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Protein
Submitted name:

AT16536p

Gene

Buffy

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: FlyBase
  • cellular response to starvation Source: FlyBase
  • ectopic germ cell programmed cell death Source: FlyBase
  • extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  • negative regulation of apoptotic process Source: FlyBase
  • positive regulation of macroautophagy Source: FlyBase
  • positive regulation of programmed cell death Source: FlyBase
  • programmed cell death Source: FlyBase
  • regulation of apoptotic process Source: FlyBase

Names & Taxonomyi

Protein namesi
Submitted name:
AT16536pImported
Submitted name:
BuffyImported
Gene namesi
Name:BuffyImported
ORF Names:CG8238Imported, Dmel_CG8238Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0040491 Buffy

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei263 – 285HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0040491

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7227.FBpp0087182

Structurei

3D structure databases

SMRiQ8T8Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
KOiK20017
OMAiPRIYNGV
OrthoDBiEOG091G0JPB

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
IPR026309 BOK
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF48 PTHR11256:SF48, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PRINTSiPR01862 BCL2FAMILY
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequencei

Sequence statusi: Complete.

Q8T8Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTSYPTNN DNFSNGFPMA TTQSERLLQA QNRRKFSFPA TLHSASLLEV
60 70 80 90 100
GGGPKETTRR RLSNVSDAVT RKLSYTIGWK AAQIPAQDII SQGRCLCGHY
110 120 130 140 150
IKRRLRRSGL FNKKLGLQRI RSILGSTSMG IVRDVFPAVQ VLGDELERMH
160 170 180 190 200
PRIYNGVARQ ICRNPGGEFH TPDAVSLLLG AVGRELFRVE ITWSKVISLF
210 220 230 240 250
AIAGGLSVDC VRQGHPEYLP KLMESVSEVI EDELVPWINE NGGWSGINTH
260 270 280 290
VLPTTNSLNP LEWTTLVIGV VFGLILVFMI LRFIFNLIVP KIYQRFTNS
Length:299
Mass (Da):33,380
Last modified:June 1, 2002 - v1
Checksum:i7FB125A6B7323B23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58628.3
AY075219 mRNA Translation: AAL68086.1
RefSeqiNP_523702.1, NM_078978.2
UniGeneiDm.3310

Genome annotation databases

EnsemblMetazoaiFBtr0088077; FBpp0087182; FBgn0040491
GeneIDi36251
KEGGidme:Dmel_CG8238
UCSCiCG8238-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ8T8Y5_DROME
AccessioniPrimary (citable) accession number: Q8T8Y5
Secondary accession number(s): Q9V612
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health