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Q8TAA3 (PSA7L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-7-like

EC=3.4.25.1
Gene names
Name:PSMA8
Synonyms:PSMA7L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
Proteasome
   Coding sequence diversityAlternative splicing
   Molecular functionHydrolase
Protease
Threonine protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Traceable author statement. Source: Reactome

RNA metabolic process

Traceable author statement. Source: Reactome

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

apoptotic process

Traceable author statement. Source: Reactome

cellular nitrogen compound metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

mitotic cell cycle

Traceable author statement. Source: Reactome

negative regulation of apoptotic process

Traceable author statement. Source: Reactome

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Traceable author statement. Source: Reactome

protein polyubiquitination

Traceable author statement. Source: Reactome

regulation of apoptotic process

Traceable author statement. Source: Reactome

regulation of cellular amino acid metabolic process

Traceable author statement. Source: Reactome

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

proteasome core complex, alpha-subunit complex

Inferred from electronic annotation. Source: InterPro

spermatoproteasome complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionthreonine-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q8TAA3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Predicted but not yet described.
Isoform 2 (identifier: Q8TAA3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     40-83: Missing.
Isoform 3 (identifier: Q8TAA3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Proteasome subunit alpha type-7-like
PRO_0000124149

Natural variations

Alternative sequence40 – 8344Missing in isoform 2.
VSP_005285
Alternative sequence77 – 826Missing in isoform 3.
VSP_018602

Experimental info

Sequence conflict2121K → R in AAH28371. Ref.4
Sequence conflict2121K → R in AAH28686. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 30, 2006. Version 3.
Checksum: 6DD04535A98BE44A

FASTA25628,530
        10         20         30         40         50         60 
MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT 

        70         80         90        100        110        120 
VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ SHKLTVEDPV TVEYITRFIA 

       130        140        150        160        170        180 
TLKQKYTQSN GRRPFGISAL IVGFDDDGIS RLYQTDPSGT YHAWKANAIG RSAKTVREFL 

       190        200        210        220        230        240 
EKNYTEDAIA SDSEAIKLAI KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI 

       250 
EKEKEEAEKK KSKKSV 

« Hide

Isoform 2 [UniParc].

Checksum: 6C361094EFCC4BB2
Show »

FASTA21223,702
Isoform 3 [UniParc].

Checksum: C204707CF06D6D17
Show »

FASTA25027,843

References

« Hide 'large scale' references
[1]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF445014 Genomic DNA. Translation: ACA06053.1.
AC091021 Genomic DNA. No translation available.
AC016839 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01214.1.
BC028371 mRNA. Translation: AAH28371.1.
BC028686 mRNA. Translation: AAH28686.1.
BC042820 mRNA. Translation: AAH42820.1.
RefSeqNP_001020267.1. NM_001025096.1.
NP_001020268.1. NM_001025097.1.
NP_653263.2. NM_144662.2.
UniGeneHs.464813.

3D structure databases

ProteinModelPortalQ8TAA3.
SMRQ8TAA3. Positions 5-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126804. 33 interactions.
STRING9606.ENSP00000311121.

Chemistry

ChEMBLCHEMBL2364701.

Protein family/group databases

MEROPST01.974.

PTM databases

PhosphoSiteQ8TAA3.

Polymorphism databases

DMDM108936006.

Proteomic databases

PaxDbQ8TAA3.
PRIDEQ8TAA3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308268; ENSP00000311121; ENSG00000154611. [Q8TAA3-1]
ENST00000343848; ENSP00000345584; ENSG00000154611. [Q8TAA3-2]
ENST00000415576; ENSP00000409284; ENSG00000154611. [Q8TAA3-5]
GeneID143471.
KEGGhsa:143471.
UCSCuc002kvo.3. human. [Q8TAA3-2]
uc002kvp.3. human. [Q8TAA3-5]
uc002kvq.3. human. [Q8TAA3-1]

Organism-specific databases

CTD143471.
GeneCardsGC18P023713.
HGNCHGNC:22985. PSMA8.
HPACAB013455.
HPA049377.
neXtProtNX_Q8TAA3.
PharmGKBPA134969470.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000091085.
HOVERGENHBG003005.
InParanoidQ8TAA3.
KOK02731.
OMAMLAKKIC.
OrthoDBEOG71VSTG.
PhylomeDBQ8TAA3.
TreeFamTF106212.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_115566. Cell Cycle.
REACT_116125. Disease.
REACT_13505. Proteasome mediated degradation of PAK-2p34.
REACT_21257. Metabolism of RNA.
REACT_21300. Mitotic M-M/G1 phases.
REACT_383. DNA Replication.
REACT_578. Apoptosis.
REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_6900. Immune System.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8TAA3.
BgeeQ8TAA3.
CleanExHS_PSMA8.
GenevestigatorQ8TAA3.

Family and domain databases

InterProIPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi143471.
NextBio84715.
PROQ8TAA3.

Entry information

Entry namePSA7L_HUMAN
AccessionPrimary (citable) accession number: Q8TAA3
Secondary accession number(s): B0YJ75 expand/collapse secondary AC list , Q8IVP4, Q8TA98, Q8TAA2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM