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Protein

Rieske domain-containing protein

Gene

RFESD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

[2Fe-2S] clusterPROSITE-ProRule annotationNote: Binds 1 [2Fe-2S] cluster per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi59Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi80Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi83Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rieske domain-containing protein
Gene namesi
Name:RFESD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29587. RFESD.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175449.
PharmGKBiPA162401171.

Polymorphism and mutation databases

BioMutaiRFESD.
DMDMi74730342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138131 – 157Rieske domain-containing proteinAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TAC1.
MaxQBiQ8TAC1.
PaxDbiQ8TAC1.
PeptideAtlasiQ8TAC1.
PRIDEiQ8TAC1.

PTM databases

iPTMnetiQ8TAC1.
PhosphoSitePlusiQ8TAC1.

Expressioni

Gene expression databases

BgeeiENSG00000175449.
CleanExiHS_RFESD.
ExpressionAtlasiQ8TAC1. baseline and differential.
GenevisibleiQ8TAC1. HS.

Organism-specific databases

HPAiCAB016546.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HBQ1P091055EBI-10271664,EBI-10193656

Protein-protein interaction databases

BioGridi130435. 1 interactor.
IntActiQ8TAC1. 1 interactor.
STRINGi9606.ENSP00000369341.

Structurei

3D structure databases

ProteinModelPortaliQ8TAC1.
SMRiQ8TAC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 94Rieske 1PROSITE-ProRule annotationAdd BLAST79
Domaini17 – 131Rieske 2PROSITE-ProRule annotationAdd BLAST115

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWA6. Eukaryota.
ENOG4111Q5H. LUCA.
GeneTreeiENSGT00390000018225.
HOGENOMiHOG000128541.
HOVERGENiHBG061590.
InParanoidiQ8TAC1.
OMAiWCSKGVK.
OrthoDBiEOG091G0S2K.
PhylomeDBiQ8TAC1.
TreeFamiTF333320.

Family and domain databases

Gene3Di2.102.10.10. 1 hit.
InterProiView protein in InterPro
IPR017941. Rieske_2Fe-2S.
PfamiView protein in Pfam
PF00355. Rieske. 1 hit.
SUPFAMiSSF50022. SSF50022. 1 hit.
PROSITEiView protein in PROSITE
PS51296. RIESKE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLDGSAQDP EKREYSSVCV GREDDIKKSE RMTAVVHDRE VVIFYHKGEY
60 70 80 90 100
HAMDIRCYHS GGPLHLGDIE DFDGRPCIVC PWHKYKITLA TGEGLYQSIN
110 120 130 140 150
PKDPSAKPKW CSKGIKQRIH TVTVDNGNIY VTLSNEPFKC DSDFYATGDF

KVIKSSS
Length:157
Mass (Da):17,762
Last modified:June 1, 2002 - v1
Checksum:iE959948673E776F8
GO
Isoform 2 (identifier: Q8TAC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKCFRNCLRPSSLSTLPLQYGILFPKLLACLVHLHFGHFSSAVISVTSFYLSM

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):23,702
Checksum:iD917F08DC8C08536
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0444521M → MLKCFRNCLRPSSLSTLPLQ YGILFPKLLACLVHLHFGHF SSAVISVTSFYLSM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008547 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW96043.1.
CH471084 Genomic DNA. Translation: EAW96045.1.
BC024023 mRNA. Translation: AAH24023.1.
BC035110 mRNA. Translation: AAH35110.1.
BC048979 mRNA. Translation: AAH48979.1.
BM263054 mRNA. No translation available.
CCDSiCCDS4075.1. [Q8TAC1-1]
CCDS47248.1. [Q8TAC1-2]
RefSeqiNP_001124537.1. NM_001131065.1. [Q8TAC1-2]
NP_001124538.1. NM_001131066.1. [Q8TAC1-2]
NP_775498.1. NM_173362.3. [Q8TAC1-1]
XP_011541662.1. XM_011543360.2. [Q8TAC1-2]
XP_011541663.1. XM_011543361.2. [Q8TAC1-1]
XP_016864902.1. XM_017009413.1. [Q8TAC1-2]
UniGeneiHs.399758.

Genome annotation databases

EnsembliENST00000311364; ENSP00000309229; ENSG00000175449. [Q8TAC1-1]
ENST00000380005; ENSP00000369341; ENSG00000175449. [Q8TAC1-2]
ENST00000458310; ENSP00000413592; ENSG00000175449. [Q8TAC1-2]
GeneIDi317671.
KEGGihsa:317671.
UCSCiuc003klf.4. human. [Q8TAC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRFESD_HUMAN
AccessioniPrimary (citable) accession number: Q8TAC1
Secondary accession number(s): J3KPH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: March 15, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM