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Protein

Probable ribonuclease 11

Gene

RNASE11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82Proton acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonuclease 11 (EC:3.1.27.-)
Short name:
RNase 11
Gene namesi
Name:RNASE11
Synonyms:C14orf6
ORF Names:UNQ5832/PRO19669
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19269. RNASE11.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929509.

Polymorphism and mutation databases

BioMutaiRNASE11.
DMDMi31340020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000003090817 – 199Probable ribonuclease 11Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi98 ↔ 158By similarity
Disulfide bondi114 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TAA1.
PeptideAtlasiQ8TAA1.
PRIDEiQ8TAA1.

PTM databases

iPTMnetiQ8TAA1.
PhosphoSitePlusiQ8TAA1.

Expressioni

Gene expression databases

BgeeiENSG00000173464.
CleanExiHS_RNASE11.
ExpressionAtlasiQ8TAA1. baseline.
GenevisibleiQ8TAA1. HS.

Organism-specific databases

HPAiHPA003724.

Interactioni

Protein-protein interaction databases

BioGridi125785. 1 interactor.
IntActiQ8TAA1. 1 interactor.
STRINGi9606.ENSP00000338288.

Structurei

3D structure databases

ProteinModelPortaliQ8TAA1.
SMRiQ8TAA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 119Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY14. Eukaryota.
ENOG4111CPE. LUCA.
GeneTreeiENSGT00510000049471.
HOGENOMiHOG000137920.
HOVERGENiHBG055829.
InParanoidiQ8TAA1.
KOiK16633.
OMAiTGHSLMS.
OrthoDBiEOG091G0UF9.
PhylomeDBiQ8TAA1.
TreeFamiTF341929.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiView protein in InterPro
IPR029743. RNASE11.
IPR001427. RNaseA.
IPR023412. RNaseA_domain.
PANTHERiPTHR11437. PTHR11437. 1 hit.
PTHR11437:SF39. PTHR11437:SF39. 1 hit.
PfamiView protein in Pfam
PF00074. RnaseA. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000535. RNaseA. 1 hit.
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TAA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METFPLLLLS LGLVLAEASE STMKIIKEEF TDEEMQYDMA KSGQEKQTIE
60 70 80 90 100
ILMNPILLVK NTSLSMSKDD MSSTLLTFRS LHYNDPKGNS SGNDKECCND
110 120 130 140 150
MTVWRKVSEA NGSCKWSNNF IRSSTEVMRR VHRAPSCKFV QNPGISCCES
160 170 180 190
LELENTVCQF TTGKQFPRCQ YHSVTSLEKI LTVLTGHSLM SWLVCGSKL
Length:199
Mass (Da):22,427
Last modified:June 1, 2002 - v1
Checksum:iBA9DBA907292F1F0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0521955P → S. Corresponds to variant dbSNP:rs17113756Ensembl.1
Natural variantiVAR_05219674T → S. Corresponds to variant dbSNP:rs35818240Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161458 mRNA. Translation: CAD61920.1.
AK098687 mRNA. Translation: BAC05378.1.
AY358794 mRNA. Translation: AAQ89154.1.
BC025410 mRNA. Translation: AAH25410.1.
CCDSiCCDS9553.1.
RefSeqiNP_660293.1. NM_145250.3.
UniGeneiHs.112761.

Genome annotation databases

EnsembliENST00000398008; ENSP00000381092; ENSG00000173464.
ENST00000398009; ENSP00000381093; ENSG00000173464.
ENST00000432835; ENSP00000395210; ENSG00000173464.
ENST00000553849; ENSP00000451318; ENSG00000173464.
ENST00000555841; ENSP00000451563; ENSG00000173464.
ENST00000620912; ENSP00000482059; ENSG00000173464.
GeneIDi122651.
KEGGihsa:122651.
UCSCiuc010ahv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRNS11_HUMAN
AccessioniPrimary (citable) accession number: Q8TAA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families