Q8TAA3 (PSA7L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type-7-like
EC=3.4.25.1

Gene names

Name:	PSMA8
Synonyms:	PSMA7L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. This may be a testis-specific subunit.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase T1A family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protease Threonine protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Traceable author statement. Source: Reactome M/G1 transition of mitotic cell cycle Traceable author statement. Source: Reactome S phase of mitotic cell cycle Traceable author statement. Source: Reactome anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome apoptotic process Traceable author statement. Source: Reactome gene expression Traceable author statement. Source: Reactome mRNA metabolic process Traceable author statement. Source: Reactome positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Traceable author statement. Source: Reactome protein polyubiquitination Traceable author statement. Source: Reactome regulation of apoptotic process Traceable author statement. Source: Reactome regulation of cellular amino acid metabolic process Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex, alpha-subunit complex Inferred from electronic annotation. Source: InterPro
Molecular_function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q8TAA3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Predicted but not yet described.

Isoform 2 (identifier: Q8TAA3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     40-83: Missing.

Isoform 3 (identifier: Q8TAA3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Proteasome subunit alpha type-7-like		PRO_0000124149
Natural variations
	Alternative sequence	40 – 83	44	Missing in isoform 2.		VSP_005285
	Alternative sequence	77 – 82	6	Missing in isoform 3.		VSP_018602
Experimental info
	Sequence conflict	212	1	K → R in AAH28371. Ref.4
	Sequence conflict	212	1	K → R in AAH28686. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 30, 2006. Version 3. Checksum: 6DD04535A98BE44A	FASTA	256	28,530
	10 20 30 40 50 60 MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT 70 80 90 100 110 120 VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ SHKLTVEDPV TVEYITRFIA 130 140 150 160 170 180 TLKQKYTQSN GRRPFGISAL IVGFDDDGIS RLYQTDPSGT YHAWKANAIG RSAKTVREFL 190 200 210 220 230 240 EKNYTEDAIA SDSEAIKLAI KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI 250 EKEKEEAEKK KSKKSV
	Isoform 2 [UniParc]. Checksum: 6C361094EFCC4BB2	FASTA	212	23,702
	10 20 30 40 50 60 MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGL TADARVVINR ARVECQSHKL 70 80 90 100 110 120 TVEDPVTVEY ITRFIATLKQ KYTQSNGRRP FGISALIVGF DDDGISRLYQ TDPSGTYHAW 130 140 150 160 170 180 KANAIGRSAK TVREFLEKNY TEDAIASDSE AIKLAIKALL EVVQSGGKNI ELAIIRRNQP 190 200 210 LKMFSAKEVE LYVTEIEKEK EEAEKKKSKK SV
	Isoform 3 [UniParc]. Checksum: C204707CF06D6D17	FASTA	250	27,843
	10 20 30 40 50 60 MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT 70 80 90 100 110 120 VRKICALDDH VCMAFAGLTA DARVVINRAR VECQSHKLTV EDPVTVEYIT RFIATLKQKY 130 140 150 160 170 180 TQSNGRRPFG ISALIVGFDD DGISRLYQTD PSGTYHAWKA NAIGRSAKTV REFLEKNYTE 190 200 210 220 230 240 DAIASDSEAI KLAIKALLEV VQSGGKNIEL AIIRRNQPLK MFSAKEVELY VTEIEKEKEE 250 AEKKKSKKSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF445014 Genomic DNA. Translation: ACA06053.1. AC091021 Genomic DNA. No translation available. AC016839 Genomic DNA. No translation available. CH471088 Genomic DNA. Translation: EAX01214.1. BC028371 mRNA. Translation: AAH28371.1. BC028686 mRNA. Translation: AAH28686.1. BC042820 mRNA. Translation: AAH42820.1.
IPI	IPI00154509. IPI00219950. IPI00748423.
RefSeq	NP_001020267.1. NM_001025096.1. NP_001020268.1. NM_001025097.1. NP_653263.2. NM_144662.2.
UniGene	Hs.464813.
3D structure databases
ProteinModelPortal	Q8TAA3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000311121.
Protein family/group databases
MEROPS	T01.974.
PTM databases
PhosphoSite	Q8TAA3.
Polymorphism databases
DMDM	108936006.
Proteomic databases
PaxDb	Q8TAA3.
PRIDE	Q8TAA3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308268; ENSP00000311121; ENSG00000154611. ENST00000343848; ENSP00000345584; ENSG00000154611. ENST00000415576; ENSP00000409284; ENSG00000154611.
GeneID	143471.
KEGG	hsa:143471.
UCSC	uc002kvo.3. human. uc002kvp.3. human. uc002kvq.3. human.
Organism-specific databases
CTD	143471.
GeneCards	GC18P023713.
HGNC	HGNC:22985. PSMA8.
HPA	CAB013455.
neXtProt	NX_Q8TAA3.
PharmGKB	PA134969470.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0638.
HOGENOM	HOG000091085.
HOVERGEN	HBG003005.
InParanoid	Q8TAA3.
KO	K02731.
OMA	NRAQVEC.
PhylomeDB	Q8TAA3.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_115566. Cell Cycle. REACT_116125. Disease. REACT_13505. Proteasome mediated degradation of PAK-2p34. REACT_21257. Metabolism of RNA. REACT_21300. Mitotic M-M/G1 phases. REACT_383. DNA Replication. REACT_578. Apoptosis. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_6900. Immune System. REACT_71. Gene Expression.
Gene expression databases
Bgee	Q8TAA3.
CleanEx	HS_PSMA8.
Genevestigator	Q8TAA3.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	143471.
NextBio	84715.

Entry information

Entry name

PSA7L_HUMAN

Accession

Primary (citable) accession number: Q8TAA3
Secondary accession number(s): B0YJ75 , Q8IVP4, Q8TA98, Q8TAA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	May 30, 2006
Last modified:	May 1, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.