C1orf216

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UPF0500 protein C1orf216
Gene namesⁱ	Name:C1orf216
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26800. C1orf216.

HGNCⁱ

HGNC:26800. C1orf216.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000142686.
PharmGKBⁱ	PA162378892.

Polymorphism and mutation databases

BioMutaⁱ	C1orf216.
DMDMⁱ	74730336.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000309178	1 – 229	UPF0500 protein C1orf216Add BLAST		229

Proteomic databases

PaxDbⁱ	Q8TAB5.
PeptideAtlas More...PeptideAtlasⁱ	Q8TAB5.
PRIDEⁱ	Q8TAB5.

PTM databases

iPTMnetⁱ	Q8TAB5.
PhosphoSitePlusⁱ	Q8TAB5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000142686.
CleanExⁱ	HS_C1orf216.
Genevisibleⁱ	Q8TAB5. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028299. HPA031343.

HPAⁱ

HPA028299.
HPA031343.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117	3	EBI-747505,EBI-717810
AMOT	Q4VCS5-2	3	EBI-747505,EBI-3891843
CCDC114	Q96M63	5	EBI-747505,EBI-10173858
CCDC136	Q96JN2-2	3	EBI-747505,EBI-10171416
CDR2	Q01850	5	EBI-747505,EBI-1181367
CEP170P1	Q96L14	3	EBI-747505,EBI-743488
GGA1	Q9UJY5	3	EBI-747505,EBI-447141
KRT13	A1A4E9	3	EBI-747505,EBI-10171552
KRT15	P19012	4	EBI-747505,EBI-739566
KRT31	Q15323	5	EBI-747505,EBI-948001
KRT38	O76015	5	EBI-747505,EBI-1047263
KRT40	Q6A162	3	EBI-747505,EBI-10171697
LINC00521	Q8NCU1	3	EBI-747505,EBI-750686
MED4	Q9NPJ6	3	EBI-747505,EBI-394607
MTUS2	Q5JR59	4	EBI-747505,EBI-742948
MYRIP	Q8NFW9	5	EBI-747505,EBI-1759414
NMI	Q13287	3	EBI-747505,EBI-372942
NMI	Q8WTW2	3	EBI-747505,EBI-10174268
NRBF2	Q96F24	3	EBI-747505,EBI-2362014
NUP62	P37198	5	EBI-747505,EBI-347978
PSMC6	P62333	3	EBI-747505,EBI-357669
RALBP1	Q15311	5	EBI-747505,EBI-749285
TPM1	P09493	3	EBI-747505,EBI-351158
TPM3	P06753	3	EBI-747505,EBI-355607
TPM3	Q5VU62	3	EBI-747505,EBI-10184033
TRAF1	Q13077	5	EBI-747505,EBI-359224
TRIM54	Q9BYV2	3	EBI-747505,EBI-2130429
USHBP1	Q8N6Y0	6	EBI-747505,EBI-739895

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Protein-protein interaction databases

BioGridⁱ	126079. 28 interactors.
IntActⁱ	Q8TAB5. 68 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1439525.
STRINGⁱ	9606.ENSP00000425166.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TAB5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the UPF0500 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IKSK. Eukaryota. ENOG410Z0RG. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001867.
HOGENOMⁱ	HOG000111275.
HOVERGENⁱ	HBG107568.
InParanoidⁱ	Q8TAB5.
OMAⁱ	NENWHGM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GC9.
PhylomeDBⁱ	Q8TAB5.
TreeFamⁱ	TF335932.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027812. DUF4653.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15546. DUF4653. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8TAB5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFAIQPGLAE GGQFLGDPPP GLCQPELQPD SNSNFMASAK DANENWHGMP 
        60         70         80         90        100
GRVEPILRRS SSESPSDNQA FQAPGSPEEG VRSPPEGAEI PGAEPEKMGG 
       110        120        130        140        150
AGTVCSPLED NGYASSSLSI DSRSSSPEPA CGTPRGPGPP DPLLPSVAQA 
       160        170        180        190        200
VQHLQVQERY KEQEKEKHHV HLVMYRRLAL LQWIRGLQHQ LIDQQARLQE 
       210        220 
SFDTILDNRK ELIRCLQQRA APSRPQDQA

Length:229

Mass (Da):24,968

Last modified:June 1, 2002 - v1

Checksum:ⁱ281250E30DC4E730

GO

Sequence cautionⁱ

The sequence BAC04799 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	P → T in BAC04799 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096303 mRNA. Translation: BAC04755.1. AK096466 mRNA. Translation: BAC04799.1. Different initiation. CH471059 Genomic DNA. Translation: EAX07403.1. CH471059 Genomic DNA. Translation: EAX07404.1. BC026909 mRNA. Translation: AAH26909.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS395.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001335620.1. NM_001348691.1. NP_689587.1. NM_152374.1.
UniGeneⁱ	Hs.112023.

Genome annotation databases

Ensemblⁱ	ENST00000270815; ENSP00000425166; ENSG00000142686.
GeneIDⁱ	127703.
KEGGⁱ	hsa:127703.
UCSC genome browser More...UCSCⁱ	uc001bzh.2. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096303 mRNA. Translation: BAC04755.1. AK096466 mRNA. Translation: BAC04799.1. Different initiation. CH471059 Genomic DNA. Translation: EAX07403.1. CH471059 Genomic DNA. Translation: EAX07404.1. BC026909 mRNA. Translation: AAH26909.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS395.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001335620.1. NM_001348691.1. NP_689587.1. NM_152374.1.
UniGeneⁱ	Hs.112023.

3D structure databases

ProteinModelPortalⁱ	Q8TAB5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126079. 28 interactors.
IntActⁱ	Q8TAB5. 68 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1439525.
STRINGⁱ	9606.ENSP00000425166.

PTM databases

iPTMnetⁱ	Q8TAB5.
PhosphoSitePlusⁱ	Q8TAB5.

Polymorphism and mutation databases

BioMutaⁱ	C1orf216.
DMDMⁱ	74730336.

Proteomic databases

PaxDbⁱ	Q8TAB5.
PeptideAtlas More...PeptideAtlasⁱ	Q8TAB5.
PRIDEⁱ	Q8TAB5.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	127703.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000270815; ENSP00000425166; ENSG00000142686.
GeneIDⁱ	127703.
KEGGⁱ	hsa:127703.
UCSC genome browser More...UCSCⁱ	uc001bzh.2. human.

Organism-specific databases

CTDⁱ	127703.
GeneCardsⁱ	C1orf216.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26800. C1orf216.
Human Protein Atlas More...HPAⁱ	HPA028299. HPA031343.
neXtProtⁱ	NX_Q8TAB5.
Open Targets More...OpenTargetsⁱ	ENSG00000142686.
PharmGKBⁱ	PA162378892.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKSK. Eukaryota. ENOG410Z0RG. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001867.
HOGENOMⁱ	HOG000111275.
HOVERGENⁱ	HBG107568.
InParanoidⁱ	Q8TAB5.
OMAⁱ	NENWHGM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GC9.
PhylomeDBⁱ	Q8TAB5.
TreeFamⁱ	TF335932.

Miscellaneous databases

GenomeRNAiⁱ	127703.
Protein Ontology More...PROⁱ	PR:Q8TAB5.

Gene expression databases

Bgeeⁱ	ENSG00000142686.
CleanExⁱ	HS_C1orf216.
Genevisibleⁱ	Q8TAB5. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027812. DUF4653.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15546. DUF4653. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CA216_HUMAN
Accessionⁱ	Q8TAB5Primary (citable) accession number: Q8TAB5 Secondary accession number(s): D3DPS1, Q8N8N6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	June 1, 2002
	Last modified:	May 10, 2017
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TAB5 (CA216_HUMAN)

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UPF0500 protein C1orf216

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ