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Protein

Protocadherin-19

Gene

PCDH19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165194-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-19
Gene namesi
Name:PCDH19
Synonyms:KIAA1313
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14270. PCDH19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 678ExtracellularSequence analysisAdd BLAST657
Transmembranei679 – 699HelicalSequence analysisAdd BLAST21
Topological domaini700 – 1148CytoplasmicSequence analysisAdd BLAST449

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Epileptic encephalopathy, early infantile, 9 (EIEE9)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by seizure with onset in infancy or early childhood, cognitive impairment, and delayed development of variable severity in some patients. Additional features include autistic signs and psychosis. The disorder is sex-limited, with the phenotype being restricted to females.
See also OMIM:300088
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06747225L → P in EIEE9. 1 Publication1
Natural variantiVAR_06747372V → G in EIEE9. 1 Publication1
Natural variantiVAR_06484081L → R in EIEE9. 1 Publication1
Natural variantiVAR_064481121D → N in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064841141A → ASEA in EIEE9. 1
Natural variantiVAR_064842146T → R in EIEE9. 1 PublicationCorresponds to variant rs796052799dbSNPEnsembl.1
Natural variantiVAR_067474153A → T in EIEE9. 1 Publication1
Natural variantiVAR_067475190L → R in EIEE9. 1 Publication1
Natural variantiVAR_067476191V → L in EIEE9. 1 PublicationCorresponds to variant rs753757730dbSNPEnsembl.1
Natural variantiVAR_064482199E → Q in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064483203H → P in EIEE9; disease features overlapping with Dravet syndrome; associated with Cys-206. 1 Publication1
Natural variantiVAR_064484206F → C in EIEE9; disease features overlapping with Dravet syndrome; associated with Pro-203. 1 PublicationCorresponds to variant rs746274631dbSNPEnsembl.1
Natural variantiVAR_064843206F → Y in EIEE9. 1 Publication1
Natural variantiVAR_067477232N → S in EIEE9. 1 Publication1
Natural variantiVAR_067478234N → S in EIEE9. 1 Publication1
Natural variantiVAR_067479236P → S in EIEE9. 1 Publication1
Natural variantiVAR_064844249E → D in EIEE9. 1 Publication1
Natural variantiVAR_067480262A → D in EIEE9. 1 Publication1
Natural variantiVAR_064485276S → P in EIEE9. 1 Publication1
Natural variantiVAR_064486340N → S in EIEE9; disease features overlapping with Dravet syndrome. 5 PublicationsCorresponds to variant rs796052839dbSNPEnsembl.1
Natural variantiVAR_064845341D → E in EIEE9. 1 Publication1
Natural variantiVAR_067481344P → R in EIEE9. 1 Publication1
Natural variantiVAR_067482377D → E in EIEE9. 1 Publication1
Natural variantiVAR_064487377D → H in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064488404T → I in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064489414E → Q in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_067483433L → P in EIEE9. 1 Publication1
Natural variantiVAR_046484441V → E in EIEE9. 1 PublicationCorresponds to variant rs132630323dbSNPEnsembl.1
Natural variantiVAR_067484513G → R in EIEE9. 1 Publication1
Natural variantiVAR_064490543L → P in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_046485557N → K in EIEE9. 2 PublicationsCorresponds to variant rs267606933dbSNPEnsembl.1
Natural variantiVAR_064846561P → R in EIEE9. 1 PublicationCorresponds to variant rs796052819dbSNPEnsembl.1
Natural variantiVAR_064847567P → L in EIEE9. 1 Publication1
Natural variantiVAR_064848618D → N in EIEE9. 1 Publication1
Natural variantiVAR_067485642V → M in EIEE9. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNETi57526.
MalaCardsiPCDH19.
MIMi300088. phenotype.
OpenTargetsiENSG00000165194.
Orphaneti33069. Dravet syndrome.
101039. Female restricted epilepsy with intellectual disability.
PharmGKBiPA33003.

Polymorphism and mutation databases

BioMutaiPCDH19.
DMDMi73620979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000400322 – 1148Protocadherin-19Add BLAST1127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi420N-linked (GlcNAc...)Sequence analysis1
Glycosylationi485N-linked (GlcNAc...)Sequence analysis1
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Glycosylationi676N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TAB3.
MaxQBiQ8TAB3.
PaxDbiQ8TAB3.
PeptideAtlasiQ8TAB3.
PRIDEiQ8TAB3.
TopDownProteomicsiQ8TAB3-3. [Q8TAB3-3]

PTM databases

iPTMnetiQ8TAB3.
PhosphoSitePlusiQ8TAB3.

Expressioni

Tissue specificityi

Moderately expressed in all regions of the brain examined, with lowest levels found in the cerebellum. Moderate expression is also found in ovary, and low expression in all other tissues tested. Also detected in primary skin fibroblast.2 Publications

Developmental stagei

Expressed in developing cortical plate, amygdala and subcortical regions and in the ganglionic eminence.1 Publication

Gene expression databases

BgeeiENSG00000165194.
CleanExiHS_PCDH19.
GenevisibleiQ8TAB3. HS.

Organism-specific databases

HPAiHPA027533.

Interactioni

Protein-protein interaction databases

BioGridi121586. 2 interactors.
IntActiQ8TAB3. 1 interactor.
STRINGi9606.ENSP00000362125.

Structurei

3D structure databases

ProteinModelPortaliQ8TAB3.
SMRiQ8TAB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 129Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini130 – 238Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini239 – 346Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini350 – 453Cadherin 4PROSITE-ProRule annotationAdd BLAST104
Domaini454 – 563Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini569 – 672Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ8TAB3.
KOiK16499.
OMAiNEGFHCR.
OrthoDBiEOG091G00QD.
PhylomeDBiQ8TAB3.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030716. Protocadherin-19.
[Graphical view]
PANTHERiPTHR24028:SF40. PTHR24028:SF40. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESLLLPVLL LLAILWTQAA ALINLKYSVE EEQRAGTVIA NVAKDAREAG
60 70 80 90 100
FALDPRQASA FRVVSNSAPH LVDINPSSGL LVTKQKIDRD LLCRQSPKCI
110 120 130 140 150
ISLEVMSSSM EICVIKVEIK DLNDNAPSFP AAQIELEISE AASPGTRIPL
160 170 180 190 200
DSAYDPDSGS FGVQTYELTP NELFGLEIKT RGDGSRFAEL VVEKSLDRET
210 220 230 240 250
QSHYSFRITA LDGGDPPRLG TVGLSIKVTD SNDNNPVFSE STYAVSVPEN
260 270 280 290 300
SPPNTPVIRL NASDPDEGTN GQVVYSFYGY VNDRTRELFQ IDPHSGLVTV
310 320 330 340 350
TGALDYEEGH VYELDVQAKD LGPNSIPAHC KVTVSVLDTN DNPPVINLLS
360 370 380 390 400
VNSELVEVSE SAPPGYVIAL VRVSDRDSGL NGRVQCRLLG NVPFRLQEYE
410 420 430 440 450
SFSTILVDGR LDREQHDQYN LTIQARDGGV PMLQSAKSFT VLITDENDNH
460 470 480 490 500
PHFSKPYYQV IVQENNTPGA YLLSVSARDP DLGLNGSVSY QIVPSQVRDM
510 520 530 540 550
PVFTYVSINP NSGDIYALRS FNHEQTKAFE FKVLAKDGGL PSLQSNATVR
560 570 580 590 600
VIILDVNDNT PVITAPPLIN GTAEVYIPRN SGIGYLVTVV KAEDYDEGEN
610 620 630 640 650
GRVTYDMTEG DRGFFEIDQV NGEVRTTRTF GESSKSSYEL IVVAHDHGKT
660 670 680 690 700
SLSASALVLI YLSPALDAQE SMGSVNLSLI FIIALGSIAG ILFVTMIFVA
710 720 730 740 750
IKCKRDNKEI RTYNCSNCLT ITCLLGCFIK GQNSKCLHCI SVSPISEEQD
760 770 780 790 800
KKTEEKVSLR GKRIAEYSYG HQKKSSKKKK ISKNDIRLVP RDVEETDKMN
810 820 830 840 850
VVSCSSLTSS LNYFDYHQQT LPLGCRRSES TFLNVENQNT RNTSANHIYH
860 870 880 890 900
HSFNSQGPQQ PDLIINGVPL PETENYSFDS NYVNSRAHLI KSSSTFKDLE
910 920 930 940 950
GNSLKDSGHE ESDQTDSEHD VQRSLYCDTA VNDVLNTSVT SMGSQMPDHD
960 970 980 990 1000
QNEGFHCREE CRILGHSDRC WMPRNPMPIR SKSPEHVRNI IALSIEATAA
1010 1020 1030 1040 1050
DVEAYDDCGP TKRTFATFGK DVSDHPAEER PTLKGKRTVD VTICSPKVNS
1060 1070 1080 1090 1100
VIREAGNGCE AISPVTSPLH LKSSLPTKPS VSYTIALAPP ARDLEQYVNN
1110 1120 1130 1140
VNNGPTRPSE AEPRGADSEK VMHEVSPILK EGRNKESPGV KRLKDIVL
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:1,148
Mass (Da):126,253
Last modified:August 16, 2005 - v3
Checksum:iAF8721355A33C1C2
GO
Isoform 2 (identifier: Q8TAB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-762: Missing.

Show »
Length:1,101
Mass (Da):121,101
Checksum:i7457D37FD53992B2
GO
Isoform 3 (identifier: Q8TAB3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-762: Missing.
     892-892: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,100
Mass (Da):121,014
Checksum:iA7EAAFE2004383D7
GO

Sequence cautioni

The sequence CAH18133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI41393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI41394 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti868V → A in CAH18133 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06747225L → P in EIEE9. 1 Publication1
Natural variantiVAR_06747372V → G in EIEE9. 1 Publication1
Natural variantiVAR_06484081L → R in EIEE9. 1 Publication1
Natural variantiVAR_064481121D → N in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064841141A → ASEA in EIEE9. 1
Natural variantiVAR_064842146T → R in EIEE9. 1 PublicationCorresponds to variant rs796052799dbSNPEnsembl.1
Natural variantiVAR_067474153A → T in EIEE9. 1 Publication1
Natural variantiVAR_067475190L → R in EIEE9. 1 Publication1
Natural variantiVAR_067476191V → L in EIEE9. 1 PublicationCorresponds to variant rs753757730dbSNPEnsembl.1
Natural variantiVAR_064482199E → Q in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064483203H → P in EIEE9; disease features overlapping with Dravet syndrome; associated with Cys-206. 1 Publication1
Natural variantiVAR_064484206F → C in EIEE9; disease features overlapping with Dravet syndrome; associated with Pro-203. 1 PublicationCorresponds to variant rs746274631dbSNPEnsembl.1
Natural variantiVAR_064843206F → Y in EIEE9. 1 Publication1
Natural variantiVAR_067477232N → S in EIEE9. 1 Publication1
Natural variantiVAR_067478234N → S in EIEE9. 1 Publication1
Natural variantiVAR_067479236P → S in EIEE9. 1 Publication1
Natural variantiVAR_064844249E → D in EIEE9. 1 Publication1
Natural variantiVAR_067480262A → D in EIEE9. 1 Publication1
Natural variantiVAR_064485276S → P in EIEE9. 1 Publication1
Natural variantiVAR_064486340N → S in EIEE9; disease features overlapping with Dravet syndrome. 5 PublicationsCorresponds to variant rs796052839dbSNPEnsembl.1
Natural variantiVAR_064845341D → E in EIEE9. 1 Publication1
Natural variantiVAR_067481344P → R in EIEE9. 1 Publication1
Natural variantiVAR_067482377D → E in EIEE9. 1 Publication1
Natural variantiVAR_064487377D → H in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064488404T → I in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_064489414E → Q in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_067483433L → P in EIEE9. 1 Publication1
Natural variantiVAR_046484441V → E in EIEE9. 1 PublicationCorresponds to variant rs132630323dbSNPEnsembl.1
Natural variantiVAR_067484513G → R in EIEE9. 1 Publication1
Natural variantiVAR_064490543L → P in EIEE9; disease features overlapping with Dravet syndrome. 1 Publication1
Natural variantiVAR_046485557N → K in EIEE9. 2 PublicationsCorresponds to variant rs267606933dbSNPEnsembl.1
Natural variantiVAR_064846561P → R in EIEE9. 1 PublicationCorresponds to variant rs796052819dbSNPEnsembl.1
Natural variantiVAR_064847567P → L in EIEE9. 1 Publication1
Natural variantiVAR_064848618D → N in EIEE9. 1 Publication1
Natural variantiVAR_067485642V → M in EIEE9. 1 Publication1
Natural variantiVAR_064491958R → Q.1 PublicationCorresponds to variant rs748581653dbSNPEnsembl.1
Natural variantiVAR_067486980R → C.1 PublicationCorresponds to variant rs3764758dbSNPEnsembl.1
Natural variantiVAR_0674871094L → V.1 PublicationCorresponds to variant rs184545774dbSNPEnsembl.1
Natural variantiVAR_0644921107R → G.2 PublicationsCorresponds to variant rs191333060dbSNPEnsembl.1
Natural variantiVAR_0674881107R → H.1 PublicationCorresponds to variant rs200021840dbSNPEnsembl.1
Natural variantiVAR_0674891134N → H.2 PublicationsCorresponds to variant rs141816797dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015081716 – 762Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_054046892Missing in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF676096 mRNA. Translation: ABX58058.1.
AL355593 Genomic DNA. Translation: CAI41393.1. Different initiation.
AL355593 Genomic DNA. Translation: CAI41394.1. Different initiation.
CR749278 mRNA. Translation: CAH18133.1. Different initiation.
AB037734 mRNA. Translation: BAA92551.1.
CCDSiCCDS43976.1. [Q8TAB3-2]
CCDS48141.1. [Q8TAB3-3]
CCDS55462.1. [Q8TAB3-1]
RefSeqiNP_001098713.1. NM_001105243.1. [Q8TAB3-2]
NP_001171809.1. NM_001184880.1. [Q8TAB3-1]
NP_065817.2. NM_020766.2. [Q8TAB3-3]
UniGeneiHs.4993.

Genome annotation databases

EnsembliENST00000255531; ENSP00000255531; ENSG00000165194. [Q8TAB3-2]
ENST00000373034; ENSP00000362125; ENSG00000165194. [Q8TAB3-1]
ENST00000420881; ENSP00000400327; ENSG00000165194. [Q8TAB3-3]
GeneIDi57526.
KEGGihsa:57526.
UCSCiuc004efw.5. human. [Q8TAB3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

X-chromosome gene database Protocadherin 19 (PCDH19)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF676096 mRNA. Translation: ABX58058.1.
AL355593 Genomic DNA. Translation: CAI41393.1. Different initiation.
AL355593 Genomic DNA. Translation: CAI41394.1. Different initiation.
CR749278 mRNA. Translation: CAH18133.1. Different initiation.
AB037734 mRNA. Translation: BAA92551.1.
CCDSiCCDS43976.1. [Q8TAB3-2]
CCDS48141.1. [Q8TAB3-3]
CCDS55462.1. [Q8TAB3-1]
RefSeqiNP_001098713.1. NM_001105243.1. [Q8TAB3-2]
NP_001171809.1. NM_001184880.1. [Q8TAB3-1]
NP_065817.2. NM_020766.2. [Q8TAB3-3]
UniGeneiHs.4993.

3D structure databases

ProteinModelPortaliQ8TAB3.
SMRiQ8TAB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121586. 2 interactors.
IntActiQ8TAB3. 1 interactor.
STRINGi9606.ENSP00000362125.

PTM databases

iPTMnetiQ8TAB3.
PhosphoSitePlusiQ8TAB3.

Polymorphism and mutation databases

BioMutaiPCDH19.
DMDMi73620979.

Proteomic databases

EPDiQ8TAB3.
MaxQBiQ8TAB3.
PaxDbiQ8TAB3.
PeptideAtlasiQ8TAB3.
PRIDEiQ8TAB3.
TopDownProteomicsiQ8TAB3-3. [Q8TAB3-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255531; ENSP00000255531; ENSG00000165194. [Q8TAB3-2]
ENST00000373034; ENSP00000362125; ENSG00000165194. [Q8TAB3-1]
ENST00000420881; ENSP00000400327; ENSG00000165194. [Q8TAB3-3]
GeneIDi57526.
KEGGihsa:57526.
UCSCiuc004efw.5. human. [Q8TAB3-1]

Organism-specific databases

CTDi57526.
DisGeNETi57526.
GeneCardsiPCDH19.
H-InvDBHIX0016913.
HGNCiHGNC:14270. PCDH19.
HPAiHPA027533.
MalaCardsiPCDH19.
MIMi300088. phenotype.
300460. gene.
neXtProtiNX_Q8TAB3.
OpenTargetsiENSG00000165194.
Orphaneti33069. Dravet syndrome.
101039. Female restricted epilepsy with intellectual disability.
PharmGKBiPA33003.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ8TAB3.
KOiK16499.
OMAiNEGFHCR.
OrthoDBiEOG091G00QD.
PhylomeDBiQ8TAB3.
TreeFamiTF352008.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165194-MONOMER.

Miscellaneous databases

GenomeRNAii57526.
PROiQ8TAB3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165194.
CleanExiHS_PCDH19.
GenevisibleiQ8TAB3. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030716. Protocadherin-19.
[Graphical view]
PANTHERiPTHR24028:SF40. PTHR24028:SF40. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCD19_HUMAN
AccessioniPrimary (citable) accession number: Q8TAB3
Secondary accession number(s): B0LDS4
, E9PAM6, Q5JTG1, Q5JTG2, Q68DT7, Q9P2N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.