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Protein

LDLR chaperone boca

Gene

boca

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: FlyBase
  • low-density lipoprotein receptor particle metabolic process Source: FlyBase
  • oogenesis Source: FlyBase
  • proboscis development Source: FlyBase
  • protein targeting to membrane Source: FlyBase
  • Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone boca
Gene namesi
Name:boca
ORF Names:CG30498
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004132. boca.

Subcellular locationi

  • Endoplasmic reticulum PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • apical part of cell Source: FlyBase
  • cytoplasm Source: FlyBase
  • endomembrane system Source: FlyBase
  • endoplasmic reticulum Source: FlyBase
  • endoplasmic reticulum lumen Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49W → R in boca1; induces lethality. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000038502119 – 180LDLR chaperone bocaAdd BLAST162

Proteomic databases

PaxDbiQ8T9B6.

Expressioni

Gene expression databases

BgeeiFBgn0004132.
GenevisibleiQ8T9B6. DM.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with Arrow and Yolkless.By similarity1 Publication

Protein-protein interaction databases

BioGridi71878. 74 interactors.
DIPiDIP-59112N.
STRINGi7227.FBpp0088027.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi94 – 103Combined sources10
Helixi106 – 122Combined sources17
Beta strandi127 – 133Combined sources7
Beta strandi136 – 143Combined sources8
Helixi144 – 146Combined sources3
Helixi147 – 154Combined sources8
Beta strandi160 – 165Combined sources6
Beta strandi168 – 171Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OFEX-ray2.29A/B88-172[»]
3OFFX-ray2.00A89-172[»]
ProteinModelPortaliQ8T9B6.
SMRiQ8T9B6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8T9B6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 166Structured coreBy similarityAdd BLAST74

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi177 – 180Prevents secretion from ER4

Domaini

The LDLR maturation activity resides in the N- and C-terminal unstructured regions.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4357. Eukaryota.
ENOG4111SG4. LUCA.
GeneTreeiENSGT00390000000993.
InParanoidiQ8T9B6.
OMAiGNPTREE.
OrthoDBiEOG091G0TTK.
PhylomeDBiQ8T9B6.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T9B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTRLVLLLL ALTPLVLAKK FKEEEKPAWA KKDIRDYSEA DLERLLDQWE
60 70 80 90 100
EDEEPLEDDE LPEHLRPQPK LDLSNLDSKS PEDLLKVSKK GRTLMTFVSV
110 120 130 140 150
TGNPTREESD TITKLWQTSL WNNHIQAERY MVDDNRAIFL FKDGTQAWDA
160 170 180
KDFLIEQERC KGVTIENKEY PGVNAKKDEL
Length:180
Mass (Da):21,002
Last modified:September 22, 2009 - v2
Checksum:iB51E057C901A6546
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15L → V in AAL39985 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59229.2.
AY069840 mRNA. Translation: AAL39985.1.
BT044294 mRNA. Translation: ACH92359.1.
RefSeqiNP_724578.1. NM_165541.2.
UniGeneiDm.14878.

Genome annotation databases

EnsemblMetazoaiFBtr0088953; FBpp0088027; FBgn0004132.
GeneIDi48986.
KEGGidme:Dmel_CG30498.
UCSCiCG30498-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59229.2.
AY069840 mRNA. Translation: AAL39985.1.
BT044294 mRNA. Translation: ACH92359.1.
RefSeqiNP_724578.1. NM_165541.2.
UniGeneiDm.14878.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OFEX-ray2.29A/B88-172[»]
3OFFX-ray2.00A89-172[»]
ProteinModelPortaliQ8T9B6.
SMRiQ8T9B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71878. 74 interactors.
DIPiDIP-59112N.
STRINGi7227.FBpp0088027.

Proteomic databases

PaxDbiQ8T9B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088953; FBpp0088027; FBgn0004132.
GeneIDi48986.
KEGGidme:Dmel_CG30498.
UCSCiCG30498-RA. d. melanogaster.

Organism-specific databases

CTDi48986.
FlyBaseiFBgn0004132. boca.

Phylogenomic databases

eggNOGiKOG4357. Eukaryota.
ENOG4111SG4. LUCA.
GeneTreeiENSGT00390000000993.
InParanoidiQ8T9B6.
OMAiGNPTREE.
OrthoDBiEOG091G0TTK.
PhylomeDBiQ8T9B6.

Miscellaneous databases

EvolutionaryTraceiQ8T9B6.
GenomeRNAii48986.
PROiQ8T9B6.

Gene expression databases

BgeeiFBgn0004132.
GenevisibleiQ8T9B6. DM.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMESD_DROME
AccessioniPrimary (citable) accession number: Q8T9B6
Secondary accession number(s): A1Z712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.