Reviewed, UniProtKB/Swiss-Prot Q8T6J5 (ABCA2_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter A family member 2
Alternative name(s):
    ABC transporter ABCA.2

Gene names

Name:	abcA2
ORF Names:	DDB_G0267438

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1621 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1621	1621	ABC transporter A family member 2		PRO_0000363834
Regions
	Transmembrane	30 – 50	21	Potential
	Transmembrane	234 – 254	21	Potential
	Transmembrane	276 – 296	21	Potential
	Transmembrane	309 – 329	21	Potential
	Transmembrane	338 – 358	21	Potential
	Transmembrane	365 – 385	21	Potential
	Transmembrane	405 – 425	21	Potential
	Transmembrane	856 – 876	21	Potential
	Transmembrane	1033 – 1053	21	Potential
	Transmembrane	1083 – 1103	21	Potential
	Transmembrane	1111 – 1131	21	Potential
	Transmembrane	1142 – 1162	21	Potential
	Transmembrane	1183 – 1203	21	Potential
	Transmembrane	1227 – 1247	21	Potential
	Domain	484 – 717	234	ABC transporter 1
	Domain	1293 – 1528	236	ABC transporter 2
	Nucleotide binding	520 – 527	8	ATP 1 Potential
	Nucleotide binding	1331 – 1338	8	ATP 2 Potential
	Compositional bias	315 – 325	11	Poly-Leu
	Compositional bias	1266 – 1269	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	Q8T6J5-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: E1CA0A8FA25358A2	FASTA	1,621	181,214
	10 20 30 40 50 60 MGEFKSQLRT LLKKNLLLKG KSKCAICCEI LFPIIVILVI FAILVLVMAF KANYDPYNAS 70 80 90 100 110 120 NFVNRFENTV LLYGNADGAL NVEQLGVMNI LKNEVATAKN LNSTQIDQLF IEINDQTAME 130 140 150 160 170 180 AFFQNKSDFV FSAVWFNNSA LSSGTNPFQY NIRVDSDDVM DTEELIKEDD TSDSEVYVKK 190 200 210 220 230 240 RFVATQVAMD QAIFSYFGLN KTLNVKGQRY PDPWTELWQK WIQGRDGIFK DAGSVFITAA 250 260 270 280 290 300 LMIFGFRLIT DLVIEKETKI RESMKMMGLN DLAYFISWMI TSLVTALPVN LIISIILKGS 310 320 330 340 350 360 SVIHHTNWGV VIFTLILYLL TLLLLAFILS MFFDKSKFCG LLSFVIIIAI NIGGIFVAKY 370 380 390 400 410 420 DFAPGAKLFL CLISPIAIAC SIFAMSARDL EEINTYNWDM MVTENQVIGM LVLDIFFYIF 430 440 450 460 470 480 LVWYLDNVVT TEFGTKQKWY FLFTKKYWFP KKCNENGDEQ DIESTYQNED VEMTPVGVGQ 490 500 510 520 530 540 KVTISIRNLR KEYNTGDGLR VAVNDLYLDM YENQIHALLG PNGSGKSTTI GMMTGLTPPT 550 560 570 580 590 600 NGNAFVHGYG ILNQMSSVRK HLGVCPQTDI IWQQLTVLDH LKIYASLKGV SPSEIQREAE 610 620 630 640 650 660 KMAVEVDLGE KIHSQAGSLS GGQKRKLCLG IAFIGRSDVI FLDEVSSGMD PLSRRVVWDF 670 680 690 700 710 720 LLKYKKGRTI ILTTHYLEEA DYLGDRIAII SHGKLRCDGS SLYLKNKFGC GYLLTCSKIL 730 740 750 760 770 780 SSMNNFNAQQ VTEFIHNYIP EATILSNAGT ELSYRLPTAS LPHFAQFFRE FDDRLQSFGL 790 800 810 820 830 840 LTYGISVTTL EEVFLSLGRE AALEKGGFNI DQNENQDLEQ LRKSIAISST GVKAGQQFKG 850 860 870 880 890 900 LLIKRIKTSI KDAKSFFLTL VIPLVFIIGS IIMYKAMDKP QIFYNNATVP LTMNLGIYSG 910 920 930 940 950 960 LENNFVPMQS SNELNWENSL NSSPYFNKFR FIPQTENFED YLIEGKTNGS FAYKSSAGAI 970 980 990 1000 1010 1020 NFTLPIDVSS TTIDYTAFYN KDYIHSLPVH INLVNDAVLR KHNNIGIQVT NMPFKHVLSN 1030 1040 1050 1060 1070 1080 FDLASEGMNI SSIVYFIIIM MAGYALMAGS FAGNVAQERT NRVKRLLYIS GCKKYVYWLS 1090 1100 1110 1120 1130 1140 NLVWDYFFSF ILILLTTCIL AGIRENYKSQ FGLMFLCLIL FCVSVVPLSY LLSYRFASFG 1150 1160 1170 1180 1190 1200 KATGAITAIH FAIGIIFVII SLNLRIQVLI DQDVDFQKAA DAVDIVFCIL SPLFAYSRIL 1210 1220 1230 1240 1250 1260 FLVSEFPGSV RVGTLKVDNY WSMDYGGSPM IILAAHCIVW VSWIMILDYT PELIGKIRNP 1270 1280 1290 1300 1310 1320 KNIEAPPPPD DEDSDVTAER TRLLSVGPND EPLQFRNLHK LFPAVGKAAP KAAVYNSTLS 1330 1340 1350 1360 1370 1380 IPKGQTFGLL GLNGAGKTTT IAMLCGDIVP SSGEVTINGH DLITDRGQAL RSNGLCPQFD 1390 1400 1410 1420 1430 1440 ALITLLSARE QLTLYCAIKG VPEDKVKEVV EAFIKMMDLG AIANSNTGGY SGGNKRKTSL 1450 1460 1470 1480 1490 1500 SIAMLGNPSI VSLDEPSTGC DAVVRKYIWN VVSELAKDKV IILTSHSMAE VEALCYRMTI 1510 1520 1530 1540 1550 1560 MRDGKMKCLG SIQHIKSKFG AGYTFDVKFK KEYLDSGIQT VLKAIPNSIV LDEHDVMASF 1570 1580 1590 1600 1610 1620 EIPNPPDNPV KISTLFESLS HLTILDDYNV SQTSLESVFL KLTGASYEDR LNLNNQKHTS D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF465304 Genomic DNA. Translation: AAL85295.1. AAFI02000003 Genomic DNA. Translation: EAL73171.1.
RefSeq	XP_647274.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3398805.
GenomeReviews	Gene locus abcA2 in contig CM000150_GR.
KEGG	ddi:DDB_0191223.
Organism-specific databases
dictyBase	DDB_G0267438. abcA2.
Phylogenomic databases
OMA	KESEVEH
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCA2_DICDI

Accession

Primary (citable) accession number: Q8T6J5
Secondary accession number(s): Q55GB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2002
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)