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Q8TA03 (6PGD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating

EC=1.1.1.44
Gene names
Name:gnd
Synonyms:PGD
ORF Names:DDB_G0277885
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4934936-phosphogluconate dehydrogenase, decarboxylating
PRO_0000327487

Regions

Nucleotide binding12 – 176NADP By similarity
Nucleotide binding35 – 373NADP By similarity
Nucleotide binding77 – 793NADP By similarity
Region131 – 1333Substrate binding By similarity
Region190 – 1912Substrate binding By similarity

Sites

Active site1871Proton acceptor By similarity
Active site1941Proton donor By similarity
Binding site1051NADP By similarity
Binding site1051Substrate By similarity
Binding site1951Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity
Binding site2931Substrate By similarity
Binding site4561Substrate; shared with dimeric partner By similarity
Binding site4621Substrate; shared with dimeric partner By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TA03 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C3FD8A0F07DFC688

FASTA49353,891
        10         20         30         40         50         60 
MTEAKGDIGL IGLAVMGENL VLNMESRGFT CSVYNRTTSK VDEFVQGRGK GKKFIGCHSL 

        70         80         90        100        110        120 
ETLVQSLKTP RRVMLMVKAG EVVDHFIQLL LPLLEKGDII IDGGNSLYTD SDRRTKDLDA 

       130        140        150        160        170        180 
KGILFIGTGV SGGEEGALLG PSIMPGGNPK AWEHVKPIFQ AISAKVQPGD QPCCDWVGDG 

       190        200        210        220        230        240 
GAGHYVKMVH NGIEYGDMQL ISEAYFILKH YLGLSNDELQ KTFAKWNTGD LDSYLIEITA 

       250        260        270        280        290        300 
DIFAKKCEKD PNTYVVDTIL DSAGQKGTGK WTAINALDVG IPLTLVAESV FARCVSSFKE 

       310        320        330        340        350        360 
ERVKASTILA GPNPNEANKK FTGDKEQVIE AVRQALFASK LVSYAQGFTM MKAAAKEYKW 

       370        380        390        400        410        420 
NLNYGNIALL WRGGCIIRST FLGEIKGAFD KNPQLDNLLT DCWFRDKLAA AQDGWRQVAS 

       430        440        450        460        470        480 
ISVLHGIPTP AFTSALSYYD SYRCAKLSAN LVQAQRDYFG AHTFQLLDDP KGAPVHVNWT 

       490 
GRGGSTHSTT YSI 

« Hide

References

« Hide 'large scale' references
[1]"A cyanobacterial gene in nonphotosynthetic protists -- an early chloroplast acquisition in eukaryotes?"
Andersson J.O., Roger A.J.
Curr. Biol. 12:115-119(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]Bienvenut W.V., Veltman D.M., Insall R.H.
Submitted (JAN-2010) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 37-48; 305-320 AND 447-456, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF394516 Genomic DNA. Translation: AAL76326.1.
AAFI02000023 Genomic DNA. Translation: EAL68115.1.
RefSeqXP_642122.1. XM_637030.1.

3D structure databases

ProteinModelPortalQ8TA03.
SMRQ8TA03. Positions 4-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0215011.

Proteomic databases

PRIDEQ8TA03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0215011; DDB0215011; DDB_G0277885.
GeneID8621331.
KEGGddi:DDB_G0277885.

Organism-specific databases

dictyBaseDDB_G0277885. gnd.

Phylogenomic databases

eggNOGCOG0362.
KOK00033.
OMAKQQIGVI.
ProtClustDBPTZ00142.

Enzyme and pathway databases

UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8TA03.

Entry information

Entry name6PGD_DICDI
AccessionPrimary (citable) accession number: Q8TA03
Secondary accession number(s): Q54YT0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase