Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynein light chain 1, axonemal

Gene

DNAL1

Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).By similarity

Miscellaneous

Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMotor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, axonemal
Alternative name(s):
Leucine-rich repeat dynein light chain
Gene namesi
Name:DNAL1
Synonyms:LRR-DLC
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona
Proteomesi
  • UP000008144 Componenti: Unassembled WGS sequence
  • UP000192222 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811351 – 190Dynein light chain 1, axonemalAdd BLAST190

Interactioni

Subunit structurei

Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.By similarity

Protein-protein interaction databases

STRINGi7719.ENSCINP00000011761.

Structurei

3D structure databases

ProteinModelPortaliQ8T888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 70LRR 1Add BLAST22
Repeati71 – 92LRR 2Add BLAST22
Repeati94 – 115LRR 3Add BLAST22
Repeati116 – 137LRR 4Add BLAST22
Domaini150 – 190LRRCTAdd BLAST41

Sequence similaritiesi

Belongs to the dynein light chain LC1-type family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016904.
HOGENOMiHOG000230603.
HOVERGENiHBG081457.
InParanoidiQ8T888.
KOiK10411.
OMAiLWISYNN.
OrthoDBiEOG091G0P8H.
TreeFamiTF323974.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequencei

Sequence statusi: Complete.

Q8T888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGTSIKEA LSKWEEKNSE KAAEAKEVKL YQMLPPIEKM DASLSTLTVC
60 70 80 90 100
EKLSLSTNCI EKIANLNGLK NLKILSLGRN NIKNLNGLEA VGDSLEELWI
110 120 130 140 150
SYNSIEKLKG IHVLKKLKVL LMSNNQVKDW GEFNKLQELP VLMELVFVGN
160 170 180 190
PLEEKHSAEG DWQDRVTKSL KALKKLDGTP IIKNDEEEED
Length:190
Mass (Da):21,406
Last modified:June 1, 2002 - v1
Checksum:i43A2374AFE92EADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080948 mRNA. Translation: BAB85851.1.
RefSeqiNP_001027642.1. NM_001032470.1.
UniGeneiCin.14200.

Genome annotation databases

EnsembliENSCINT00000011761; ENSCINP00000011761; ENSCING00000005688.
GeneIDi445644.
KEGGicin:445644.

Similar proteinsi

Entry informationi

Entry nameiDNAL1_CIOIN
AccessioniPrimary (citable) accession number: Q8T888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families