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Protein

Serine protease/ABC transporter B family protein tagD

Gene

tagD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338Charge relay systemBy similarity1
Active sitei384Charge relay systemBy similarity1
Active sitei652Charge relay systemBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1611 – 1618ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • transport Source: dictyBase

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processTransport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS08.A57.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease/ABC transporter B family protein tagD (EC:3.4.21.-)
Alternative name(s):
Serine protease/ABC transporter tagD
Gene namesi
Name:tagD
ORF Names:DDB_G0286123
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0286123. tagD.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei971 – 991HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1071 – 1091HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1116 – 1136HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1189 – 1209HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1210 – 1230HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1304 – 1324HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1327 – 1347HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: dictyBase

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000033036227 – 1825Serine protease/ABC transporter B family protein tagDAdd BLAST1799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi629N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi781N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi849N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi896N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1018N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1424N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1580N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1755N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8T9W1.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191427.

Structurei

3D structure databases

ProteinModelPortaliQ8T9W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini311 – 713Peptidase S8Add BLAST403
Domaini1075 – 1358ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini1576 – 1813ABC transporterPROSITE-ProRule annotationAdd BLAST238

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 97Asn-richAdd BLAST68
Compositional biasi1011 – 1047Gly-richAdd BLAST37
Compositional biasi1381 – 1384Poly-Glu4
Compositional biasi1387 – 1527Asn-richAdd BLAST141
Compositional biasi1477 – 1525Asp-richAdd BLAST49

Sequence similaritiesi

In the N-terminal section; belongs to the peptidase S8 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
KOG0058. Eukaryota.
COG1132. LUCA.
InParanoidiQ8T9W1.
PhylomeDBiQ8T9W1.

Family and domain databases

CDDicd04842. Peptidases_S8_Kp43_protease. 1 hit.
Gene3Di1.20.1560.10. 1 hit.
3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR008979. Galactose-bd-like_sf.
IPR027417. P-loop_NTPase.
IPR000209. Peptidase_S8/S53_dom.
IPR036852. Peptidase_S8/S53_dom_sf.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR034058. TagA/B/C/D_pept_dom.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF52743. SSF52743. 3 hits.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T9W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSNTNIRVL LVSGLILIFI FLGIKFEFIN KNNNDKIGIN RKLEFSYFTK
60 70 80 90 100
NNNNNNNNNF KQDQLKNKKD KRILLKNEII DTNIKKNIKK NNQKNNNEEI
110 120 130 140 150
FPNFISRLLK SNDDMEIQQF TYRKSHYIVQ FKDHINDETR EQFKQFLINT
160 170 180 190 200
DIVLDEQPYQ SHIVNYIPHD SFLVLMNDEQ SNLLSSKEWV SWIGEFEPSN
210 220 230 240 250
KIHLNYNEKS IGLPVYIKLS DSTNSLIQRW ENTLNSILTS YNSKVKLTLI
260 270 280 290 300
NQKKLKSIVY CNDESSSQSS CSLVSSEKLV YQWISEQSES NYIERSEKFQ
310 320 330 340 350
TANRLSPKAI FGTKDTLVNN DRIDIPLRGK GQILSIADTG LDGSHCFFSD
360 370 380 390 400
SNNPIPYNSV NLNHRKVVTY IGSLHDNEDY VDGHGTHVCG SAAGAPEDSS
410 420 430 440 450
LAISSFSGLA TDAKIAFFDL ASDPSNNEPV PPEDYSQLYQ PLYNAGARVH
460 470 480 490 500
GDSWGSLSIQ GYLGSYSDDA GSIDDFLYTH PDFIILRAAG NNEQYSSLLS
510 520 530 540 550
QATAKNVITV GAEQTTHESY TTDALEYSNF ETVAKSTLNS LCQSFDDKYC
560 570 580 590 600
TYTTAQCCTE YSTVKGLSGC CTSYIKNSYA SIFSSQPELY NENNICSFSS
610 620 630 640 650
KGPTHDGRLK PDIVAPGQYI TSARSNGANT TDQCGDGSLP NTNALLSESG
660 670 680 690 700
TSMATPLATA ATTILRQYLV DGYYPTGSIV ESNKLQPTGS LLKALMINNA
710 720 730 740 750
QLLNGTFPLS STNTNPSNAV FDTFAGANFV QGWGSLRMSE WLYVESSGVK
760 770 780 790 800
PKPSRWVGIG ELGKDKKASN WKEYSLSTGQ NVSYCFTYKP SSSGSNSGGI
810 820 830 840 850
PRIVATLVWT DPPSYSGAKL NLVNNLDLTM TNTESEFIFY SNSGGSSYNG
860 870 880 890 900
TKGTTLPLQD SINNVEGIIY TPINTKSEIS FRFIIAGTNI PIGPQNFSFV
910 920 930 940 950
FHGENGEFDW ADSCMQCNPD DTQPCFIENG VGSQTCGDDY LWGRCLVQSC
960 970 980 990 1000
NNNYNYNSIS DKCSKFLSYN YIVIIVAGGT MSLIITVLIL IKYMEYKENG
1010 1020 1030 1040 1050
NKFSLKEFFS GVLGTGKNVS GGGKGGSGGS GSGSGTLKDG TIDDGTGIHV
1060 1070 1080 1090 1100
RPKPKDAPVT PPDLYSLLSP FIIEITISTA CSLVATAASI LQPYYIGQII
1110 1120 1130 1140 1150
QDIPTTKGIG DLRDQFIIIF LLALLEFVFS TISSWISGIV NEKMVMRLQN
1160 1170 1180 1190 1200
KVFRALIAQD MGFFQKNSAA VLMNVLIVDT PMLRSSLTGI LLSVSVGICK
1210 1220 1230 1240 1250
FVGSLVFIFT ISWKLSLAFF ATVPVLAIVT QVQSKFTKRL TRRLLFHNSK
1260 1270 1280 1290 1300
ASQHGQESMV NMHVVSNYCK QDREIAKYSE QLMMVFQISR RLIINNTFAA
1310 1320 1330 1340 1350
SIKWLMVESL AFIILYFGAY LAIQKQFTVG LLVSFSLYIG YVIDSSTTLF
1360 1370 1380 1390 1400
GVYSSYVQCL ASATRVFLIL RSAPRKRTTL EEEELDNIID TNQDNNNNNN
1410 1420 1430 1440 1450
NDDISDSSSD DDDDNNNNKN SKNNKTKSGE SDDSSSEDAE YKKNKNKRNN
1460 1470 1480 1490 1500
GKMTTKLSNS PPLVGEGIDN NNNNNNDNNI NDDNNQQDPN NNNNEIDDDG
1510 1520 1530 1540 1550
DDDGDDDDEG EDENNNNNNN DDPNDNNGIE MLTEKQLRKR KRQMKKEFYK
1560 1570 1580 1590 1600
KTGISCLELN LIPSAYTELT ECRGEIEFKN VSFCYPSRAD VGVLYNIDLK
1610 1620 1630 1640 1650
FESGKCYGLV GPSGSGKSTL LELISRFYSL HPSGGKIYMD GIDIAKIRPS
1660 1670 1680 1690 1700
NLRSFVTNVH QHPFLFDATI SENIGYALDN PTQEDIIEAA KLANAHEFIQ
1710 1720 1730 1740 1750
SLPKQYDTML TDGGNLSGGQ KKRIAVARAI CAKRKIMLLD EITAELDPES
1760 1770 1780 1790 1800
EEAINKSIKV LTRGHTVVMV AHKVAAVRDC DKIFVLDKGQ IVEQGTHNQL
1810 1820
MAKKGKYYRM FAFSEDDDYA PLLVL
Length:1,825
Mass (Da):202,642
Last modified:June 1, 2002 - v1
Checksum:iE28160BC78613A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466309 Genomic DNA. Translation: AAL74253.1.
AAFI02000085 Genomic DNA. Translation: EAL64354.1.
RefSeqiXP_637863.1. XM_632771.1.

Genome annotation databases

EnsemblProtistsiEAL64354; EAL64354; DDB_G0286123.
GeneIDi8625460.
KEGGiddi:DDB_G0286123.

Entry informationi

Entry nameiTAGD_DICDI
AccessioniPrimary (citable) accession number: Q8T9W1
Secondary accession number(s): Q54M85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families