Reviewed, UniProtKB/Swiss-Prot Q8T8P3 (ABCD2_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter D family member 2
Alternative name(s):
    ABC transporter ABCD.2

Gene names

Name:	abcD2
ORF Names:	DDB_G0293194

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 741	741	ABC transporter D family member 2		PRO_0000370850
Regions
	Transmembrane	39 – 59	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	260 – 280	21	Potential
	Domain	131 – 409	279	ABC transmembrane type-1
	Domain	518 – 740	223	ABC transporter
	Nucleotide binding	551 – 558	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8T8P3-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: D0882DE94D1EA623	FASTA	741	83,689
	10 20 30 40 50 60 MEANFVSSAL AGVQNNRSVK RSLDRLKSLF SSGQHQLNGS LGKKVFILLA LGGGAFSLVK 70 80 90 100 110 120 FYKAKNEGSS KQSGLIIDLK DKNSKKDKKR NVTRVDAVFF RRLAKIIRIV IPSLKSKEFL 130 140 150 160 170 180 SLLYLTALLF ARTMLSVSIA EIAGKNAQNL VARKWKEMRN GVLKFALVSI PASFVNASLK 190 200 210 220 230 240 YETDMLALRF RKRLSEYVHK EYLEGVNFYK ASHLGGADRI DNADQRVTSD IEQFCNSMSS 250 260 270 280 290 300 LYTTLFKPFL DLVLFTRKLV VVMGWGSPLL MFSYFIVSGF LKKLIMPPFG RLTAKQSELE 310 320 330 340 350 360 GNYRTVHQRL ITNAEEIAFY DGSRKERQII NLSFGDIYNH TGYVSYLKCL VGIFDGFLVK 370 380 390 400 410 420 YCASIVGYGC MVLPIYTGIR GSSGKDSTEL TKDYIRNTQL MVALSQAIGQ LVLLGNKVTL 430 440 450 460 470 480 MAGYTSRVSE LLEMIKSIKE RGTSQFTIVH EDDVPNPLTN SPVNDKYDTS VDMSSWLEDW 490 500 510 520 530 540 RKRSDQTRIV KRQQSNRSSA SGATTVYGGG TFVEGDFIKF ENVSIVSPEG KLLVENLDFQ 550 560 570 580 590 600 VMPNQNVMIT GPNGSGKSSL FRILGELWPL HCGTVIKPRK EDILFVPQKP YLVLGTLRDQ 610 620 630 640 650 660 IIYPHSHDDM KKLGVTDDDL QHLLATVDPN LTIIRQWNWD DTKDWFTALS GGQKQRIAMA 670 680 690 700 710 720 RLFYHRPQYA ILDECTSAVS DEVEGKIYET CKKLGITLFT VSHRPQLRAY HDYVLLFNGR 730 740 GGWEWSKIDH DDDHLKKPLS H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY077633 Genomic DNA. Translation: AAL78684.1. AAFI02000200 Genomic DNA. Translation: EAL60796.1.
RefSeq	XP_629252.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8T8P3.
Genome annotation databases
GeneID	3385873.
GenomeReviews	Gene locus abcD2 in contig CM000155_GR.
KEGG	ddi:DDB_0214891.
Organism-specific databases
dictyBase	DDB_G0293194. abcD2.
Phylogenomic databases
OMA	NERQISQ
Family and domain databases
InterPro	IPR010509. ABC_Ald_N. IPR011527. ABC_TM_1. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF06472. ABC_membrane_2. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCD2_DICDI

Accession

Primary (citable) accession number: Q8T8P3
Secondary accession number(s): Q54C14

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	June 1, 2002
Last modified:	November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)