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Protein
Submitted name:

UDP-galactose 4-epimerase

Gene

galE

Organism
Trypanosoma brucei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

NAD+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117NADCombined sources1
Binding sitei173NADCombined sources1
Binding sitei177NADCombined sources1
Binding sitei202UDPCombined sources1
Binding sitei203NAD; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12NADCombined sources3
Nucleotide bindingi32 – 36NADCombined sources5
Nucleotide bindingi75 – 76NADCombined sources2
Nucleotide bindingi98 – 99NADCombined sources2
Nucleotide bindingi220 – 222UDPCombined sources3
Nucleotide bindingi253 – 255UDPCombined sources3
Nucleotide bindingi266 – 268UDPCombined sources3
Nucleotide bindingi335 – 338UDPCombined sources4

GO - Molecular functioni

  • coenzyme binding Source: InterPro
  • nucleotide binding Source: UniProtKB-KW
  • UDP-glucose 4-epimerase activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported
LigandNADUniRule annotationCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
UDP-galactose 4-epimeraseImported (EC:5.1.3.2Imported)
Gene namesi
Name:galEImported
OrganismiTrypanosoma bruceiImported
Taxonomic identifieri5691 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1169595.
DrugBankiDB03435. Uridine-5'-Diphosphate.

PTM / Processingi

Proteomic databases

PaxDbiQ8T8E9.

Interactioni

Chemistry databases

BindingDBiQ8T8E9.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GY8X-ray2.00A/B/C/D1-395[»]
2CNBX-ray2.70A/B/C/D1-395[»]
ProteinModelPortaliQ8T8E9.
SMRiQ8T8E9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8T8E9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 291EpimeraseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1371. Eukaryota.
COG1087. LUCA.

Family and domain databases

CDDicd05247. UDP_G4E_1_SDR_e. 1 hit.
InterProiView protein in InterPro
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR005886. UDP_G4E.
PfamiView protein in Pfam
PF01370. Epimerase. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01179. galE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8T8E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLVCGGAG YIGSHFVRAL LRDTNHSVVI VDSLVGTHGK SDHVETRENV
60 70 80 90 100
ARKLQQSDGP KPPWADRYAA LEVGDVRNED FLNGVFTRHG PIDAVVHMCA
110 120 130 140 150
FLAVGESVRD PLKYYDNNVV GILRLLQAML LHKCDKIIFS SSAAIFGNPT
160 170 180 190 200
MGSVSTNAEP IDINAKKSPE SPYGESKLIA ERMIRDCAEA YGIKGICLRY
210 220 230 240 250
FNACGAHEDG DIGEHYQGST HLIPIILGRV MSDIAPDQRL TIHEDASTDK
260 270 280 290 300
RMPIFGTDYP TPDGTCVRDY VHVCDLASAH ILALDYVEKL GPNDKSKYFS
310 320 330 340 350
VFNLGTSRGY SVREVIEVAR KTTGHPIPVR ECGRREGDPA YLVAASDKAR
360 370 380 390
EVLGWKPKYD TLEAIMETSW KFQRTHPNGY ASQENGTPGG RTTKL
Length:395
Mass (Da):43,520
Last modified:June 1, 2002 - v1
Checksum:i9381DAE61A6BF5C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430490 Genomic DNA. Translation: CAD23117.1.

Genome annotation databases

GeneDBiTb927.11.2730:pep.

Similar proteinsi

Entry informationi

Entry nameiQ8T8E9_9TRYP
AccessioniPrimary (citable) accession number: Q8T8E9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources