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Protein

Sperm protein associated with the nucleus on the X chromosome E

Gene

SPANXE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome E
Alternative name(s):
Nuclear-associated protein SPAN-Xe
Short name:
SPANX-E
SPANX family member E
Gene namesi
Name:SPANXE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:18408. SPANXE.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Associated with nuclear craters.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Sperm protein associated with the nucleus on the X chromosome EPRO_0000189553Add
BLAST

Proteomic databases

PRIDEiQ8TAD1.

Expressioni

Tissue specificityi

Detected in testis, sperm and a melanoma cell line.1 Publication

Developmental stagei

Detected in round and elongating spermatids.1 Publication

Gene expression databases

ExpressionAtlasiQ8TAD1. baseline.
GenevestigatoriQ8TAD1.

Organism-specific databases

HPAiHPA046423.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi83 – 864Poly-Glu

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000111796.
HOVERGENiHBG059401.
InParanoidiQ8TAD1.
OMAiDMMPETP.
PhylomeDBiQ8TAD1.

Family and domain databases

InterProiIPR010007. SPANX_prot.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI
60 70 80 90
LVVRYRRNVK RTSPEELVND HARENRINPL QMEEEEFMEI MVEIPAK
Length:97
Mass (Da):10,982
Last modified:June 1, 2002 - v1
Checksum:iD253EC18FF9F8C6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681V → L.3 Publications
Corresponds to variant rs5953618 [ dbSNP | Ensembl ].
VAR_021164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457792 Genomic DNA. Translation: CAD29841.1.
AJ457795 mRNA. Translation: CAD29844.1.
AY787086 Genomic DNA. Translation: AAW47310.1.
AY787096 Genomic DNA. Translation: AAW47318.1.
AY787102 Genomic DNA. Translation: AAW47324.1.
AY787104 Genomic DNA. Translation: AAW47326.1.
AY787110 Genomic DNA. Translation: AAW47332.1.
AY787119 Genomic DNA. Translation: AAW47341.1.
DQ994211 Genomic DNA. Translation: ABK19852.1.
DQ994214 Genomic DNA. Translation: ABK19855.1.
DQ994217 Genomic DNA. Translation: ABK19858.1.
DQ994218 Genomic DNA. Translation: ABK19859.1.
DQ994219 Genomic DNA. Translation: ABK19860.1.
DQ994220 Genomic DNA. Translation: ABK19861.1.
DQ994222 Genomic DNA. Translation: ABK19863.1.
DQ994233 Genomic DNA. Translation: ABK19874.1.
DQ994234 Genomic DNA. Translation: ABK19875.1.
DQ994235 Genomic DNA. Translation: ABK19876.1.
EF101635 Genomic DNA. Translation: ABK96942.1.
EF101636 Genomic DNA. Translation: ABK96943.1.
EF101638 Genomic DNA. Translation: ABK96945.1.
EF101639 Genomic DNA. Translation: ABK96946.1.
EF101640 Genomic DNA. Translation: ABK96947.1.
EF101642 Genomic DNA. Translation: ABK96949.1.
EF101647 Genomic DNA. Translation: ABK96954.1.
EF101648 Genomic DNA. Translation: ABK96955.1.
EF101649 Genomic DNA. Translation: ABK96956.1.
EF101652 Genomic DNA. Translation: ABK96959.1.
EF101653 Genomic DNA. Translation: ABK96960.1.
EF101655 Genomic DNA. Translation: ABK96962.1.
EF101657 Genomic DNA. Translation: ABK96964.1.
EF101658 Genomic DNA. Translation: ABK96965.1.
BC005382 mRNA. Translation: AAH05382.1.
BC062672 mRNA. Translation: AAH62672.1.
RefSeqiNP_073152.2. NM_022661.3.
UniGeneiHs.375036.
Hs.558533.

Genome annotation databases

GeneIDi64663.
KEGGihsa:64663.
UCSCiuc004fbq.3. human.

Polymorphism databases

DMDMi85700154.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457792 Genomic DNA. Translation: CAD29841.1.
AJ457795 mRNA. Translation: CAD29844.1.
AY787086 Genomic DNA. Translation: AAW47310.1.
AY787096 Genomic DNA. Translation: AAW47318.1.
AY787102 Genomic DNA. Translation: AAW47324.1.
AY787104 Genomic DNA. Translation: AAW47326.1.
AY787110 Genomic DNA. Translation: AAW47332.1.
AY787119 Genomic DNA. Translation: AAW47341.1.
DQ994211 Genomic DNA. Translation: ABK19852.1.
DQ994214 Genomic DNA. Translation: ABK19855.1.
DQ994217 Genomic DNA. Translation: ABK19858.1.
DQ994218 Genomic DNA. Translation: ABK19859.1.
DQ994219 Genomic DNA. Translation: ABK19860.1.
DQ994220 Genomic DNA. Translation: ABK19861.1.
DQ994222 Genomic DNA. Translation: ABK19863.1.
DQ994233 Genomic DNA. Translation: ABK19874.1.
DQ994234 Genomic DNA. Translation: ABK19875.1.
DQ994235 Genomic DNA. Translation: ABK19876.1.
EF101635 Genomic DNA. Translation: ABK96942.1.
EF101636 Genomic DNA. Translation: ABK96943.1.
EF101638 Genomic DNA. Translation: ABK96945.1.
EF101639 Genomic DNA. Translation: ABK96946.1.
EF101640 Genomic DNA. Translation: ABK96947.1.
EF101642 Genomic DNA. Translation: ABK96949.1.
EF101647 Genomic DNA. Translation: ABK96954.1.
EF101648 Genomic DNA. Translation: ABK96955.1.
EF101649 Genomic DNA. Translation: ABK96956.1.
EF101652 Genomic DNA. Translation: ABK96959.1.
EF101653 Genomic DNA. Translation: ABK96960.1.
EF101655 Genomic DNA. Translation: ABK96962.1.
EF101657 Genomic DNA. Translation: ABK96964.1.
EF101658 Genomic DNA. Translation: ABK96965.1.
BC005382 mRNA. Translation: AAH05382.1.
BC062672 mRNA. Translation: AAH62672.1.
RefSeqiNP_073152.2. NM_022661.3.
UniGeneiHs.375036.
Hs.558533.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi85700154.

Proteomic databases

PRIDEiQ8TAD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64663.
KEGGihsa:64663.
UCSCiuc004fbq.3. human.

Organism-specific databases

CTDi64663.
GeneCardsiGC0XU900006.
HGNCiHGNC:18408. SPANXE.
HPAiHPA046423.
MIMi300671. gene.
neXtProtiNX_Q8TAD1.
PharmGKBiPA38327.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111796.
HOVERGENiHBG059401.
InParanoidiQ8TAD1.
OMAiDMMPETP.
PhylomeDBiQ8TAD1.

Miscellaneous databases

NextBioi89270.
PROiQ8TAD1.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ8TAD1. baseline.
GenevestigatoriQ8TAD1.

Family and domain databases

InterProiIPR010007. SPANX_prot.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."
    Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.
    Gene 309:125-133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  2. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
    Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
    Genome Res. 15:1477-1486(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
  3. "Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer."
    Larionov V., Kouprina N.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-68.
    Tissue: Bone marrow and Testis.

Entry informationi

Entry nameiSPNXE_HUMAN
AccessioniPrimary (citable) accession number: Q8TAD1
Secondary accession number(s): Q32WL2, Q32WM0, Q9BS24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:12758128, SPANXE has high homology to SPANXD and is identified in clone AC025096, though not represented so far in the human genome sequence. The number of copies in this gene family may change according to haplotypes.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.