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Protein

Luminal-binding protein 2

Gene

bip2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_341046. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Luminal-binding protein 2
Short name:
BiP 2
Gene namesi
Name:bip2
ORF Names:DDB_G0276445
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276445.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  • endoplasmic reticulum lumen Source: UniProtKB-SubCell
  • phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 658638Luminal-binding protein 2PRO_0000327978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi611 – 6111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8T869.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0233663.

Structurei

3D structure databases

ProteinModelPortaliQ8T869.
SMRiQ8T869. Positions 32-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi655 – 6584Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
InParanoidiQ8T869.
KOiK09490.
OMAiMRNQIND.
PhylomeDBiQ8T869.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSIYALLC LLLLISFAAA AEKKEEEKKD YGSVIGIDLG TTYSCVGVFK
60 70 80 90 100
KGKVEIIPND QGNRITPSYV AFTETERLIG EAAKNQATLN PENTIFDIKR
110 120 130 140 150
LIGRRFDDEE VQRDMKLLPY KIVSKNNKPY VVVKVKGEEK TYSPEEISAM
160 170 180 190 200
ILGRMKEIAE ASLGKTVTHA VVTCPAYFND AQRAATKDAG VIAGLEVLRV
210 220 230 240 250
INEPTAAALA YGFDATGDKE KNILVYDLGG GTFDVSVLSI EDGVFEVRST
260 270 280 290 300
NGDTHLGGED FDQRVMKHFL TVFQKKTGKD ASKDKKSLQK LRRAAENAKR
310 320 330 340 350
ILSTSPQTQL EIENFFDGKD LIETLTRAKF EELNMDLFKK TLDPVKKVLE
360 370 380 390 400
DAKFKKSQIH EVVLVGGSTR IPKIQQLLKD FFNGKEPNRG VHPDEAVAYG
410 420 430 440 450
AAVQGGIFTN EEGTDTLVLL DIAPLTLGIE TVGGVMTALI PRGTFVPTKK
460 470 480 490 500
SQVFSTYQDN QDRVSIQIYE GERSMTKDNN LLGKFDLSGI PPAQRGVPQI
510 520 530 540 550
EVTFEMDVNG ILHVSAEDKA SGSKESITIT NDKERLSQAD IDRMVKEAAD
560 570 580 590 600
AADEDKAAKE RVEAKNTLEN YIYQIKNTIG DKDKIGGKIE SDDKETIETA
610 620 630 640 650
ISDALSWLDV NSSAEKEEFD EQYKILEKIV QPIFSKLYGA AGGSPNGAGE

DMPNHDEL
Length:658
Mass (Da):72,538
Last modified:June 1, 2002 - v1
Checksum:i5DE36C98EF85620A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69176.1.
RefSeqiXP_643155.1. XM_638063.1.

Genome annotation databases

EnsemblProtistsiDDB0233663; DDB0233663; DDB_G0276445.
GeneIDi8620562.
KEGGiddi:DDB_G0276445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69176.1.
RefSeqiXP_643155.1. XM_638063.1.

3D structure databases

ProteinModelPortaliQ8T869.
SMRiQ8T869. Positions 32-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233663.

Proteomic databases

PRIDEiQ8T869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0233663; DDB0233663; DDB_G0276445.
GeneIDi8620562.
KEGGiddi:DDB_G0276445.

Organism-specific databases

dictyBaseiDDB_G0276445.

Phylogenomic databases

eggNOGiCOG0443.
InParanoidiQ8T869.
KOiK09490.
OMAiMRNQIND.
PhylomeDBiQ8T869.

Enzyme and pathway databases

ReactomeiREACT_341046. Platelet degranulation.

Miscellaneous databases

PROiQ8T869.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
    Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
    Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.

Entry informationi

Entry nameiBIP2_DICDI
AccessioniPrimary (citable) accession number: Q8T869
Secondary accession number(s): Q551H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.