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Q8T869

- BIP2_DICDI

UniProt

Q8T869 - BIP2_DICDI

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Protein
Luminal-binding protein 2
Gene
bip2, DDB_G0276445
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_218007. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Luminal-binding protein 2
Short name:
BiP 2
Gene namesi
Name:bip2
ORF Names:DDB_G0276445
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276445.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 658638Luminal-binding protein 2
PRO_0000327978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi611 – 6111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8T869.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0167089.

Structurei

3D structure databases

ProteinModelPortaliQ8T869.
SMRiQ8T869. Positions 32-573.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi655 – 6584Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
KOiK09490.
OMAiTEWVESE.
PhylomeDBiQ8T869.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T869-1 [UniParc]FASTAAdd to Basket

« Hide

MNKSIYALLC LLLLISFAAA AEKKEEEKKD YGSVIGIDLG TTYSCVGVFK    50
KGKVEIIPND QGNRITPSYV AFTETERLIG EAAKNQATLN PENTIFDIKR 100
LIGRRFDDEE VQRDMKLLPY KIVSKNNKPY VVVKVKGEEK TYSPEEISAM 150
ILGRMKEIAE ASLGKTVTHA VVTCPAYFND AQRAATKDAG VIAGLEVLRV 200
INEPTAAALA YGFDATGDKE KNILVYDLGG GTFDVSVLSI EDGVFEVRST 250
NGDTHLGGED FDQRVMKHFL TVFQKKTGKD ASKDKKSLQK LRRAAENAKR 300
ILSTSPQTQL EIENFFDGKD LIETLTRAKF EELNMDLFKK TLDPVKKVLE 350
DAKFKKSQIH EVVLVGGSTR IPKIQQLLKD FFNGKEPNRG VHPDEAVAYG 400
AAVQGGIFTN EEGTDTLVLL DIAPLTLGIE TVGGVMTALI PRGTFVPTKK 450
SQVFSTYQDN QDRVSIQIYE GERSMTKDNN LLGKFDLSGI PPAQRGVPQI 500
EVTFEMDVNG ILHVSAEDKA SGSKESITIT NDKERLSQAD IDRMVKEAAD 550
AADEDKAAKE RVEAKNTLEN YIYQIKNTIG DKDKIGGKIE SDDKETIETA 600
ISDALSWLDV NSSAEKEEFD EQYKILEKIV QPIFSKLYGA AGGSPNGAGE 650
DMPNHDEL 658
Length:658
Mass (Da):72,538
Last modified:June 1, 2002 - v1
Checksum:i5DE36C98EF85620A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69176.1.
RefSeqiXP_643155.1. XM_638063.1.

Genome annotation databases

EnsemblProtistsiDDB0233663; DDB0233663; DDB_G0276445.
GeneIDi8620562.
KEGGiddi:DDB_G0276445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69176.1 .
RefSeqi XP_643155.1. XM_638063.1.

3D structure databases

ProteinModelPortali Q8T869.
SMRi Q8T869. Positions 32-573.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0167089.

Proteomic databases

PRIDEi Q8T869.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233663 ; DDB0233663 ; DDB_G0276445 .
GeneIDi 8620562.
KEGGi ddi:DDB_G0276445.

Organism-specific databases

dictyBasei DDB_G0276445.

Phylogenomic databases

eggNOGi COG0443.
KOi K09490.
OMAi TEWVESE.
PhylomeDBi Q8T869.

Enzyme and pathway databases

Reactomei REACT_218007. ATF6-alpha activates chaperone genes.

Miscellaneous databases

PROi Q8T869.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
    Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
    Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.

Entry informationi

Entry nameiBIP2_DICDI
AccessioniPrimary (citable) accession number: Q8T869
Secondary accession number(s): Q551H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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