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Protein

GrpE protein homolog 2, mitochondrial

Gene

GRPEL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 2, mitochondrial
Alternative name(s):
Mt-GrpE#2
Gene namesi
Name:GRPEL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164284.14.
HGNCiHGNC:21060. GRPEL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164284.
PharmGKBiPA134885090.

Polymorphism and mutation databases

BioMutaiGRPEL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionBy similarityAdd BLAST32
ChainiPRO_000001305233 – 225GrpE protein homolog 2, mitochondrialAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TAA5.
MaxQBiQ8TAA5.
PaxDbiQ8TAA5.
PeptideAtlasiQ8TAA5.
PRIDEiQ8TAA5.

PTM databases

iPTMnetiQ8TAA5.
PhosphoSitePlusiQ8TAA5.

Expressioni

Gene expression databases

BgeeiENSG00000164284.
CleanExiHS_GRPEL2.
ExpressionAtlasiQ8TAA5. baseline and differential.
GenevisibleiQ8TAA5. HS.

Organism-specific databases

HPAiHPA018173.
HPA023211.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126391. 11 interactors.
IntActiQ8TAA5. 1 interactor.
STRINGi9606.ENSP00000329558.

Structurei

3D structure databases

ProteinModelPortaliQ8TAA5.
SMRiQ8TAA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000069905.
HOVERGENiHBG051846.
InParanoidiQ8TAA5.
KOiK03687.
OMAiVPAEGMQ.
OrthoDBiEOG091G0O5D.
PhylomeDBiQ8TAA5.
TreeFamiTF105284.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiView protein in InterPro
IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiView protein in Pfam
PF01025. GrpE. 1 hit.
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiView protein in PROSITE
PS01071. GRPE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRSLWAGR LRVQRLLAWS AAWESKGWPL PFSTATQRTA GEDCRSEDPP
60 70 80 90 100
DELGPPLAER ALRVKAVKLE KEVQDLTVRY QRAIADCENI RRRTQRCVED
110 120 130 140 150
AKIFGIQSFC KDLVEVADIL EKTTECISEE SEPEDQKLTL EKVFRGLLLL
160 170 180 190 200
EAKLKSVFAK HGLEKLTPIG DKYDPHEHEL ICHVPAGVGV QPGTVALVRQ
210 220
DGYKLHGRTI RLARVEVAVE SQRRL
Length:225
Mass (Da):25,431
Last modified:June 1, 2002 - v1
Checksum:i8AC63CD9664593FC
GO
Isoform 2 (identifier: Q8TAA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-122: VRYQRAIADC...LVEVADILEK → ESRVSVRTWW...WRRSSEGCCF
     123-225: Missing.

Note: No experimental confirmation available.
Show »
Length:122
Mass (Da):14,277
Checksum:iBA5C335CBBBC1B28
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05702078 – 122VRYQR…DILEK → ESRVSVRTWWRWLTFWRRLQ SAFLKNRSLRTKSSLWRRSS EGCCF in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_057021123 – 225Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074293 mRNA. Translation: BAB85040.1.
AK294005 mRNA. Translation: BAG57367.1.
AC131025 Genomic DNA. No translation available.
BC036678 mRNA. Translation: AAH36678.1.
BC070090 mRNA. Translation: AAH70090.1.
CCDSiCCDS4295.1. [Q8TAA5-1]
RefSeqiNP_689620.2. NM_152407.3. [Q8TAA5-1]
UniGeneiHs.511816.

Genome annotation databases

EnsembliENST00000329271; ENSP00000329558; ENSG00000164284. [Q8TAA5-1]
ENST00000416916; ENSP00000397302; ENSG00000164284. [Q8TAA5-2]
GeneIDi134266.
KEGGihsa:134266.
UCSCiuc003lqj.4. human. [Q8TAA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGRPE2_HUMAN
AccessioniPrimary (citable) accession number: Q8TAA5
Secondary accession number(s): B4DFA6, Q49AJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families