Q8T6J0 (ABCA7_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter A family member 7

Alternative name(s):
ABC transporter ABCA.7

Gene names

Name:	abcA7
ORF Names:	DDB_G0271140

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	839 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity Ref.1. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 839	839	ABC transporter A family member 7		PRO_0000363839
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	238 – 258	21	Helical; Potential
	Transmembrane	286 – 306	21	Helical; Potential
	Transmembrane	321 – 341	21	Helical; Potential
	Transmembrane	352 – 372	21	Helical; Potential
	Transmembrane	378 – 398	21	Helical; Potential
	Transmembrane	419 – 439	21	Helical; Potential
	Domain	525 – 756	232	ABC transporter
	Nucleotide binding	559 – 566	8	ATP Potential
	Compositional bias	495 – 499	5	Poly-Asp

Sequences

	Sequence		Length	Mass (Da)
	Q8T6J0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 8CF4B6F2AD1EBF23	FASTA	839	95,309
	10 20 30 40 50 60 MKYNANTSNQ FRAMFFKNAT FLKRQKCSLG VQIAIPMALV IVLVILKLWI ESQIENNSGP 70 80 90 100 110 120 VGDSSGDDIM GSYISYKFDY MQGWFYTINP NNITNIGYKD GYGNGTGLLG GINQYEIYWN 130 140 150 160 170 180 GSDLWVPYTV AVESGQKMND MVLAQKQQLG QSSMGPLTFP IAGIQFNEFN PQNNLIDLTI 190 200 210 220 230 240 TCEQQIRYAY NNFENNLIYV LSQIQTSFIN YLLNGNGVVV KTQISTLPYI YKSQQFDIAS 250 260 270 280 290 300 LLGGSFFPFA LSFVLPLFMY SIVYEKQEKL RDLSLMMGLK MRNYWIMTFI FNFLTYVVIV 310 320 330 340 350 360 SVISLICSAA KVSLFVKGSP FALFLLLFLW GLSMVSFAFF LSTFFKRTRA ASIFGYFFVM 370 380 390 400 410 420 VMVNLNSTLS LFNTSVPVFY YWVPILAFSR GISTLCGLCG NGLCPPLSQY TWDFELSRIL 430 440 450 460 470 480 FWLFIDTIVY LTLAVYLDKV LPREFGVPSH PLFFIKDLKE LFSKKGKYRK LRDGDGINEK 490 500 510 520 530 540 TKLINEYTID GINNDDDDDG LMDEDVKKER DMIVKGEYNP EEMTLIVQGL RKQFPGRPKP 550 560 570 580 590 600 ALSNLYLSVK KGEVLGYLGP NGAGKTTSIS ILTGLYTPTS GTAHIAGLDI RYDMDKIHQV 610 620 630 640 650 660 IGVVMQFDVL WEDLTCEETI LYYTRLKGTP KSIEFESTHN ILKEVNLLDV KDRFVKELSG 670 680 690 700 710 720 GMKRRLSFAI AMTGESSIIF LDEPTTGLSI ETRKDLWGTI NELKKNRSII LTTHSMQEAD 730 740 750 760 770 780 ILSDRIAIVS QGKLQCIGTQ THLKQKFGDG YSVRIDIQED YQNTHNPTDL IKSFSPSATL 790 800 810 820 830 SETFNGSYVY RLPKDSIISD LYEYLVLNKE QYHLQEWSLS QTSLEDVFLK ISANDDTVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF465309 Genomic DNA. Translation: AAL85300.1. AAFI02000006 Genomic DNA. Translation: EAL71700.1.
RefSeq	XP_645693.1. XM_640601.1.
3D structure databases
ProteinModelPortal	Q8T6J0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0215337; DDB0215337; DDB_G0271140.
GeneID	8617886.
GenomeReviews	Gene locus abcA7 in contig CM000151_GR.
KEGG	ddi:DDB_G0271140.
Organism-specific databases
dictyBase	DDB_G0271140. abcA7.
Phylogenomic databases
eggNOG	KOG0059.
GeneTree	EPrGT00050000002981.
HOGENOM	HBG082640.
InParanoid	Q8T6J0.
OMA	SKVKTVT.
ProtClustDB	CLSZ2429466.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCA7_DICDI

Accession

Primary (citable) accession number: Q8T6J0
Secondary accession number(s): Q55BB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2002
Last modified:	September 21, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)