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Q8TA03

- 6PGD_DICDI

UniProt

Q8TA03 - 6PGD_DICDI

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei105 – 1051NADPBy similarity
    Binding sitei105 – 1051SubstrateBy similarity
    Active sitei187 – 1871Proton acceptorBy similarity
    Active sitei194 – 1941Proton donorBy similarity
    Binding sitei195 – 1951SubstrateBy similarity
    Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity
    Binding sitei293 – 2931SubstrateBy similarity
    Binding sitei456 – 4561Substrate; shared with dimeric partnerBy similarity
    Binding sitei462 – 4621Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NADPBy similarity
    Nucleotide bindingi35 – 373NADPBy similarity
    Nucleotide bindingi77 – 793NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway
    3. response to reactive oxygen species Source: dictyBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Synonyms:PGD
    ORF Names:DDB_G0277885
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0277885. gnd.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4934936-phosphogluconate dehydrogenase, decarboxylatingPRO_0000327487Add
    BLAST

    Proteomic databases

    PRIDEiQ8TA03.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0215011.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TA03.
    SMRiQ8TA03. Positions 4-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 1333Substrate bindingBy similarity
    Regioni190 – 1912Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    KOiK00033.
    OMAiNSHEDKS.
    PhylomeDBiQ8TA03.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TA03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEAKGDIGL IGLAVMGENL VLNMESRGFT CSVYNRTTSK VDEFVQGRGK    50
    GKKFIGCHSL ETLVQSLKTP RRVMLMVKAG EVVDHFIQLL LPLLEKGDII 100
    IDGGNSLYTD SDRRTKDLDA KGILFIGTGV SGGEEGALLG PSIMPGGNPK 150
    AWEHVKPIFQ AISAKVQPGD QPCCDWVGDG GAGHYVKMVH NGIEYGDMQL 200
    ISEAYFILKH YLGLSNDELQ KTFAKWNTGD LDSYLIEITA DIFAKKCEKD 250
    PNTYVVDTIL DSAGQKGTGK WTAINALDVG IPLTLVAESV FARCVSSFKE 300
    ERVKASTILA GPNPNEANKK FTGDKEQVIE AVRQALFASK LVSYAQGFTM 350
    MKAAAKEYKW NLNYGNIALL WRGGCIIRST FLGEIKGAFD KNPQLDNLLT 400
    DCWFRDKLAA AQDGWRQVAS ISVLHGIPTP AFTSALSYYD SYRCAKLSAN 450
    LVQAQRDYFG AHTFQLLDDP KGAPVHVNWT GRGGSTHSTT YSI 493
    Length:493
    Mass (Da):53,891
    Last modified:June 1, 2002 - v1
    Checksum:iC3FD8A0F07DFC688
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394516 Genomic DNA. Translation: AAL76326.1.
    AAFI02000023 Genomic DNA. Translation: EAL68115.1.
    RefSeqiXP_642122.1. XM_637030.1.

    Genome annotation databases

    EnsemblProtistsiDDB0215011; DDB0215011; DDB_G0277885.
    GeneIDi8621331.
    KEGGiddi:DDB_G0277885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394516 Genomic DNA. Translation: AAL76326.1 .
    AAFI02000023 Genomic DNA. Translation: EAL68115.1 .
    RefSeqi XP_642122.1. XM_637030.1.

    3D structure databases

    ProteinModelPortali Q8TA03.
    SMRi Q8TA03. Positions 4-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0215011.

    Proteomic databases

    PRIDEi Q8TA03.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0215011 ; DDB0215011 ; DDB_G0277885 .
    GeneIDi 8621331.
    KEGGi ddi:DDB_G0277885.

    Organism-specific databases

    dictyBasei DDB_G0277885. gnd.

    Phylogenomic databases

    eggNOGi COG0362.
    KOi K00033.
    OMAi NSHEDKS.
    PhylomeDBi Q8TA03.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Miscellaneous databases

    PROi Q8TA03.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cyanobacterial gene in nonphotosynthetic protists -- an early chloroplast acquisition in eukaryotes?"
      Andersson J.O., Roger A.J.
      Curr. Biol. 12:115-119(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. Bienvenut W.V., Veltman D.M., Insall R.H.
      Submitted (JAN-2010) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 37-48; 305-320 AND 447-456, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry namei6PGD_DICDI
    AccessioniPrimary (citable) accession number: Q8TA03
    Secondary accession number(s): Q54YT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3