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Protein

Secretory carrier-associated membrane protein 5

Gene

SCAMP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.1 Publication

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • negative regulation of endocytosis Source: UniProtKB
  • positive regulation of calcium ion-dependent exocytosis Source: UniProtKB
  • positive regulation of cytokine secretion Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • response to endoplasmic reticulum stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-31073-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 5
Short name:
Secretory carrier membrane protein 5
Short name:
hSCAMP5
Gene namesi
Name:SCAMP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:30386. SCAMP5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 67ExtracellularSequence analysis7
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 102CytoplasmicSequence analysisAdd BLAST14
Transmembranei103 – 125HelicalSequence analysisAdd BLAST23
Topological domaini126 – 148ExtracellularSequence analysisAdd BLAST23
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 235CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • Golgi membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • recycling endosome membrane Source: UniProtKB
  • synaptic vesicle membrane Source: UniProtKB-SubCell
  • trans-Golgi network membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi192683.
OpenTargetsiENSG00000198794.
PharmGKBiPA134962580.

Polymorphism and mutation databases

BioMutaiSCAMP5.
DMDMi47117253.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912621 – 235Secretory carrier-associated membrane protein 5Add BLAST235

Proteomic databases

MaxQBiQ8TAC9.
PaxDbiQ8TAC9.
PeptideAtlasiQ8TAC9.
PRIDEiQ8TAC9.

PTM databases

iPTMnetiQ8TAC9.
PhosphoSitePlusiQ8TAC9.
SwissPalmiQ8TAC9.

Expressioni

Tissue specificityi

Expressed both by neuronal and non-neuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculata of the cortex region (at protein level).1 Publication

Inductioni

By endoplasmic reticulum stress.1 Publication

Gene expression databases

BgeeiENSG00000198794.
CleanExiHS_SCAMP5.
ExpressionAtlasiQ8TAC9. baseline and differential.
GenevisibleiQ8TAC9. HS.

Organism-specific databases

HPAiHPA046645.

Interactioni

Subunit structurei

Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Syt1P460962EBI-2695784,EBI-445340From a different organism.
Syt2P460972EBI-2695784,EBI-457969From a different organism.

Protein-protein interaction databases

BioGridi128182. 4 interactors.
IntActiQ8TAC9. 10 interactors.
MINTiMINT-4723804.
STRINGi9606.ENSP00000355387.

Structurei

3D structure databases

ProteinModelPortaliQ8TAC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family. SCAMP5 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiQ8TAC9.
KOiK19995.
OMAiQGAMQQN.
OrthoDBiEOG091G0ID2.
PhylomeDBiQ8TAC9.
TreeFamiTF313797.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEKVNNFPP LPKFIPLKPC FYQDFEADIP PQHVSMTKRL YYLWMLNSVT
60 70 80 90 100
LAVNLVGCLA WLIGGGGATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD
110 120 130 140 150
SSFSFMAFFF TFMAQLVISI IQAVGIPGWG VCGWIATISF FGTNIGSAVV
160 170 180 190 200
MLIPTVMFTV MAVFSFIALS MVHKFYRGSG GSFSKAQEEW TTGAWKNPHV
210 220 230
QQAAQNAAMG AAQGAMNQPQ TQYSATPNYT YSNEM
Length:235
Mass (Da):26,104
Last modified:June 1, 2002 - v1
Checksum:iD3CFF3C9EF2FC6FF
GO
Isoform 2 (identifier: Q8TAC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-132: C → CPTLASSCS

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):26,851
Checksum:iA97414ADB7E732B3
GO
Isoform 3 (identifier: Q8TAC9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MAEKVNNFPP...WFRPIYKAFK → MFLPRLRGRYSSPACQHDQAPLLPLDV

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):17,932
Checksum:i2DD71AD52AA4C700
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0369341 – 98MAEKV…YKAFK → MFLPRLRGRYSSPACQHDQA PLLPLDV in isoform 3. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_010206132C → CPTLASSCS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495715 mRNA. Translation: AAM18052.1.
AK056438 mRNA. Translation: BAG51709.1.
AK126940 mRNA. Translation: BAG54404.1.
AK127480 mRNA. Translation: BAG54511.1.
AK301505 mRNA. Translation: BAH13498.1.
AL834226 mRNA. Translation: CAD38904.1.
CH471136 Genomic DNA. Translation: EAW99277.1.
CH471136 Genomic DNA. Translation: EAW99278.1.
CH471136 Genomic DNA. Translation: EAW99280.1.
CH471136 Genomic DNA. Translation: EAW99283.1.
BC024700 mRNA. Translation: AAH24700.1.
CCDSiCCDS45306.1. [Q8TAC9-1]
RefSeqiNP_001171582.1. NM_001178111.1. [Q8TAC9-1]
NP_001171583.1. NM_001178112.1. [Q8TAC9-1]
NP_620417.1. NM_138967.3. [Q8TAC9-1]
XP_006720484.1. XM_006720421.1. [Q8TAC9-1]
XP_006720485.1. XM_006720422.3. [Q8TAC9-3]
XP_016877478.1. XM_017021989.1. [Q8TAC9-3]
UniGeneiHs.374180.

Genome annotation databases

EnsembliENST00000361900; ENSP00000355387; ENSG00000198794. [Q8TAC9-1]
ENST00000425597; ENSP00000406547; ENSG00000198794. [Q8TAC9-1]
ENST00000562212; ENSP00000455313; ENSG00000198794. [Q8TAC9-2]
GeneIDi192683.
KEGGihsa:192683.
UCSCiuc002azk.3. human. [Q8TAC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495715 mRNA. Translation: AAM18052.1.
AK056438 mRNA. Translation: BAG51709.1.
AK126940 mRNA. Translation: BAG54404.1.
AK127480 mRNA. Translation: BAG54511.1.
AK301505 mRNA. Translation: BAH13498.1.
AL834226 mRNA. Translation: CAD38904.1.
CH471136 Genomic DNA. Translation: EAW99277.1.
CH471136 Genomic DNA. Translation: EAW99278.1.
CH471136 Genomic DNA. Translation: EAW99280.1.
CH471136 Genomic DNA. Translation: EAW99283.1.
BC024700 mRNA. Translation: AAH24700.1.
CCDSiCCDS45306.1. [Q8TAC9-1]
RefSeqiNP_001171582.1. NM_001178111.1. [Q8TAC9-1]
NP_001171583.1. NM_001178112.1. [Q8TAC9-1]
NP_620417.1. NM_138967.3. [Q8TAC9-1]
XP_006720484.1. XM_006720421.1. [Q8TAC9-1]
XP_006720485.1. XM_006720422.3. [Q8TAC9-3]
XP_016877478.1. XM_017021989.1. [Q8TAC9-3]
UniGeneiHs.374180.

3D structure databases

ProteinModelPortaliQ8TAC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128182. 4 interactors.
IntActiQ8TAC9. 10 interactors.
MINTiMINT-4723804.
STRINGi9606.ENSP00000355387.

PTM databases

iPTMnetiQ8TAC9.
PhosphoSitePlusiQ8TAC9.
SwissPalmiQ8TAC9.

Polymorphism and mutation databases

BioMutaiSCAMP5.
DMDMi47117253.

Proteomic databases

MaxQBiQ8TAC9.
PaxDbiQ8TAC9.
PeptideAtlasiQ8TAC9.
PRIDEiQ8TAC9.

Protocols and materials databases

DNASUi192683.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361900; ENSP00000355387; ENSG00000198794. [Q8TAC9-1]
ENST00000425597; ENSP00000406547; ENSG00000198794. [Q8TAC9-1]
ENST00000562212; ENSP00000455313; ENSG00000198794. [Q8TAC9-2]
GeneIDi192683.
KEGGihsa:192683.
UCSCiuc002azk.3. human. [Q8TAC9-1]

Organism-specific databases

CTDi192683.
DisGeNETi192683.
GeneCardsiSCAMP5.
HGNCiHGNC:30386. SCAMP5.
HPAiHPA046645.
MIMi613766. gene.
neXtProtiNX_Q8TAC9.
OpenTargetsiENSG00000198794.
PharmGKBiPA134962580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiQ8TAC9.
KOiK19995.
OMAiQGAMQQN.
OrthoDBiEOG091G0ID2.
PhylomeDBiQ8TAC9.
TreeFamiTF313797.

Enzyme and pathway databases

BioCyciZFISH:G66-31073-MONOMER.

Miscellaneous databases

ChiTaRSiSCAMP5. human.
GeneWikiiSCAMP5.
GenomeRNAii192683.
PROiQ8TAC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198794.
CleanExiHS_SCAMP5.
ExpressionAtlasiQ8TAC9. baseline and differential.
GenevisibleiQ8TAC9. HS.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM5_HUMAN
AccessioniPrimary (citable) accession number: Q8TAC9
Secondary accession number(s): B3KPJ7
, B7Z762, D3DW71, Q8N3M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.