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Protein

UPF0500 protein C1orf216

Gene

C1orf216

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0500 protein C1orf216
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26800. C1orf216.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378892.

Polymorphism and mutation databases

BioMutaiC1orf216.
DMDMi74730336.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229UPF0500 protein C1orf216PRO_0000309178Add
BLAST

Proteomic databases

EPDiQ8TAB5.
PaxDbiQ8TAB5.
PeptideAtlasiQ8TAB5.
PRIDEiQ8TAB5.

PTM databases

iPTMnetiQ8TAB5.
PhosphoSiteiQ8TAB5.

Expressioni

Gene expression databases

BgeeiQ8TAB5.
CleanExiHS_C1orf216.
GenevisibleiQ8TAB5. HS.

Organism-specific databases

HPAiHPA028299.
HPA031343.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-747505,EBI-717810
AMOTQ4VCS5-23EBI-747505,EBI-3891843
CCDC114Q96M633EBI-747505,EBI-10173858
CCDC136Q96JN2-23EBI-747505,EBI-10171416
CDR2Q018503EBI-747505,EBI-1181367
GGA1Q9UJY53EBI-747505,EBI-447141
KRT13A1A4E93EBI-747505,EBI-10171552
KRT15P190124EBI-747505,EBI-739566
KRT31Q153233EBI-747505,EBI-948001
KRT38O760153EBI-747505,EBI-1047263
KRT40Q6A1623EBI-747505,EBI-10171697
LINC00521Q8NCU13EBI-747505,EBI-750686
MED4Q9NPJ63EBI-747505,EBI-394607
MTUS2Q5JR594EBI-747505,EBI-742948
MYRIPQ8NFW93EBI-747505,EBI-1759414
NMIQ132873EBI-747505,EBI-372942
NMIQ8WTW23EBI-747505,EBI-10174268
NRBF2Q96F243EBI-747505,EBI-2362014
NUP62P371983EBI-747505,EBI-347978
RALBP1Q153113EBI-747505,EBI-749285
TPM1P094933EBI-747505,EBI-351158
TPM3Q5VU623EBI-747505,EBI-10184033
TRAF1Q130773EBI-747505,EBI-359224
TRIM54Q9BYV23EBI-747505,EBI-2130429
USHBP1Q8N6Y04EBI-747505,EBI-739895

Protein-protein interaction databases

BioGridi126079. 28 interactions.
IntActiQ8TAB5. 30 interactions.
MINTiMINT-1439525.
STRINGi9606.ENSP00000425166.

Structurei

3D structure databases

ProteinModelPortaliQ8TAB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0500 family.Curated

Phylogenomic databases

eggNOGiENOG410IKSK. Eukaryota.
ENOG410Z0RG. LUCA.
GeneTreeiENSGT00390000001867.
HOGENOMiHOG000111275.
HOVERGENiHBG107568.
InParanoidiQ8TAB5.
OMAiIRGLQHQ.
OrthoDBiEOG7JX36W.
PhylomeDBiQ8TAB5.
TreeFamiTF335932.

Family and domain databases

InterProiIPR027812. DUF4653.
[Graphical view]
PfamiPF15546. DUF4653. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAIQPGLAE GGQFLGDPPP GLCQPELQPD SNSNFMASAK DANENWHGMP
60 70 80 90 100
GRVEPILRRS SSESPSDNQA FQAPGSPEEG VRSPPEGAEI PGAEPEKMGG
110 120 130 140 150
AGTVCSPLED NGYASSSLSI DSRSSSPEPA CGTPRGPGPP DPLLPSVAQA
160 170 180 190 200
VQHLQVQERY KEQEKEKHHV HLVMYRRLAL LQWIRGLQHQ LIDQQARLQE
210 220
SFDTILDNRK ELIRCLQQRA APSRPQDQA
Length:229
Mass (Da):24,968
Last modified:June 1, 2002 - v1
Checksum:i281250E30DC4E730
GO

Sequence cautioni

The sequence BAC04799.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191P → T in BAC04799 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096303 mRNA. Translation: BAC04755.1.
AK096466 mRNA. Translation: BAC04799.1. Different initiation.
CH471059 Genomic DNA. Translation: EAX07403.1.
CH471059 Genomic DNA. Translation: EAX07404.1.
BC026909 mRNA. Translation: AAH26909.1.
CCDSiCCDS395.1.
RefSeqiNP_689587.1. NM_152374.1.
XP_011538984.1. XM_011540682.1.
UniGeneiHs.112023.

Genome annotation databases

EnsembliENST00000270815; ENSP00000425166; ENSG00000142686.
GeneIDi127703.
KEGGihsa:127703.
UCSCiuc001bzh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096303 mRNA. Translation: BAC04755.1.
AK096466 mRNA. Translation: BAC04799.1. Different initiation.
CH471059 Genomic DNA. Translation: EAX07403.1.
CH471059 Genomic DNA. Translation: EAX07404.1.
BC026909 mRNA. Translation: AAH26909.1.
CCDSiCCDS395.1.
RefSeqiNP_689587.1. NM_152374.1.
XP_011538984.1. XM_011540682.1.
UniGeneiHs.112023.

3D structure databases

ProteinModelPortaliQ8TAB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126079. 28 interactions.
IntActiQ8TAB5. 30 interactions.
MINTiMINT-1439525.
STRINGi9606.ENSP00000425166.

PTM databases

iPTMnetiQ8TAB5.
PhosphoSiteiQ8TAB5.

Polymorphism and mutation databases

BioMutaiC1orf216.
DMDMi74730336.

Proteomic databases

EPDiQ8TAB5.
PaxDbiQ8TAB5.
PeptideAtlasiQ8TAB5.
PRIDEiQ8TAB5.

Protocols and materials databases

DNASUi127703.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270815; ENSP00000425166; ENSG00000142686.
GeneIDi127703.
KEGGihsa:127703.
UCSCiuc001bzh.2. human.

Organism-specific databases

CTDi127703.
GeneCardsiC1orf216.
HGNCiHGNC:26800. C1orf216.
HPAiHPA028299.
HPA031343.
neXtProtiNX_Q8TAB5.
PharmGKBiPA162378892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKSK. Eukaryota.
ENOG410Z0RG. LUCA.
GeneTreeiENSGT00390000001867.
HOGENOMiHOG000111275.
HOVERGENiHBG107568.
InParanoidiQ8TAB5.
OMAiIRGLQHQ.
OrthoDBiEOG7JX36W.
PhylomeDBiQ8TAB5.
TreeFamiTF335932.

Miscellaneous databases

GenomeRNAii127703.
PROiQ8TAB5.

Gene expression databases

BgeeiQ8TAB5.
CleanExiHS_C1orf216.
GenevisibleiQ8TAB5. HS.

Family and domain databases

InterProiIPR027812. DUF4653.
[Graphical view]
PfamiPF15546. DUF4653. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiCA216_HUMAN
AccessioniPrimary (citable) accession number: Q8TAB5
Secondary accession number(s): D3DPS1, Q8N8N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.