Q8T8B9 (ACMSD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
EC=4.1.1.45

Alternative name(s):
Picolinate carboxylase

Gene names

Name:	acmsd
ORF Names:	Y71D11A.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS) By similarity. UniProtKB Q8TDX5
Catalytic activity	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.
Pathway	Secondary metabolite metabolism; quinolate metabolism.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the ACMSD family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	quinolinate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	aminocarboxymuconate-semialdehyde decarboxylase activity Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase		PRO_0000190983
Sites
	Metal binding	18	1	Zinc By similarity
	Metal binding	20	1	Zinc By similarity
	Metal binding	234	1	Zinc By similarity
	Metal binding	352	1	Zinc By similarity
	Binding site	59	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8T8B9 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 0F74E2BD2FD71D87	FASTA	401	45,746
	10 20 30 40 50 60 MPICEFSATS KSRKIDVHAH VLPKNIPDFQ EKFGYPGFVR LDHKEDGTTH MVKDGKLFRV 70 80 90 100 110 120 VEPNCFDTET RIADMNRANV NVQCLSTVPV MFSYWAKPAD TEIVARFVND DLLAECQKFP 130 140 150 160 170 180 DRLVPLGTLP MNDVQRAVEI FGKRIFFFEI WSPAKKSPEE VKRCVSMGIK GFEVGSHVAE 190 200 210 220 230 240 KSLDHRDFWP LYKLTESFKL STIMPGFCEF FENWGLTTKT PGICEELSVV LFVHPWDMHM 250 260 270 280 290 300 WDGRLDKYWM PWLVGMPSET AQAICSVLMG NILVLFPKLK LCFAHGGGAY PQIRGRVSHG 310 320 330 340 350 360 WNVRPDLCAG KCKVAPNKLD GLLWTDSLVH DPKALELLIN TVGKEHIVLG TDYPFPLGEL 370 380 390 400 EVGRVVEEYK PFSAKDREDL LWKNAVKMLD IDENLLFNKD F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'." Fukuoka S., Ishiguro K., Yanagihara K., Tanabe A., Egashira Y., Sanada H., Shibata K. J. Biol. Chem. 277:35162-35167(2002) [PubMed: 12140278] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB071420 mRNA. Translation: BAB86940.1. FO081503 Genomic DNA. Translation: CCD72053.1.
RefSeq	NP_001022935.1. NM_001027764.1.
UniGene	Cel.9282.
3D structure databases
ProteinModelPortal	Q8T8B9.
SMR	Q8T8B9. Positions 13-393.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8T8B9.
Proteomic databases
PRIDE	Q8T8B9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	Y71D11A.3b; Y71D11A.3b; Y71D11A.3.
GeneID	175280.
KEGG	cel:Y71D11A.3.
NMPDR	fig|6239.3.peg.8657.
UCSC	Y71D11A.3a. c. elegans.
Organism-specific databases
CTD	175280.
WormBase	Y71D11A.3b; CE32030; WBGene00022104.
Phylogenomic databases
eggNOG	meNOG05662.
GeneTree	EMGT00050000019685.
HOGENOM	HBG344784.
InParanoid	Q8T8B9.
OMA	GSHINTW.
Gene expression databases
ArrayExpress	Q8T8B9.
Family and domain databases
InterPro	IPR006992. Amidohydro_2. [Graphical view]
KO	K03392.
Pfam	PF04909. Amidohydro_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	887504.

Entry information

Entry name

ACMSD_CAEEL

Accession

Primary (citable) accession number: Q8T8B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project