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Q8T869 (BIP2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Luminal-binding protein 2

Short name=BiP 2
Gene names
Name:bip2
ORF Names:DDB_G0276445
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length658 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

phagocytic vesicle

Inferred from direct assay Ref.3PubMed 19482547. Source: dictyBase

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 658638Luminal-binding protein 2
PRO_0000327978

Regions

Motif655 – 6584Prevents secretion from ER Potential

Amino acid modifications

Glycosylation6111N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8T869 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 5DE36C98EF85620A

FASTA65872,538
        10         20         30         40         50         60 
MNKSIYALLC LLLLISFAAA AEKKEEEKKD YGSVIGIDLG TTYSCVGVFK KGKVEIIPND 

        70         80         90        100        110        120 
QGNRITPSYV AFTETERLIG EAAKNQATLN PENTIFDIKR LIGRRFDDEE VQRDMKLLPY 

       130        140        150        160        170        180 
KIVSKNNKPY VVVKVKGEEK TYSPEEISAM ILGRMKEIAE ASLGKTVTHA VVTCPAYFND 

       190        200        210        220        230        240 
AQRAATKDAG VIAGLEVLRV INEPTAAALA YGFDATGDKE KNILVYDLGG GTFDVSVLSI 

       250        260        270        280        290        300 
EDGVFEVRST NGDTHLGGED FDQRVMKHFL TVFQKKTGKD ASKDKKSLQK LRRAAENAKR 

       310        320        330        340        350        360 
ILSTSPQTQL EIENFFDGKD LIETLTRAKF EELNMDLFKK TLDPVKKVLE DAKFKKSQIH 

       370        380        390        400        410        420 
EVVLVGGSTR IPKIQQLLKD FFNGKEPNRG VHPDEAVAYG AAVQGGIFTN EEGTDTLVLL 

       430        440        450        460        470        480 
DIAPLTLGIE TVGGVMTALI PRGTFVPTKK SQVFSTYQDN QDRVSIQIYE GERSMTKDNN 

       490        500        510        520        530        540 
LLGKFDLSGI PPAQRGVPQI EVTFEMDVNG ILHVSAEDKA SGSKESITIT NDKERLSQAD 

       550        560        570        580        590        600 
IDRMVKEAAD AADEDKAAKE RVEAKNTLEN YIYQIKNTIG DKDKIGGKIE SDDKETIETA 

       610        620        630        640        650 
ISDALSWLDV NSSAEKEEFD EQYKILEKIV QPIFSKLYGA AGGSPNGAGE DMPNHDEL 

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: AX2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000015 Genomic DNA. Translation: EAL69176.1.
RefSeqXP_643155.1. XM_638063.1.

3D structure databases

ProteinModelPortalQ8T869.
SMRQ8T869. Positions 32-573.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0167089.

Proteomic databases

PRIDEQ8T869.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0233663; DDB0233663; DDB_G0276445.
GeneID8620562.
KEGGddi:DDB_G0276445.

Organism-specific databases

dictyBaseDDB_G0276445.

Phylogenomic databases

eggNOGCOG0443.
OMATEWVESE.
PhylomeDBQ8T869.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8T869.

Entry information

Entry nameBIP2_DICDI
AccessionPrimary (citable) accession number: Q8T869
Secondary accession number(s): Q551H9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase