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Q8TAA5

- GRPE2_HUMAN

UniProt

Q8TAA5 - GRPE2_HUMAN

Protein

GrpE protein homolog 2, mitochondrial

Gene

GRPEL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 By similarity.By similarity

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. protein folding Source: InterPro
    3. protein targeting to mitochondrion Source: Reactome

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_118595. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GrpE protein homolog 2, mitochondrial
    Alternative name(s):
    Mt-GrpE#2
    Gene namesi
    Name:GRPEL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:21060. GRPEL2.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134885090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3232MitochondrionBy similarityAdd
    BLAST
    Chaini33 – 225193GrpE protein homolog 2, mitochondrialPRO_0000013052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei142 – 1421N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8TAA5.
    PaxDbiQ8TAA5.
    PRIDEiQ8TAA5.

    PTM databases

    PhosphoSiteiQ8TAA5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TAA5.
    BgeeiQ8TAA5.
    CleanExiHS_GRPEL2.
    GenevestigatoriQ8TAA5.

    Organism-specific databases

    HPAiHPA018173.
    HPA023211.

    Interactioni

    Subunit structurei

    Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19.By similarity

    Protein-protein interaction databases

    BioGridi126391. 3 interactions.
    STRINGi9606.ENSP00000329558.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAA5.
    SMRiQ8TAA5. Positions 65-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GrpE family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0576.
    HOVERGENiHBG051846.
    InParanoidiQ8TAA5.
    KOiK03687.
    OMAiVPAEGMQ.
    PhylomeDBiQ8TAA5.
    TreeFamiTF105284.

    Family and domain databases

    Gene3Di2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPiMF_01151. GrpE.
    InterProiIPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view]
    PANTHERiPTHR21237. PTHR21237. 1 hit.
    PfamiPF01025. GrpE. 1 hit.
    [Graphical view]
    PRINTSiPR00773. GRPEPROTEIN.
    SUPFAMiSSF51064. SSF51064. 1 hit.
    PROSITEiPS01071. GRPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TAA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRSLWAGR LRVQRLLAWS AAWESKGWPL PFSTATQRTA GEDCRSEDPP    50
    DELGPPLAER ALRVKAVKLE KEVQDLTVRY QRAIADCENI RRRTQRCVED 100
    AKIFGIQSFC KDLVEVADIL EKTTECISEE SEPEDQKLTL EKVFRGLLLL 150
    EAKLKSVFAK HGLEKLTPIG DKYDPHEHEL ICHVPAGVGV QPGTVALVRQ 200
    DGYKLHGRTI RLARVEVAVE SQRRL 225
    Length:225
    Mass (Da):25,431
    Last modified:June 1, 2002 - v1
    Checksum:i8AC63CD9664593FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074293 mRNA. Translation: BAB85040.1.
    BC036678 mRNA. Translation: AAH36678.1.
    BC070090 mRNA. Translation: AAH70090.1.
    CCDSiCCDS4295.1.
    RefSeqiNP_689620.2. NM_152407.3.
    UniGeneiHs.511816.

    Genome annotation databases

    EnsembliENST00000329271; ENSP00000329558; ENSG00000164284.
    GeneIDi134266.
    KEGGihsa:134266.
    UCSCiuc003lqj.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074293 mRNA. Translation: BAB85040.1 .
    BC036678 mRNA. Translation: AAH36678.1 .
    BC070090 mRNA. Translation: AAH70090.1 .
    CCDSi CCDS4295.1.
    RefSeqi NP_689620.2. NM_152407.3.
    UniGenei Hs.511816.

    3D structure databases

    ProteinModelPortali Q8TAA5.
    SMRi Q8TAA5. Positions 65-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126391. 3 interactions.
    STRINGi 9606.ENSP00000329558.

    PTM databases

    PhosphoSitei Q8TAA5.

    Proteomic databases

    MaxQBi Q8TAA5.
    PaxDbi Q8TAA5.
    PRIDEi Q8TAA5.

    Protocols and materials databases

    DNASUi 134266.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329271 ; ENSP00000329558 ; ENSG00000164284 .
    GeneIDi 134266.
    KEGGi hsa:134266.
    UCSCi uc003lqj.3. human.

    Organism-specific databases

    CTDi 134266.
    GeneCardsi GC05P148705.
    HGNCi HGNC:21060. GRPEL2.
    HPAi HPA018173.
    HPA023211.
    neXtProti NX_Q8TAA5.
    PharmGKBi PA134885090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0576.
    HOVERGENi HBG051846.
    InParanoidi Q8TAA5.
    KOi K03687.
    OMAi VPAEGMQ.
    PhylomeDBi Q8TAA5.
    TreeFami TF105284.

    Enzyme and pathway databases

    Reactomei REACT_118595. Mitochondrial protein import.

    Miscellaneous databases

    GenomeRNAii 134266.
    NextBioi 83345.
    PROi Q8TAA5.

    Gene expression databases

    ArrayExpressi Q8TAA5.
    Bgeei Q8TAA5.
    CleanExi HS_GRPEL2.
    Genevestigatori Q8TAA5.

    Family and domain databases

    Gene3Di 2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPi MF_01151. GrpE.
    InterProi IPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view ]
    PANTHERi PTHR21237. PTHR21237. 1 hit.
    Pfami PF01025. GrpE. 1 hit.
    [Graphical view ]
    PRINTSi PR00773. GRPEPROTEIN.
    SUPFAMi SSF51064. SSF51064. 1 hit.
    PROSITEi PS01071. GRPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Placenta.
    3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGRPE2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAA5
    Secondary accession number(s): Q49AJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3