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Q8TA03

- 6PGD_DICDI

UniProt

Q8TA03 - 6PGD_DICDI

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd, PGD, DDB_G0277885
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051NADP By similarity
Binding sitei105 – 1051Substrate By similarity
Active sitei187 – 1871Proton acceptor By similarity
Active sitei194 – 1941Proton donor By similarity
Binding sitei195 – 1951Substrate By similarity
Binding sitei266 – 2661Substrate; via amide nitrogen By similarity
Binding sitei293 – 2931Substrate By similarity
Binding sitei456 – 4561Substrate; shared with dimeric partner By similarity
Binding sitei462 – 4621Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NADP By similarity
Nucleotide bindingi35 – 373NADP By similarity
Nucleotide bindingi77 – 793NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
  3. response to reactive oxygen species Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Synonyms:PGD
ORF Names:DDB_G0277885
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277885. gnd.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4934936-phosphogluconate dehydrogenase, decarboxylatingPRO_0000327487Add
BLAST

Proteomic databases

PRIDEiQ8TA03.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0215011.

Structurei

3D structure databases

ProteinModelPortaliQ8TA03.
SMRiQ8TA03. Positions 4-484.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 1333Substrate binding By similarity
Regioni190 – 1912Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiNSHEDKS.
PhylomeDBiQ8TA03.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TA03-1 [UniParc]FASTAAdd to Basket

« Hide

MTEAKGDIGL IGLAVMGENL VLNMESRGFT CSVYNRTTSK VDEFVQGRGK    50
GKKFIGCHSL ETLVQSLKTP RRVMLMVKAG EVVDHFIQLL LPLLEKGDII 100
IDGGNSLYTD SDRRTKDLDA KGILFIGTGV SGGEEGALLG PSIMPGGNPK 150
AWEHVKPIFQ AISAKVQPGD QPCCDWVGDG GAGHYVKMVH NGIEYGDMQL 200
ISEAYFILKH YLGLSNDELQ KTFAKWNTGD LDSYLIEITA DIFAKKCEKD 250
PNTYVVDTIL DSAGQKGTGK WTAINALDVG IPLTLVAESV FARCVSSFKE 300
ERVKASTILA GPNPNEANKK FTGDKEQVIE AVRQALFASK LVSYAQGFTM 350
MKAAAKEYKW NLNYGNIALL WRGGCIIRST FLGEIKGAFD KNPQLDNLLT 400
DCWFRDKLAA AQDGWRQVAS ISVLHGIPTP AFTSALSYYD SYRCAKLSAN 450
LVQAQRDYFG AHTFQLLDDP KGAPVHVNWT GRGGSTHSTT YSI 493
Length:493
Mass (Da):53,891
Last modified:June 1, 2002 - v1
Checksum:iC3FD8A0F07DFC688
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394516 Genomic DNA. Translation: AAL76326.1.
AAFI02000023 Genomic DNA. Translation: EAL68115.1.
RefSeqiXP_642122.1. XM_637030.1.

Genome annotation databases

EnsemblProtistsiDDB0215011; DDB0215011; DDB_G0277885.
GeneIDi8621331.
KEGGiddi:DDB_G0277885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394516 Genomic DNA. Translation: AAL76326.1 .
AAFI02000023 Genomic DNA. Translation: EAL68115.1 .
RefSeqi XP_642122.1. XM_637030.1.

3D structure databases

ProteinModelPortali Q8TA03.
SMRi Q8TA03. Positions 4-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0215011.

Proteomic databases

PRIDEi Q8TA03.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0215011 ; DDB0215011 ; DDB_G0277885 .
GeneIDi 8621331.
KEGGi ddi:DDB_G0277885.

Organism-specific databases

dictyBasei DDB_G0277885. gnd.

Phylogenomic databases

eggNOGi COG0362.
KOi K00033.
OMAi NSHEDKS.
PhylomeDBi Q8TA03.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .

Miscellaneous databases

PROi Q8TA03.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cyanobacterial gene in nonphotosynthetic protists -- an early chloroplast acquisition in eukaryotes?"
    Andersson J.O., Roger A.J.
    Curr. Biol. 12:115-119(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. Bienvenut W.V., Veltman D.M., Insall R.H.
    Submitted (JAN-2010) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 37-48; 305-320 AND 447-456, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry namei6PGD_DICDI
AccessioniPrimary (citable) accession number: Q8TA03
Secondary accession number(s): Q54YT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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