Q8TAD1 (SPNXE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sperm protein associated with the nucleus on the X chromosome E

Alternative name(s):
Nuclear-associated protein SPAN-Xe
Short name=SPANX-E
SPANX family member E

Gene names

Name:

SPANXE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Associated with nuclear craters By similarity.
Tissue specificity	Detected in testis, sperm and a melanoma cell line. Ref.1
Developmental stage	Detected in round and elongating spermatids. Ref.1
Sequence similarities	Belongs to the SPAN-X family.
Caution	According to Ref.1, SPANXE has high homology to SPANXD and is identified in clone AC025096, though not represented so far in the human genome sequence. The number of copies in this gene family may change according to haplotypes.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 97	97	Sperm protein associated with the nucleus on the X chromosome E		PRO_0000189553
Regions
	Motif	37 – 45	9	Nuclear localization signal Potential
	Compositional bias	83 – 86	4	Poly-Glu
Natural variations
	Natural variant	68	1	V → L. Ref.2 Ref.3 Ref.4 Corresponds to variant rs5953618 [ dbSNP | Ensembl ].		VAR_021164

Sequences

	Sequence		Length	Mass (Da)
	Q8TAD1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: D253EC18FF9F8C6A	FASTA	97	10,982
	10 20 30 40 50 60 MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI LVVRYRRNVK 70 80 90 RTSPEELVND HARENRINPL QMEEEEFMEI MVEIPAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines." Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P. Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[2]	"Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27." Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V. Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
[3]	"Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer." Larionov V., Kouprina N. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-68. Tissue: Bone marrow and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ457792 Genomic DNA. Translation: CAD29841.1. AJ457795 mRNA. Translation: CAD29844.1. AY787086 Genomic DNA. Translation: AAW47310.1. AY787096 Genomic DNA. Translation: AAW47318.1. AY787102 Genomic DNA. Translation: AAW47324.1. AY787104 Genomic DNA. Translation: AAW47326.1. AY787110 Genomic DNA. Translation: AAW47332.1. AY787119 Genomic DNA. Translation: AAW47341.1. DQ994211 Genomic DNA. Translation: ABK19852.1. DQ994214 Genomic DNA. Translation: ABK19855.1. DQ994217 Genomic DNA. Translation: ABK19858.1. DQ994218 Genomic DNA. Translation: ABK19859.1. DQ994219 Genomic DNA. Translation: ABK19860.1. DQ994220 Genomic DNA. Translation: ABK19861.1. DQ994222 Genomic DNA. Translation: ABK19863.1. DQ994233 Genomic DNA. Translation: ABK19874.1. DQ994234 Genomic DNA. Translation: ABK19875.1. DQ994235 Genomic DNA. Translation: ABK19876.1. EF101635 Genomic DNA. Translation: ABK96942.1. EF101636 Genomic DNA. Translation: ABK96943.1. EF101638 Genomic DNA. Translation: ABK96945.1. EF101639 Genomic DNA. Translation: ABK96946.1. EF101640 Genomic DNA. Translation: ABK96947.1. EF101642 Genomic DNA. Translation: ABK96949.1. EF101647 Genomic DNA. Translation: ABK96954.1. EF101648 Genomic DNA. Translation: ABK96955.1. EF101649 Genomic DNA. Translation: ABK96956.1. EF101652 Genomic DNA. Translation: ABK96959.1. EF101653 Genomic DNA. Translation: ABK96960.1. EF101655 Genomic DNA. Translation: ABK96962.1. EF101657 Genomic DNA. Translation: ABK96964.1. EF101658 Genomic DNA. Translation: ABK96965.1. BC005382 mRNA. Translation: AAH05382.1. BC062672 mRNA. Translation: AAH62672.1.
IPI	IPI00152037.
RefSeq	NP_663698.1. NM_145665.1.
UniGene	Hs.375036.
3D structure databases
ModBase	Search...
Polymorphism databases
DMDM	85700154.
Proteomic databases
PRIDE	Q8TAD1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	171489.
KEGG	hsa:171489.
UCSC	uc004fbq.3. human.
Organism-specific databases
CTD	171489.
GeneCards	GC0XU900006.
HGNC	HGNC:18408. SPANXE.
HPA	HPA046423.
MIM	300671. gene.
neXtProt	NX_Q8TAD1.
PharmGKB	PA38327.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG059401.
InParanoid	Q8TAD1.
Gene expression databases
Genevestigator	Q8TAD1.
GermOnline	ENSG00000196406. Homo sapiens.
Family and domain databases
InterPro	IPR010007. SPANX_prot. [Graphical view]
PANTHER	PTHR23425. PTHR23425. 1 hit.
Pfam	PF07458. SPAN-X. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	171489.
NextBio	89270.
SOURCE	Search...

Entry information

Entry name

SPNXE_HUMAN

Accession

Primary (citable) accession number: Q8TAD1
Secondary accession number(s): Q32WL2, Q32WM0, Q9BS24

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.