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Q8TAD1

- SPNXE_HUMAN

UniProt

Q8TAD1 - SPNXE_HUMAN

Protein

Sperm protein associated with the nucleus on the X chromosome E

Gene

SPANXE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome E
    Alternative name(s):
    Nuclear-associated protein SPAN-Xe
    Short name:
    SPANX-E
    SPANX family member E
    Gene namesi
    Name:SPANXE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:18408. SPANXE.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Associated with nuclear craters.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38327.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9797Sperm protein associated with the nucleus on the X chromosome EPRO_0000189553Add
    BLAST

    Proteomic databases

    PRIDEiQ8TAD1.

    Expressioni

    Tissue specificityi

    Detected in testis, sperm and a melanoma cell line.1 Publication

    Developmental stagei

    Detected in round and elongating spermatids.1 Publication

    Gene expression databases

    GenevestigatoriQ8TAD1.

    Organism-specific databases

    HPAiHPA046423.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi83 – 864Poly-Glu

    Sequence similaritiesi

    Belongs to the SPAN-X family.Curated

    Phylogenomic databases

    HOVERGENiHBG059401.
    InParanoidiQ8TAD1.
    OMAiDMMPETP.
    PhylomeDBiQ8TAD1.

    Family and domain databases

    InterProiIPR010007. SPANX_prot.
    [Graphical view]
    PANTHERiPTHR23425. PTHR23425. 1 hit.
    PfamiPF07458. SPAN-X. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI   50
    LVVRYRRNVK RTSPEELVND HARENRINPL QMEEEEFMEI MVEIPAK 97
    Length:97
    Mass (Da):10,982
    Last modified:June 1, 2002 - v1
    Checksum:iD253EC18FF9F8C6A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681V → L.3 Publications
    Corresponds to variant rs5953618 [ dbSNP | Ensembl ].
    VAR_021164

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ457792 Genomic DNA. Translation: CAD29841.1.
    AJ457795 mRNA. Translation: CAD29844.1.
    AY787086 Genomic DNA. Translation: AAW47310.1.
    AY787096 Genomic DNA. Translation: AAW47318.1.
    AY787102 Genomic DNA. Translation: AAW47324.1.
    AY787104 Genomic DNA. Translation: AAW47326.1.
    AY787110 Genomic DNA. Translation: AAW47332.1.
    AY787119 Genomic DNA. Translation: AAW47341.1.
    DQ994211 Genomic DNA. Translation: ABK19852.1.
    DQ994214 Genomic DNA. Translation: ABK19855.1.
    DQ994217 Genomic DNA. Translation: ABK19858.1.
    DQ994218 Genomic DNA. Translation: ABK19859.1.
    DQ994219 Genomic DNA. Translation: ABK19860.1.
    DQ994220 Genomic DNA. Translation: ABK19861.1.
    DQ994222 Genomic DNA. Translation: ABK19863.1.
    DQ994233 Genomic DNA. Translation: ABK19874.1.
    DQ994234 Genomic DNA. Translation: ABK19875.1.
    DQ994235 Genomic DNA. Translation: ABK19876.1.
    EF101635 Genomic DNA. Translation: ABK96942.1.
    EF101636 Genomic DNA. Translation: ABK96943.1.
    EF101638 Genomic DNA. Translation: ABK96945.1.
    EF101639 Genomic DNA. Translation: ABK96946.1.
    EF101640 Genomic DNA. Translation: ABK96947.1.
    EF101642 Genomic DNA. Translation: ABK96949.1.
    EF101647 Genomic DNA. Translation: ABK96954.1.
    EF101648 Genomic DNA. Translation: ABK96955.1.
    EF101649 Genomic DNA. Translation: ABK96956.1.
    EF101652 Genomic DNA. Translation: ABK96959.1.
    EF101653 Genomic DNA. Translation: ABK96960.1.
    EF101655 Genomic DNA. Translation: ABK96962.1.
    EF101657 Genomic DNA. Translation: ABK96964.1.
    EF101658 Genomic DNA. Translation: ABK96965.1.
    BC005382 mRNA. Translation: AAH05382.1.
    BC062672 mRNA. Translation: AAH62672.1.
    RefSeqiNP_073152.2. NM_022661.3.
    UniGeneiHs.375036.
    Hs.558533.

    Genome annotation databases

    GeneIDi64663.
    KEGGihsa:171489.
    UCSCiuc004fbq.3. human.

    Polymorphism databases

    DMDMi85700154.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ457792 Genomic DNA. Translation: CAD29841.1 .
    AJ457795 mRNA. Translation: CAD29844.1 .
    AY787086 Genomic DNA. Translation: AAW47310.1 .
    AY787096 Genomic DNA. Translation: AAW47318.1 .
    AY787102 Genomic DNA. Translation: AAW47324.1 .
    AY787104 Genomic DNA. Translation: AAW47326.1 .
    AY787110 Genomic DNA. Translation: AAW47332.1 .
    AY787119 Genomic DNA. Translation: AAW47341.1 .
    DQ994211 Genomic DNA. Translation: ABK19852.1 .
    DQ994214 Genomic DNA. Translation: ABK19855.1 .
    DQ994217 Genomic DNA. Translation: ABK19858.1 .
    DQ994218 Genomic DNA. Translation: ABK19859.1 .
    DQ994219 Genomic DNA. Translation: ABK19860.1 .
    DQ994220 Genomic DNA. Translation: ABK19861.1 .
    DQ994222 Genomic DNA. Translation: ABK19863.1 .
    DQ994233 Genomic DNA. Translation: ABK19874.1 .
    DQ994234 Genomic DNA. Translation: ABK19875.1 .
    DQ994235 Genomic DNA. Translation: ABK19876.1 .
    EF101635 Genomic DNA. Translation: ABK96942.1 .
    EF101636 Genomic DNA. Translation: ABK96943.1 .
    EF101638 Genomic DNA. Translation: ABK96945.1 .
    EF101639 Genomic DNA. Translation: ABK96946.1 .
    EF101640 Genomic DNA. Translation: ABK96947.1 .
    EF101642 Genomic DNA. Translation: ABK96949.1 .
    EF101647 Genomic DNA. Translation: ABK96954.1 .
    EF101648 Genomic DNA. Translation: ABK96955.1 .
    EF101649 Genomic DNA. Translation: ABK96956.1 .
    EF101652 Genomic DNA. Translation: ABK96959.1 .
    EF101653 Genomic DNA. Translation: ABK96960.1 .
    EF101655 Genomic DNA. Translation: ABK96962.1 .
    EF101657 Genomic DNA. Translation: ABK96964.1 .
    EF101658 Genomic DNA. Translation: ABK96965.1 .
    BC005382 mRNA. Translation: AAH05382.1 .
    BC062672 mRNA. Translation: AAH62672.1 .
    RefSeqi NP_073152.2. NM_022661.3.
    UniGenei Hs.375036.
    Hs.558533.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 85700154.

    Proteomic databases

    PRIDEi Q8TAD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64663.
    KEGGi hsa:171489.
    UCSCi uc004fbq.3. human.

    Organism-specific databases

    CTDi 64663.
    GeneCardsi GC0XU900006.
    HGNCi HGNC:18408. SPANXE.
    HPAi HPA046423.
    MIMi 300671. gene.
    neXtProti NX_Q8TAD1.
    PharmGKBi PA38327.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG059401.
    InParanoidi Q8TAD1.
    OMAi DMMPETP.
    PhylomeDBi Q8TAD1.

    Miscellaneous databases

    GenomeRNAii 171489.
    NextBioi 89270.
    PROi Q8TAD1.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8TAD1.

    Family and domain databases

    InterProi IPR010007. SPANX_prot.
    [Graphical view ]
    PANTHERi PTHR23425. PTHR23425. 1 hit.
    Pfami PF07458. SPAN-X. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."
      Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.
      Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    2. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
      Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
      Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
    3. "Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer."
      Larionov V., Kouprina N.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-68.
      Tissue: Bone marrow and Testis.

    Entry informationi

    Entry nameiSPNXE_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAD1
    Secondary accession number(s): Q32WL2, Q32WM0, Q9BS24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    According to PubMed:12758128, SPANXE has high homology to SPANXD and is identified in clone AC025096, though not represented so far in the human genome sequence. The number of copies in this gene family may change according to haplotypes.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3