Synonyms:	IL27
ORF Names:	UNQ3096/PRO21175

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. Ref.2
Subcellular location	Secreted.
Tissue specificity	Expressed preferentially in adipose, skeletal muscle and CNS. Ref.2
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 202	187	Interleukin-17D		PRO_0000015430
Amino acid modifications
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	78	1	A → G in AAQ89471. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8TAD2 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: D171C5FB2DD039C3	FASTA	202	21,893
	10 20 30 40 50 60 MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV LSAFHHTLQL 70 80 90 100 110 120 GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY DPARYPRYLP EAYCLCRGCL 130 140 150 160 170 180 TGLFGEEDVR FRSAPVYMPT VVLRRTPACA GGRSVYTEAY VTIPVGCTCV PEPEKDADSI 190 200 NSSIDKQGAK LLLGPNDAPA GP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interleukin 27 (IL27): a newly identified cytokine." Hadj-Slimane R., Bobe P. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis." Starnes T., Broxmeyer H.E., Robertson M.J., Hromas R. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 169:642-646(2002) Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[3]	Gilbert J.M., Gorman D.M. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY078238 mRNA. Translation: AAL86911.1. AF479775 mRNA. Translation: AAM12734.1. AF458062 mRNA. Translation: AAM77566.1. AY359113 mRNA. Translation: AAQ89471.1. AL161772, AL512652 Genomic DNA. Translation: CAH70875.1. AL512652, AL161772 Genomic DNA. Translation: CAH71796.1. CH471075 Genomic DNA. Translation: EAX08276.1. BC036243 mRNA. Translation: AAH36243.1.
IPI	IPI00152038.
RefSeq	NP_612141.1. NM_138284.1.
UniGene	Hs.655142.
3D structure databases
ProteinModelPortal	Q8TAD2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000302924.
PTM databases
PhosphoSite	Q8TAD2.
Polymorphism databases
DMDM	46576614.
Proteomic databases
PaxDb	Q8TAD2.
PRIDE	Q8TAD2.
Protocols and materials databases
DNASU	53342.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304920; ENSP00000302924; ENSG00000172458.
GeneID	53342.
KEGG	hsa:53342.
UCSC	uc001unm.3. human.
Organism-specific databases
CTD	53342.
GeneCards	GC13P021276.
HGNC	HGNC:5984. IL17D.
MIM	607587. gene.
neXtProt	NX_Q8TAD2.
PharmGKB	PA29798.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42020.
HOGENOM	HOG000049074.
HOVERGEN	HBG058772.
InParanoid	Q8TAD2.
KO	K05492.
OMA	ISPWAYR.
OrthoDB	EOG4Q84ZQ.
PhylomeDB	Q8TAD2.
Gene expression databases
Bgee	Q8TAD2.
CleanEx	HS_IL17D. HS_IL27.
Genevestigator	Q8TAD2.
GermOnline	ENSG00000172458. Homo sapiens.
Family and domain databases
InterPro	IPR010345. Interleukin-17. IPR020440. Interleukin-17_chordata. [Graphical view]
PANTHER	PTHR21295. PTHR21295. 1 hit.
Pfam	PF06083. IL17. 1 hit. [Graphical view]
PRINTS	PR01932. INTRLEUKIN17.
ProtoNet	Search...
Other
GenomeRNAi	53342.
NextBio	55976.
SOURCE	Search...

Entry information

Entry name

IL17D_HUMAN

Accession

Primary (citable) accession number: Q8TAD2
Secondary accession number(s): B1AM69

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.