Reviewed, UniProtKB/Swiss-Prot Q8T6J2 (ABCA5_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter A family member 5
Alternative name(s):
    ABC transporter ABCA.5

Gene names

Name:	abcA5
ORF Names:	DDB_G0274119

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1662 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1662	1662	ABC transporter A family member 5		PRO_0000363837
Regions
	Transmembrane	30 – 50	21	Potential
	Transmembrane	242 – 262	21	Potential
	Transmembrane	284 – 304	21	Potential
	Transmembrane	317 – 337	21	Potential
	Transmembrane	346 – 366	21	Potential
	Transmembrane	377 – 397	21	Potential
	Transmembrane	417 – 437	21	Potential
	Transmembrane	872 – 892	21	Potential
	Transmembrane	1052 – 1072	21	Potential
	Transmembrane	1102 – 1122	21	Potential
	Transmembrane	1130 – 1150	21	Potential
	Transmembrane	1163 – 1183	21	Potential
	Transmembrane	1201 – 1221	21	Potential
	Transmembrane	1246 – 1266	21	Potential
	Domain	505 – 739	235	ABC transporter 1
	Domain	1322 – 1557	236	ABC transporter 2
	Nucleotide binding	541 – 548	8	ATP 1 Potential
	Nucleotide binding	1360 – 1367	8	ATP 2 Potential
	Compositional bias	284 – 427	144	Ile-rich
	Compositional bias	486 – 491	6	Poly-Asn
	Compositional bias	1165 – 1222	58	Ile-rich
	Compositional bias	1284 – 1288	5	Poly-Pro
	Compositional bias	1314 – 1319	6	Poly-Gly
	Compositional bias	1651 – 1656	6	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q8T6J2-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: F4D61AC43E08855B	FASTA	1,662	185,773
	10 20 30 40 50 60 MGEKSSQLKT LLKKNLLLKS KSKCGICCEI VFPIIIVLLV FAILVLVQLF KPNYDLIKTT 70 80 90 100 110 120 QFSNRINENN IIIYGGKAGS LNVEQKGVID MMKFQLSNEL NKSISEVDVY FKEINDKSEM 130 140 150 160 170 180 ENYFQINSTQ VFGGIWFESN QLSSVANTTN TNTTTNSFKY SIRLDSNSVL DSNKVKDNGI 190 200 210 220 230 240 DSSDYLTKNW AYIQIAMDQA IFGYFGLDYK LVINGQRYPD PYVELWQKWI NGRESVFKSA 250 260 270 280 290 300 GSVFVSAALL IFTFRLVTEL VVEKETKIRE GMSIMGLNQY CYFISWIITS LVTALPIDLI 310 320 330 340 350 360 IIVILKGSQV IHSTSWIIVI VTLILYLLTL QLLAFIFSMF FDKSKFAGLL TFLTILLINI 370 380 390 400 410 420 CGIFIGEYEI INIHIKLLLC CIFSPIGIAC SFYIMSIRDI PDTISTINLN QVISEKQIIG 430 440 450 460 470 480 TFVFNIIFYT FLIWYLDKIV KTEYGTKEPW YFLFTKRYWT VGAGKINKKN KNKEYNYNDI 490 500 510 520 530 540 ESTIQNNNND NIEMVPIEVR NKTTISIRNL RKEFKTGDGL RIAVNDLNLD MFDGQIHGLL 550 560 570 580 590 600 GPNGSGKSTT ISMLTGLLSP TSGTAFILGN DITYQMNEIR KCTGVCLQTD IIWNQLTVLE 610 620 630 640 650 660 HLEIYASLKG ITNKKQIKSE SLKMANEIDL GEKLHTPAGS LSGGQKRKLC LGIAFIGRST 670 680 690 700 710 720 IIFLDEVSSG MDPSSRRKVW DFLLSHKKGK TIILTTHYLD EADYLSDRIS IISHGKLITD 730 740 750 760 770 780 GSSLFLKNKY GVGYLLTCSK SLNTIDQFNV DQVTQFIRDQ IPDVTVLSNA GSEISFRLPT 790 800 810 820 830 840 ASLPVFSKFF KDFDENLSNF HIDSYGISVT TLEEVFLKIG TDIDTDALSI ADGNGNDDEL 850 860 870 880 890 900 KRSIGVSSTG IKSKQQLKAL LIKRVKTSSK DFKAFLLSLL LPLLVIIGSI IVFKEVDNEV 910 920 930 940 950 960 IFYNNSTEPL TFSLLQQYGK NDIVPIQLAG TTSEFDFNKF LSNSPYFNQF QYLNNSINFN 970 980 990 1000 1010 1020 QYLINNYKQS SGSINFTIPL SSSLINNTTK VISYNSLFNF NYIHSWPVHV NLINDALLRN 1030 1040 1050 1060 1070 1080 HNGIGIECTS LPFDHILTSF QKASQGMNIQ SIVYFIVIMM AGFSLMAGSF AGSISQERTN 1090 1100 1110 1120 1130 1140 RIKRLLYISG CKKYIYWVSN LLWDYFFAFI LLLITCIILA IVDDKFNDQF GLFFLSLVLF 1150 1160 1170 1180 1190 1200 SLSIIPLSYL FSFKFSSFGK STGAITAIHF SIGVIMTIAM IILRIEVIIK NSSSLENIAD 1210 1220 1230 1240 1250 1260 IIDIVFNILS PLYAFSRVIF IISGFPGSLR LGALKIDDYW SLHYASTPII ILSVHVVVWT 1270 1280 1290 1300 1310 1320 IFILLIDYSP EFKGYLRNPK TILPPPPPID EDSDVSAERI RLESMSPIPS TDQGSGGGGD 1330 1340 1350 1360 1370 1380 MLQYKGLHKL FIGKGKNPNK NAVYNSTLGI PQGQTFGLLG LNGAGKTTTV SMLAGDILPT 1390 1400 1410 1420 1430 1440 SGQITINGHD LVTDRAQALR GVSVCPQFDA LITLLTAREQ LSLYCAIKGV PDDKISLVVE 1450 1460 1470 1480 1490 1500 AFIKMMDLGK IANSNTGGYS GGNKRKVSLS IAMLGNPSVV LIDEASSGCD PIIRYRQCQV 1510 1520 1530 1540 1550 1560 ISELGKNKVI ILTSHSMSEI QALCSRMTIM RDGQFKCLGS TQHIKSKFGA GYSVEVKFKK 1570 1580 1590 1600 1610 1620 SCLEVGIPQS LQCVLECFPN ATILDQHDLM ASLELPNPPE NPIKVSEIFN ILSTELSSIL 1630 1640 1650 1660 DDYSVSQTSL EQVFLKLTGA THEDRLNLNN QQQQQQTIPN SD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF465307 Genomic DNA. Translation: AAL85298.1. AC117070 Genomic DNA. Translation: AAM09305.2. AC123513 Genomic DNA. Translation: AAM44362.1. AAFI02000012 Genomic DNA. Translation: EAL69952.1.
RefSeq	XP_644031.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3395442.
GenomeReviews	Gene locus abcA5 in contig CM000151_GR.
KEGG	ddi:DDB_0191224.
Organism-specific databases
dictyBase	DDB_G0274119. abcA5.
Phylogenomic databases
OMA	FMISAFF
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCA5_DICDI

Accession

Primary (citable) accession number: Q8T6J2
Secondary accession number(s): Q555N5, Q8T162

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2002
Last modified:	November 24, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)