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Q8TAD1 (SPNXE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sperm protein associated with the nucleus on the X chromosome E
Alternative name(s):
Nuclear-associated protein SPAN-Xe
Short name=SPANX-E
SPANX family member E
Gene names
Name:SPANXE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Associated with nuclear craters By similarity.

Tissue specificity

Detected in testis, sperm and a melanoma cell line. Ref.1

Developmental stage

Detected in round and elongating spermatids. Ref.1

Sequence similarities

Belongs to the SPAN-X family.

Caution

According to Ref.1, SPANXE has high homology to SPANXD and is identified in clone AC025096, though not represented so far in the human genome sequence. The number of copies in this gene family may change according to haplotypes.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from direct assay PubMed 21630459. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9797Sperm protein associated with the nucleus on the X chromosome E
PRO_0000189553

Regions

Motif37 – 459Nuclear localization signal Potential
Compositional bias83 – 864Poly-Glu

Natural variations

Natural variant681V → L. Ref.2 Ref.3 Ref.4
Corresponds to variant rs5953618 [ dbSNP | Ensembl ].
VAR_021164

Sequences

Sequence LengthMass (Da)Tools
Q8TAD1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: D253EC18FF9F8C6A

FASTA9710,982
        10         20         30         40         50         60 
MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI LVVRYRRNVK 

        70         80         90 
RTSPEELVND HARENRINPL QMEEEEFMEI MVEIPAK 

« Hide

References

« Hide 'large scale' references
[1]"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."
Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.
Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[2]"Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
[3]"Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer."
Larionov V., Kouprina N.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-68.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-68.
Tissue: Bone marrow and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ457792 Genomic DNA. Translation: CAD29841.1.
AJ457795 mRNA. Translation: CAD29844.1.
AY787086 Genomic DNA. Translation: AAW47310.1.
AY787096 Genomic DNA. Translation: AAW47318.1.
AY787102 Genomic DNA. Translation: AAW47324.1.
AY787104 Genomic DNA. Translation: AAW47326.1.
AY787110 Genomic DNA. Translation: AAW47332.1.
AY787119 Genomic DNA. Translation: AAW47341.1.
DQ994211 Genomic DNA. Translation: ABK19852.1.
DQ994214 Genomic DNA. Translation: ABK19855.1.
DQ994217 Genomic DNA. Translation: ABK19858.1.
DQ994218 Genomic DNA. Translation: ABK19859.1.
DQ994219 Genomic DNA. Translation: ABK19860.1.
DQ994220 Genomic DNA. Translation: ABK19861.1.
DQ994222 Genomic DNA. Translation: ABK19863.1.
DQ994233 Genomic DNA. Translation: ABK19874.1.
DQ994234 Genomic DNA. Translation: ABK19875.1.
DQ994235 Genomic DNA. Translation: ABK19876.1.
EF101635 Genomic DNA. Translation: ABK96942.1.
EF101636 Genomic DNA. Translation: ABK96943.1.
EF101638 Genomic DNA. Translation: ABK96945.1.
EF101639 Genomic DNA. Translation: ABK96946.1.
EF101640 Genomic DNA. Translation: ABK96947.1.
EF101642 Genomic DNA. Translation: ABK96949.1.
EF101647 Genomic DNA. Translation: ABK96954.1.
EF101648 Genomic DNA. Translation: ABK96955.1.
EF101649 Genomic DNA. Translation: ABK96956.1.
EF101652 Genomic DNA. Translation: ABK96959.1.
EF101653 Genomic DNA. Translation: ABK96960.1.
EF101655 Genomic DNA. Translation: ABK96962.1.
EF101657 Genomic DNA. Translation: ABK96964.1.
EF101658 Genomic DNA. Translation: ABK96965.1.
BC005382 mRNA. Translation: AAH05382.1.
BC062672 mRNA. Translation: AAH62672.1.
RefSeqNP_073152.2. NM_022661.3.
UniGeneHs.375036.
Hs.558533.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM85700154.

Proteomic databases

PRIDEQ8TAD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID64663.
KEGGhsa:171489.
UCSCuc004fbq.3. human.

Organism-specific databases

GeneCardsGC0XU900006.
HGNCHGNC:18408. SPANXE.
HPAHPA046423.
MIM300671. gene.
neXtProtNX_Q8TAD1.
PharmGKBPA38327.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG059401.
InParanoidQ8TAD1.
OMADMMPETP.
PhylomeDBQ8TAD1.

Gene expression databases

GenevestigatorQ8TAD1.

Family and domain databases

InterProIPR010007. SPANX_prot.
[Graphical view]
PANTHERPTHR23425. PTHR23425. 1 hit.
PfamPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi171489.
NextBio89270.
PROQ8TAD1.
SOURCESearch...

Entry information

Entry nameSPNXE_HUMAN
AccessionPrimary (citable) accession number: Q8TAD1
Secondary accession number(s): Q32WL2, Q32WM0, Q9BS24
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM