Reviewed, UniProtKB/Swiss-Prot Q8T6H8 (ABCC1_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter C family member 1
Alternative name(s):
    ABC transporter ABCC.1

Gene names

Name:	abcC1
ORF Names:	DDB_G0280541

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Coiled coil Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1359	1359	ABC transporter C family member 1		PRO_0000363847
Regions
	Transmembrane	119 – 139	21	Potential
	Transmembrane	147 – 167	21	Potential
	Transmembrane	214 – 234	21	Potential
	Transmembrane	244 – 264	21	Potential
	Transmembrane	332 – 352	21	Potential
	Transmembrane	363 – 383	21	Potential
	Transmembrane	773 – 793	21	Potential
	Transmembrane	819 – 839	21	Potential
	Transmembrane	884 – 904	21	Potential
	Transmembrane	906 – 926	21	Potential
	Transmembrane	999 – 1021	23	Potential
	Domain	111 – 394	284	ABC transmembrane type-1 1
	Domain	470 – 690	221	ABC transporter 1
	Domain	763 – 1061	299	ABC transmembrane type-1 2
	Domain	1116 – 1350	235	ABC transporter 2
	Nucleotide binding	502 – 509	8	ATP Potential
	Nucleotide binding	1150 – 1157	8	ATP Potential
	Coiled coil	1073 – 1102	30	Potential
	Compositional bias	420 – 426	7	Poly-Glu
	Compositional bias	697 – 702	6	Poly-Gln
	Compositional bias	722 – 725	4	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q8T6H8-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: F746150C99C7578A	FASTA	1,359	155,511
	10 20 30 40 50 60 MLKNLRNKIK EKLTYSLLSS QEFDNNKDYY QQPCPEDNAN LWSRLTFGWA QRMLISGYFN 70 80 90 100 110 120 GPLEMSDIND LPKDIKVQSS IQLLNNINLN KNNNSRWPLI KHFYKQFLYR NKLTIFLQIL 130 140 150 160 170 180 TNILSILSPL SLKYFIQFIQ STNKERSFLA GIGYCILLLI ASFSYTFSQQ LLMWFAMKSS 190 200 210 220 230 240 LEIKGCLSIK VYEKTLKLTT CGGKNYNPGS IMNLLSVDVG IISNFFWIEH MGIFAFSSQM 250 260 270 280 290 300 IGLLALLCWV IGWSGLVGFA IMVITFPINT YIGSKIGKNL KESMGYSDKR TNLTSEFING 310 320 330 340 350 360 IRFLKMYAWE KLFLDRIEEQ RSLQLKYLYK RMIFWIFAEM MKQAVNAIVL VLTFIVYSIN 370 380 390 400 410 420 NEITLEVAFT TISIFVSLRI PLLRLPNSIQ QLQSLIPIAK RVEDFLKSPE IQQNHSSNRE 430 440 450 460 470 480 EEEEDEYDDD INSDGDISIH NGSFNWNQVD SNGSGNGNGN QQQQQQQQQQ QQQQQQQQQQ 490 500 510 520 530 540 QSYTLNNINF KAPAGKLTII CGVVGSGKTS LVSGLIGEIY KVSGRVNTPN KISFTTQQSF 550 560 570 580 590 600 LLSTSLRENI LFGNEMNLER YKKVIEACCL APDLLQLAAK DLTEIGERGI NLSGGQKQRI 610 620 630 640 650 660 SLARALYANS DCYILDEPLS AVDPEVATHL FNHCIQGMMN DKTRILITHQ LQFIPSADHI 670 680 690 700 710 720 VVVDNGKLVQ GTYSELKSKG IDFESIMKTK KLNIDNQQQQ QQHEKENDIV LSDEDSNNSI 730 740 750 760 770 780 KNNNNISNLI DIDEVISDEN DSNLIERSKL LVDEDRNEGS VNLRVYKEYF KHGSSIPLFI 790 800 810 820 830 840 MTCIVYMISQ IIYQMSDFWL STWSQRSIPD KTDKYYISIY LLFIVGFIIF LVIRYFMMAH 850 860 870 880 890 900 VTFSASKNLH QSLLKSVGFA SCQFFDTNPS GRILNRFSKD ISDVDLLLFD LFSDVLYCGS 910 920 930 940 950 960 TVLVSIGIMI YISPLIIIPF LLLIGIYYFI QRLYTESSRE LKRLEAISRS PIFSLLQESF 970 980 990 1000 1010 1020 NGLVTIRSYK QQNKFISMMQ DRINTNHRLS YYGFSVHRWV AVRLEFISSI VVFLAAFFSL 1030 1040 1050 1060 1070 1080 FNSNAGFSVL SVTTALGMCS YLNWTVRQMV ELEVKMNSVE RIESYLNIPK EGNSKINFFR 1090 1100 1110 1120 1130 1140 NEQQEEEEEE EEEFDFDNDD YDGFKLSKKW LTKGEIEFRN VEIKYGHSGE SSLKNFTLKI 1150 1160 1170 1180 1190 1200 NQKDHIGIVG RTGAGKSTIG NGLFRMVECS KGSILIDGVD ISKIGLHELR SSLGIVPQDP 1210 1220 1230 1240 1250 1260 FIFSGTIRLN IDPFNKYTDS EIWVALEKVK LKSTISSMPL KLETMIEEGG DGLSFGQKQL 1270 1280 1290 1300 1310 1320 LCLSRTILKN SKVVLMDEAT SGIDYVTSDL IKQTINNCFK NCTMLTIAHR LDTIIDSTKI 1330 1340 1350 AVIDKGKLIE YDTPNNLIEN QESRFSKLVK HHHNLFKEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF474333 Genomic DNA. Translation: AAL85704.1. AAFI02000037 Genomic DNA. Translation: EAL67072.1.
RefSeq	XP_641050.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ModBase	Search...
Genome annotation databases
GeneID	3392168.
GenomeReviews	Gene locus abcC1 in contig CM000152_GR.
KEGG	ddi:DDB_0215360.
Organism-specific databases
dictyBase	DDB_G0280541. abcC1.
Phylogenomic databases
OMA	WANELET
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCC1_DICDI

Accession

Primary (citable) accession number: Q8T6H8
Secondary accession number(s): Q54V81

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2002
Last modified:	November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)