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Q8TAD2 (IL17D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17D

Short name=IL-17D
Alternative name(s):
Interleukin-27
Short name=IL-27
Gene names
Name:IL17D
Synonyms:IL27
ORF Names:UNQ3096/PRO21175
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. Ref.2

Subcellular location

Secreted.

Tissue specificity

Expressed preferentially in adipose, skeletal muscle and CNS. Ref.2

Sequence similarities

Belongs to the IL-17 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinflammatory response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 202187Interleukin-17D
PRO_0000015430

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict781A → G in AAQ89471. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8TAD2 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: D171C5FB2DD039C3

FASTA20221,893
        10         20         30         40         50         60 
MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV LSAFHHTLQL 

        70         80         90        100        110        120 
GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY DPARYPRYLP EAYCLCRGCL 

       130        140        150        160        170        180 
TGLFGEEDVR FRSAPVYMPT VVLRRTPACA GGRSVYTEAY VTIPVGCTCV PEPEKDADSI 

       190        200 
NSSIDKQGAK LLLGPNDAPA GP 

« Hide

References

« Hide 'large scale' references
[1]"Interleukin 27 (IL27): a newly identified cytokine."
Hadj-Slimane R., Bobe P.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis."
Starnes T., Broxmeyer H.E., Robertson M.J., Hromas R.
J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 169:642-646(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[3]Gilbert J.M., Gorman D.M.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY078238 mRNA. Translation: AAL86911.1.
AF479775 mRNA. Translation: AAM12734.1.
AF458062 mRNA. Translation: AAM77566.1.
AY359113 mRNA. Translation: AAQ89471.1.
AL161772, AL512652 Genomic DNA. Translation: CAH70875.1.
AL512652, AL161772 Genomic DNA. Translation: CAH71796.1.
CH471075 Genomic DNA. Translation: EAX08276.1.
BC036243 mRNA. Translation: AAH36243.1.
CCDSCCDS9292.1.
RefSeqNP_612141.1. NM_138284.1.
UniGeneHs.655142.

3D structure databases

ProteinModelPortalQ8TAD2.
SMRQ8TAD2. Positions 89-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000302924.

PTM databases

PhosphoSiteQ8TAD2.

Polymorphism databases

DMDM46576614.

Proteomic databases

PaxDbQ8TAD2.
PRIDEQ8TAD2.

Protocols and materials databases

DNASU53342.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304920; ENSP00000302924; ENSG00000172458.
GeneID53342.
KEGGhsa:53342.
UCSCuc001unm.3. human.

Organism-specific databases

CTD53342.
GeneCardsGC13P021276.
HGNCHGNC:5984. IL17D.
HPAHPA060475.
MIM607587. gene.
neXtProtNX_Q8TAD2.
PharmGKBPA29798.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42020.
HOGENOMHOG000049074.
HOVERGENHBG058772.
InParanoidQ8TAD2.
KOK05492.
OMAISPWAYR.
OrthoDBEOG7KSX9Z.
PhylomeDBQ8TAD2.
TreeFamTF314701.

Gene expression databases

BgeeQ8TAD2.
CleanExHS_IL17D.
HS_IL27.
GenevestigatorQ8TAD2.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERPTHR21295. PTHR21295. 1 hit.
PfamPF06083. IL17. 1 hit.
[Graphical view]
PRINTSPR01932. INTRLEUKIN17.
SUPFAMSSF57501. SSF57501. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi53342.
NextBio55976.
PROQ8TAD2.
SOURCESearch...

Entry information

Entry nameIL17D_HUMAN
AccessionPrimary (citable) accession number: Q8TAD2
Secondary accession number(s): B1AM69
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM