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Protein

Vang-like protein 1

Gene

VANGL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vang-like protein 1
Alternative name(s):
Loop-tail protein 2 homolog
Short name:
LPP2
Strabismus 2
Van Gogh-like protein 1
Gene namesi
Name:VANGL1
Synonyms:STB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15512. VANGL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini139 – 15113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini173 – 18210CytoplasmicSequence Analysis
Transmembranei183 – 20321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini204 – 22219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini244 – 524281CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Neural tube defects (NTD)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionCongenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.

See also OMIM:182940
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831S → L in NTD; unknown pathological significance. 1 Publication
Corresponds to variant rs146695372 [ dbSNP | Ensembl ].
VAR_062322
Natural varianti153 – 1531F → S in NTD; unknown pathological significance. 1 Publication
VAR_062323
Natural varianti181 – 1811R → Q in NTD; unknown pathological significance. 1 Publication
VAR_062325
Natural varianti202 – 2021L → F in NTD; unknown pathological significance. 1 Publication
VAR_062326
Natural varianti274 – 2741R → Q in NTD; does not abolish ability to interact with DVL1, DVL2 and DVL3. 1 Publication
VAR_035210
Natural varianti328 – 3281M → T in NTD; does not abolish ability to interact with DVL1, DVL2 and DVL3. 1 Publication
VAR_035211
Natural varianti404 – 4041A → S in NTD; unknown pathological significance. 1 Publication
VAR_062329
Sacral defect with anterior meningocele (SDAM)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionForm of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant.

See also OMIM:600145
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti239 – 2391V → I in SDAM; abolishes ability to interact with DVL1, DVL2 and DVL3. 1 Publication
VAR_035209

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi182940. phenotype.
600145. phenotype.
Orphaneti3027. Caudal regression sequence.
268392. Cervical spina bifida aperta.
268762. Cervical spina bifida cystica.
268397. Cervicothoracic spina bifida aperta.
268766. Cervicothoracic spina bifida cystica.
1768. Familial caudal dysgenesis.
268388. Lumbosacral spina bifida aperta.
268758. Lumbosacral spina bifida cystica.
268384. Thoracolumbosacral spina bifida aperta.
268752. Thoracolumbosacral spina bifida cystica.
268377. Total spina bifida aperta.
268748. Total spina bifida cystica.
268740. Upper thoracic spina bifida aperta.
268770. Upper thoracic spina bifida cystica.
PharmGKBiPA37971.

Polymorphism and mutation databases

BioMutaiVANGL1.
DMDMi38258809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Vang-like protein 1PRO_0000186193Add
BLAST

Proteomic databases

MaxQBiQ8TAA9.
PaxDbiQ8TAA9.
PRIDEiQ8TAA9.

PTM databases

PhosphoSiteiQ8TAA9.

Expressioni

Tissue specificityi

According to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.2 Publications

Gene expression databases

BgeeiQ8TAA9.
CleanExiHS_VANGL1.
ExpressionAtlasiQ8TAA9. baseline and differential.
GenevisibleiQ8TAA9. HS.

Organism-specific databases

HPAiHPA025235.

Interactioni

Subunit structurei

Heterodimer with VANGL2. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD82P277016EBI-682393,EBI-682379

Protein-protein interaction databases

BioGridi123595. 19 interactions.
IntActiQ8TAA9. 10 interactions.
STRINGi9606.ENSP00000310800.

Structurei

3D structure databases

ProteinModelPortaliQ8TAA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Vang family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268286.
GeneTreeiENSGT00390000012496.
HOGENOMiHOG000230590.
HOVERGENiHBG058215.
InParanoidiQ8TAA9.
KOiK04510.
OMAiKSVTIQP.
OrthoDBiEOG7MSMNR.
PhylomeDBiQ8TAA9.
TreeFamiTF313467.

Family and domain databases

InterProiIPR009539. Strabismus.
[Graphical view]
PANTHERiPTHR20886. PTHR20886. 1 hit.
PfamiPF06638. Strabismus. 1 hit.
[Graphical view]
PIRSFiPIRSF007991. Strabismus. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTESTYSGY SYYSSHSKKS HRQGERTRER HKSPRNKDGR GSEKSVTIQP
60 70 80 90 100
PTGEPLLGND STRTEEVQDD NWGETTTAIT GTSEHSISQE DIARISKDME
110 120 130 140 150
DSVGLDCKRY LGLTVASFLG LLVFLTPIAF ILLPPILWRD ELEPCGTICE
160 170 180 190 200
GLFISMAFKL LILLIGTWAL FFRKRRADMP RVFVFRALLL VLIFLFVVSY
210 220 230 240 250
WLFYGVRILD SRDRNYQGIV QYAVSLVDAL LFIHYLAIVL LELRQLQPMF
260 270 280 290 300
TLQVVRSTDG ESRFYSLGHL SIQRAALVVL ENYYKDFTIY NPNLLTASKF
310 320 330 340 350
RAAKHMAGLK VYNVDGPSNN ATGQSRAMIA AAARRRDSSH NELYYEEAEH
360 370 380 390 400
ERRVKKRKAR LVVAVEEAFI HIQRLQAEEQ QKAPGEVMDP REAAQAIFPS
410 420 430 440 450
MARALQKYLR ITRQQNYHSM ESILQHLAFC ITNGMTPKAF LERYLSAGPT
460 470 480 490 500
LQYDKDRWLS TQWRLVSDEA VTNGLRDGIV FVLKCLDFSL VVNVKKIPFI
510 520
ILSEEFIDPK SHKFVLRLQS ETSV
Length:524
Mass (Da):59,975
Last modified:June 1, 2002 - v1
Checksum:i65CB263D26274585
GO
Isoform 2 (identifier: Q8TAA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-68: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):59,748
Checksum:i8E06DD3BE2003F02
GO

Sequence cautioni

The sequence AAH32773.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251E → K.1 Publication
VAR_062321
Natural varianti83 – 831S → L in NTD; unknown pathological significance. 1 Publication
Corresponds to variant rs146695372 [ dbSNP | Ensembl ].
VAR_062322
Natural varianti116 – 1161A → T.1 Publication
Corresponds to variant rs4839469 [ dbSNP | Ensembl ].
VAR_027143
Natural varianti153 – 1531F → S in NTD; unknown pathological significance. 1 Publication
VAR_062323
Natural varianti175 – 1751R → Q.1 Publication
Corresponds to variant rs201441696 [ dbSNP | Ensembl ].
VAR_062324
Natural varianti181 – 1811R → Q in NTD; unknown pathological significance. 1 Publication
VAR_062325
Natural varianti202 – 2021L → F in NTD; unknown pathological significance. 1 Publication
VAR_062326
Natural varianti239 – 2391V → I in SDAM; abolishes ability to interact with DVL1, DVL2 and DVL3. 1 Publication
VAR_035209
Natural varianti251 – 2511T → M.1 Publication
VAR_062327
Natural varianti274 – 2741R → Q in NTD; does not abolish ability to interact with DVL1, DVL2 and DVL3. 1 Publication
VAR_035210
Natural varianti290 – 2901Y → H.1 Publication
VAR_062328
Natural varianti328 – 3281M → T in NTD; does not abolish ability to interact with DVL1, DVL2 and DVL3. 1 Publication
VAR_035211
Natural varianti347 – 3471E → A.
Corresponds to variant rs34059106 [ dbSNP | Ensembl ].
VAR_035435
Natural varianti404 – 4041A → S in NTD; unknown pathological significance. 1 Publication
VAR_062329
Natural varianti468 – 4681D → E.1 Publication
VAR_062330

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 682Missing in isoform 2. 1 PublicationVSP_008742

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075805 mRNA. Translation: BAB86362.1.
AB057596 mRNA. Translation: BAB86334.1.
AF481859 mRNA. Translation: AAO61751.1.
AL450389 Genomic DNA. Translation: CAI23371.1.
AL450389 Genomic DNA. Translation: CAI23372.1.
CH471122 Genomic DNA. Translation: EAW56630.1.
CH471122 Genomic DNA. Translation: EAW56631.1.
BC032773 mRNA. Translation: AAH32773.1. Different initiation.
BC065272 mRNA. Translation: AAH65272.1.
CCDSiCCDS53350.1. [Q8TAA9-2]
CCDS883.1. [Q8TAA9-1]
RefSeqiNP_001165882.1. NM_001172411.1. [Q8TAA9-2]
NP_001165883.1. NM_001172412.1. [Q8TAA9-1]
NP_620409.1. NM_138959.2. [Q8TAA9-1]
UniGeneiHs.515130.

Genome annotation databases

EnsembliENST00000310260; ENSP00000310800; ENSG00000173218. [Q8TAA9-1]
ENST00000355485; ENSP00000347672; ENSG00000173218. [Q8TAA9-1]
ENST00000369509; ENSP00000358522; ENSG00000173218. [Q8TAA9-1]
ENST00000369510; ENSP00000358523; ENSG00000173218. [Q8TAA9-2]
GeneIDi81839.
KEGGihsa:81839.
UCSCiuc001efv.1. human. [Q8TAA9-1]
uc009wgy.1. human. [Q8TAA9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075805 mRNA. Translation: BAB86362.1.
AB057596 mRNA. Translation: BAB86334.1.
AF481859 mRNA. Translation: AAO61751.1.
AL450389 Genomic DNA. Translation: CAI23371.1.
AL450389 Genomic DNA. Translation: CAI23372.1.
CH471122 Genomic DNA. Translation: EAW56630.1.
CH471122 Genomic DNA. Translation: EAW56631.1.
BC032773 mRNA. Translation: AAH32773.1. Different initiation.
BC065272 mRNA. Translation: AAH65272.1.
CCDSiCCDS53350.1. [Q8TAA9-2]
CCDS883.1. [Q8TAA9-1]
RefSeqiNP_001165882.1. NM_001172411.1. [Q8TAA9-2]
NP_001165883.1. NM_001172412.1. [Q8TAA9-1]
NP_620409.1. NM_138959.2. [Q8TAA9-1]
UniGeneiHs.515130.

3D structure databases

ProteinModelPortaliQ8TAA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123595. 19 interactions.
IntActiQ8TAA9. 10 interactions.
STRINGi9606.ENSP00000310800.

PTM databases

PhosphoSiteiQ8TAA9.

Polymorphism and mutation databases

BioMutaiVANGL1.
DMDMi38258809.

Proteomic databases

MaxQBiQ8TAA9.
PaxDbiQ8TAA9.
PRIDEiQ8TAA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310260; ENSP00000310800; ENSG00000173218. [Q8TAA9-1]
ENST00000355485; ENSP00000347672; ENSG00000173218. [Q8TAA9-1]
ENST00000369509; ENSP00000358522; ENSG00000173218. [Q8TAA9-1]
ENST00000369510; ENSP00000358523; ENSG00000173218. [Q8TAA9-2]
GeneIDi81839.
KEGGihsa:81839.
UCSCiuc001efv.1. human. [Q8TAA9-1]
uc009wgy.1. human. [Q8TAA9-2]

Organism-specific databases

CTDi81839.
GeneCardsiGC01P116184.
HGNCiHGNC:15512. VANGL1.
HPAiHPA025235.
MIMi182940. phenotype.
600145. phenotype.
610132. gene.
neXtProtiNX_Q8TAA9.
Orphaneti3027. Caudal regression sequence.
268392. Cervical spina bifida aperta.
268762. Cervical spina bifida cystica.
268397. Cervicothoracic spina bifida aperta.
268766. Cervicothoracic spina bifida cystica.
1768. Familial caudal dysgenesis.
268388. Lumbosacral spina bifida aperta.
268758. Lumbosacral spina bifida cystica.
268384. Thoracolumbosacral spina bifida aperta.
268752. Thoracolumbosacral spina bifida cystica.
268377. Total spina bifida aperta.
268748. Total spina bifida cystica.
268740. Upper thoracic spina bifida aperta.
268770. Upper thoracic spina bifida cystica.
PharmGKBiPA37971.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG268286.
GeneTreeiENSGT00390000012496.
HOGENOMiHOG000230590.
HOVERGENiHBG058215.
InParanoidiQ8TAA9.
KOiK04510.
OMAiKSVTIQP.
OrthoDBiEOG7MSMNR.
PhylomeDBiQ8TAA9.
TreeFamiTF313467.

Miscellaneous databases

ChiTaRSiVANGL1. human.
GenomeRNAii81839.
NextBioi72138.
PROiQ8TAA9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAA9.
CleanExiHS_VANGL1.
ExpressionAtlasiQ8TAA9. baseline and differential.
GenevisibleiQ8TAA9. HS.

Family and domain databases

InterProiIPR009539. Strabismus.
[Graphical view]
PANTHERiPTHR20886. PTHR20886. 1 hit.
PfamiPF06638. Strabismus. 1 hit.
[Graphical view]
PIRSFiPIRSF007991. Strabismus. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of Strabismus 2 (STB2)."
    Katoh M.
    Int. J. Oncol. 20:993-998(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma."
    Yagyu R., Hamamoto R., Furukawa Y., Okabe H., Yamamura T., Nakamura Y.
    Int. J. Oncol. 20:1173-1178(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Identification of LPP2, a second Vang-like protein."
    Doudney K., Paternotte C., Murdoch J.N., Copp A.J., Stanier P.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate and Skin.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralogue Vangl1 in neural tube defect patients."
    Doudney K., Ybot-Gonzalez P., Paternotte C., Stevenson R.E., Greene N.D., Moore G.E., Copp A.J., Stanier P.
    Am. J. Med. Genet. A 136:90-92(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-116.
  11. Cited for: VARIANT SDAM ILE-239, VARIANTS NTD GLN-274 AND THR-328, CHARACTERIZATION OF VARIANT SDAM ILE-239, CHARACTERIZATION OF VARIANTS NTD GLN-274 AND THR-328.
  12. Cited for: VARIANTS NTD LEU-83; SER-153; GLN-181; PHE-202 AND SER-404, VARIANTS LYS-25; GLN-175; MET-251; HIS-290 AND GLU-468.

Entry informationi

Entry nameiVANG1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAA9
Secondary accession number(s): Q5T1D3
, Q5T1D4, Q86WG8, Q8N559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2002
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.