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Protein
Submitted name:

UDP-galactose 4-epimerase

Gene

galE

Organism
Trypanosoma brucei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

NAD+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98NAD; via carbonyl oxygenCombined sources1
Binding sitei117NADCombined sources1
Binding sitei173NADCombined sources1
Binding sitei177NADCombined sources1
Binding sitei202UDPCombined sources1
Binding sitei203NAD; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12NADCombined sources3
Nucleotide bindingi32 – 36NADCombined sources5
Nucleotide bindingi75 – 76NADCombined sources2
Nucleotide bindingi220 – 222UDPCombined sources3
Nucleotide bindingi253 – 255UDPCombined sources3
Nucleotide bindingi266 – 268UDPCombined sources3
Nucleotide bindingi335 – 338UDPCombined sources4

GO - Molecular functioni

  • coenzyme binding Source: InterPro
  • nucleotide binding Source: UniProtKB-KW
  • UDP-glucose 4-epimerase activity Source: GeneDB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotationCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
UDP-galactose 4-epimeraseImported (EC:5.1.3.2Imported)
Gene namesi
Name:galEImported
OrganismiTrypanosoma bruceiImported
Taxonomic identifieri5691 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1169595.

PTM / Processingi

Proteomic databases

PaxDbiQ8T8E9.

Interactioni

Protein-protein interaction databases

STRINGi5691.EAN79244.

Chemistry databases

BindingDBiQ8T8E9.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GY8X-ray2.00A/B/C/D1-395[»]
2CNBX-ray2.70A/B/C/D1-395[»]
ProteinModelPortaliQ8T8E9.
SMRiQ8T8E9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8T8E9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 291EpimeraseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1371. Eukaryota.
COG1087. LUCA.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR001509. Epimerase_deHydtase.
IPR005886. GalE.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01179. galE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8T8E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLVCGGAG YIGSHFVRAL LRDTNHSVVI VDSLVGTHGK SDHVETRENV
60 70 80 90 100
ARKLQQSDGP KPPWADRYAA LEVGDVRNED FLNGVFTRHG PIDAVVHMCA
110 120 130 140 150
FLAVGESVRD PLKYYDNNVV GILRLLQAML LHKCDKIIFS SSAAIFGNPT
160 170 180 190 200
MGSVSTNAEP IDINAKKSPE SPYGESKLIA ERMIRDCAEA YGIKGICLRY
210 220 230 240 250
FNACGAHEDG DIGEHYQGST HLIPIILGRV MSDIAPDQRL TIHEDASTDK
260 270 280 290 300
RMPIFGTDYP TPDGTCVRDY VHVCDLASAH ILALDYVEKL GPNDKSKYFS
310 320 330 340 350
VFNLGTSRGY SVREVIEVAR KTTGHPIPVR ECGRREGDPA YLVAASDKAR
360 370 380 390
EVLGWKPKYD TLEAIMETSW KFQRTHPNGY ASQENGTPGG RTTKL
Length:395
Mass (Da):43,520
Last modified:June 1, 2002 - v1
Checksum:i9381DAE61A6BF5C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430490 Genomic DNA. Translation: CAD23117.1.

Genome annotation databases

GeneDBiTb927.11.2730:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430490 Genomic DNA. Translation: CAD23117.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GY8X-ray2.00A/B/C/D1-395[»]
2CNBX-ray2.70A/B/C/D1-395[»]
ProteinModelPortaliQ8T8E9.
SMRiQ8T8E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5691.EAN79244.

Chemistry databases

BindingDBiQ8T8E9.
ChEMBLiCHEMBL1169595.

Proteomic databases

PaxDbiQ8T8E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.11.2730:pep.

Phylogenomic databases

eggNOGiKOG1371. Eukaryota.
COG1087. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ8T8E9.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR001509. Epimerase_deHydtase.
IPR005886. GalE.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01179. galE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8T8E9_9TRYP
AccessioniPrimary (citable) accession number: Q8T8E9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.