Reviewed, UniProtKB/Swiss-Prot Q8TA03 (6PGD_DICDI)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	gnd
Synonyms:	PGD
ORF Names:	DDB_G0277885

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000327487

Sequences

	Sequence		Length	Mass (Da)
	Q8TA03-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: C3FD8A0F07DFC688	FASTA	493	53,891
	10 20 30 40 50 60 MTEAKGDIGL IGLAVMGENL VLNMESRGFT CSVYNRTTSK VDEFVQGRGK GKKFIGCHSL 70 80 90 100 110 120 ETLVQSLKTP RRVMLMVKAG EVVDHFIQLL LPLLEKGDII IDGGNSLYTD SDRRTKDLDA 130 140 150 160 170 180 KGILFIGTGV SGGEEGALLG PSIMPGGNPK AWEHVKPIFQ AISAKVQPGD QPCCDWVGDG 190 200 210 220 230 240 GAGHYVKMVH NGIEYGDMQL ISEAYFILKH YLGLSNDELQ KTFAKWNTGD LDSYLIEITA 250 260 270 280 290 300 DIFAKKCEKD PNTYVVDTIL DSAGQKGTGK WTAINALDVG IPLTLVAESV FARCVSSFKE 310 320 330 340 350 360 ERVKASTILA GPNPNEANKK FTGDKEQVIE AVRQALFASK LVSYAQGFTM MKAAAKEYKW 370 380 390 400 410 420 NLNYGNIALL WRGGCIIRST FLGEIKGAFD KNPQLDNLLT DCWFRDKLAA AQDGWRQVAS 430 440 450 460 470 480 ISVLHGIPTP AFTSALSYYD SYRCAKLSAN LVQAQRDYFG AHTFQLLDDP KGAPVHVNWT 490 GRGGSTHSTT YSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cyanobacterial gene in nonphotosynthetic protists -- an early chloroplast acquisition in eukaryotes?" Andersson J.O., Roger A.J. Curr. Biol. 12:115-119(2002) [PubMed: 11818061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF394516 Genomic DNA. Translation: AAL76326.1. AAFI02000023 Genomic DNA. Translation: EAL68115.1.
RefSeq	XP_642122.1.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
SMR	Q8TA03. Positions 4-484.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TA03.
Genome annotation databases
GeneID	8621331.
KEGG	ddi:DDB_0215011.
Organism-specific databases
dictyBase	DDB_G0277885. gnd.
Phylogenomic databases
eggNOG	KOG2653.
HOGENOM	HBG286913.
OMA	HTFRVLP.
PhylomeDB	Q8TA03.
Enzyme and pathway databases
BRENDA	1.1.1.44. 424.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_DICDI

Accession

Primary (citable) accession number: Q8TA03
Secondary accession number(s): Q54YT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 1, 2002
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)