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Q8T9B6

- MESD_DROME

UniProt

Q8T9B6 - MESD_DROME

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Protein

LDLR chaperone boca

Gene

boca

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway.1 Publication

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: FlyBase
  2. low-density lipoprotein receptor particle metabolic process Source: FlyBase
  3. oogenesis Source: FlyBase
  4. proboscis development Source: FlyBase
  5. protein targeting to membrane Source: FlyBase
  6. Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone boca
Gene namesi
Name:boca
ORF Names:CG30498
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004132. boca.

Subcellular locationi

Endoplasmic reticulum 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. apical part of cell Source: FlyBase
  2. cytoplasm Source: FlyBase
  3. endoplasmic reticulum Source: FlyBase
  4. endoplasmic reticulum lumen Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi49 – 491W → R in boca1; induces lethality. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 180162LDLR chaperone bocaPRO_0000385021Add
BLAST

Proteomic databases

PaxDbiQ8T9B6.
PRIDEiQ8T9B6.

Expressioni

Gene expression databases

BgeeiQ8T9B6.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with Arrow and Yolkless.By similarity1 Publication

Protein-protein interaction databases

BioGridi71878. 74 interactions.
DIPiDIP-59112N.
STRINGi7227.FBpp0088027.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi94 – 10310Combined sources
Helixi106 – 12217Combined sources
Beta strandi127 – 1337Combined sources
Beta strandi136 – 1438Combined sources
Helixi144 – 1463Combined sources
Helixi147 – 1548Combined sources
Beta strandi160 – 1656Combined sources
Beta strandi168 – 1714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OFEX-ray2.29A/B88-172[»]
3OFFX-ray2.00A89-172[»]
ProteinModelPortaliQ8T9B6.
SMRiQ8T9B6. Positions 31-172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8T9B6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 16674Structured coreBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi177 – 1804Prevents secretion from ER

Domaini

The LDLR maturation activity resides in the N- and C-terminal unstructured regions.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
InParanoidiQ8T9B6.
OMAiAIFLFKD.
OrthoDBiEOG7XPZ76.
PhylomeDBiQ8T9B6.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T9B6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTRLVLLLL ALTPLVLAKK FKEEEKPAWA KKDIRDYSEA DLERLLDQWE
60 70 80 90 100
EDEEPLEDDE LPEHLRPQPK LDLSNLDSKS PEDLLKVSKK GRTLMTFVSV
110 120 130 140 150
TGNPTREESD TITKLWQTSL WNNHIQAERY MVDDNRAIFL FKDGTQAWDA
160 170 180
KDFLIEQERC KGVTIENKEY PGVNAKKDEL
Length:180
Mass (Da):21,002
Last modified:September 22, 2009 - v2
Checksum:iB51E057C901A6546
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151L → V in AAL39985. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59229.2.
AY069840 mRNA. Translation: AAL39985.1.
BT044294 mRNA. Translation: ACH92359.1.
RefSeqiNP_724578.1. NM_165541.2.
UniGeneiDm.14878.

Genome annotation databases

EnsemblMetazoaiFBtr0088953; FBpp0088027; FBgn0004132.
GeneIDi48986.
KEGGidme:Dmel_CG30498.
UCSCiCG30498-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59229.2 .
AY069840 mRNA. Translation: AAL39985.1 .
BT044294 mRNA. Translation: ACH92359.1 .
RefSeqi NP_724578.1. NM_165541.2.
UniGenei Dm.14878.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OFE X-ray 2.29 A/B 88-172 [» ]
3OFF X-ray 2.00 A 89-172 [» ]
ProteinModelPortali Q8T9B6.
SMRi Q8T9B6. Positions 31-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 71878. 74 interactions.
DIPi DIP-59112N.
STRINGi 7227.FBpp0088027.

Proteomic databases

PaxDbi Q8T9B6.
PRIDEi Q8T9B6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088953 ; FBpp0088027 ; FBgn0004132 .
GeneIDi 48986.
KEGGi dme:Dmel_CG30498.
UCSCi CG30498-RA. d. melanogaster.

Organism-specific databases

CTDi 48986.
FlyBasei FBgn0004132. boca.

Phylogenomic databases

eggNOGi NOG286690.
GeneTreei ENSGT00390000000993.
InParanoidi Q8T9B6.
OMAi AIFLFKD.
OrthoDBi EOG7XPZ76.
PhylomeDBi Q8T9B6.

Miscellaneous databases

EvolutionaryTracei Q8T9B6.
GenomeRNAii 48986.
NextBioi 839609.
PROi Q8T9B6.

Gene expression databases

Bgeei Q8T9B6.

Family and domain databases

InterProi IPR019330. Mesoderm_development_cand-2.
[Graphical view ]
Pfami PF10185. Mesd. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila."
    Culi J., Mann R.S.
    Cell 112:343-354(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARROW AND YOLKLESS, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-49.

Entry informationi

Entry nameiMESD_DROME
AccessioniPrimary (citable) accession number: Q8T9B6
Secondary accession number(s): A1Z712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3