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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (g6pd-1)
  2. Probable 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105NADPBy similarity1
Binding sitei105SubstrateBy similarity1
Active sitei187Proton acceptorBy similarity1
Active sitei194Proton donorBy similarity1
Binding sitei195SubstrateBy similarity1
Binding sitei266Substrate; via amide nitrogenBy similarity1
Binding sitei293SubstrateBy similarity1
Binding sitei456Substrate; shared with dimeric partnerBy similarity1
Binding sitei462Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADPBy similarity6
Nucleotide bindingi35 – 37NADPBy similarity3
Nucleotide bindingi77 – 79NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

ReactomeiR-DDI-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Synonyms:PGD
ORF Names:DDB_G0277885
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277885 gnd

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003274871 – 4936-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST493

Proteomic databases

PaxDbiQ8TA03
PRIDEiQ8TA03

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0215011

Structurei

3D structure databases

ProteinModelPortaliQ8TA03
SMRiQ8TA03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 133Substrate bindingBy similarity3
Regioni190 – 191Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2653 Eukaryota
COG0362 LUCA
InParanoidiQ8TA03
KOiK00033
OMAiQALYMGK
PhylomeDBiQ8TA03

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TA03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAKGDIGL IGLAVMGENL VLNMESRGFT CSVYNRTTSK VDEFVQGRGK
60 70 80 90 100
GKKFIGCHSL ETLVQSLKTP RRVMLMVKAG EVVDHFIQLL LPLLEKGDII
110 120 130 140 150
IDGGNSLYTD SDRRTKDLDA KGILFIGTGV SGGEEGALLG PSIMPGGNPK
160 170 180 190 200
AWEHVKPIFQ AISAKVQPGD QPCCDWVGDG GAGHYVKMVH NGIEYGDMQL
210 220 230 240 250
ISEAYFILKH YLGLSNDELQ KTFAKWNTGD LDSYLIEITA DIFAKKCEKD
260 270 280 290 300
PNTYVVDTIL DSAGQKGTGK WTAINALDVG IPLTLVAESV FARCVSSFKE
310 320 330 340 350
ERVKASTILA GPNPNEANKK FTGDKEQVIE AVRQALFASK LVSYAQGFTM
360 370 380 390 400
MKAAAKEYKW NLNYGNIALL WRGGCIIRST FLGEIKGAFD KNPQLDNLLT
410 420 430 440 450
DCWFRDKLAA AQDGWRQVAS ISVLHGIPTP AFTSALSYYD SYRCAKLSAN
460 470 480 490
LVQAQRDYFG AHTFQLLDDP KGAPVHVNWT GRGGSTHSTT YSI
Length:493
Mass (Da):53,891
Last modified:June 1, 2002 - v1
Checksum:iC3FD8A0F07DFC688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394516 Genomic DNA Translation: AAL76326.1
AAFI02000023 Genomic DNA Translation: EAL68115.1
RefSeqiXP_642122.1, XM_637030.1

Genome annotation databases

EnsemblProtistsiEAL68115; EAL68115; DDB_G0277885
GeneIDi8621331
KEGGiddi:DDB_G0277885

Similar proteinsi

Entry informationi

Entry namei6PGD_DICDI
AccessioniPrimary (citable) accession number: Q8TA03
Secondary accession number(s): Q54YT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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