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Q8TAA3

- PSA7L_HUMAN

UniProt

Q8TAA3 - PSA7L_HUMAN

Protein

Proteasome subunit alpha type-7-like

Gene

PSMA8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (30 May 2006)
      Previous versions | rss
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    Functioni

    Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. apoptotic process Source: Reactome
    6. cellular nitrogen compound metabolic process Source: Reactome
    7. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
    8. gene expression Source: Reactome
    9. mitotic cell cycle Source: Reactome
    10. mRNA metabolic process Source: Reactome
    11. negative regulation of apoptotic process Source: Reactome
    12. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    13. protein polyubiquitination Source: Reactome
    14. regulation of apoptotic process Source: Reactome
    15. regulation of cellular amino acid metabolic process Source: Reactome
    16. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    17. RNA metabolic process Source: Reactome
    18. small molecule metabolic process Source: Reactome
    19. viral process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Protein family/group databases

    MEROPSiT01.974.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-7-like (EC:3.4.25.1)
    Gene namesi
    Name:PSMA8
    Synonyms:PSMA7L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:22985. PSMA8.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProt
    3. proteasome core complex, alpha-subunit complex Source: InterPro
    4. spermatoproteasome complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134969470.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Proteasome subunit alpha type-7-likePRO_0000124149Add
    BLAST

    Proteomic databases

    MaxQBiQ8TAA3.
    PaxDbiQ8TAA3.
    PRIDEiQ8TAA3.

    PTM databases

    PhosphoSiteiQ8TAA3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TAA3.
    BgeeiQ8TAA3.
    CleanExiHS_PSMA8.
    GenevestigatoriQ8TAA3.

    Organism-specific databases

    HPAiCAB013455.
    HPA049377.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.By similarity

    Protein-protein interaction databases

    BioGridi126804. 33 interactions.
    STRINGi9606.ENSP00000311121.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAA3.
    SMRiQ8TAA3. Positions 5-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    HOGENOMiHOG000091085.
    HOVERGENiHBG003005.
    InParanoidiQ8TAA3.
    KOiK02731.
    OMAiPLKMLDR.
    OrthoDBiEOG71VSTG.
    PhylomeDBiQ8TAA3.
    TreeFamiTF106212.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q8TAA3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK    50
    SVAKLQDERT VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ 100
    SHKLTVEDPV TVEYITRFIA TLKQKYTQSN GRRPFGISAL IVGFDDDGIS 150
    RLYQTDPSGT YHAWKANAIG RSAKTVREFL EKNYTEDAIA SDSEAIKLAI 200
    KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI EKEKEEAEKK 250
    KSKKSV 256

    Note: Predicted but not yet described.

    Length:256
    Mass (Da):28,530
    Last modified:May 30, 2006 - v3
    Checksum:i6DD04535A98BE44A
    GO
    Isoform 2 (identifier: Q8TAA3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         40-83: Missing.

    Show »
    Length:212
    Mass (Da):23,702
    Checksum:i6C361094EFCC4BB2
    GO
    Isoform 3 (identifier: Q8TAA3-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-82: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:250
    Mass (Da):27,843
    Checksum:iC204707CF06D6D17
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti212 – 2121K → R in AAH28371. (PubMed:15489334)Curated
    Sequence conflicti212 – 2121K → R in AAH28686. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei40 – 8344Missing in isoform 2. 1 PublicationVSP_005285Add
    BLAST
    Alternative sequencei77 – 826Missing in isoform 3. 1 PublicationVSP_018602

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF445014 Genomic DNA. Translation: ACA06053.1.
    AC091021 Genomic DNA. No translation available.
    AC016839 Genomic DNA. No translation available.
    CH471088 Genomic DNA. Translation: EAX01214.1.
    BC028371 mRNA. Translation: AAH28371.1.
    BC028686 mRNA. Translation: AAH28686.1.
    BC042820 mRNA. Translation: AAH42820.1.
    CCDSiCCDS32808.1. [Q8TAA3-1]
    CCDS45842.1. [Q8TAA3-5]
    CCDS45843.1. [Q8TAA3-2]
    RefSeqiNP_001020267.1. NM_001025096.1. [Q8TAA3-5]
    NP_001020268.1. NM_001025097.1. [Q8TAA3-2]
    NP_653263.2. NM_144662.2. [Q8TAA3-1]
    UniGeneiHs.464813.

    Genome annotation databases

    EnsembliENST00000308268; ENSP00000311121; ENSG00000154611. [Q8TAA3-1]
    ENST00000343848; ENSP00000345584; ENSG00000154611. [Q8TAA3-2]
    ENST00000415576; ENSP00000409284; ENSG00000154611. [Q8TAA3-5]
    GeneIDi143471.
    KEGGihsa:143471.
    UCSCiuc002kvo.3. human. [Q8TAA3-2]
    uc002kvp.3. human. [Q8TAA3-5]
    uc002kvq.3. human. [Q8TAA3-1]

    Polymorphism databases

    DMDMi108936006.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF445014 Genomic DNA. Translation: ACA06053.1 .
    AC091021 Genomic DNA. No translation available.
    AC016839 Genomic DNA. No translation available.
    CH471088 Genomic DNA. Translation: EAX01214.1 .
    BC028371 mRNA. Translation: AAH28371.1 .
    BC028686 mRNA. Translation: AAH28686.1 .
    BC042820 mRNA. Translation: AAH42820.1 .
    CCDSi CCDS32808.1. [Q8TAA3-1 ]
    CCDS45842.1. [Q8TAA3-5 ]
    CCDS45843.1. [Q8TAA3-2 ]
    RefSeqi NP_001020267.1. NM_001025096.1. [Q8TAA3-5 ]
    NP_001020268.1. NM_001025097.1. [Q8TAA3-2 ]
    NP_653263.2. NM_144662.2. [Q8TAA3-1 ]
    UniGenei Hs.464813.

    3D structure databases

    ProteinModelPortali Q8TAA3.
    SMRi Q8TAA3. Positions 5-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126804. 33 interactions.
    STRINGi 9606.ENSP00000311121.

    Chemistry

    ChEMBLi CHEMBL2364701.

    Protein family/group databases

    MEROPSi T01.974.

    PTM databases

    PhosphoSitei Q8TAA3.

    Polymorphism databases

    DMDMi 108936006.

    Proteomic databases

    MaxQBi Q8TAA3.
    PaxDbi Q8TAA3.
    PRIDEi Q8TAA3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308268 ; ENSP00000311121 ; ENSG00000154611 . [Q8TAA3-1 ]
    ENST00000343848 ; ENSP00000345584 ; ENSG00000154611 . [Q8TAA3-2 ]
    ENST00000415576 ; ENSP00000409284 ; ENSG00000154611 . [Q8TAA3-5 ]
    GeneIDi 143471.
    KEGGi hsa:143471.
    UCSCi uc002kvo.3. human. [Q8TAA3-2 ]
    uc002kvp.3. human. [Q8TAA3-5 ]
    uc002kvq.3. human. [Q8TAA3-1 ]

    Organism-specific databases

    CTDi 143471.
    GeneCardsi GC18P023713.
    HGNCi HGNC:22985. PSMA8.
    HPAi CAB013455.
    HPA049377.
    neXtProti NX_Q8TAA3.
    PharmGKBi PA134969470.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0638.
    HOGENOMi HOG000091085.
    HOVERGENi HBG003005.
    InParanoidi Q8TAA3.
    KOi K02731.
    OMAi PLKMLDR.
    OrthoDBi EOG71VSTG.
    PhylomeDBi Q8TAA3.
    TreeFami TF106212.

    Enzyme and pathway databases

    Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Miscellaneous databases

    GenomeRNAii 143471.
    NextBioi 84715.
    PROi Q8TAA3.

    Gene expression databases

    ArrayExpressi Q8TAA3.
    Bgeei Q8TAA3.
    CleanExi HS_PSMA8.
    Genevestigatori Q8TAA3.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Testis.

    Entry informationi

    Entry nameiPSA7L_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAA3
    Secondary accession number(s): B0YJ75
    , Q8IVP4, Q8TA98, Q8TAA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3