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Protein
Submitted name:

Purine nucleoside phosphorylase

Gene

PNP

Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. purine-nucleoside phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16356.
BRENDAi2.4.2.1. 1455.

Names & Taxonomyi

Protein namesi
Submitted name:
Purine nucleoside phosphorylaseImported (EC:2.4.2.1Imported)
Gene namesi
Name:PNPImported
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

PTM / Processingi

Proteomic databases

PRIDEiQ8T9Z7.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ8T9Z7.
SMRiQ8T9Z7. Positions 3-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2820.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8T9Z7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNLLRHLKI SKEQITPVVL VVGDPGRVDK IKVVCDSYVD LAYNREYKSV
60 70 80 90 100
ECHYKGQKFL CVSHGVGSAG CAVCFEELCQ NGAKVIIRAG SCGSLQPDLI
110 120 130 140 150
KRGDICICNA AVREDRVSHL LIHGDFPAVG DFDVYDTLNK CAQELNVPVF
160 170 180 190 200
NGISVSSDMY YPNKIIPSRL EDYSKANAAV VEMELATLMV IGTLRKVKTG
210 220 230 240
GILIVDGCPF KWDEGDFDNN LVPHQLENMI KIALGACAKL ATKYA
Length:245
Mass (Da):26,858
Last modified:June 1, 2002 - v1
Checksum:i2159E9731C410A23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426159 Genomic DNA. Translation: AAL74412.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426159 Genomic DNA. Translation: AAL74412.1.

3D structure databases

ProteinModelPortaliQ8T9Z7.
SMRiQ8T9Z7. Positions 3-245.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ8T9Z7.
ChEMBLiCHEMBL5648.

Proteomic databases

PRIDEiQ8T9Z7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG2820.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16356.
BRENDAi2.4.2.1. 1455.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum."
    Kicska G.A., Tyler P.C., Evans G.B., Furneaux R.H., Kim K., Schramm V.L.
    J. Biol. Chem. 277:3219-3225(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8T9Z7_PLAFA
AccessioniPrimary (citable) accession number: Q8T9Z7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.