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Q8TAA3

- PSA7L_HUMAN

UniProt

Q8TAA3 - PSA7L_HUMAN

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Protein

Proteasome subunit alpha type-7-like

Gene

PSMA8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. apoptotic process Source: Reactome
  6. cellular nitrogen compound metabolic process Source: Reactome
  7. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
  8. gene expression Source: Reactome
  9. mitotic cell cycle Source: Reactome
  10. mRNA metabolic process Source: Reactome
  11. negative regulation of apoptotic process Source: Reactome
  12. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  13. protein polyubiquitination Source: Reactome
  14. regulation of apoptotic process Source: Reactome
  15. regulation of cellular amino acid metabolic process Source: Reactome
  16. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  17. RNA metabolic process Source: Reactome
  18. small molecule metabolic process Source: Reactome
  19. viral process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_11063. Degradation of beta-catenin by the destruction complex.
REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_111178. ER-Phagosome pathway.
REACT_1156. Orc1 removal from chromatin.
REACT_118656. Activation of NF-kappaB in B cells.
REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_13565. Regulation of ornithine decarboxylase (ODC).
REACT_150471. Separation of Sister Chromatids.
REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_200766. degradation of AXIN.
REACT_200841. degradation of DVL.
REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_206597. Degradation of GLI2 by the proteasome.
REACT_228111. Hedgehog ligand biogenesis.
REACT_228209. Hh ligand biogenesis disease.
REACT_231645. GLI3 is processed to GLI3R by the proteasome.
REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_267605. Degradation of GLI1 by the proteasome.
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_9031. Vpu mediated degradation of CD4.
REACT_9453. Vif-mediated degradation of APOBEC3G.

Protein family/group databases

MEROPSiT01.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-7-like (EC:3.4.25.1)
Gene namesi
Name:PSMA8
Synonyms:PSMA7L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:22985. PSMA8.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProtKB
  3. nucleus Source: UniProt
  4. proteasome core complex, alpha-subunit complex Source: InterPro
  5. spermatoproteasome complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Proteasome subunit alpha type-7-likePRO_0000124149Add
BLAST

Proteomic databases

MaxQBiQ8TAA3.
PaxDbiQ8TAA3.
PRIDEiQ8TAA3.

PTM databases

PhosphoSiteiQ8TAA3.

Expressioni

Gene expression databases

BgeeiQ8TAA3.
CleanExiHS_PSMA8.
ExpressionAtlasiQ8TAA3. baseline and differential.
GenevestigatoriQ8TAA3.

Organism-specific databases

HPAiCAB013455.
HPA049377.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Component of the spermatoproteasome, a form of the proteasome specifically found in testis.By similarity

Protein-protein interaction databases

BioGridi126804. 34 interactions.
STRINGi9606.ENSP00000311121.

Structurei

3D structure databases

ProteinModelPortaliQ8TAA3.
SMRiQ8TAA3. Positions 5-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074753.
HOGENOMiHOG000091085.
HOVERGENiHBG003005.
InParanoidiQ8TAA3.
KOiK02731.
OMAiPLKMLDR.
OrthoDBiEOG71VSTG.
PhylomeDBiQ8TAA3.
TreeFamiTF106212.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q8TAA3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK
60 70 80 90 100
SVAKLQDERT VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ
110 120 130 140 150
SHKLTVEDPV TVEYITRFIA TLKQKYTQSN GRRPFGISAL IVGFDDDGIS
160 170 180 190 200
RLYQTDPSGT YHAWKANAIG RSAKTVREFL EKNYTEDAIA SDSEAIKLAI
210 220 230 240 250
KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI EKEKEEAEKK

KSKKSV

Note: Predicted but not yet described.

Length:256
Mass (Da):28,530
Last modified:May 30, 2006 - v3
Checksum:i6DD04535A98BE44A
GO
Isoform 2 (identifier: Q8TAA3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-83: Missing.

Show »
Length:212
Mass (Da):23,702
Checksum:i6C361094EFCC4BB2
GO
Isoform 3 (identifier: Q8TAA3-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.

Note: No experimental confirmation available.

Show »
Length:250
Mass (Da):27,843
Checksum:iC204707CF06D6D17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2121K → R in AAH28371. (PubMed:15489334)Curated
Sequence conflicti212 – 2121K → R in AAH28686. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei40 – 8344Missing in isoform 2. 1 PublicationVSP_005285Add
BLAST
Alternative sequencei77 – 826Missing in isoform 3. 1 PublicationVSP_018602

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF445014 Genomic DNA. Translation: ACA06053.1.
AC091021 Genomic DNA. No translation available.
AC016839 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01214.1.
BC028371 mRNA. Translation: AAH28371.1.
BC028686 mRNA. Translation: AAH28686.1.
BC042820 mRNA. Translation: AAH42820.1.
CCDSiCCDS32808.1. [Q8TAA3-1]
CCDS45842.1. [Q8TAA3-5]
CCDS45843.1. [Q8TAA3-2]
RefSeqiNP_001020267.1. NM_001025096.1. [Q8TAA3-5]
NP_001020268.1. NM_001025097.1. [Q8TAA3-2]
NP_653263.2. NM_144662.2. [Q8TAA3-1]
UniGeneiHs.464813.

Genome annotation databases

EnsembliENST00000308268; ENSP00000311121; ENSG00000154611. [Q8TAA3-1]
ENST00000343848; ENSP00000345584; ENSG00000154611. [Q8TAA3-2]
ENST00000415576; ENSP00000409284; ENSG00000154611. [Q8TAA3-5]
GeneIDi143471.
KEGGihsa:143471.
UCSCiuc002kvo.3. human. [Q8TAA3-2]
uc002kvp.3. human. [Q8TAA3-5]
uc002kvq.3. human. [Q8TAA3-1]

Polymorphism databases

DMDMi108936006.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF445014 Genomic DNA. Translation: ACA06053.1 .
AC091021 Genomic DNA. No translation available.
AC016839 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01214.1 .
BC028371 mRNA. Translation: AAH28371.1 .
BC028686 mRNA. Translation: AAH28686.1 .
BC042820 mRNA. Translation: AAH42820.1 .
CCDSi CCDS32808.1. [Q8TAA3-1 ]
CCDS45842.1. [Q8TAA3-5 ]
CCDS45843.1. [Q8TAA3-2 ]
RefSeqi NP_001020267.1. NM_001025096.1. [Q8TAA3-5 ]
NP_001020268.1. NM_001025097.1. [Q8TAA3-2 ]
NP_653263.2. NM_144662.2. [Q8TAA3-1 ]
UniGenei Hs.464813.

3D structure databases

ProteinModelPortali Q8TAA3.
SMRi Q8TAA3. Positions 5-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126804. 34 interactions.
STRINGi 9606.ENSP00000311121.

Chemistry

ChEMBLi CHEMBL2364701.

Protein family/group databases

MEROPSi T01.974.

PTM databases

PhosphoSitei Q8TAA3.

Polymorphism databases

DMDMi 108936006.

Proteomic databases

MaxQBi Q8TAA3.
PaxDbi Q8TAA3.
PRIDEi Q8TAA3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308268 ; ENSP00000311121 ; ENSG00000154611 . [Q8TAA3-1 ]
ENST00000343848 ; ENSP00000345584 ; ENSG00000154611 . [Q8TAA3-2 ]
ENST00000415576 ; ENSP00000409284 ; ENSG00000154611 . [Q8TAA3-5 ]
GeneIDi 143471.
KEGGi hsa:143471.
UCSCi uc002kvo.3. human. [Q8TAA3-2 ]
uc002kvp.3. human. [Q8TAA3-5 ]
uc002kvq.3. human. [Q8TAA3-1 ]

Organism-specific databases

CTDi 143471.
GeneCardsi GC18P023713.
HGNCi HGNC:22985. PSMA8.
HPAi CAB013455.
HPA049377.
neXtProti NX_Q8TAA3.
PharmGKBi PA134969470.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0638.
GeneTreei ENSGT00550000074753.
HOGENOMi HOG000091085.
HOVERGENi HBG003005.
InParanoidi Q8TAA3.
KOi K02731.
OMAi PLKMLDR.
OrthoDBi EOG71VSTG.
PhylomeDBi Q8TAA3.
TreeFami TF106212.

Enzyme and pathway databases

Reactomei REACT_11063. Degradation of beta-catenin by the destruction complex.
REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_111178. ER-Phagosome pathway.
REACT_1156. Orc1 removal from chromatin.
REACT_118656. Activation of NF-kappaB in B cells.
REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_13565. Regulation of ornithine decarboxylase (ODC).
REACT_150471. Separation of Sister Chromatids.
REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_200766. degradation of AXIN.
REACT_200841. degradation of DVL.
REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_206597. Degradation of GLI2 by the proteasome.
REACT_228111. Hedgehog ligand biogenesis.
REACT_228209. Hh ligand biogenesis disease.
REACT_231645. GLI3 is processed to GLI3R by the proteasome.
REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_267605. Degradation of GLI1 by the proteasome.
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_9031. Vpu mediated degradation of CD4.
REACT_9453. Vif-mediated degradation of APOBEC3G.

Miscellaneous databases

GenomeRNAii 143471.
NextBioi 84715.
PROi Q8TAA3.

Gene expression databases

Bgeei Q8TAA3.
CleanExi HS_PSMA8.
ExpressionAtlasi Q8TAA3. baseline and differential.
Genevestigatori Q8TAA3.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Testis.

Entry informationi

Entry nameiPSA7L_HUMAN
AccessioniPrimary (citable) accession number: Q8TAA3
Secondary accession number(s): B0YJ75
, Q8IVP4, Q8TA98, Q8TAA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 30, 2006
Last modified: November 26, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3